Pleural Mesothelioma 2013:

The Penn Mesothelioma and Pleural Program and Penn Presbyterian Medical Center Present Pleural Mesothelioma 2013: Multidisciplinary Diagnosis, Treatment and Investigation A C M E / C E - C E R T I F I E D C O U R S E 7:30-8:30 AM - Registration 8:30 AM - 4:50 PM - Course C O U R S E D I R E C T O R Joseph S. Friedberg, MD Rittenhouse Hotel

Pleural Mesothelioma 2013: Multidisciplinary Diagnosis, Treatment and Investigation Program Overview & Target Audience This course is a state-of-the-art review of the etiology, diagnosis, treatment and investigation of malignant pleural mesothelioma. The faculty of national and international experts have been selected to provide the full spectrum of perspectives on the many challenging and controversial topics surrounding this cancer. The review covers the gamut from the pearls and pitfalls associated with diagnosing mesothelioma and palliating recurrent effusions to the current state of, and indications for, standard and investigational treatments to the criteria for initiating palliative care. Presented for clinicians, there will be a select review of the most cutting edge genetic, translational and clinical research. Each topic section will conclude with an audience interactive panel discussion and the course will conclude with an audience interactive mock multidisciplinary tumor board addressing commonly encountered, yet challenging, clinical scenarios. This course will be of interest and use to anyone who interfaces with malignant pleural mesothelioma: internists, pulmonologists, gerontologists, oncologists, radiation oncologists, thoracic/general/oncologic surgeons, pathologists, radiologists, researchers, research nurses, nurse practitioners, physician assistants and any trainees. Learning Objectives: After attending this course participants should be able to: Review the diagnosis of patients with malignant pleural mesothelioma, including common pitfalls to avoid and seemingly inconsequential decisions at the diagnostic stage that can have major impact during the treatment stage Describe the potential role for, and combinations of, standard treatment modalities as well as current and upcoming investigational modalities Discuss the current research on malignant pleural mesothelioma, as it pertains to clinicians Discuss the criticality of a multidisciplinary approach to treating patients with malignant pleural mesothelioma, after having participated in a tumor board reviewing commonly encountered and challenging case studies Hosting Department and Organization Pleural Mesothelioma 2013: Multidisciplinary Diagnosis, Treatment and Investigation is hosted by the Penn Mesothelioma and Pleural Program and Penn Presbyterian Medical Center. Accreditation Physicians: The Perelman School of Medicine at the University of Pennsylvania is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. Nurses: Penn Presbyterian Medical Center, Department of Nursing Development and Education, is an approved provider of continuing nursing education by the PA State Nurses Association, an accredited approver by the American Nurses Credentialing Center s Commission on Accreditation. Designation of Credit Physicians: The Perelman School of Medicine at the University of Pennsylvania designated this live activity for a maximum of 7 AMA PRA Category 1 Credits TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity Nurses: Penn Presbyterian Medical Center Department of Nursing Development and Education awards this activity 7.0 contact hours. AAPA: AAPA accepts certificates of participation for educational activities certified for Category 1 credit from AOACCME, prescribed credit from AAFP, and AMA PRA Category 1 Credit from organizations accredited by ACCME or a recognized state medical society. Physician assistants may receive a maximum of 7 AMA PRA Category 1 Credits for completing this program. Disclosures The Perelman School of Medicine at the University of Pennsylvania, Office of Continuing Medical Education, adheres to the ACCME Standards for Commercial Support. Faculty disclosure information will be made available in the conference materials and syllabus. Faculty members are also expected to disclose to participants any discussions of off-label and/or investigational uses of pharmaceutical products within their presentations. Registration Fees The registration fees for Pleural Mesothelioma 2013: Multidisciplinary Diagnosis, Treatment and Investigation are discounted for those registering on or before October 15, 2013. Please plan to register early. The registration fee for Practicing Physicians is $150 on or before October 15, 2013 and $200 after October 15, 2013. The registration fee for Allied Health Professionals is $75 on or before October 15, 2013 and $100 after October 15, 2013. A special registration rate will be applied to trainees and Penn Faculty and Staff. The registration fee includes attendance to the conference, a course booklet and a link to view the presentations online, continental breakfast, mid-morning and afternoon refreshments and lunch. You may register online for the course by visiting www.penncmeonline.com and click on CME Activities. You may also mail or fax your completed registration form and payment. Checks should be made payable to Trustees of the University of Pennsylvania CME. All registrations will be confirmed if received by November 1, 2013

Except as otherwise indicated, the course directors and faculty are from Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA COURSE DIRECTOR Joseph S. Friedberg, MD Professor of Surgery Division of Thoracic Surgery COURSE FACULTY Guest Faculty Paul Baas, MD, PhD Professor of Medicine Department of Thoracic Oncology The Netherlands Cancer Institute Amsterdam, The Netherlands Raffit Hassan, MD Professor of Medicine Solid Tumor Immunotherapy Section Center for Cancer Research - National Cancer Institute Bethesda, MD Mary Hesdorffer, CRNP Executive Director, Mesothelioma Applied Research Foundation Alexandria, VA Lee Krug, MD Associate Professor of Medicine Division of Medical Oncology Memorial Sloan-Kettering Cancer Center New York, New York Joseph R. Testa, PhD Professor and Carol & Kenneth E. Weg Chair in Human Genetics Fox Chase Cancer Center Philadelphia, PA Penn Faculty Steven Albelda, MD William Maul Measy Professor of Medicine Division of Pulmonary and Critical Care Evan Alley, MD, PhD Associate Professor of Medicine Division of Hematology-Oncology Keith Cengel, MD, PhD Associate Professor of Radiation Oncology Melissa Culligan RN, MS Director of Clinical Research Penn Mesothelioma and Pleural Program Department of Surgery Chi Van Dang, MD, PhD John H Glick, MD Abramson Cancer Center Director s Professor, Medicine Director, Abramson Cancer Center University of Pennsylvania Stephen Hahn, MD Henry K. Pancoast Professor and Chair, Department of Radiation Oncology Sharyn Katz, MD Assistant Professor of Radiology Department of Radiology Anthony Lanfranco, MD Assistant Professor of Medicine Division of Pulmonary and Critical Care Medicine Leslie Litzky, MD Professor of Pathology and Laboratory Medicine Anna Moran, MD Assistant Professor of Pathology and Laboratory Medicine Anjana Ranganathan, MD Palliative Care Fellow Department of Medicine Charles Simone III, MD Assistant Professor of Radiation Oncology Daniel Sterman, MD Associate Professor of Medicine Division of Pulmonary and Critical Care Medicine Cancellation and Refund Policy In order to process refunds for course withdrawals, cancellations must be received in writing by November 1, 2013 and are subject to a service charge equivalent to 10% of the registration fee. No refunds will be issued thereafter. The University reserves the right to cancel or postpone this course due to unforeseen circumstances. In the event of a cancellation or postponement, the University will refund registration fees but is not responsible for related costs or expenses to participants, including cancellation fees assessed by hotels, airlines, and travel agencies. Meeting Location Pleural Mesothelioma 2013: Multidisciplinary Diagnosis, Treatment and Investigation will be held on at Rittenhouse Hotel,, Hotel Information If overnight accommodations are needed, please contact The Rittenhouse Hotel and mention your intention to attend the Meso 2013 conference and a special hotel rate will be applied. The Rittenhouse Hotel Reservations: 1-800-635-1042 www.rittenhousehotel.com

A CME/CE-CERTIFIED COURSE Pleural Mesothelioma 2013: Multidisciplinary Diagnosis, AGENDA 7:30 AM Registration and Continental Breakfast 8:30 AM Opening remarks Chi Van Dang, MD, PhD 8:35 AM Introduction Joseph Friedberg, MD 8:40 AM Catching zebras Critical elements of diagnosing mesothelioma and pitfalls to avoid 8:50 AM Treatment and Investigation 10:20 AM When is enough, enough the role for palliative care Although the nihilistic view toward patients with this cancer is on the wane, there is still a clear role for palliative care, the topic of this presentation. 11:00 AM Mesothelioma, what I have seen and what I see a global perspective Anthony Lanfranco, MD Paul Baas, MD, PhD Needles and fluid Can you diagnose mesothelioma with cytology? This presentation will review the benefits and limitations of cytology in diagnosing malignant pleural mesothelioma, both on pleural fluid and fine needle aspirations. Cores and more How do you diagnose mesothelioma with pathology? This presentation will discuss the current state-of-the-art in systemic chemotherapy for treating patients with malignant pleural mesothelioma and will also review current and upcoming investigational agents. 9:30 AM Mesothelioma Is there a standard of care, is there a staging system? This presentation, by an acknowledged world leader, will discuss the current staging of malignant pleural mesothelioma, including the limitations of this system, and will review what is currently considered standard treatment. Charles Simone III, MD 10:05 AM Does surgery have a standard role in treating mesothelioma? This talk will review the different diagnostic and therapeutic surgical approaches for a patient with malignant pleural mesothelioma, including the relative risks and benefits of each approach. Joseph Friedberg, MD Daniel Sterman, MD 3:15 PM Panel Question and answer session 3:45 PM Expert panel case presentations challenging cases that are commonly seen This mock tumor board will serve as a vehicle for audience participation as commonly encountered clinical scenarios are presented and discussed, highlighting the benefits and necessity of viewing this cancer from a multidisciplinary perspective and tying together the major points of the day s course. Stephen Hahn, MD 1:00 PM Melissa Culligan, RN, MS Session Moderator Panel participants: Steven Albelda, MD, Evan Alley, MD, PhD, Paul Baas, MD, Keith Cengel, MD, PhD, Joseph Friedberg, MD, Raffit Hassan, MD, Stephen Hahn, MD, Lee Krug, MD, Anthony Lanfranco, MD, Anjana Ranganathan, MD, Charles Simone, MD, Daniel Sterman, MD Photodynamic therapy and flax seed muffins future, fad or fancy? This presentation will review the results, science and rationale for some unconventional treatments for patients with malignant pleural mesothelioma and will present intriguing research that may serve as the basis for future therapies. Keith Cengel, MD, PhD 1:15 PM 4:40 PM Closing remarks Joseph Friedberg, MD 4:50 PM Adjourn Immunotherapy what s out there now, what s coming down the road? This presentation, from one of the fathers of the field of immunotherapy for mesothelioma, will review the results of past and current therapies as well as future directions for this treatment modality. Bridging the lab and the clinic, bridging the community and specialty center how do we move the field forward for our patients? This presentation will provide the background and perspective to help the audience become active members of the collaborative community that is necessary to benefit current and future patients with malignant pleural mesothelioma by adopting a whole is greater than the sum of the parts mentality. This presentation will review current investigational radiation treatments for patients with malignant pleural mesothelioma and will also discuss future directions for this treatment modality. Steven Albelda, MD 1:35 PM Mesothelin targeted therapies The NIH experience This presentation, by the world s foremost expert, will present the theory, science and results of biotherapeutic targeted therapy being performed at the National Cancer Institute. Does radiation have a standard role in treating mesothelioma? This presentation will review the different roles radiation can play in the treatment of a patient with malignant pleural mesothelioma, including the different applications for different widely available modalities. 2:55 PM 12:45 PM Protons, photons and the future of radiation for mesothelioma Lee Krug, MD 9:50 AM Mary Hesdorfer, CRNP Evan Alley, MD, PhD Leslie Litzky, MD Panel Question and answer session This presentation, by the person with likely the greatest number of contacts with mesothelioma patients in the world, will review what is being done for these patients and what could and should be done. 12:30 PM Systemic therapy, have we stalled out or is there more? This presentation will discuss the key elements in diagnosing malignant pleural mesothelioma, including how much tissue is required, and will review the different subtypes of the cancer. 9:15 AM The mesothelioma patient what are the unmet needs? 11:30 AM Lunch Anna Moran, MD 9:05 AM Panel Question and answer session 10:50 AM Break Sharyn Katz, MD 9:00 AM 2:15 PM 2:35 PM 10:30 AM Panel Question and answer session This presentation, an overview from an international expert, will take the audience on a guided tour of the diagnosis and treatment of patients with malignant pleural mesothelioma past, present and future. This presentation will review current modalities used in the imaging of patients with malignant pleural mesothelioma, including the relative benefits of each modality and the situations in which they should be employed. Rittenhouse Hotel Anjana Ranganathan, MD This presentation reviews the initial steps in diagnosing a patient with malignant pleural mesothelioma, including seemingly inconsequential initial decisions that can profoundly affect a patient s subsequent course. CT s and SUV s How do you image mesothelioma? Raffit Hassan, MD 1:55 PM BAP 1 the genetic basis of mesothelioma and what the future holds Presented by the investigator who, along with his collaborators, discovered the first inherited genetic mutation predisposing a person to develop malignant pleural mesothelioma, this presentation will review the current state of knowledge regarding genetics of this cancer and where this knowledge is taking us. Joseph Testa, PhD Services for the Disabled If special arrangements are required for an individual with a disability to attend this meeting, please contact Melissa Culligan at 215-662-9194. Nondiscrimination Statement The University of Pennsylvania values diversity and seeks talentedstudents, faculty, and staff from diverse backgrounds. The University of Pennsylvania does not discriminate on the basis of race, sex, sexual orientation, gender identity, religion, color, national or ethnic origin, age, disability, or status as a Vietnam Era Veteran or disabled veteran in the administration of educational policies, programs or activities; admissions policies; scholarship and loan awards; athletic, or other University administered programs or employment. Questions or complaints regarding this policy should be directed to Executive Director, Office of Affirmative Action and Equal Opportunity Programs, 3600 Chestnut Street, Sansom Place East Suite 228, Philadelphia, PA 19104-6106 or 215-898-6993 (Voice) or 215-898-7803 (TDD). www.upenn.edu/affirm-action.

CME REGISTRATION FORM Pleural Mesothelioma 2013: Multidisciplinary Diagnosis, Treatment and Investigation To register, please send the completed registration form along with a check payable to The Trustees of the University of Pennsylvania CME. Registration also available online at www.penncmeonline.com and click on CME Activities. Mail Payment and Registration Information to: Conference Coordinator Perelman School of Medicine at the University of Pennsylvania Office of Continuing Medical Education 333 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104-6021 Phone: 215-898-8005; fax: 215-898-1888 PLEASE PRINT OR TYPE Name (First) (Last) Academic Degree Medical Specialty Affiliation (Hospital, Office, or Company) Address ( affiliation home) City State Zip Phone Fax E-mail Registration Fees Includes continental breakfast, luncheon, refreshment breaks and a course booklet. Before October 15 After October 15 Physicians $150 $200 Residents / Fellows $50 $75 Allied Health Professionals $75 $100 Penn Staff and Faculty $50 $50 PPMC Nurses $0 $0 Payment Method Make check payable to The Trustees of the University of Pennsylvania/CME Visa MasterCard Discover American Express Authorization Signature Cardholder Name Card # Security Code Exp. Date Please Note: Walk-in registrants must bring payment to the program and seating may be limited. For additional information you may visit www.penncmeonline.com and click on CME Activities.

333 Blockley Hall 423 Guardian Drive Philadelphia, Pennsylvania 19104-6021 Pleural Mesothelioma 2013: Multidisciplinary Diagnosis, Treatment and Investigation Rittenhouse Hotel Non-Profit Org. U.S. Postage P A I D Permit No. 2563 Phila., PA 19104