Journée des Industriels du Réseau TRIGGERSEP

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1 Journée des Industriels du Réseau TRIGGERSEP Djillali ANNANE Hôpital Raymond Poincaré (AP-HP) Lab Cell Death Inflamation & Infection UMR1173 UVSQ/INSERM Mercredi 3 juin 2015 Institut Pasteur Paris

2 Expertise: Clinical Trials Design and Coordination - Sepsis Expertise: Logistical Research Coordination - Sepsis Expertise: Scientific Coordination Sepsis Jean-Paul Mira WP3 «Scientific Board» Leader Bruno François Co-Coordinator and WP2 «Investigation Support» Leader Djillali Annane Coordinator Pierre-François Dequin WP1 «Clinical Investigation Support» Leader Expertise: Clinical Investigation Coordination Pierre-François Laterre Expertise: Sepsis Trial Europe Interaction WP4 Expertise: Basic Research, Sepsis Jean-Daniel Chiche Genomic Research Sylvie Chevret Responsible for development on new trial design for Sepsis Guillaume Monneret Immunology and Cytometry exploration Fabrice Chrétien Neuro-Immunology and Histology Expertise: Human and animal model Histopathology Experimental pathology - Neuropathology Expertise: Biostatistics, Clinical Trials, Cohort Studies, Prognosis Expertise: Immunology of Sepsis

3 Plateformes d Investigation Clinique 5 CIC Unité de récherche 4 UMR TRIGGERSEP Biostatistique Réseau de centres hospitaliers académiques et non académiques 15 centres 3

4 CICs Specificities CIC1435 (Limoges) Linked with ICU Organization expertise in Emergency Trials field Coordination of CRICS effector network CIC1415 (Tours) Statistic expertise Methodological involvement in CRICS academic research Critical Care Medicine identified as an axis CIC1414 (Rennes) Data management and biostatistics in Sepsis therapeutic trials Pharmacology and pharmaco-epidemiology of Sepsis Specific team Pharmacology of Sepsis and septic shock [quadrennial ] CIC1429 (Garches) Scientific expertise of the coordinating physician in therapeutic trials on Sepsis Scientific expertise in medical devices and other innovative technologies CIC1417 (Cochin Pasteur) Scientific expertise in vaccines with possible development High dynamic of research of the site in Resuscitation and Sepsis field

5 Hospitals network TRIGGERSEP investigation network: 15 academic and non-academic hospitals in France and Belgium 310 beds (total for ICU and emergency services) More than admissions in 2014 including 60% of ventilated patients septic patients (severe sepsis and septic shock) per year 3451 patients participating in clinical trials in 2014

6 Lab facilities and links to translational research 5 UMR: Jean Daniel Chiche & Jean Paul Mira «Innate immunity, Toll-like receptors & variability of inflammatory response» INSERM U1016, Cochin Institute. Guillaume Monneret joint unit Pathophysiology of injury-induced immunosuppression (Lyon I HCL BioMérieux) Fabrice Chrétien «Research Unit Human Histopathology and animal models, Institut Pasteur, Paris Sylvie Chevret ECSTRA, INSERM U1153, Paris Diderot University (Biostatistics and Clinical Epidemiology), Paris, Djillali ANNANE Cell Death Inflamation &Infection, INSERM U1173, UVSQ, Montigny Le Bretonneux

7 International Recognitions International Task Force on Sepsis Definition (Jean Daniel Chiche & Djillali Annane) Surviving Sepsis Campaign (Jean Daniel Chiche & Djillali Annane) International Sepsis Forum (Jean Paul Mira) SCCM/ESICM Task Force on Corticosteroid Insufficiency in Critical Illness (Djillali Annane) Senior coordinators for many international studies Board members of trials committees, of scientific journals, meetings

8 Scientific Achievements NEJM: 12 JAMA: 16 Lancet: 15 Nature Medicine: 2

9 TRIGGERSEP Scientific Project Toward personalized medicine for sepsis! Individual vs. population-based approach Biomarkers Immuno-Monitoring Genomic data Innovative tools for sepsis investigations Databases datamining / «big» data Adaptive designs Research on the influence of qualitative aspects of investigation centres

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