CONTENTS. Volume 7 Supplement th International Symposium on HIV and Emerging Infectious Diseases Marseille, France March 2010

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1 CONTENTS Volume 7 Supplement Open Access 16th International Symposium on HIV and Emerging Infectious Diseases Marseille, France March 2010 Editor-in-chief Kuan-Teh Jeang I1-I32 Invited speaker presentations O1-O16 Oral presentations P1-P192 Poster presentations Retrovirology (http://www. retrovirology.com) is an open access journal published by BioMed Central Ltd. The journal publishes stringently peer-reviewed, high-impact articles on basic retrovirus research. Retrovirology (ISSN ) is indexed/tracked/covered by PubMed Central, MEDLINE, Thomson Reuters (ISI), Biosis, CAS, CABI, Embase and Current Contents. Contact BioMed Central biomedcentral.com

2 16 th HIV & Emerging Infectious Diseases VIH & Maladies Infectieuses Emergentes International Symposium Symposium International March/Mars 2010 Parc Chanot Marseille,France FINAL PROGRAMME PROGRAMME FINAL

3 SUMMARY SOMMAIRE Committees / Comités...p. 02 Welcome Address / Message de bienvenue... p. 03 General Information / Informations générales... p. 04 Parc Chanot map / Plan du Parc Chanot... p. 09 Programme at a glance / Synopsis... p. 12 Wednesday 24 March / Mercredi 24 mars... p. 14 Thursday 25 March / Jeudi 25 mars... p. 18 Friday 26 March / Vendredi 26 mars... p. 22 Posters / Communications affichées... p. 28 Authors index / Liste des auteurs... p. 49 Industry satellite symposia / Symposia satellites de l industrie... p. 59 Exhibition / Exposition... p. 60 Sponsors / Partenaires... p. 62 COMMITTEES / COMITÉS 2010 Chairman / Président Alain LAFEUILLADE (France) 2010 Steering Committee / Comité d organisation 2010 Jean-François DELFRAISSY (France) Jose GATELL (Spain) Guido POLI (Italy) Christine ROUZIOUX (France) Vicente SORIANO (Spain) Hans-J. STELLBRINK (Germany) Stefano VELLA (Italy) 2010 Scientific Committee / Comité Scientifique 2010 Antoine CHERET (France) Patricia ENEL (France) Robert GALLO (USA) Gilles HITTINGER (France) Leondios KOSTRIKIS (Cyprus) John KALDOR (Australia) Denis LACOSTE (France) Mark NELSON (UK) Cecile POGGI (France) Isabelle POIZOT-MARTIN (France) Alain RIEU (France) Paolo RIZZARDI (Italy) Jurgen ROCKSTROH (Germany) Caroline SOLAS (France) Catherine TAMALET (France) Giuseppe TAMBUSSI (Italy) Jean-Claude TARDY (France) 2

4 WELCOME ADDRESS MESSAGE DE BIENVENUE Welcome to the 16 th ISHEID! I have the pleasure to welcome you to this new edition of the International Symposium on HIV & Emerging Infectious Diseases, held for the first time in Marseille. As you are aware, over the last 15 years, this event grew from a local meeting to an internationally renowned congress. It is henceforth the stage welcoming the most distinguished experts, allowing fruitful exchanges, and addressing the most exciting topics in the fields of HIV, hepatitis viruses and emerging pathogens. The ISHEID principles are primarily driven by Science and by the need to offer a better clinical care to our patients. This is why the Steering Committee and the Scientific Committee are keen to offer a cutting edge program in all sessions, including the satellite symposia. I would like to thank particularly all the members of these Committees who helped me building this captivating program, and all the speakers who agreed to be part of it. I also thank all the participants for the increased number of abstracts submitted this year. This led to tough selection choices for oral presentations, but also to a high quality in the poster sessions. This year, the new location of Marseille allows better accommodation and accessibility than in the past: we hope that you will appreciate this choice and keep some extra time to discover this charming city. Kindest regards; Alain Lafeuillade, MD, On behalf of the Steering Committee Bienvenue au 16 ème ISHEID! Au nom du Comité d Organisation, j ai le plaisir de vous accueillir à cette édition du «Symposium International sur le VIH et les Maladies Infectieuses Emergentes» qui se tient pour la première fois à Marseille. Ce congrès a évolué sur les 15 dernières années d une manifestation régionale à un rassemblement scientifique de renommée internationale. Il est la scène sur laquelle vous rencontrez les experts les plus avertis, où les sujets les plus «brûlants» sont traités, dans les domaines du VIH, des hépatites virales, et des infections émergentes. Sa dimension permet au congrès d assurer des échanges fructueux directs entre participants et experts. Les préoccupations essentielles de l ISHEID sont scientifiques, ainsi que le besoin d apporter à nos patients une meilleure prise en charge. C est pourquoi nous avons veillé à la haute tenue du programme au sein de toutes les sessions, y compris les symposia satellites. Je tiens à ce propos à remercier les membres des Comités d Organisation et Scientifique qui m ont aidé à construire un programme riche et captivant, et l ensemble des orateurs qui ont accepté d y intervenir. Je remercie également les participants pour avoir soumis un nombre accru de résumés cette année, avec une qualité toujours croissante. Cela a eu, paradoxalement, l effet de conduire à des choix difficiles dans la sélection finale. Cette année, la ville de Marseille permet aussi une meilleure accessibilité et un choix plus complet d hôtels. J espère que vous saurez apprécier cette nouvelle destination et lui consacrerez aussi un peu de temps. En vous souhaitant un bon congrès ; Dr Alain Lafeuillade, au nom du Comité d Organisation 3

5 GENERAL INFORMATION INFORMATIONS GENERALES DATES & LOCATION/DATES ET LIEU BADGE A name badge will be provided on-site with your registration documents. The wearing of this badge is compulsory both inside the conference rooms and in the exhibition area. Un badge nominatif vous sera remis sur place accompagné de vos documents de congrès. Le port du badge est obligatoire dans l ensemble des salles de conférences et à la zone d exposition. Colour code / Code couleur The 16 th ISHEID congress will be held from Wednesday 24 March to Friday 26 March 2010 and will take place at: Le 16 ème congrès ISHEID se tiendra du mercredi 24 mars au vendredi 26 mars 2010 au : PARC CHANOT DE MARSEILLE BP Marseille Cedex 08 Delegates / Participants Speakers / Orateurs Exhibitors / Exposants Organisation white / blanc turquoise purple / violet red / rouge IMPORTANT: Always keep your badge after ISHEID. You will need to remove your certificate functions of CME credits. IMPORTANT : pensez à conserver votre badge à l issue d ISHEID. Il vous sera indispensable pour retirer votre attestation d attributions de points CME. ACCESS TO THE PARC CHANOT / ACCÈS AU PARC CHANOT By metro / En métro From Saint Charles station: 13 minutes. Direction: Sainte Marguerite. Exit station «Rond Point du Prado». More information: A partir de la Gare Saint Charles : 13 minutes. Direction : Sainte Marguerite. Sortie station «Rond Point du Prado». Pour plus d information : Taxi from station / Taxi gare Tel : +33 (0) CELLULAR PHONES / TÉLÉPHONES PORTABLES Thank you for not using your cell phone in conference rooms. Nous vous remercions de ne pas utiliser votre téléphone portable dans les salles de conférence. CERTIFICATES OF ATTENDANCE / CERTIFICATS DE PRÉSENCE Certificates of attendance will be issued to pre-registered delegates during the withdrawal of their badge. Registered delegates on site will receive this certificate upon registration. Les certificats de présence seront remis à chaque participant pré-inscrit lors du retrait de leur badge. Les participants inscrits sur place se verront remettre ce certificat lors de leur inscription. 4 CLOAKROOM / VESTIAIRE A free cloakroom is at participant s disposal during the welcome desk opening hours. It is located on level 2, hall des pas perdus. Please make sure that no personal belongings are left after closing each day. Un vestiaire gratuit est à la disposition des participants pendant les heures d ouverture de l accueil. Il est situé au niveau 2, hall des pas perdus.

6 Veuillez vous assurer qu aucun effet personnel n est laissé après la clôture de chaque jour. CME CREDITS / CRÉDITS CME The 16 th International Symposium on HIV and Emerging Infectious Diseases is accredited by the European Accreditation Council for Continuing Medical Education (EACCME) to provide the following CME activity for medical specialists. The EACCME is an institution of the European Union of Medical Specialists (UEMS): The 16 th International Symposium on HIV and Emerging Infectious Diseases is designated for a maximum of (or for up to) 18 hours of European external CME credits. Each medical specialist should claim only those hours of credit that he/she actually spent in the educational activity. The EACCME credit system is based on 1 ECMEC per hour with a maximum of 3 ECMECs for half a day and 6 ECMECs for a full-day event. EACCME credits are recognized by the American Medical Association towards the Physician s Recognition Award (PRA). To convert EACCME credit to AMA PRA category 1 credit, contact the AMA: Le 16 ème ISHEID est accrédité par l EACCME (European Accreditation Council for Continuing Medical Education) concernant les activités de CME (Continuing Medical Education) pour les médecins spécialistes. L EACCME est une institution de l UEMS (European Union of Medical Specialists) : Le 16 ème ISHEID est prévu pour un maximum de 18 heures de crédits CME externes européens. Les médecins spécialistes ne peuvent se prévaloir que des heures qu ils ont effectivement passées dans une activité éducative. Le système de crédits CME est basé sur 1 crédit CME par heure avec un maximum de 3 crédits CME pour une demi-journée et 6 crédits pour une journée entière. Les crédits EACCME sont reconnus par l AMA (American Medical Association towards the Physician s Recognition Award). Afin de convertir un crédit EACCME en AMAPRA catégorie 1, prière de contacter l AMA : The certificates will be issued the week following the conference via the website: Access will be using your last name, first name and number on your badge (think of keeping it after the conference). Les attestations seront délivrées la semaine suivant le congrès via le site Internet : L accès se fera à l aide de votre nom, prénom et du numéro figurant sur votre badge (penser à garder celui-ci après le congrès). COFFEE BREAKS / PAUSES CAFÉS Coffee breaks will take place in the exhibition area with the support of Gilead. Les pauses-cafés auront lieu sur la zone d exposition avec le soutien de Gilead. CONGRESS SECRETARIAT / SECRÉTARIAT DU CONGRÈS During the meeting / Durant le congrès PARC CHANOT Information and registration desks: Level 2, Hall des pas perdus Information et bureau des inscriptions : Niveau 2, Hall des pas perdus OPENING HOURS / HEURES D OUVERTURE Wednesday 24 March / Mercredi 24 mars : 08:00-19:30 Thursday 25 March / Jeudi 25 mars : 07:30-18:30 Friday 26 March / Vendredi 26 mars : 07:30-17:00 After the meeting / Après le congrès ISHEID 2010 c/o Colloquium 12 rue de la Croix-Faubin Paris Cedex 11 Tel: + 33 (0) Fax: + 33 (0) CURRENCY / MONNAIE The national currency in France is the EURO (1 Euro= 100 Cents). Coins of 1, 2 and 5 Cents are copper-coloured; coins of 10, 20 and 50 Cents are gold-coloured; 1 and 2 Euro coins are gold-and-silver coloured. Euro notes come in denominations of 5, 10, 20, 50, 100, 200 and 500. Credit cards as well as most major currencies are widely accepted. For currency exchange, please ask your hotel for further information. La monnaie nationale en France est l EURO (1 euro = 100 cents). Les pièces de 1, 2 et 5 Centimes sont cuivrées ; les pièces de 10, 20 et 50 Centimes sont dorées ; les pièces de 1 et 2 Euro sont dorées et argentées. Les billets en Euro comportent des coupures de 5, 10, 20, 50, 100, 200 et 500. Les cartes de crédit de même que la plupart des monnaies principales sont largement acceptées. Pour changer de l argent, merci de vous adresser à votre hôtel. 5

7 GENERAL INFORMATION INFORMATIONS GENERALES CYBER-SPACE / CYBER-ESPACE A cyber-space is located in the exhibition area, next to the Tibotec booth. Computers stations will be at your disposal for your internet connections. Un cyber-espace est situé dans la zone d exposition à côté du stand Tibotec. Des ordinateurs sont à votre disposition pour vos connexions internet. Headsets will be distributed at the entrance of the Congress Hall, in exchange for the voucher which is in your delegate pack. La langue officielle du congrès est l anglais excepté les sessions où un drapeau français apparaît sur le programme. Les casques de traductions sont distribués à l accueil en échange de votre bon d échange qui est dans votre dossier congressiste. ELECTRICITY / ELECTRICITÉ The electrical supply in most areas of France is 220 V, 50 Hz. Plug sockets are European continental standard (two round pins). La charge électrique dans la plupart des régions de France est 220 V, 50 Hz. Les prises électriques sont au standard européen continental (prise ronde bipolaire). LOST AND FOUND / OBJETS TROUVÉS Lost items should be returned to the Congress Information desk (level 2, hall des pas perdus) which is at your disposal in case of loss of items. Les objets trouvés doivent être retournés à la banque d information de l accueil (Niveau 2, hall des pas perdus) qui se tient à votre disposition en cas de perte d objet. EXHIBITION / EXPOSITION Located at Level 2, the exhibition is open every day of the conference. It allows you to develop and enrich your communication with our partners and discover their products. Située au niveau 2, l exposition est ouverte tous les jours du congrès. Elle vous permet de développer et enrichir vos échanges avec nos partenaires et de découvrir leurs produits. OPENING HOURS / HORAIRES D OUVERTURES Wednesday 24 March / Mercredi 24 mars : 08:00-19:30 Thursday 25 March / Jeudi 25 mars : 07:30-18:30 Friday 26 March / Vendredi 26 mars : 07:30-17:00 POSTERS / COMMUNICATIONS AFFICHÉES Posters are located in the Goudes Room, level 2 / Les communications affichées sont situées dans la salle les Goudes, niveau 2. Opening hours / Horaires d ouvertures : Wednesday 24 March/Mercredi 24 mars: 09:00-19:30 Thursday 25 March/Jeudi 25 mars: 07:30-18:30 Friday 26 March/Vendredi 26 mars: 07:30-15:30. The best poster will be awarded on Friday, March 26 at 10:30 at the end of the plenary session in the Auditorium. Le prix du meilleur poster sera remis le vendredi 26 mars à 10h30 à la fin de la plénière dans l Auditorium. INSURANCE POLICY / ASSURANCE ET RESPONSABILITÉ The Symposium Organiser can not accept liability for personal injury, loss of or damage to belongings of Symposium participants, either during or as a result of the Symposium. Please check the validity of your own insurance. L organisateur du Symposium ne peut être rendu responsable en cas de dommages aux personnes, de pertes ou de dommages aux effets des participants du Symposium, ni pendant, ni après celui-ci. Merci de vérifier la validité de votre propre assurance. LANGUAGE / LANGUES The official congress language is English except for sessions where a French flag appears on the programme. PROGRAMME CHANGES / CHANGEMENTS DANS LE PROGRAMME The organisers cannot assume liability for any changes in the programme due to external or unforeseen circumstances. Les organisateurs n assument aucune responsabilité pour des changements dans le programme qui seraient dus à des circonstances extérieures ou imprévisibles. PUBLICATION OF ABSTRACTS / PUBLICATION DES ABSTRACTS All accepted abstracts are published on the CD-Rom that will be given at Gilead booth number 7 upon presentation of the voucher included in the congress bag. All accepted abstracts will be published also after the congress in "Retrovirology": 6

8 Les résumés acceptés sont publiés sur le CD-Rom qui vous sera remis sur le stand de Gilead, numéro 7, sur presentation du voucher situé dans la sacoche. Les résumés acceptés seront également publiés après le congrès dans «Retrovirology» : WELCOME RECEPTION / COCKTAIL DE BIENVENUE The Welcome Reception on Wednesday 24 March 2010 will take place from 18:30 to 19:30 in the exhibition area. Le cocktail de bienvenue aura lieu le mercredi 24 mars 2010 de 18:30 à 19:30 dans l exposition. SMOKING POLICY / TABAC It is forbidden to smoke anywhere in the Parc Chanot. Il est interdit de fumer dans l ensemble des espaces du Parc Chanot. SPEAKER PREVIEW ROOM / SALLE DES ORATEURS The speaker preview room is located in the Morgiou Room, level 2 at the Parc Chanot. La salle des orateurs est située dans la salle Morgiou, niveau 2 du Parc Chanot. Speakers please proceed to the preview room At last 1 hour before the session for MORNING presentations Between 9:00 am and 12:00 am on the day of the session for AFTERNOON presentations. Les orateurs sont pries de se rendre en salle de pré-projection Au moins une heure avant la session pour les présentations du matin Entre 9 :00 et 12 :00 le jour de la session pour les présentations de l après-midi. USEFUL WEB SITES / SITES UTILES ISHEID 2010: Venue / Centre de conférence : Tourism / Office de tourisme : National airline company / Compagnie aérienne nationale : National train network / Réseau ferré national : Metro, bus in Marseille /Métro, bus dans Marseille : 7

9 GENERAL INFORMATION INFORMATIONS GENERALES CONGRESS REGISTRATION & CANCELLATION CONDITIONS / INSCRIPTIONS CONGRÈS ET CONDITIONS D ANNULATIONS All rates are in Euros, French VAT 19,6% included/ Tous les tarifs sont exprimés en euros TTC. Inscriptions sur place/registration on site Participant 460 Reduced rate* / Tarif réduit* 110 Reduced rate applicable to the following categories: AIDS Association Member Students / Residents (please present a copy of your student card). Low and Middle income countries (World Bank List Nurses Le tarif réduit est applicable aux catégories suivantes : Membres d associations de lutte contre le SIDA Etudiants et internes (Sur envoi d un justificatif : photocopie de la carte d étudiant pour l année en cours) Pays à faible et moyen revenus (World Bank List Infirmier(e)s REGISTRATION FEES INCLUDE / LES DROITS D INSCRIPTION INCLUENT : Name Badge / Badge nominatif Admission to all congress sessions, poster area and exhibition area from Wednesday 24 March to Friday 26 March / la participation aux sessions du congrès, aux présentations posters et à la zone d exposition du mercredi 24 mars au vendredi 26 mars. Invitation to the welcome reception / Invitation au cocktail de bienvenue Congress documents (congress bag, final programme, Abstracts CD-Rom, writing pads and pens) / les documents du congrès (sacoches, programme final, CD- Rom des abstracts, blocs-notes et stylos) Coffee breaks from Wednesday 24 March to Friday 26 March / les pauses café du mercredi 24 mars au vendredi 26 mars. Please note that no funds are available for scholarships / Aucune bourse ou subvention ne sera accordée. CANCELLATION POLICY FOR INDIVIDUAL REGISTRATIONS / CONDITIONS D ANNULATION INSCRIPTIONS INDIVIDUELLES All cancellations must be notified in writing to: / Toutes annulations doivent être notifiées par écrit à : ISHEID 2010 c/o Colloquium 12 rue de la Croix-Faubin Paris, France Fax : AFTER JANUARY, 15: NO REFUND. With no payment received before that date, the total amount will still remain due to the Congress office. / En l absence de paiement reçu avant cette date, le montant total restera dû au secrétariat du Congrès. APRÈS LE 15 JANVIER : AUCUN REMBOURSEMENT All refunds will be issued after the congress. Requests will not be accepted after the 30 April / Tous les remboursements seront effectués après le congrès et aucune demande ne sera traitée après le 30 avril ACCOMMODATION/ HÉBERGEMENT WIP is the official hotel reservation centre in charge of accommodation for the 2010 ISHEID Congress. WIP est la centrale de réservation hôtelière officielle pour la gestion de l hébergement du congrès ISHEID For any information please contact / Pour toute information, veuillez contacter : Marie Cohade Tel :

10 PARC CHANOT MAP PLAN DU PARC CHANOT GOUDES ROOM / SALLE LES GOUDES POSTERS AUDITORIUM MORGIOU ROOM / SALLE MORGIOU PREVIEW CLOAKROOM / VESTIAIRE ENTRANCE / ENTRÉE AMPHITHEATER CALLELONGUE / AMPHITHÉÂTRE CALLELONGUE EXHIBITION AREA / ZONE D EXPOSITION WELCOME AREA/ ZONE D ACCUEIL 9

11 GENERAL NOTES INFORMATION INFORMATIONS GENERALES 10

12 11

13 PROGRAMME AT A GLANCE SYNOPSIS WEDNESDAY 24 MARCH :30 Auditorium Amphitheater Callelongue Plenary Session Emerging Infectious Diseases 11:00 11:30 Coffee break sponsored by Gilead Parallel Sessions Parallel Sessions Long Term HIV Management (I) Pharmacology of HIV 13:00 14:00 Session COREVIH In French only Plenary Session Immunology of HIV 15:30 16:00 Coffee break sponsored by Gilead 17:00 18:30 Keynote Lecture by Robert GALLO 25 Years after Discovering HIV as the Cause of AIDS: Prospects for a Vaccine Industry Satellite Symposium Schering Plough Shapping the Future of HIV-HCV Co-infected Patients Industry Satellite Symposium MSD Steering for New Strategies THURSDAY 25 MARCH :30 Auditorium Amphitheater Callelongue Plenary Session HIV Reservoirs & Primary Infection 10:30 11:00 Coffee break sponsored by Gilead 12:30 14:00 Parallel Sessions HIV Resistance Plenary Session Antiretroviral Strategies 15:30 16:00 Coffee break sponsored by Gilead 17:00 18:30 Keynote Lecture by Albert OSTERHAUS The Global Challenge of Emerging Infectious Diseases Parallel Sessions Free Oral Presentations (I) Industry Satellite Symposium Tibotec Janssen-Cilag Switching from Stable Regimen: Which Risks, Which Benefi ts? Industry Satellite Symposium Abbot Virology HIV, a Chronic Disease: what Priorities to manage? FRIDAY 26 MARCH :30 Auditorium Amphitheater Callelongue Plenary Session Co-Infections 10:30 11:00 Coffee break sponsored by Gilead 12:30 14:00 Parallel Sessions HIV Controllers Parallel Sessions Long Term HIV Management (II) with the support of Bristol Myers Squibb Parallel Sessions Towards an HIV Vaccine 15:00 15:30 Coffee break sponsored by Gilead 16:30 Reporter Session Parallel Sessions Free Oral Presentations (II) Parallel Sessions Discussed Posters Parallel Sessions Post-CROI 12

14 MERCREDI 24 MARS :30 Auditorium Amphithéâtre Callelongue Session Plénière Maladies Infectieuses Émergentes 11:00 11:30 Pause - café sponsorisée par Gilead 13:00 14:00 Sessions Parallèles Gestion à Long Terme de l Infection à VIH (I) Session COREVIH En français seulement 15:30 16:00 Pause - café sponsorisée par Gilead 17:00 18:30 Session Plénière Immunologie du VIH Conférence Plénière par Robert GALLO 25 Ans après avoir découvert le VIH comme Agent Causal du SIDA : Recherche d un Vaccin Sessions Parallèles VIH, Session Pharmacologique Symposium Satellite de l Industrie Schering Plough Modeler l Avenir des Patients Co-infectés VIH-VHC Symposium Satellite de l Industrie MSD Mettre le Cap sur de Nouvelles Stratégies JEUDI 25 MARS :30 Auditorium Amphithéâtre Callelongue 10:30 Session Plénière Réservoirs du VIH & Primo-infection 11:00 Pause - café sponsorisée par Gilead 12:30 Sessions Parallèles Résistances du VIH Sessions Parallèles Présentations Orales Libres (I) 14:00 Symposium Satellite de l Industrie Tibotec Janssen-Cilag Changement de Traitement Antirétroviral chez les Patients en Succès Virologique : Quels Risques, Quels Bénéfices? 15:30 Session Plénière Stratégies Antirétrovirales 16:00 Pause - café sponsorisée par Gilead Conférence Plénière par Albert OSTERHAUS 17:00 Le Défi Mondial des Maladies Émergentes Symposium Satellite de l Industrie Abbot Virology Le VIH, une Pathologie Chronique : 18:30 Quelles Priorités à prendre en charge? VENDREDI 26 MARS :30 Auditorium Amphithéâtre Callelongue Session Plénière Co-Infections 10:30 11:00 Pause - café sponsorisée par Gilead 12:30 14:00 Sessions Parallèles Patients VIH «Non Progresseurs» Sessions Parallèles Gestion à Long Terme de l Infection à VIH (II) avec le Support de Bristol Myers Squibb Sessions Parallèles Mise au point d un Vaccin contre le VIH 15:00 15:30 Pause - café sponsorisée par Gilead 16:30 L essentiel du Symposium Sessions Parallèles Présentations Orales Libres (II) Sessions Parallèles Posters Discutés Sessions Parallèles «Post-CROI» 13

15 WEDNESDAY 24 MARCH MERCREDI 24 MARS 9:20 9:30 Welcoming Message / Message de Bienvenue On Behalf of the Steering Commitee / Au nom du Comité d Organisation Alain Lafeuillade, Toulon, France 9:30 11:00 Plenary session / Session plénière EMERGING INFECTIOUS DISEASES / MALADIES INFECTIEUSES EMERGENTES Auditorium Chairpersons: Pierre Dellamonica (Nice, France), Gilles Hittinger (Toulon, France) 9:30 I-01 Hepatitis E: State-of-the-Art / Hépatite E : Etat des Lieux Harry Dalton, Royal Cornwall Hospital & Virus Reference Department, London, UK 10:00 I-02 Lessons Learned from Chikungunya / Chikungunya : Leçons et Perspectives Giovanni Rezza, Istituto Superiore di Sanità, Rome, Italy 10:30 I-03 The Influenza Challenge / Le Défi Grippal Tim Nguyen, World Health Organisation (WHO), Geneva 11:00 11:30 Coffee break sponsored by / Pause café sponsorisée par 11:30 13:00 Parallel session / Sessions parallèles LONG-TERM HIV MANAGEMENT (I) / GESTION A LONG TERME DE L INFECTION A VIH (I) Auditorium Chairpersons: Isabelle Poizot-Martin (Marseille, France), Hervé Tissot-Dupont (Marseille, France) 11:30 I-04 Ageing with HIV: Next Challenges / Vieillir avec le VIH : Défis à Venir Martin Fisher, Brighton and Sussex University Hospital, NHS, Brighton, UK 12:00 I-05 Cardiovascular Disease and HIV / Risque Cardiovasculaire et VIH Esteban Martinez, Hospital Clínic-IDIBAPS, University of Barcelona, Barcelona, Spain 12:15 I-06 Ageing Metabolism and HIV / Vieillissement Métabolique et VIH Jacqueline Capeau, INSERM, Paris, France 12:35 I-07 Neurodegeneration in the HAART Era / Dégénérescence Neurologique à l Epoque des Trithérapies Bruce Brew, University of New South Wales, Sydney, Australia 14 Traduction simultanéé FR/AN and AN/FR Simultaneous translation FR/EN and EN/FR

16 WEDNESDAY 24 MARCH / MERCREDI 24 MARS PHARMACOLOGY OF HIV / VIH, SESSION PHARMACOLOGIQUE Amphitheater Callelongue / Amphithéâtre Callelongue Chairpersons: Rodolfe Garraffo (Nice, France), Caroline Solas (Marseille, France) 11:30 I-08 Diffusion of New Antiretroviral Drugs in CSF / Diffusion des Nouveaux anti-rétroviraux dans le LCR Francesca Aweeka, University of California San Francisco, San Francisco, USA 11:50 I-09 Inhibitory Quotient in HIV Pharmacology / Le Quotient Inhibiteur en Pharmacologie VIH Charles La Porte, Ottawa Health Research Institute, Ottawa, Canada 12:10 I-10 Drug-Drug Interactions - It is not only CYP450 s which Matter / Interactions Pharmacologiques en dehors du Cytochrome P450 David Back, University of Liverpool, Liverpool, UK 12:30 I-11 Evidence-based TDM for Antiretroviral Drugs / Le Suivi Pharmacologique des ARV Fondé sur les Preuves Caroline Solas, Hôpital de la Timone, Marseille, France 13:00 14:00 Industry Satellite Symposium / Symposium Satellite de l Industrie SCHERING PLOUGH SHAPPING THE FUTURE OF HIV-HCV CO-INFECTED PATIENTS / MODELER L AVENIR DES PATIENTS CO-INFECTES VIH-VHC Amphitheater Callelongue / Amphithéâtre Callelongue Chairperson: Stanislas Pol (Paris, France) 13:00 Characteristics and Care of HIV-HCV Coinfected Patients (Prospecth study 2009) / Profil et Prise en Charge des Patients Co-Infectés VIH-VHC en 2009 (Etude Prospecth 2009) Patrice Cacoub, Service de Médecine Interne, CHU Pitié Salpétrière, Paris, France 13:15 Maximizing Chances of Cure for HIV-HCV Coinfected Patients / Optimiser les Chances de Guérison chez les Patients Co-infectés VIH-VHC Stéphanie Dominguez, Service d Immunologie Clinique, Hôpital Henri Mondor, Paris, France 13:30 Protease Inhibitor: Efficacy and Mutations Management / Anti-Protéases : Efficacité et Gestion des Résistances Christian Payan, Département de Microbiologie, CHU Hôpital Morvan, Brest, France 13:45 Protease Inhibitor: a Trial in HIV-HCV Coinfecetd Patients / Anti-Protéases : un Protocole chez les Patients Co-infectés VIH-VHC Stanislas Pol, Unité d Hépatologie, Hôpital Cochin, Paris, France 13:50 Questions - Answers / Questions Réponses 15

17 WEDNESDAY 24 MARCH MERCREDI 24 MARS 13:00 14:00 Session COREVIH Session in French only / Session en français uniquement LE DEPISTAGE COMMUNAUTAIRE Auditorium Modérateurs : Isabelle Ravaux (Marseille, France), Chantal Vernay-Vaïsse (Marseille, France) 13:00 Introduction sur le COREVIH Isabelle Ravaux, PH en infectiologie, AP-HM, vice-présidente du Corevih Paca Ouest Corse 13:05 Introduction sur le Dépistage Rapide Chantal Vernay-Vaïsse, chef de service Prévention IST, Conseil Général des Bouches du Rhône 13:10 Dépistage Rapide Auprès des Gays : le projet ANRS «DRAG» Bruno Spire, chercheur en sociologie, Inserm U 912, président de AIDES, Marseille, France 13:25 Aspects Sociaux du Dépistage ou Expériences Européennes Jean-Yves Le Talec, chercheur en sociologie, Université de Toulouse - Le Mirail, Toulouse, France 13:40 Discussion avec la salle 14:00 15:30 Plenary session / Session plénière IMMUNOLOGY OF HIV / IMMUNOLOGIE DU VIH Auditorium Chairpersons: Giuseppe Tambussi (Milan, Italy), Jean-François Delfraissy (Paris, France) 14:00 I-12 Is there a Role for Cytokine-Immune Based Therapy in HIV Disease Therapy? / Les Traitements Immunologique avec des Cytokine ont-ils une Place dans le VIH? Guido Poli, Istituto San Raffaele, Milan, Italy 14:30 I-13 IL-2/IL-7 Therapies in HIV Infection. From CD4 Increases to Clinical Outcomes / Immunothérapie de l infection par le VIH par IL-2 et IL-7 Yves Lévy, Hôpital Henri Mondor, Créteil, France 15:00 I-14 NK Cells and Immune Activation in HIV / Cellules NK et Activation Immune dans l Infection à VIH Martin R. Goodier, Imperial College London, London, UK 15:30 16:00 Coffee break sponsored by / Pause café sponsorisée par 16 Traduction simultanéé FR/AN and AN/FR Simultaneous translation FR/EN and EN/FR

18 WEDNESDAY 24 MARCH / MERCREDI 24 MARS 16:00 17:00 Keynote lecture / Conférence plénière Auditorium KL-1 25 Years after Discovering HIV as the Cause of AIDS: Prospects for a Vaccine / 25 Ans Après Avoir Découvert le VIH Comme Agent Causal du SIDA : Recherche d un Vaccin Robert Gallo, University of Maryland School of Medicine, Institute of Human Virology, Baltimore, USA 17: Industry Satellite Symposium / Symposium Satellite de l Industrie MSD Symposium in French only / Symposium en français uniquement STEERING FOR NEW STRATEGIES / METTRE LE CAP SUR DE NOUVELLES STRATÉGIES Amphitheater Callelongue / Amphithéâtre Callelongue Chairpersons: Alain Lafeuillade (Toulon, France), Jacques Izopet (Toulouse, France) Can we Expect more than Undetectable Viremia Today? / Peut-on Attendre Plus que l Indétectabilité Virologique Aujourd hui Constance Delaugerre, Service de Virologie, CHU Saint Louis, Paris, France New Pharmacological Needs: Diffusion Outside the Blood Compartment? / Nouvelles Exigences Pharmacologiques : Diffusion Extra-Plasmatique? Rodolphe Garraffo, Hôpital Pasteur, Nice, France First Line HAART: a Decisive Choice for the Long-Term / Première Ligne de Traitement : un Choix Décisif pour le Long Terme Isabelle Poizot Martin, HIV-Clinical center, Hospital Sainte Marguerite, Marseille, France 17

19 THURSDAY 25 MARCH JEUDI 25 MARS 8:30 10:30 Plenary session / Session plénière HIV RESERVOIRS & PRIMARY INFECTION / RESERVOIRS DU VIH ET PRIMO-INFECTION Auditorium Chairpersons: Jacques Izopet (Toulouse, France), Alain Lafeuillade (Toulon, France) 8:30 I-15 HIV Latency Explained to Clinicians / La Latence du VIH expliquée aux Cliniciens Jose Alcami, Instituto de Salud Carlos III, Madrid, Spain 9:00 I-16 Update on HIV Reservoirs / Actualités sur les Réservoirs du VIH Sarah Palmer, Swedish Institute for Infectious Disease Control and Karolinska Institute, Stockholm, Sweden 9:30 I-17 Anti-HIV Latency Drugs / Traitements Anti-Latence David Margolis, University of North Carolina, Chapel Hill, USA 10:00 I-18 Translational Research at Acute HIV Infection / Recherche Translationnelle au Stade de Primo-infection Jean-Pierre Routy, McGill University, Montreal, Canada 10:30 11:00 Coffee break sponsored by / Pause café sponsorisée par 11:00 12:30 Parallel sessions / Sessions parallèles HIV RESISTANCE / RESISTANCE DU VIH Auditorium Chairpersons: Catherine Tamalet (Marseille, France), Jean-Claude Tardy (Lyon, France) 11:00 I-19 Use of New Technologies to Detect and Understand HIV Drug Resistance / Utilisation de Nouvelles Technologies pour Détecter et Comprendre les Résistances du VIH Michael Kozal, Yale University, New Haven, USA 11:30 I-20 Resistance to New Antiretrovirals (ETV, Anti-Integrases, Entry Inhibitors) / Résistance aux Nouveaux Anti-rétroviraux (Etravirine, anti-intégrase, anti-ccr5) Francesca Ceccherini-Silberstein, University of Rome Tor Vergata, Rome, Italy 12:00 I-21 Use of New Drug Resistance Markers to Predict Virologic Response to Antiretrovirals / Utilisation de Nouveaux Marqueurs de Résistance pour Prédire la Réponse Virologique aux Anti-rétroviraux Mark Wainberg, McGill University, Montreal, Canada 18 Traduction simultanéé FR/AN and AN/FR Simultaneous translation FR/EN and EN/FR

20 THURSDAY 25 MARCH / JEUDI 25 MARS 11:00 12:30 FREE ORAL PRESENTATIONS I / PRESENTATIONS ORALES LIBRES I Amphitheater Callelongue / Amphithéâtre Callelongue Chairpersons: Patricia Enel (Marseille, France), Philippe Halfon (Marseille, France) * indicates the presenting author / * indique le présentateur 11:00 O-01 Evolution of Tuberculosis/HIV Co-Infection in California During the Haart Era, John Metcalfe (1)* Matt Facer (2) Mark Damesyn (2) Qiang Xia (2) James Watt (3) Julia Hill (3) Philip Hopewell (1) Janice Westenhouse (3) Jennifer Flood (3) (1) UCSF, San Francisco, USA (2) Office of AIDS, California Department of Public Health, San Francisco, USA (3) TB Control Unit, California Department of Public Health, Richmond, USA O-02 CANCELLED 11:10 O-03 Screening of Differentially Expression Gene in HIV/HCV Coinfection Patients. zhengrong Yang (1)* Jing Zhao (1) Lin Chen (1) (1) Shenzhen Center for Disease Control and Prevention, Shenzhen, China 11:20 O-04 Nk- pdc Cross-Talk Leads to the Generation of Mtrail+Ifn-Α+Cytotoxic pdc s Following HIV-1 Infection of pdc s. Consequences on the Control of Viral Replication Héla Saïdi (1) Marlene Bras (1)* Formaglio Pauline (1) Melki Marie-thérèse (1) Gougeon Marie-Lise (1) (1) Institut Pasteur, Paris, France 11:30 O-05 Th1/Th17 Gammadelta T Cells Are Expanded in HIV-1 Infected Patients and Respond to Candida Albicans. Alessandro Poggi (1)* Daniela Fenoglio (2) Florinda Battaglia (2) Silvia Catellani (3) Alessandra Musso (1, 6) Maurizio Setti (4) Giuseppe Murdaca (5) Maria Raffaella Zocchi (6) (1) National Institute for Cancer Research, Genoa, Italy (2) CEBR, University of Genoa, Genoa, Italy (3) Department of Oncohematology, University of Genoa, Genoa, Italy (4) Department of Internal Medicine, University of Genoa, Genoa, Italy (5) Department of Semiotics, University of Genoa, Genoa, Italy (6) Scientific Institute San Raffaele, Department of Immunology, Milan, Italy 11:40 O-06 NK-Dependent Survival of HIV-1 Infected DCs. Pivotal Role of HMGB1. Marie-Thérèse Melki (1)* Héla Saïdi (1) Marie-Lise Gougeon (1) (1) Institut Pasteur, Paris, France 11:50 O-07 γδ T Cells are ADCC Effectors in Elite HIV Controllers Bhawna Poonia (1) David Riedel (1) Cristiana Cairo (1) Mohammed Sajadi (1) Cheryl Armstrong (1) David Pauza (1)* (1) Institute of Human Virology, University of Maryland Medical School, Baltimore, USA 12:00 O-08 CpG Methylation Controls Reactivation of HIV from Latency Jana Blazkova (1, 2, 3)* Katerina Trejbalova (1, 2) Francoise Gondois-Rey (1) Halfon Philippe (4) Philibert Patrick (5) Eric Verdin (6) Daniel Olive (1) Carine van Lint (3) Jiri Hejnar (2) Ivan Hirsch (1) (1) INSERM, UMR891, Centre de Recherche en Cancérologie de Marseille and Institut Paoli-Calmettes, and Université Méditerranée, Marseille, France (2) Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic (3) Laboratory of Molecular Virology, Institute for Molecular Biology and Medicine (IBMM) University of Brussels (ULB), Gosselies, Belgium (4) Department of Virology, Alphabio Laboratory, Marseille, France (5) Department of Infectious Diseases, Hôpital Ambroise Paré, Marseille, France (6) Gladstone Institute of Virology and Immunology, San Francisco, USA 19

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