Targeted Cancer Gene Analysis For Research Use Only - Not Intended for Clinical Use

Targeted Cancer Gene Analysis For Research Use Only - Not Intended for Clinical Use PGDX ID Sample ID Mutation Position Nucleotide (genomic) Amino Acid (protein) Mutation Type Consequence PGDX2163N_NotchCp SK100 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2115N_NotchCp SK51 chr9_138511764-138511764_t_g 2083H>P Substitution Nonsynonymous coding PGDX2115N_NotchCp SK51 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2115N_NotchCp SK51 chr9_138537987-138537987_c_t NA Substitution Splice site donor PGDX2116N_NotchCp SK52 chr9_138511764-138511764_t_g 2083H>P Substitution Nonsynonymous coding PGDX2116N_NotchCp SK52 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2117N_NotchCp SK53 chr9_138527305-138527305_a_c 819L>R Substitution Nonsynonymous coding PGDX2117N_NotchCp SK53 chr9_138538200-138538200_t_g 65S>R Substitution Nonsynonymous coding PGDX2118N_NotchCp SK54 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2119N_NotchCp SK55 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2120N_NotchCp SK56 chr9_138538200-138538200_t_g 65S>R Substitution Nonsynonymous coding PGDX2120N_NotchCp SK56 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2121N_NotchCp SK57 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2122N_NotchCp SK58 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2123N_NotchCp SK59 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2124N_NotchCp SK60 chr9_138538200-138538200_t_g 65S>R Substitution Nonsynonymous coding PGDX2124N_NotchCp SK60 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2125N_NotchCp SK61 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2126N_NotchCp SK62 chr9_138511764-138511764_t_g 2083H>P Substitution Nonsynonymous coding PGDX2126N_NotchCp SK62 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2127N_NotchCp SK63 chr9_138511764-138511764_t_g 2083H>P Substitution Nonsynonymous coding PGDX2127N_NotchCp SK63 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2128N_NotchCp SK64 chr9_138511764-138511764_t_g 2083H>P Substitution Nonsynonymous coding PGDX2128N_NotchCp SK64 chr9_138538200-138538200_t_g 65S>R Substitution Nonsynonymous coding PGDX2128N_NotchCp SK64 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2129N_NotchCp SK65 chr9_138538200-138538200_t_g 65S>R Substitution Nonsynonymous coding PGDX2129N_NotchCp SK65 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2130N_NotchCp SK66 chr9_138511764-138511764_t_g 2083H>P Substitution Nonsynonymous coding PGDX2130N_NotchCp SK66 chr9_138538200-138538200_t_g 65S>R Substitution Nonsynonymous coding PGDX2130N_NotchCp SK66 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2131N_NotchCp SK68 chr9_138511764-138511764_t_g 2083H>P Substitution Nonsynonymous coding PGDX2131N_NotchCp SK68 chr9_138538200-138538200_t_g 65S>R Substitution Nonsynonymous coding PGDX2131N_NotchCp SK68 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2132N_NotchCp SK69 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2133N_NotchCp SK70 chr9_138538200-138538200_t_g 65S>R Substitution Nonsynonymous coding PGDX2133N_NotchCp SK70 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2134N_NotchCp SK71 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2135N_NotchCp SK72 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2136N_NotchCp SK73 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2137N_NotchCp SK74 chr9_138519373-138519373_g_t 1531L>M Substitution Nonsynonymous coding PGDX2137N_NotchCp SK74 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2138N_NotchCp SK75 chr9_138527305-138527305_a_c 819L>R Substitution Nonsynonymous coding PGDX2138N_NotchCp SK75 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2139N_NotchCp SK76 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2140N_NotchCp SK77 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2141N_NotchCp SK78 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2142N_NotchCp SK79 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2143N_NotchCp SK80 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2144N_NotchCp SK81 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2145N_NotchCp SK82 chr9_138520123-138520123_g_a 1349A>V Substitution Nonsynonymous coding PGDX2145N_NotchCp SK82 chr9_138537131-138537131_c_t 245C>Y Substitution Nonsynonymous coding PGDX2145N_NotchCp SK82 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2146N_NotchCp SK83 chr9_138522337-138522337_t_c 1134Q>R Substitution Nonsynonymous coding PGDX2146N_NotchCp SK83 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2147N_NotchCp SK84 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2148N_NotchCp SK85 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2149N_NotchCp SK86 chr9_138527305-138527305_a_c 819L>R Substitution Nonsynonymous coding PGDX2149N_NotchCp SK86 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2150N_NotchCp SK87 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2151N_NotchCp SK88 chr9_138522337-138522337_t_c 1134Q>R Substitution Nonsynonymous coding PGDX2151N_NotchCp SK88 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2152N_NotchCp SK89 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2153N_NotchCp SK90 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2154N_NotchCp SK91 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2155N_NotchCp SK92 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2156N_NotchCp SK93 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2157N_NotchCp SK94 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2158N_NotchCp SK95 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2159N_NotchCp SK96 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2159N_NotchCp SK96 chr9_138537122-138537122_c_t NA Substitution Splice site donor PGDX2160N_NotchCp SK97 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2161N_NotchCp SK98 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor PGDX2162N_NotchCp SK99 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Supplemental Table 6

Targeted Cancer Gene Analysis For Research Use Only - Not Intended for Clinical Use PGDX ID Sample ID Nucleotide (genomic) Mutation Position Amino Acid (protein) PGDX2040T_NotchCp SK1 chr9_138511764-138511764_t_g 2083H>P Substitution Nonsynonymous coding #N/A Yes PGDX2040T_NotchCp SK1 chr9_138527305-138527305_a_c 819L>R Substitution Nonsynonymous coding #N/A Yes PGDX2040T_NotchCp SK1 chr9_138538200-138538200_t_g 65S>R Substitution Nonsynonymous coding #N/A Yes PGDX2040T_NotchCp SK1 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2048T_NotchCp SK10 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2087D_NotchCp SK101 chr9_138527305-138527305_a_c 819L>R Substitution Nonsynonymous coding #N/A Yes PGDX2087D_NotchCp SK101 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2088D_NotchCp SK102 chr9_138527305-138527305_a_c 819L>R Substitution Nonsynonymous coding #N/A Yes PGDX2088D_NotchCp SK102 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2089D_NotchCp SK103 chr9_138527305-138527305_a_c 819L>R Substitution Nonsynonymous coding #N/A Yes PGDX2089D_NotchCp SK103 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2090D_NotchCp SK104 chr9_138527305-138527305_a_c 819L>R Substitution Nonsynonymous coding #N/A Yes PGDX2090D_NotchCp SK104 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2091D_NotchCp SK105 chr9_138527305-138527305_a_c 819L>R Substitution Nonsynonymous coding #N/A Yes PGDX2091D_NotchCp SK105 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2092D_NotchCp SK106 chr9_138527305-138527305_a_c 819L>R Substitution Nonsynonymous coding #N/A Yes PGDX2092D_NotchCp SK106 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2093D_NotchCp SK107 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2094D_NotchCp SK108 chr9_138527305-138527305_a_c 819L>R Substitution Nonsynonymous coding #N/A Yes PGDX2094D_NotchCp SK108 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2095D_NotchCp SK109 chr9_138527305-138527305_a_c 819L>R Substitution Nonsynonymous coding #N/A Yes PGDX2095D_NotchCp SK109 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2049T_NotchCp SK11 chr9_138511764-138511764_t_g 2083H>P Substitution Nonsynonymous coding #N/A Yes PGDX2049T_NotchCp SK11 chr9_138527305-138527305_a_c 819L>R Substitution Nonsynonymous coding #N/A Yes PGDX2049T_NotchCp SK11 chr9_138538200-138538200_t_g 65S>R Substitution Nonsynonymous coding #N/A Yes PGDX2049T_NotchCp SK11 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2096D_NotchCp SK110 chr9_138527305-138527305_a_c 819L>R Substitution Nonsynonymous coding #N/A Yes PGDX2096D_NotchCp SK110 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2097D_NotchCp SK111 chr9_138527305-138527305_a_c 819L>R Substitution Nonsynonymous coding #N/A Yes PGDX2097D_NotchCp SK111 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2098D_NotchCp SK112 chr9_138527305-138527305_a_c 819L>R Substitution Nonsynonymous coding #N/A Yes PGDX2098D_NotchCp SK112 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2069D_NotchCp SK117 chr9_138527305-138527305_a_c 819L>R Substitution Nonsynonymous coding #N/A Yes PGDX2069D_NotchCp SK117 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2070D_NotchCp SK118 chr9_138527305-138527305_a_c 819L>R Substitution Nonsynonymous coding #N/A Yes PGDX2070D_NotchCp SK118 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2071D_NotchCp SK119 chr9_138527305-138527305_a_c 819L>R Substitution Nonsynonymous coding #N/A Yes PGDX2071D_NotchCp SK119 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2072D_NotchCp SK120 chr9_138527305-138527305_a_c 819L>R Substitution Nonsynonymous coding #N/A Yes PGDX2072D_NotchCp SK120 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2073D_NotchCp SK121 chr9_138527305-138527305_a_c 819L>R Substitution Nonsynonymous coding #N/A Yes PGDX2073D_NotchCp SK121 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2074D_NotchCp SK122 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2075D_NotchCp SK123 chr9_138527305-138527305_a_c 819L>R Substitution Nonsynonymous coding #N/A Yes PGDX2075D_NotchCp SK123 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2076D_NotchCp SK124 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2077D_NotchCp SK125 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2078D_NotchCp SK126 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2079D_NotchCp SK127 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2080D_NotchCp SK128 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2081D_NotchCp SK129 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2050T_NotchCp SK13 chr9_138511764-138511764_t_g 2083H>P Substitution Nonsynonymous coding #N/A Yes PGDX2050T_NotchCp SK13 chr9_138538200-138538200_t_g 65S>R Substitution Nonsynonymous coding #N/A Yes PGDX2050T_NotchCp SK13 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2082D_NotchCp SK130 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2083D_NotchCp SK131 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2084D_NotchCp SK132 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2085D_NotchCp SK133 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2086D_NotchCp SK134 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2099D_NotchCp SK135 chr9_138511764-138511764_t_g 2083H>P Substitution Nonsynonymous coding #N/A Yes PGDX2099D_NotchCp SK135 chr9_138538200-138538200_t_g 65S>R Substitution Nonsynonymous coding #N/A Yes PGDX2099D_NotchCp SK135 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2100D_NotchCp SK136 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2101D_NotchCp SK137 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2102D_NotchCp SK138 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2103D_NotchCp SK139 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2104D_NotchCp SK140 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2105D_NotchCp SK141 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2106D_NotchCp SK142 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2107D_NotchCp SK143 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2108D_NotchCp SK144 chr9_138511764-138511764_t_g 2083H>P Substitution Nonsynonymous coding #N/A Yes PGDX2108D_NotchCp SK144 chr9_138538200-138538200_t_g 65S>R Substitution Nonsynonymous coding #N/A Yes PGDX2108D_NotchCp SK144 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2109D_NotchCp SK145 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2110D_NotchCp SK146 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2111D_NotchCp SK147 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2112D_NotchCp SK148 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2113D_NotchCp SK149 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2114D_NotchCp SK150 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2051T_NotchCp SK19 chr9_138511764-138511764_t_g 2083H>P Substitution Nonsynonymous coding #N/A Yes PGDX2051T_NotchCp SK19 chr9_138527305-138527305_a_c 819L>R Substitution Nonsynonymous coding #N/A Yes PGDX2051T_NotchCp SK19 chr9_138538200-138538200_t_g 65S>R Substitution Nonsynonymous coding #N/A Yes PGDX2051T_NotchCp SK19 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2041T_NotchCp SK2 chr9_138511764-138511764_t_g 2083H>P Substitution Nonsynonymous coding #N/A Yes PGDX2041T_NotchCp SK2 chr9_138527305-138527305_a_c 819L>R Substitution Nonsynonymous coding #N/A Yes PGDX2041T_NotchCp SK2 chr9_138538200-138538200_t_g 65S>R Substitution Nonsynonymous coding #N/A Yes PGDX2041T_NotchCp SK2 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2052T_NotchCp SK22 chr9_138511764-138511764_t_g 2083H>P Substitution Nonsynonymous coding #N/A Yes PGDX2052T_NotchCp SK22 chr9_138527305-138527305_a_c 819L>R Substitution Nonsynonymous coding #N/A Yes PGDX2052T_NotchCp SK22 chr9_138538200-138538200_t_g 65S>R Substitution Nonsynonymous coding #N/A Yes PGDX2052T_NotchCp SK22 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2053T_NotchCp SK23 chr9_138511764-138511764_t_g 2083H>P Substitution Nonsynonymous coding #N/A Yes PGDX2053T_NotchCp SK23 chr9_138527305-138527305_a_c 819L>R Substitution Nonsynonymous coding #N/A Yes PGDX2053T_NotchCp SK23 chr9_138538200-138538200_t_g 65S>R Substitution Nonsynonymous coding #N/A Yes PGDX2053T_NotchCp SK23 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2054T_NotchCp SK24 chr9_138511764-138511764_t_g 2083H>P Substitution Nonsynonymous coding #N/A Yes PGDX2054T_NotchCp SK24 chr9_138527305-138527305_a_c 819L>R Substitution Nonsynonymous coding #N/A Yes PGDX2054T_NotchCp SK24 chr9_138538200-138538200_t_g 65S>R Substitution Nonsynonymous coding #N/A Yes PGDX2054T_NotchCp SK24 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2055T_NotchCp SK25 chr9_138511764-138511764_t_g 2083H>P Substitution Nonsynonymous coding #N/A Yes PGDX2055T_NotchCp SK25 chr9_138527305-138527305_a_c 819L>R Substitution Nonsynonymous coding #N/A Yes PGDX2055T_NotchCp SK25 chr9_138538200-138538200_t_g 65S>R Substitution Nonsynonymous coding #N/A Yes PGDX2055T_NotchCp SK25 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2056T_NotchCp SK27 chr9_138511764-138511764_t_g 2083H>P Substitution Nonsynonymous coding #N/A Yes PGDX2056T_NotchCp SK27 chr9_138538200-138538200_t_g 65S>R Substitution Nonsynonymous coding #N/A Yes PGDX2056T_NotchCp SK27 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2057T_NotchCp SK28 chr9_138511764-138511764_t_g 2083H>P Substitution Nonsynonymous coding #N/A Yes PGDX2057T_NotchCp SK28 chr9_138527305-138527305_a_c 819L>R Substitution Nonsynonymous coding #N/A Yes PGDX2057T_NotchCp SK28 chr9_138538200-138538200_t_g 65S>R Substitution Nonsynonymous coding #N/A Yes PGDX2057T_NotchCp SK28 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2058T_NotchCp SK29 chr9_138511764-138511764_t_g 2083H>P Substitution Nonsynonymous coding #N/A Yes PGDX2058T_NotchCp SK29 chr9_138527305-138527305_a_c 819L>R Substitution Nonsynonymous coding #N/A Yes PGDX2058T_NotchCp SK29 chr9_138538200-138538200_t_g 65S>R Substitution Nonsynonymous coding #N/A Yes PGDX2058T_NotchCp SK29 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2042T_NotchCp SK3 chr9_138511764-138511764_t_g 2083H>P Substitution Nonsynonymous coding #N/A Yes PGDX2042T_NotchCp SK3 chr9_138527305-138527305_a_c 819L>R Substitution Nonsynonymous coding #N/A Yes PGDX2042T_NotchCp SK3 chr9_138538200-138538200_t_g 65S>R Substitution Nonsynonymous coding #N/A Yes PGDX2042T_NotchCp SK3 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2059T_NotchCp SK30 chr9_138511764-138511764_t_g 2083H>P Substitution Nonsynonymous coding #N/A Yes PGDX2059T_NotchCp SK30 chr9_138527305-138527305_a_c 819L>R Substitution Nonsynonymous coding #N/A Yes PGDX2059T_NotchCp SK30 chr9_138538200-138538200_t_g 65S>R Substitution Nonsynonymous coding #N/A Yes PGDX2059T_NotchCp SK30 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2060T_NotchCp SK32 chr9_138511764-138511764_t_g 2083H>P Substitution Nonsynonymous coding #N/A Yes PGDX2060T_NotchCp SK32 chr9_138527305-138527305_a_c 819L>R Substitution Nonsynonymous coding #N/A Yes PGDX2060T_NotchCp SK32 chr9_138538200-138538200_t_g 65S>R Substitution Nonsynonymous coding #N/A Yes PGDX2060T_NotchCp SK32 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2061T_NotchCp SK34 chr9_138511764-138511764_t_g 2083H>P Substitution Nonsynonymous coding #N/A Yes PGDX2061T_NotchCp SK34 chr9_138527305-138527305_a_c 819L>R Substitution Nonsynonymous coding #N/A Yes PGDX2061T_NotchCp SK34 chr9_138538200-138538200_t_g 65S>R Substitution Nonsynonymous coding #N/A Yes PGDX2061T_NotchCp SK34 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2062T_NotchCp SK38 chr9_138511764-138511764_t_g 2083H>P Substitution Nonsynonymous coding #N/A Yes PGDX2062T_NotchCp SK38 chr9_138527305-138527305_a_c 819L>R Substitution Nonsynonymous coding #N/A Yes PGDX2062T_NotchCp SK38 chr9_138538200-138538200_t_g 65S>R Substitution Nonsynonymous coding #N/A Yes PGDX2062T_NotchCp SK38 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2043T_NotchCp SK4 chr9_138511764-138511764_t_g 2083H>P Substitution Nonsynonymous coding #N/A Yes PGDX2043T_NotchCp SK4 chr9_138527305-138527305_a_c 819L>R Substitution Nonsynonymous coding #N/A Yes PGDX2043T_NotchCp SK4 chr9_138538200-138538200_t_g 65S>R Substitution Nonsynonymous coding #N/A Yes PGDX2043T_NotchCp SK4 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2063T_NotchCp SK40 chr9_138511764-138511764_t_g 2083H>P Substitution Nonsynonymous coding #N/A Yes PGDX2063T_NotchCp SK40 chr9_138527305-138527305_a_c 819L>R Substitution Nonsynonymous coding #N/A Yes PGDX2063T_NotchCp SK40 chr9_138538200-138538200_t_g 65S>R Substitution Nonsynonymous coding #N/A Yes PGDX2063T_NotchCp SK40 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2064T_NotchCp SK41 chr9_138511764-138511764_t_g 2083H>P Substitution Nonsynonymous coding #N/A Yes PGDX2064T_NotchCp SK41 chr9_138527305-138527305_a_c 819L>R Substitution Nonsynonymous coding #N/A Yes PGDX2064T_NotchCp SK41 chr9_138538200-138538200_t_g 65S>R Substitution Nonsynonymous coding #N/A Yes PGDX2064T_NotchCp SK41 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2065T_NotchCp SK42 chr9_138511764-138511764_t_g 2083H>P Substitution Nonsynonymous coding #N/A Yes PGDX2065T_NotchCp SK42 chr9_138538200-138538200_t_g 65S>R Substitution Nonsynonymous coding #N/A Yes PGDX2065T_NotchCp SK42 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2068D_NotchCp SK46 chr9_138511764-138511764_t_g 2083H>P Substitution Nonsynonymous coding #N/A Yes PGDX2068D_NotchCp SK46 chr9_138527305-138527305_a_c 819L>R Substitution Nonsynonymous coding #N/A Yes PGDX2068D_NotchCp SK46 chr9_138538200-138538200_t_g 65S>R Substitution Nonsynonymous coding #N/A Yes PGDX2068D_NotchCp SK46 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2044T_NotchCp SK5 chr9_138511764-138511764_t_g 2083H>P Substitution Nonsynonymous coding #N/A Yes PGDX2044T_NotchCp SK5 chr9_138527305-138527305_a_c 819L>R Substitution Nonsynonymous coding #N/A Yes PGDX2044T_NotchCp SK5 chr9_138538200-138538200_t_g 65S>R Substitution Nonsynonymous coding #N/A Yes PGDX2044T_NotchCp SK5 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2066T_NotchCp SK50 chr9_138511764-138511764_t_g 2083H>P Substitution Nonsynonymous coding #N/A Yes PGDX2066T_NotchCp SK50 chr9_138527305-138527305_a_c 819L>R Substitution Nonsynonymous coding #N/A Yes PGDX2066T_NotchCp SK50 chr9_138537131-138537131_c_t 245C>Y Substitution Nonsynonymous coding #N/A Yes PGDX2066T_NotchCp SK50 chr9_138538200-138538200_t_g 65S>R Substitution Nonsynonymous coding #N/A Yes PGDX2066T_NotchCp SK50 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2045T_NotchCp SK6 chr9_138511764-138511764_t_g 2083H>P Substitution Nonsynonymous coding #N/A Yes PGDX2045T_NotchCp SK6 chr9_138527305-138527305_a_c 819L>R Substitution Nonsynonymous coding #N/A Yes PGDX2045T_NotchCp SK6 chr9_138538200-138538200_t_g 65S>R Substitution Nonsynonymous coding #N/A Yes PGDX2045T_NotchCp SK6 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2067T_NotchCp SK67 chr9_138511764-138511764_t_g 2083H>P Substitution Nonsynonymous coding #N/A Yes PGDX2067T_NotchCp SK67 chr9_138527305-138527305_a_c 819L>R Substitution Nonsynonymous coding #N/A Yes PGDX2067T_NotchCp SK67 chr9_138538200-138538200_t_g 65S>R Substitution Nonsynonymous coding #N/A Yes PGDX2067T_NotchCp SK67 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2046T_NotchCp SK7 chr9_138511764-138511764_t_g 2083H>P Substitution Nonsynonymous coding #N/A Yes PGDX2046T_NotchCp SK7 chr9_138527305-138527305_a_c 819L>R Substitution Nonsynonymous coding #N/A Yes PGDX2046T_NotchCp SK7 chr9_138538200-138538200_t_g 65S>R Substitution Nonsynonymous coding #N/A Yes PGDX2046T_NotchCp SK7 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes PGDX2047T_NotchCp SK8 chr9_138511764-138511764_t_g 2083H>P Substitution Nonsynonymous coding #N/A Yes PGDX2047T_NotchCp SK8 chr9_138527305-138527305_a_c 819L>R Substitution Nonsynonymous coding #N/A Yes PGDX2047T_NotchCp SK8 chr9_138538200-138538200_t_g 65S>R Substitution Nonsynonymous coding #N/A Yes PGDX2047T_NotchCp SK8 chr9_138525082-138525082_c_t NA Substitution Splice site acceptor Yes Yes Supplemental Table 7 Mutation Type Consequence In dbsnp In Normal Samples

Normals # Nonsynonymous Mutations in Normal Samples 73 # Unique Nonsyn Mutations in Normal Samples 49 Comment Unmatched Tumors # Nonsyn Mutations Also Present in Normal Samples 107 Includes 28 below as single mutation in dbsnp was also seen in normal samples # Nonsyn Mutations Also Present in dbsnp 28 # Nonsyn Mutations NOT Present in Normals/dbSNP 30 Previously reported Unmatched Dysplasia # Nonsyn Mutations Also Present in Normal Samples 71 Includes 47 below as single mutation in dbsnp was also seen in normal samples # Nonsyn Mutations Also Present in dbsnp 47 # Nonsyn Mutations NOT Present in Normals/dbSNP 50 Previously reported Supplemental Table 8

Sample ID Amino Acid (protein) Type Domain Exon # 1901E>K Missense Ankyrin repeats Ank_1 31 SK9 1662R>W Missense Heterodimerisation domain - N 26 718N>S Missense EGF-like domain (19) 13 1922N>S Missense Ankyrin repeats Ank_1 31 SK12 952D>N Missense EGF-like domain (24) 18 1419K>E Missense Next to Lin-12/Notch repeats (LNR)(1442-1479) 25 SK16 1789E>G Missense RBP-Jkappa-associated module (RAM) 28 SK17 1817D>G Missense RBP-Jkappa-associated module (RAM) 29 1731P>S Missense Heterodimerisation domain - C 28 SK21 NA Indel SK26 1788G>S Missense RBP-Jkappa-associated module (RAM) 28 1545C>Y Missense LNR-3 26 1880D>N Missense Ankyrin repeats Ank_1 30/31 SK33 1116C>R Missense EGF-like domain (29) 21 2386Q>R Missense PEST 34 2198S>P Missense TAD 34 1779S>N Missense RBP-Jkappa-associated module (RAM) 28 SK35 1014T>M Missense EGF-like domain (26) 19 497S>N Missense EGF-like domain (13) 9 NA Splice site acceptor 105A>V Missense EGF-like domain (3) 3 SK36 231G>D Missense EGF-like domain (6) 4 SK37 571D>A Missense EGF-like domain (15) 11 SK39 1952A>T Missense Ankyrin repeats Ank_2 31 1333I>V Missense EGF-like domain (34) 24 2540P>P Synonymous PEST 34 SK39 2407S>S Synonymous PEST 34 1794L>L Synonymous RBP-Jkappa-associated module (RAM) 28 SK1 2429L>L Synonymous PEST 34 877P>P Synonymous EGF-like domain (23) 17 SK2 352D>Y Missense EGF-like domain (9) 6 SK5 1792V>A Missense RBP-Jkappa-associated module (RAM) 28 1176H>H Synonymous EGF-like domain (30) 22 SK7 1627R>C Missense Heterodimerisation domain - N 26 413V>V Synonymous EGF-like domain (11) 7 SK8 1115L>P Missense EGF-like domain (29) 21 SK11 NA Indel SK13 _ISV-4> Splice site acceptor 1539H>P Missense LNR-3 26 516C>R Missense EGF-like domain (13) 9 SK19 2263R>Q Missense TAD 34 786P>P Synonymous EGF-like domain (20) 15 SK23 NA Splice site donor SK24 1531L>Q Missense LNR-2 26 517P>H Missense EGF-like domain (13) 9 SK28 1240N>D Missense EGF-like domain (32) 23 977G>G Synonymous EGF-like domain (25) 18 SK29 2514P>L Missense PEST 34 814K>R Missense EGF-like domain (21) 15 NA Splice site donor SK30 2145Y>X Nonsense TAD 34 1818L>P Missense RBP-Jkappa-associated module (RAM) 29 SK32 2253P>P Synonymous TAD 34 455E>K Missense EGF-like domain (12) 8 SK40 1531L>P Missense LNR-2 26 SK42 1970S>P Missense Ankyrin repeats Ank_3 31 SK50 1821K>E Missense RBP-Jkappa-associated module (RAM) 29 SK67 2028G>G Synonymous Ankyrin repeats Ank_5 34 Song et al C1397F missense EGF-like domain (36) 25 SCC 1 P1641L missense Heterodimerisation domain - N 26 P1641S missense Heterodimerisation domain - N 26 SCC 4 C1218Y missense EGF-like domain (31) 23 SCC 5 C1133Y missense EGF-like domain (29) 21 Q1733 nonsense Heterodimerisation domain - C 28 R203C missense EGF-like domain (5) 4 R217W missense EGF-like domain (6) 4 R1762W missense RBP-Jkappa-associated module (RAM) 28 SCC 9 T232I missense EGF-like domain (6) 4 S1189F missense EGF-like domain (31) 22 N1347D missense EGF-like domain (34/35) 25 P1641L missense Heterodimerisation domain - N 26 S1389I missense EGF-like domain (36) 25 M1737I missense Trans-membrane region 28 SCC 10 P1641S missense Heterodimerisation domain - N 26 SCC 14 C1133Y missense EGF-like domain (29) 21 N1713S missense Heterodimerisation domain - C 27 SCC 15 C1133Y missense EGF-like domain (29) 21 SCC 19 E606 nonsense EGF-like domain (16) 11 SCC 21 N1489D missense LNR-3 25 SCC 22 Q1134R missense EGF-like domain (29) 21 SCC 23 Q1134R missense EGF-like domain (29) 21 SCC 26 E1084D missense EGF-like domain (28) 20 N1713S missense Heterodimerisation domain - C 27 SCC 28 Q1134R missense EGF-like domain (29) 21 SCC 31 N994K missense EGF-like domain (26) 19 P1641S missense Heterodimerisation domain - N 26 SCC 32 C1074Y missense EGF-like domain (28) 20 SCC 33 E424K missense EGF-like domain (11) 8 Q1080 nonsense EGF-like domain (28) 20 SCC 35 W1474 nonsense LNR-1 25 N1713S missense Heterodimerisation domain - C 27 SCC 42 R1107 nonsense EGF-like domain (28/29) 20 N548D missense EGF-like domain (14) 10 SCC 47 E606G missense EGF-like domain (16) 11 P1641L missense Heterodimerisation domain - N 26 P1641S missense Heterodimerisation domain - N 26 SCC 48 R1107 nonsense EGF-like domain (28/29) 20 W1474 nonsense LNR-1 25 SCC 50 E1084D missense EGF-like domain (28) 20 SCC 51 R1784Q missense RBP-Jkappa-associated module (RAM) 28 Supplemental Figure 9

Sample Amino acid (protein) Mutation type Domain Exon # HN14PT p.p391s Missense EGF-like domain (10) 7 478 p.g484v Missense EGF-like domain (12) 9 HN 102 PT p.e450k Missense EGF-like domain (11) 8 HN 105 PT p.g812w Missense EGF-like domain (21) 15 HN 115 PT p.g1340a Missense EGF-like domain (34) 25 HN 117 PT p.g310r Missense EGF-like domain (8) 6 HN 117 PT p.c456r Missense EGF-like domain (12) 8 HN 142 PT p.r353h Missense EGF-like domain (9) 6 HN 142 PT p.m2011r Missense Ankyrin repeats Ank_4 32 HN 148 PT p.g1638v Missense Heterodimerisation domain - N 26 HN 148 PT p.p2272s Missense TAD 34 HN 208 PT p.r365c Missense EGF-like domain (9) 6 HN 208 PT p.r1280c Missense EGF-like domain (33) 23 HN 227 PT p.r365c Missense EGF-like domain (9) 6 HN 251 PT p.f1292l Missense EGF-like domain (33) 23 HN 255 PT p.v2039l Missense Ankyrin repeats Ank_5 33 HN 255 PT p.v2039e Missense Ankyrin repeats Ank_5 33 HN12PT p.w1843x Nonsense RBP-Jkappa-associated module (RAM) 30 385 p.r1984x Nonsense Ankyrin repeats Ank_5 32 600 Q290X Nonsense EGF-like domain (7) 6 HN 105 PT fs Indel HN 107 PT p.s402x Nonsense EGF-like domain (10) 7 HN 115 PT fs Indel HN 130 PT p.e949x Nonsense EGF-like domain (25) 18 HN 139 PT p.c554x Nonsense EGF-like domain (14) 10 HN 183 PT p.q1958x Nonsense Ankyrin repeats Ank_3 31 HN 194 PT fs Indel HN 245 PT fs Indel HN_63080-Tumor S953N Missense EGF-like domain (25) 18 HN_62318-Tumor D1517N Missense LRN repeat 2 25 HN_62755-Tumor Q1214* Nonsense EGF-like domain (31) 22 HN_63081-Tumor E719* Nonsense EGF-like domain (19) 13 HN_00076-Tumor Splice_Site HN_62863-Tumor G481S Missense EGF-like domain (12) 8 HN_62469-Tumor E424K Missense EGF-like domain (11) 8 HN_62995-Tumor P422S Missense EGF-like domain (11) 8 HN_62298-Tumor F357del Indel HN_62699-Tumor Splice_Site OSCJM-PT12-478-T G484V Missense EGF-like domain (12) 9 OSCJM-PT15-391-T S458L Missense EGF-like domain (12) 8 OSCJM-PT20-600-T Q290X Nonsense EGF-like domain (7) 6 OSCJM-PT11-385-T R1984X Nonsense Ankyrin repeats Ank_5 32 X39 R56* Nonsense EGF-like domain (1) 3 X17 Q154* Nonsense EGF-like domain (4) 4 X12 T1138I Missense EGF-like domain (29) 21 X48 E1294* Nonsense EGF-like domain (33) 23 X12 W1843* Nonsense RBP-Jkappa-associated module (RAM) 30 TCGA-BA-4076 G481C Missense EGF-like domain (12) 8 TCGA-BA-6868 C387Y Missense EGF-like domain (10) 7 TCGA-BB-4225 C461Y Missense EGF-like domain (12) 8 TCGA-CN-4723 D142H Missense EGF-like domain (4) 4 TCGA-CN-4729 C1085Y Missense EGF-like domain (28) 20 TCGA-CN-4736 C478S Missense EGF-like domain (12) 8 TCGA-CN-4742 P422S Missense EGF-like domain (11) 8 TCGA-CN-5369 Q1845* Nonsense RBP-Jkappa-associated module (RAM) 30 TCGA-CN-6011 E1305K Missense EGF-like domain (33) 24 TCGA-CN-6016 V1222M Missense EGF-like domain (32) 23 TCGA-CN-6989 C739* Nonsense EGF-like domain (19) 14 TCGA-CN-6994 P67T Missense EGF-like domain (2) 3 TCGA-CQ-5329 A2023T Missense Ankyrin repeats Ank_4 32 TCGA-CQ-5334 G1119* Nonsense EGF-like domain (29) 20/21 TCGA-CR-5243 C1085W Missense EGF-like domain (28) 20 TCGA-CR-7365 E1404K Missense EGF-like domain (36) 25 TCGA-CR-7376 G484V Missense EGF-like domain (12) 9 TCGA-CR-7377 E1450* Nonsense LRN repeat 1 25 TCGA-CR-7379 N1875K Missense Ankyrin repeats Ank_1 30 TCGA-CR-7380 C893S Missense EGF-like domain (23) 17 TCGA-CR-7390 Q1080* Nonsense EGF-like domain (28) 20 TCGA-CR-7394 Q1974* Nonsense Ankyrin repeats Ank_3 31 TCGA-CR-7395 P2064L Missense Ankyrin repeats Ank_6 34 TCGA-CV-5436 C478Y Missense EGF-like domain (12) 8 TCGA-CV-5971 R353C Missense EGF-like domain (9) 6 TCGA-CV-5973 R1984* Nonsense Ankyrin repeats Ank_5 32 TCGA-CV-6436 G310R Missense EGF-like domain (8) 6 TCGA-CV-6955 D1520H Missense LRN repeat 1 25 TCGA-CV-6955 N454T Missense EGF-like domain (12) 8 TCGA-CV-6959 R879W Missense EGF-like domain (23) 17 TCGA-CV-6962 C429Y Missense EGF-like domain (11) 8 TCGA-CV-7089 S385F Missense EGF-like domain (10) 7 TCGA-CV-7099 K1317N Missense EGF-like domain (34) 24 TCGA-CV-7101 T1996M Missense Ankyrin repeats Ank_4 32 TCGA-CV-7236 A465T Missense EGF-like domain (12) 8 TCGA-CV-7238 Q803* Nonsense EGF-like domain (21) 15 TCGA-CV-7410 E663K Missense EGF-like domain (17) 12 TCGA-CV-7410 E851Q Missense EGF-like domain (22) 16 TCGA-CV-7411 C1225* Nonsense EGF-like domain (32) 23 TCGA-CV-7427 W1089* Nonsense EGF-like domain (28) 20 TCGA-CV-7433 C440F Missense EGF-like domain (11) 8 TCGA-CX-7085 E455K Missense EGF-like domain (12) 8 TCGA-DQ-5625 D352V Missense EGF-like domain (9) 6 TCGA-DQ-5631 C440R Missense EGF-like domain (11) 8 TCGA-BA-4075 C449Y Missense EGF-like domain (11) 8 TCGA-CQ-6219 R353H Missense EGF-like domain (9) 6 TCGA-CV-5439 G95W Missense EGF-like domain (2) 3 TCGA-CN-5355 G1215_splice Splice_Site TCGA-CN-5363 F1977fs Indel TCGA-CN-6021 F357del IF-Indel TCGA-CQ-6220 S417fs Indel TCGA-BA-6873 P380fs Indel TCGA-CR-7365 K542fs Indel TCGA-CV-5441 A796fs Indel TCGA-CV-5966 T634fs Indel TCGA-CV-6938 E1148fs Indel TCGA-CV-6942 G684fs Indel TCGA-CV-6955 T123fs Indel TCGA-CV-7089 C1063fs Indel TCGA-BA-5149 Q513fs Indel TCGA-BB-7861 P2415del IF-Indel TCGA-BB-7863 G1380fs Indel TCGA-BB-7864 G115fs Indel TCGA-BB-7872 G736_splice Splice_Site IF - In Frame Supplemental Table 10

Sample ID Site HPV status HN14PT OC N 478 OC N HN 102 PT OC N HN 105 PT OC N HN 107 PT OC N HN 115 PT OC N HN 117 PT OC N HN 130 PT L N HN 139 PT OP N HN 142 PT OP P HN 148 PT OP N HN 183 PT OC N HN 194 PT OC N HN 208 PT OC N HN 227 PT HP N HN 245 PT OC N HN 251 PT OP P HN 255 PT OP N HN12PT OC N 385 OC N 600 OC N HN_63080-Tumor OC N HN_62318-Tumor OP P HN_62755-Tumor L N HN_63081-Tumor OP N HN_00076-Tumor OC N HN_62863-Tumor L N HN_62469-Tumor OC N HN_62995-Tumor OC N HN_62298-Tumor OC N HN_62699-Tumor HP N TCGA-BA-4076 L N TCGA-BA-5149 OC N TCGA-BA-6868 L N TCGA-BA-6873 OC P TCGA-BB-4225 OP P TCGA-CN-4723 L N TCGA-CN-4729 OC N TCGA-CN-4736 OC N TCGA-CN-4742 OC N TCGA-CN-5355 L N TCGA-CN-5363 L N TCGA-CN-5369 OC N TCGA-CN-6011 OC N TCGA-CN-6016 OC N TCGA-CN-6021 L N TCGA-CN-6989 L N TCGA-CN-6994 OC N TCGA-CQ-5329 OC N TCGA-CQ-5334 OC N TCGA-CQ-6220 OC N TCGA-CR-5243 OP P TCGA-CR-7365 OC N TCGA-CR-7376 OC N TCGA-CR-7377 OC N TCGA-CR-7379 OC N TCGA-CR-7380 OC N TCGA-CR-7390 OC N TCGA-CR-7394 OC N TCGA-CR-7395 OC N TCGA-CV-5436 OC N TCGA-CV-5441 L N TCGA-CV-5966 OC N TCGA-CV-5971 OC P TCGA-CV-5973 OC N TCGA-CV-6436 OC N TCGA-CV-6938 OC N TCGA-CV-6942 OC N TCGA-CV-6955 OC N TCGA-CV-6959 OC N TCGA-CV-6962 L N TCGA-CV-7089 L N TCGA-CV-7099 OC N TCGA-CV-7101 L N TCGA-CV-7236 OC N TCGA-CV-7238 OC N TCGA-CV-7410 L N TCGA-CV-7411 OC N TCGA-CV-7427 OC N TCGA-CV-7433 L N TCGA-CX-7085 OC N TCGA-DQ-5625 OC N TCGA-DQ-5631 OC N TCGA-BA-4075 OC ND TCGA-BB-7861 OP ND TCGA-BB-7863 OC ND TCGA-BB-7864 L ND TCGA-BB-7872 OC ND TCGA-CQ-6219 OC ND TCGA-CV-5439 OP N OSCJM-PT12-478- OC N OSCJM-PT15-391- OC N OSCJM-PT20-600- OC N OSCJM-PT11-385- OC ND X39 OC N X17 OC N X12 OC N X48 OC N OC - Oral Cavity OP - Oropharynx HP - Hypopharynx L - Larynx N - Negative P - Positive ND - Not defined Supplemental Table 11