THE VIRAL HEPATITIS CONGRESS September 2015, Kap Europa, Frankfurt, Germany THE VIRAL HEPATITIS CONGRESS. Scientific Programme

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1 THE VIRAL HEPATITIS CONGRESS THE VIRAL HEPATITIS CONGRESS September 2015, Kap Europa, Frankfurt, Germany Scientific Programme

2 PRE-CONGRESS WORKSHOP SPONSOR ACHILLION Achillion is seeking to apply its expertise in biology and structure-guided design and a deep understanding of patient and clinician needs to develop innovative treatment solutions aimed at improving patients lives. On May 19, 2015, Achillion announced it had granted Janssen Pharmaceuticals, Inc. (Janssen), one of the Janssen Pharmaceutical Companies of Johnson & Johnson, an exclusive, worldwide license to develop and, upon regulatory approval, commercialize HCV products and regimens containing one or more of Achillion s HCV assets which include odalasvir (ACH-3102), ACH-3422, and sovaprevir. A key objective of the collaboration is to develop a short-duration, highly effective, pan-genotypic, oral regimen for the treatment of HCV. Founded in 2000 and headquartered in New Haven, CT, Achillion believes that its scientific excellence, integrated capabilities and experienced team position it to successfully achieve its goal of advancing new products along the entire continuum from the bench to the patient. PRE-CONGRESS WORKSHOP PRE-CONGRESS WORKSHOP , Thursday 10 September Welcome and introduction Ira Jacobson (US) The changing face of hepatitis C: new patients, new challenges Heiner Wedemeyer (Germany) Discussion: new patients, new challenges Two interactive case challenges and discussion including audience voting by colour cards Cases introduced by: Ira Jacobson Heiner Wedemeyer Summary and close Ira Jacobson (US) 51

3 JANSSEN At Janssen, we are dedicated to addressing and solving some of the most important unmet medical needs of our time in oncology, immunology, neuroscience, infectious diseases and vaccines, and cardiovascular and metabolic diseases. Driven by our commitment to patients, we develop innovative products, services and healthcare solutions to help people throughout the world. About Janssen's Hepatitis C Development Program The goal of the Janssen HCV clinical development program is to provide physicians with multiple treatment options in order to offer patients the best possible chance of achieving a cure. Ongoing studies focus on the investigation of the NS3/4A protease inhibitor simeprevir in a number of different treatment combinations and HCV patient populations, including those who are difficult to cure. Following the acquisition of Alios BioPharma by Johnson & Johnson in November 2014 and the recent collaboration with Achillion Pharmaceuticals Inc., the Janssen HCV pipeline includes AL-335, a uridine based nucleotide analog; AL-516, a guanosine-based nucleotide analog NS5B polymerase inhibitor; odalasvir (ACH-3102), an NS5A inhibitor; ACH-3422, a nucleotide pro-drug of a uridine analog; and sovaprevir, a protease inhibitor. These compounds are being developed with the express intent of targeting critical steps of the HCV virus replication cycle with the potential of delivering new treatment options for patients. About Hepatitis C Virus Hepatitis C virus (HCV), a blood-borne infectious disease of the liver and a leading cause of chronic liver disease, is a major global public health concern. Eleven HCV genotypes with several distinct subtypes have been identified throughout the world. These diversities have distinct consequences: although different strains have not been shown to differ dramatically in their virulence or pathogenicity, different genotypes vary in their responsiveness to therapy. Approximately 150 million people are infected with hepatitis C worldwide and 350,000 people per year die from the disease globally. When left untreated, hepatitis C can cause significant damage to the liver, including cirrhosis. Additionally, hepatitis C may increase the risk of developing complications from cirrhosis, which may include liver failure , Thursday 10 September Hepatitis C treatment in the spotlight: where do we stand, where do we go? Opening and introduction Christoph Sarrazin What have we learnt from short IFN-free regimens in non-cirrhotic patients? Ashley Brown How should we treat cirrhotic patients? Christoph Sarrazin Hepatitis C: an outlook to the future Christophe Hézode Panel discussion and close All 52

4 ABBVIE AbbVie is a global, research-based biopharmaceutical company formed in 2013 following separation from Abbott Laboratories. The company s mission is to use its expertise, dedicated people and unique approach to innovation to develop and market advanced therapies that address some of the world s most complex and serious diseases. Together with its wholly-owned subsidiary, Pharmacyclics, AbbVie employs more than 28,000 people worldwide and markets medicines in more than 170 countries , Friday 11 September IFN-free for HCV: From Clinical Trials to Clinical Reality Welcome and Introduction: From Clinical Trials to Clinical Reality Stefan Zeuzem, Germany IFN-free for HCV: Learnings from the Phase III Clinical Trials Tram Tran, USA IFN-free for HCV: Moving from Clinical Trials into the Real-World Tania Welzel, Germany IFN-free for HCV: Key Observations from Real-World Study Data Robert Brown, USA Q&A and summary Stefan Zeuzem & Jörg Petersen, Germany 53

5 BRISTOL-MYERS SQUIBB Bristol-Myers Squibb is a global Specialty Care BioPharma company firmly focused on its mission to discover, develop and deliver innovative medicines that help patients prevail over serious diseases such as cancer, HIV/AIDS, hepatitis B and C, rheumatoid arthritis and cardiovascular disease , Friday 11 September Difficult-to-treat Hepatitis C patients: the real life story in Europe Welcome and introduction REAL-WORLD EUROPEAN STORIES: Patients with advanced liver disease in Germany Tania Welzel (Germany) Patients with GT-3 infection in the UK Graham Foster (UK) Patients with HIV/HCV coinfection in France Karine Lacombe (France) PANEL DISCUSSION: Cure of hepatitis C infection from a global perspective All Summary and close 54

6 GILEAD Gilead Sciences, a research based biopharmaceutical company, discovers, develops and commercialises innovative medicines in areas of unmet medical need. Gilead s therapeutic areas of focus include HIV/AIDS, liver diseases, cancer and inflammation, and serious respiratory and cardiovascular conditions. Founded in 1987 in Foster City, California, Gilead now employs approximately 7,000 people in offices across five continents. Over 25 years, Gilead has become a leading biopharmaceutical company with a rapidly expanding product portfolio and a growing pipeline of investigational drugs. With each new discovery and investigational drug candidate, we seek to improve the care of patients living with life threatening diseases around the world , Saturday 12 September Conquering C leaving no one behind Conquering C possibilities in the DAA era New realities for diagnosis and fibrosis staging Ira Jacobson (USA) Real world success in practice Peter Buggisch (Germany) Practical realities for patient management Stanislas Pol (France) Realities for elimination in specific populations Graham R Foster (UK) Discussion Panel Conquering C realities in the DAA era 55

7 SPONSORS Alongside exhibitions from the four major sponsors, we are pleased to welcome: ECHOSENS Echosens is a pioneer in non-invasive diagnosis solutions in hepatology. FribroScan, based on proprietary Vibration Control Transient Elastography, is the only worldwide clinically validated medical device using elastography with more than 900 peer-reviewed publications. FibroMeter is a range of scores combining several blood biomarkets to measure the degree of fibrosis in the liver. You can follow Echosens on WI-FI SPONSORS 56

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