Genetics & Genomics: Integration into Clinical Practice



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Cleveland Clinic Genomic Medicine Institute Genetics & Genomics: Integration into Clinical Practice September 10, 2015 InterContinental Hotel & Conference Center Cleveland, OH 44106 Register online at www.ccfcme.org/genetics

An Invitation from Dr. Charis Eng Dear Colleagues, I am delighted to invite you to the Genomic Medicine Institute s 3rd annual Genetics Education Symposium, which marks the 10th anniversary of our. We are planning an engaging agenda, which includes presentations such as: History and Progress of Medical Genetics Principles of Pharmacogenomics Tumor Genetic Profiling Reimbursement of Genetic Testing This day provides an opportunity to connect with healthcare professionals and share knowledge and experience supporting the integration of genetic and genomic information to enhance the quality of patient care. I am sure you will enjoy this day of education and discussion centered on our common interests in genetic and genomic medicine. We will close the day with my presentation on wine and genetics, followed by a reception! Sincerely, Sondra J and Stephen R Hardis Chair of Cancer Genomic Medicine Chair, Genomic Medicine Institute Director, Planning Committee (Course Director) Peggy Bird Kim Linger Ryan Noss, MS, LGC Amy Shealy, MS, LGC

Activity Director Sondra J and Stephen R Hardis Chair of Cancer Genomic Medicine Chair, Genomic Medicine Institute Director, Cleveland Clinic Faculty Angelika Erwin, MD, PhD J. Kevin Hicks, Pharm.D., PhD Department of Pharmacy Guest Faculty Stephen R. Lucht, MD Corporate Medical Director, CareSource Rocio Moran, MD Division Director, Genetics MetroHealth Joanne Ngeow, MBBS, MRCP, MPH Head, Cancer Genetics Service, Division of Medical Oncology National Cancer Centre Singapore Anthony Wynshaw-Boris, MD, PhD Chair, Department of Genetics and Genome Sciences Case Western Reserve University, School of Medicine University Hospitals Case Medical Center Jessica Marquard, MS, LGC Timothy Moss, MD, PhD Ryan Noss, MS, LGC Jacquelyn Riley, MS, LGC Molecular Pathology Laboratory Bruce Rogen, MD, MPH, FACP Chief Medical Officer, Cleveland Clinic Employee Health Plan Amy Shealy, MS, LGC Marissa Smith, MS, LGC Davendra Sohal, MD, MPH Hematology and Oncology Daniel Sullivan, MD Internal Medicine W.H. Wilson Tang, MD Center for Clinical Genomics Course Overview This program, presented by Cleveland Clinic s Genomic Medicine Institute, will provide the opportunity to review the latest advances in genetics and genomics and provide state-of-the-art information to healthcare providers treating patients with genetic conditions. Expert Cleveland Clinic and guest faculty will present case-based presentations highlighting the integration of genetics and genomics into clinical practice across multiple disciplines. Target Audience This activity is designed for healthcare providers specializing in Primary Care, Cardiology, Genetics, Oncology, Pediatrics and Nursing. Trainees and students with an interest in expanding their knowledge of genomic medicine and related topics are encouraged to attend. Course Objectives At the end of this educational activity, attendees will be able to do the following: Explore the current and future landscape of genetic & genomic medicine in clinical practice Review ethical, social, and legal implications (ELSIs) impacting the delivery of care for patients with genetic disorders Discuss practical approaches for the diagnosis, evaluation and management of patients with common genetic disorders Explore reimbursement and cost-saving strategies for genetic and genomic services Analyze current, emerging, and future genetic testing technologies

Agenda Thursday, September 10, 2015 7:00 AM Registration & Continental Breakfast 8:00 AM Opening Remarks 8:15 AM Genetics Primer & Clinical Updates Rocio Moran, MD 8:45 AM History & Progress of Medical Genetics Timothy Moss, MD, PhD 9:15 AM Cancer Predisposition: Role and Challenges with Panel Testing Joanne Ngeow, MBBS, MRCP, MPH 9:45 AM Break 10:00 AM Tumor Genetic Profiling: Current Status, Future Directions Davendra Sohal, MD, MPH 10:30 AM Milestones in the Treatment of Lysosomal Storage Disease Angelika Erwin, MD, PhD 11:00 AM Panel Discussion: Incidental Findings of Genetic Testing Ryan Noss, MS, LGC, Jessica Marquard, MS, LGC Amy Shealy, MS, LGC, Marissa Smith, MS, LGC 11:45 AM Lunch 12:45 PM Principles of Pharmacogenomics J. Kevin Hicks, Pharm.D., PhD 1:15 PM Referring Patients to Genetic Counseling/Testing Daniel Sullivan, MD 1:45 PM Integration of Genetic Strategies in the Management of Cardiomyopathy W.H. Wilson Tang, MD 2:15 PM Break 2:30 PM Chromosome Therapy: Rescue of Ring Chromosomes by Cellular Reprogramming Anthony Wynshaw-Boris, MD, PhD 3:00 PM Reimbursement of Genetic Testing Stephen Lucht, MD, Jacquelyn Riley, MS, LGC, Bruce Rogen, MD, MPH, FACP Moderator: Timothy Moss, MD, PhD 3:45 PM Your Genes, Your Wine, Your Health 4:00 PM Reception

Venue & Accommodations InterContinental Hotel & Conference Center 9801 Carnegie Ave., Cleveland OH 44106 Please call 216.707.4100 or 855.364.5195 or visit www.ichotelsgroup.com to reserve your room Parking Parking is available in the 100th Street visitor s parking garage (Parking Lot 2) for a charge of $10 per day. Valet parking is available at the hotel for an additional charge. Americans with Disabilities Act The Cleveland Clinic Foundation Center for Continuing Education fully intends to comply with the legal requirements of the Americans with Disabilities Act. If you need assistance, please notify Peggy Bird, Genomic Medicine Institute, 216.444.1295 at least two weeks prior to the activity. General Information For additional information about this activity, contact the Continuing Medical Education (CME) office at: Local: 216.444.9990 Email: cmeregistration@ccf.org Web Address: www.ccfcme.org/genetics Accreditation The Cleveland Clinic Foundation Center for Continuing Education is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The Cleveland Clinic Foundation Center for Continuing Education designates this live activity for a maximum of 6.50 AMA PRA Category 1 Credits. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Participants claiming CME credit from this activity may submit the credit hours to the American Osteopathic Association for Category 2 credit. The Ohio Board of Nursing will accept at face value the number of contact hours awarded for an educational activity that has been approved for CE by a nationally accredited system of CE approval. Nurses are able to obtain CE that has been approved or provided by a nationally recognized accreditation system of continuing education. Examples include: The American Nurses Credentialing Center (ANCC) The Accreditation Council for Continuing Medical Education (ACCME) The International Association for Continuing Education and Training (IACET) National Society of Genetic Counselors (NSGC) Category 1 CEU credit pending.

Faculty Disclosure The Cleveland Clinic Foundation Center for Continuing Education has implemented a policy to comply with the current Accreditation Council for Continuing Medical Education Standards for Commercial Support requiring resolution of all faculty conflicts of interest. Faculty declaring a relevant commercial interest will be identified in the activity syllabus. Deadline for Registration and Cancellation Preregistrations are accepted until 5:00 pm ET, September 7, 2015. Register on site after this date. In case of cancellation, a full refund will be made if canceled by August 30, 2015. After August 30, 2015, a $25 cancellation fee will be deducted from your refund. Written notification of your cancellation is required to process your refund. No refunds will be issued after October 31, 2015. Genomic Medicine Institute Launched in 2005, the Genomic Medicine Institute (GMI) is housed in the Lerner Research Institute s Center for Genomics Research Building. GMI is specifically designed to enhance translational genomic medicine. The open design laboratory space is next to GMI s clinical unit, the Center for Personalized Genetic Healthcare (CPGH), the Genomic Medicine Biorepository (GMB) and the Genomics Core Facility. Vision To bring genetic and genomic expertise to all Cleveland Clinic s clinical care subspecialties. Mission To translate genetic research discoveries into better patient care by engaging in clinical practice, research and education; to provide a work culture that enables us to bring genetics and genomics, through our research and clinics, into all subspecialties of the Cleveland Clinic s healthcare system; and to foster innovation toward realizing the benefits of personalized genomic-based healthcare. Clinical Expertise CPGH is the Cleveland Clinic s first comprehensive clinical genetics program, providing family historybased disease risk assessment and management for prenatal to adult onset disorders. CPGH s genetic experts (5 Geneticists and 12 Genetic Counselors) work closely with Cleveland Clinic s healthcare professionals to provide genetic counseling services and, if appropriate, genetic testing. Clinical genetics care is integrated throughout the Cleveland Clinic system in 9 Clinical Institutes and 2 regional hospitals (over 22 Cleveland Clinic locations). CPGH provides genetic counseling and testing services in the areas of General genetics Cancer genetics Cardiovascular genetics Preconception & Prenatal genetics Neurogenetics and Neurometabolism Appointments 216.636.1768/Toll Free 800.998.4785 EPIC Order: Consult to Genetic Counseling Visit us at www.ccf.org/genetics

Registration Form Course #0201498 Genetics & Genomics: Integration into Clinical Practice Thursday, Sept. 10, 2015 InterContinental Hotel Cleveland 9801 Carnegie Ave., Cleveland OH 44106 PLEASE PRINT First Name MI Last Name Degree Company Address City State Zip Phone Fax Specialty Email Payment must be received prior to admittance to the course. Purchase orders are not acccepted. Go to: www.ccfcme.org/genetics CCF employees should check fees and register online at the above web-address. COURSE FEES Includes syllabus, continental breakfast, refreshment breaks and two luncheons Physician $100 Resident/Fellow NO CHARGE Non-Physician NO CHARGE I will require a vegetarian lunch I will be attending the reception Total amount enclosed or to be charged: $ PAYMENT Make check payable to: The Cleveland Clinic Educational Foundation, P.O. Box 931653, Cleveland, OH 44193-1082 If you would like to register using a credit card, please go to www.ccfcme.org/genetics or call 216.448.8710 where it will be handled directly by a certified processor.