1 Bone Tissue Chapter 7 Tissues and organs of the skeletal system Histology of osseous tissue Bone development Physiology of osseous tissue Bone disorders
2 Bone Tissue Bone is alive and continuously changing. Bone tissue (osseous tissue) is a type of connective tissue with cells, vessels, nerves and a matrix hardened by minerals (mostly calcium phosphate) Bones are units of the skeletal system individual bones are made up of bone tissue, marrow, cartilage and periosteum Functions of the skeletal system include support, protection, movement, blood formation, calcium and phosphate reservoir, ph balance
3 Compact Bone and Spongy Bone Compact Bone does not have any spaces or hollows in the bone matrix that are visible to the eye. Compact bone forms the thick-walled tube of the shaft (or diaphysis) of long bones, which surrounds the marrow cavity (or medullary cavity). A thin layer of compact bone also covers the epiphyses of long bones. Spongy Bone (also called trabecular bone or cancellous bone) consists of a delicate network of trabeculae which branch and intersect to form a sponge-like tissue. The ends of long bones (or epiphyses) contain mainly spongy bone.
4 Compact Bone and Spongy Bone Spongy Bone Compact Bone
5 Features of Long Bones Diaphysis (shaft) is a cylinder of compact bone containing the marrow cavity (medullary cavity) Diaphysis covered with periosteum Marrow Cavity contains hematopoeitic tissue Epiphyses (enlarged ends) are spongy bone covered with a thin layer of compact bone enlarged ends strengthen joint and provide attachment of tendons and ligaments Joint Surface is covered with articular cartilage (smooth, low friction hyaline cartilage and synovial fluid)
6 Features of Long Bones
7 Periosteum is a layer of vascular, innervated, dense connective tissue surrounding the non-articular surfaces of bone. Perforating Fibers (also called Sharpey s fibers) are collagen fibers that connect the periosteum to the bone matrix. The endosteum is a thin layer of connective tissue that lines the inside of the marrow cavity and any canals passing through the compact bone. Both the periosteum and the endosteum membranes are osteogenic they contain cells that can produce bone. During growth or following injury, osteogenic cells can differentiate into bone-forming osteoblasts. Periosteum and Endosteum Endosteum Perforating Fibers
8 Structure of a Flat Bone External and internal surfaces of flat bone are composed of compact bone. Middle layer is spongy bone and it is also called the diploe. An impact to the skull may fracture the outer layer and crush the spongy bone, but not harm inner compact bone or the underlying brain.
9 Osteogenic Cells Osteogenic Cells are found in the endosteum and periosteum. arise from embryonic mesenchymal cells multiply continuously and differentiate into osteoblasts in response to stress or fractures Osteoblasts produce an extracellular matrix of about 35% collagen fibers and 65% mineral (mostly calcium phosphate). Osteocytes are osteoblasts that have completely surrounded themselves with the extracellular matrix they produce. Spicules are isolated, newly formed pieces of bone.
10 Osteocytes Osteocytes are completely surrounded by bone matrix. Lacunae are the pits in the matrix occupied by the cells. Filopods (also called pseudopods, cytoplasmic extensions, dendritic processes) are long thin extensions of the osteocytes that produce bone matrix around the cell. Filopods are inside tiny canals in the matrix called canaliculi.
11 Osteocytes Osteocytes are arranged in rings called lamellae that are around a central canal that contains blood vessels and nerves. Tips of filopods absorb nutrients from the central canal. Adjacent osteocytes are inter-connected with gap junctions at the tips of the filopods. Osteocytes transfer nutrients from one cell to another through gap junctions.
12 Osteoclasts Macrophages Some stem cells in bone marrow develop into macrophages white blood cells called macrophages. Some macrophages leave the blood and move into bone tissue. In the bone, 3-50 of these macrophages can merge into giant, multinucleated cells called osteoclasts. A single cell formed by the fusion of several cells is called a syncitium. The surface of an osteoclast facing bone is folded into a ruffled border that releases lysosomes that contain enzymes and acids that erode bone matrix and produce pits in the matrix called resorption bays (also called Howship s lacunae).
13 Osteoclasts Four multinucleated osteoclasts producing resorption bays ( Howship s lacunae) in the blue-stained bone matrix. The ruffled border of the osteoclasts is facing the the bone matrix. Dissolved components of the bone matrix (calcium and amino acids) accumulate in the interstitial space and are reabsorbed into the blood.
14 Bone Matrix Bone Matrix is about 35% organic and 65% inorganic Bone Organic matter consists of: collagen glycosaminoglycans (chondroitin sulfate) proteoglycans glycoproteins Bone Inorganic matter consists of: 85% hydroxyapatite (calcium phosphate crystals) 10% calcium carbonate 5% other minerals (fluoride, sulfate, potassium, magnesium) Combination of organic and inorganic materials makes bones both strong and resilient minerals resist compression collagen give some flexibility Bone matrix is similar to fiberglass that is composed of strong glass fibers embedded in a flexible polymer
15 Bone Matrix
16 Compact Bone Osteon (Haversian system) is the basic structural unit of bone. Osteons are cylinders of bone tissue formed from layers (concentric lamellae) of osteocytes and matrix arranged around a central (Haversian) canal. Central Canal is lined with endosteum and contains a neurovascular bundle. Neurovascular Bundles contain an artery, vein, nerve and lymphatic vessel Osteocytes are connected to each other and their blood supply by thin pseudopods within canaliculi. Perforating Canals (Volkmann s canals) are perpendicular branches of the central (Haversian) canal Circumferential lamellae ring the outer circumference and the marrow cavity. Bony trabeculae branch off the compact bone surrounding the marrow cavity, filling the cavity with spongy bone.
17 Osteon = Haversian System Circumferential lamellae
20 Perforating (Volkman s) Canal Central (Haversian) Canal
21 Development of an Osteon 5/student_view0/chapter 6/animation bone_gro wth_in_width.html
22 Spongy Bone Spongelike appearance formed by rods and plates of bone called trabeculae spaces among the trabeculae are filled with bone marrow Light weight but strong trabeculae develop along bone s lines of stress
23 Bone Marrow Bone Marrow is a soft tissue that occupies the medullary cavity of long bones and the spaces among the trabeculae of spongy bone Red Marrow looks like thick blood bone marrow is the adult hemopoietic tissue that produces blood cells and platelets found in vertebrae, ribs, sternum, pelvic girdle and proximal heads of femur and humerus in adults Yellow Marrow fatty marrow in shaft of long bones in adults Gelatinous Marrow reddish, jelly-like marrow in old individuals
24 Red Bone Marrow
25 Two types of Bone Development Intramembranous Ossification produces the flat bones of the skull. Endochondral Ossification produces most of the other bones of the skeleton including the long bones of the extremities (arms and legs). The principal difference between intramembranous bone formation and endochondral bone formation is what is replaced during development. The tissue replaced during development in intramembranous ossification is embryonic CT. The tissue replaced in endrochondral ossification is hyaline cartilage. The two processes can occur side by side, and do, in the case of fracture healing and in the development of the the mandible and the clavicle which develop partially from intramembranous ossification and partially from endochondral ossification.
26 Intramembranous Ossification Produces flat bones of skull Steps of the process: 1) Mesenchyme condenses into a sheet of vascular, soft tissue 2) Some mesenchymal cells develop into osteoblasts that form osteoid tissue (uncalcified bone matrix). Other mesencymal cells develop into fibroblasts that form the periosteum membrane. Calcium is deposited in the matrix and it hardens. Osteoblasts develop into osteocytes as they become surrounded by bone. 3) Bony trabeculae form spongy bone. 4) Spaces between trabeculae fill with bone in the surface layers forming compact bone that is covered with periosteum
27 Intramembranous Ossification of the Skull
29 Intramembranous Ossification periosteum bone periosteum This is a cross section of fetal skull bone developing by intramembranous ossification. The irregularly shaped pink areas are developing spicules of bone.
30 Intramembranous Ossification Ob HC Oc T ECT T Ocl T HC Embryonic connective tissue (ECT) is gradually replaced by trabeculae (T) of bone that developes around blood vessels in Haversian canals (HC). Osteoblasts (Ob) cover the developing trabecular bone (T) and become osteocytes (Oc) once completely surrounded by matrix. Multinucleated osteoclasts (Ocl) demineralize and remodel the bone matrix.
31 Endochondral Ossification Long Bones form from endochondral ossification as a hyaline cartilage model that is gradually replaced by bone. Endochondral Ossification proceeds as follows: a primary ossification center forms in the cartilage model cartilage becomes hypertrophic (chondrocytes swell as they form the primary ossification center). hypertrophic cartilage is removed by macrophages primary marrow space is formed as cartilage is removed blood vessels and nerves grow into the marrow space osteogenic cells (mesenchymal-like fibroblasts) from the perichondrial/periosteal membrane invade the spaces created by the macrophages and transform into osteoblasts osteoblasts deposit osteoid tissue and calcified matrix
32 Ossification Centers The primary ossification center forms as cartilage in the center of the cartilage model becomes hypertrophic from a growing blood supply. Hypertrophic cartilage calcifies and dies. Osteoclasts remove of the dead hypertrophic cartilage and then blood vessels, nerves and osteoblasts grow into that space. The same process begins in each epiphysis forming secondary ossification centers that will develop into spongy bone.
33 Osteoblasts in the Primary ossification center Secondary ossification center Langman s
34 Perichondrium Ossification Centers
35 Zones of Ossification E Cartilage proliferates, becomes hypertrophic, calcifies, dies and is removed and is replaced with new bone tissue.
36 Zones of Ossification A) Zone of Reserve Cartilage is a layer of resting hyaline cartilage B) Zone of Cell Proliferation is a layer of chondrocytes that multiply forming columns of flattened lacunae C) Zone of Cell Hypertrophy is a region of swollen chondrocytes D) Zone of Calcification is where the cartilage matrix mineralizes and the chondrocytes die E) Zone of Bone Deposition is where mineralized cartilage matrix is replaced by bone. Voids are filled with osteoblasts and blood vessels forming Haversian canals and osteons
37 Secondary Ossification Centers develop in the Epiphyses Secondary Ossification Center Diaphysis Metaphysis Epiphysis Epiphyseal plate Metaphysis is cartilaginous tissue between the primary and secondary ossification centers. The epiphyseal plate (growth plate) is a temporary layer of cartilaginous tissue between the spongy bone of the medullary cavity (marrow cavity) and the spongy bone in the epiphyses that persists until growth of the bone is complete.
38 Secondary Ossification Centers Secondary ossification centers begin to form in the epiphyses near time of birth. Bone development does not proceed all the way to the end of the bone. Hyaline cartilage remains over epiphysis as the articular cartilage of the joint surface. The metaphysis is at the junction of the diaphysis and epiphysis and forms an epiphyseal plate (also called a growth plate) until growth ends.
39 epiphyseal plate
40 The Fetal Skeleton at 12 Weeks stained red for bone tissue. Cartilage is unstained.
41 Cranial ossification is incomplete at birth Soft regions of the skull called fontanels are regions of dense irregular connective tissue. There are usually 6 fontanels at birth Most fontanels close by 12 months and all are usually closed by 24 months.
42 Epiphyseal Plates
43 Bone Growth and Remodeling Bones grow and remodel throughout life exercise or manual labor increases density and mass of bone pulling of muscle on periosteum stimulates bone growth on that side of the bone osteoclasts are stimulated by increased pressure osteoblasts are stimulated by decreased pressure Dental braces reposition teeth by creating greater pressure on the bone on one side of the tooth socket and less pressure on the other side of the tooth socket which remodels the jaw bone as the tooth moves
44 Factors Affecting Bone Growth 20 or more hormones, vitamins and growth factors affect bone and not all the mechanisms are known. Bone growth is especially rapid at puberty growth hormones and sex hormones stimulate proliferation of osteogenic cells and chondrocytes in growth plate adolescent girls grow faster than boys and reach their full height earlier (estrogen has strong effect on bone growth) males grow for a longer time due to sustained high levels of testosterone resulting in larger average stature Growth ceases when epiphyseal plate closes anabolic steroids may cause premature closure of growth plate producing short adult stature
45 Achondroplastic Dwarfism Achondroplastic dwarfism is a genetic disorder resulting in short stature but normal-sized head and trunk Long bones of the limbs stop growing in childhood but other bones are unaffected.
46 Gigantism A pituitary giant can result from an excess of growth hormone during skeletal growth. 8 tall adult
47 Gigantism Robert Pershing Wadlow in 1938, at age 20 with actresses Maureen O Sullivan, left, and Ann Morris. Smithsonian August 2005 p. 76.
48 Robert Pershing Wadlow, with his mother at his side, had grown to a record height of 8 11 by the time of his death at age 22.
49 7 pounds at age 2 There are over 200 different types of dwarfism, all of which involve bone growth disorders (osteodysplasia) that result in short stature (adult height less than 4 ft. 10 in. tall). Primordial Dwarfism is a group of disorders in which growth is proportional but severely delayed, beginning in the womb. This results in some of the smallest people in the world. The individual pictured has Majewski osteodysplastic primordial dwarfism (MOPD) Type II. Only about 100 individuals worldwide have been identified as having MOPD type II. Both males and females of all ethnic backgrounds are affected. Some families have more than one child with MOPD Type II, which suggests that the disorder is inherited in an autosomal recessive manner. Majewski osteodysplastic primordial dwarfism type II (MOPD II): Natural History and Clinical Findings. Hall, Flora, Scott, Pauli, Tanaka, Am J. Med Genet A Sep 15 ; 130A(1):55-72.
50 Mineralization of Bone Matrix Mineralization is a process in which ions (mostly calcium and phosphate) are removed from blood plasma and are deposited in the matrix of bone tissue. Steps of the mineralization process: osteoblasts produce collagen fibers fibers become encrusted with minerals Image taken using a Scanning Electron Microscope showing collagen fibers produced by osteoblast cells on a polyurethane foam scaffold mimicking the bone matrix production and mineralization processes.
51 Mineral Resorption Bone is dissolved by the osteoclast ruffled border and dissolved calcium and phosphate are released into the blood pumps in the cell membrane secrete hydrogen ions into the space between the osteoclast and the bone and chloride ions follow forming hydrochloric acid (HCl) hydrochloric acid with a ph of 4 dissolves bone minerals an enzyme is also released that digests the collagen
52 Calcium Balance Calcium levels outside of normal values cause: hypocalcemia (deficiency of blood calcium) causes excessive excitability of nervous system by increasing the gradient for diffusion of cations out of the cell which leads to: muscle spasms, tremors or tetany laryngospasm may cause suffocation hypercalcemia (excessive of blood calcium) depresses nervous system activity by decreasing the ionic gradient across the neuron membrane Calcium phosphate homeostasis depends on a balance of calcitriol, calcitonin and parathyroid hormone (PTH)
53 Calcitriol (Activated Vitamin D) UV radiation of epidermal keratinocytes converts a cholesterol derivative into Vitamin D 3 (cholecalciferol) which is absorbed into the blood. Liver and kidney enzymes convert Vitamin D 3 into the hormone calcitriol. Actions of calcitriol include: stimulates the intestines to absorb calcium and phosphate stimulates the kidneys to retain calcium stimulates osteoclasts to release calcium from bone
54 Calcitriol Synthesis and Action
55 Calcitonin Secreted by C cells of the thyroid gland when calcium is abundant in the blood Functions: reduces blood calcium levels reduces osteoclast activity increases the number and activity of osteoblasts Calcitonin has a powerful effect in children, but it is less effective in adults calcitonin deficiency is not known to cause any disease in adults, but it may be useful in reducing bone loss in osteoporosis
56 Parathyroid Hormone (PTH) Secreted by the parathyroid glands when the calcium level is too low in the blood. Functions promotes calcitriol synthesis stimulates osteoclast multiplication and activity inhibits collagen and bone matrix synthesis by osteoblasts promotes calcium resorption by the kidneys promotes phosphate excretion by the kidneys
58 Osteoporosis Most common bone disease Bones lose mass and become brittle due to loss of both organic matrix and minerals increases risk of fracture of hip, wrist and vertebral column hump results from deformed spine Best treatment is prevention: exercise and a recommended calcium intake of 1000 mg/day between ages 25 and 40.
59 Effects of Osteoporosis
60 Healing of Fractures Normally healing takes 8-12 weeks (longer in elderly) Stages of healing: see next slide 1. fracture hematoma is a blood clot resulting from broken blood vessels 2. soft callus of collagen and fibrocartilage is formed by fibroblasts and infiltrated by capillaries at site of break 3. a soft callus is gradually replaced by a hard callus of spongy bone in about 6 weeks 4. remodeling occurs over 6 months as spongy bone is replaced with compact bone
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