ON CLINICAL PHARMACOLOGY OF ANTIRETROVIRALS 10 RESIDENTIAL COURSE January Starhotels Majestic. corso Vittorio Emanuele II 54 - TURIN

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1 TH 10 RESIDENTIAL COURSE ON CLINICAL PHARMACOLOGY OF ANTIRETROVIRALS Starhotels Majestic corso Vittorio Emanuele II 54 - TURIN January 2015

2

3 TH 10 RESIDENTIAL COURSE ON CLINICAL PHARMACOLOGY OF ANTIRETROVIRALS Course Director Prof. G. Di Perri Unit of Infectious Diseases, Department of Medical Sciences, University of Turin, Italy Scientific Secretariat Prof. S. Bonora Unit of Infectious Diseases, Department of Medical Sciences, University of Turin, Italy Phone: / , Fax: Organizing Secretariat and CME Provider HealthData Consulting S.r.l. Via Morghen, 27 Turin - Italy Phone Fax Please note, that this programme may be subject to alteration and the organizers reserve the right to do so without giving prior notice. The current programme is available at

4 COURSE RATIONALE The effectiveness of Highly Active Antiretroviral Therapy (HAART) has dramatically changed the life expectancy of HIV-positive individuals. In last years, availability of new drugs and new classes of compounds led to increase therapeutical choices for HIV patients. However, drug development in this field has been particularly rapid, and many issues related to long-term drug efficacy and safety have still to be evaluated in the clinical setting. Moreover, focus on individual needs of HIV patients according to genetic, demographical and clinical characteristics, suggested by a modern viewpoint of management of this longlife treatment, emphasizes the need of personalization and optimization of the regimens. Under this viewpoint, knowledge of clinical pharmacology of antiretrovirals seems crucial for a modern approach to HIV therapy. A proper use of drugs according to pharmacokinetic and pharmacodynamic properties can maximize the benefits and limit the drawbacks of the treatment. AIM OF THE COURSE The aim of the 3-day curse is to address the clinicians to a correct management of antiretroviral therapy based on a sound and comprehensive evaluation of the PK/PD characteristics of antiretroviral drugs. The course contents will consist of lectures, clinical case' presentations, roundtables and plenary discussions in order to stimulate confrontation and improve understanding of critical issues. o TARGET AUDIENCE AND CME CREDITS Healthcare professionals who routinely take care of patients with HIV infection. Provider HealthData Consulting s.r.l. (n.546) has assigned 14 CME credits according to Italian Health Ministry s criteria. CME credits will only be awarded to Italian participants who attend the entire course. These categories of health professionals are eligible for CME credit assignment: phisicians, hospital pharmacists and biologists. FACULTY M. Andreoni, Department of Infectious Diseases, University Tor Vergata, Rome, Italy. A. Antinori, Department of Infectious Diseases, IRCCS Lazzaro Spallanzani, Rome Italy. D. Back, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK. M. Boffito, St Stephen's AIDS Trust, Chelsea and Westminster Hospital, London, UK. S. Bonora, Unit of Infectious Diseases, Department of Medical Sciences, University of Turin, Italy. M. Bracchi, Department of Infectious Diseases, University of Turin, Italy. A. Calcagno, Unit of Infectious Diseases, Department of Medical Sciences, University of Turin, Italy.

5 D. Cattaneo, Clinical Pharmacology Unit, Luigi Sacco Hospital, Milan, Italy. P. Cinque, Infectious Diseases Unit, Fondazione Centro S. Raffaele Monte Tabor - H.S. Raffaele, Milan, Italy. F. Ceccherini-Silberstein, Virology Unit, University Tor Vergata, Rome, Italy. A. D'Avolio, Department of Infectious Diseases, University of Turin, Italy. G. Di Perri, Unit of Infectious Diseases, Department of Medical Sciences, University of Turin, Italy. C. V. Fletcher, Departments of Pharmacy Practice and Division of Infectious Diseases, Department of Internal Medicine at the University of Nebraska Medical Center, USA. C. Flexner, Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. M. Galli, Department of Infectious Diseases, University of Milan, Italy. R. Garraffo, Pharmacology Laboratory, CHU Pasteur, Nice, France. V. Ghisetti, Microbiology and Virology Laboratory, Amedeo di Savoia Hospital, Turin, Italy. A. Hill, Pharmacology Research Laboratories, University of Liverpool, UK. S. Khoo, Department of Pharmacology & Therapeutics, University of Liverpool, UK. M. Kurowski, Department of Immunodeficiency Diseases, Ludwig Maximilians University, Berlin, Germany. A. Jackson, SSAT Clinical Trials Unit, St Stephen's Centre, Chelsea and Westminster Hospital, London, UK. M. Lamorde, Research Department, Infectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Uganda. S. Letendre, Department of Medicine, University of California San Diego, La Jolla, CA, USA. L. Marinaro, Department of Infectious Diseases, University of Turin, Italy. A. Marzano, Department of Gastroenterology, University of Turin, Italy. C. Marzolini, Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland. A. Owen, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK. C. F. Perno, Virology Unit, University Tor Vergata, Rome, Italy. M. Puoti, Infectious Diseases Unit, Niguarda Ca' Granda Hospital, Milan, Italy. M. Rizzetto, Department of Gastroenterology, University of Turin, Italy. M. Siccardi, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK. L. Trentini, Department of Infectious Diseases, University of Turin, Italy.

6 21 JANUARY, st 21 JANUARY, AFTERNOON SESSION 14:15 Welcome and introduction 14:30 Lecture: Ten years of Course on Clinical Pharmacology of ARVs (G. Di Perri) Does one size fit all? (Chair: M. Kurowski, R. Garaffo) 15:10 New issues in management of drug-drug interactions (C. Marzolini) 15:30 Case presentations of drug-drug interaction (M. Bracchi, L. Trentini) 16:00 Clinical pharmacology of toxicity (G. Di Perri) 16:30 Coffee break 17: 00 TDM in clinical practice (L. Marinaro) 17:30 Role of clinical pharmacology in developing countries (M. Lamorde) 18:00 Dosing of ARVs: time for review (A. Hill) 22 JANUARY, nd 22 JANUARY, MORNING SESSION Lecture (Chair: G. Di Perri) 09:00 Lecture: Clinical pharmacology of ARVs in last 10 years: achievements and gaps (D. Back) New standards/strategies: present and future (Chair: A. Owen, M. Galli) 09:30 Pharmacology of INIs (M. Boffito) 10:00 Pharmacology of Less Drug Regimens (S. Bonora) 10:30 New drugs and formulations: pharmacology of the pipeline (C. Flexner) 11:00 Coffee break 11:30 Nanomedicine of infectious diseases (M. Siccardi) 12:00 Pharmacology of generics (D. Cattaneo) 12: 30 Clinician's viewpoint on generics : what's to like and what's not (S. Khoo) 13:00 Lunch

7 AFTERNOON SESSION Stop HIV, early or later (Chair: G. Di Perri, M. Andreoni) 14:00 Pharmacokinetics and Pharmacodynamics in HIV Prevention (A. Jackson) 14:30 Virology of eradication (C. F. Perno) 15:00 Pharmacology of eradication: insight the reservoirs (C. Fletcher) 15:30 Drugs inside: intracellular penetration (A. D'Avolio) 16:00 Coffee break How to control HIV in the brain? (Chair: A. Antinori) 16:30 Introduction 16:40 Selecting the right drugs (S. Letendre) 17:00 Searching the right target (A. Calcagno) 17:20 Lowering immune activation and inflammation (P. Cinque) 17:40 Plenary discussion 23 JANUARY, rd 23 JANUARY, MORNING SESSION HCV/HBV: surfing the wave (Chair: M. Rizzetto, V. Ghisetti) 09:00 Pharmacological features of liver impairment (G. Di Perri) 09:30 New drugs and strategies for HCV treatment (M. Puoti) 10:00 Advances in treatment of HBV (A. Marzano) 10:30 Coffee break 11:00 Drug drug interactions of new HCV and HBV drugs (S. Bonora) 11:30 Virological variables of anti-hcv/hbv therapies (F. Ceccherini-Silberstein) 12:00 Plenary discussion 12:20 Closing remarks (G. Di Perri) 12:50 CME test

8 COURSE LOCATION and HOTEL ACCOMODATION Starhotels Majestic corso Vittorio Emanuele II 54, Turin Tel Fax

9 REGISTRATION INCLUDES - Admission to all course sessions - Name tag - Satchel - Free onsite wireless for attendee use - Catering as per below Please see what meals are included with your registration below: DAY BREAKFAST MORNING BREAK LUNCH AFTERNOON BREAK DINNER Wednesday st 21 January Not included Not included Not included* Starhotels Majestic Starhotels Majestic Thursday nd 22 January Not included Starhotels Majestic Starhotels Majestic Starhotels Majestic Social Dinner Friday rd 23 January Starhotels Not included Not included** Not included Majestic Not included * Welcome refreshment ** Light refreshment The Course offers to all the attendees of the event a Social Dinner at Palazzo Barolo, Via delle Orfane 7, Turin. Social dinner is free of charge for participants, but is essential to confirm your presence. In confirming your participation, let us know if you require a vegetarian meal, or if you have any food intollerance or allergies.

10 NOTES

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