Quiz name: genomes and gene regulation 2 (KK)

Transcription

1 Quiz Name and Quiz name: genomes and gene regulation 2 (KK) Enable SOC Question 1 (): Question: What are chromosomes made of? Answer 1: DNA and proteins Answer 2: DNA, RNA and proteins Answer 3: DNA and euchromatin Answer 4: DNA, heterochromatin and histones Answer 5: DNA Question 2 (): Question: Transcription in eukaryotes requires in addition to RNA polymerase... Answer 1: ribosomes and trna Answer 2: start and stop codons Answer 3: aminoacyl synthetase Answer 4: several transcription factors Answer 5: the protein product of the promoter Question 3 (): Question: A eukaryotic transcript unit is 8000 nucleotides long, uses 1200 nucleotides to make a protein consisting of 400 amino acid Answer 1: there are terminators exons near the beginning of mrna Answer 2: nucleotides break off and are lost during transcription Answer 3: there is redundancy in the genetic code Answer 4: many non coding stretches of nucleotides are present in the DNA Answer 5: mayn nucleotides are needed to code for each amino acid Question 4 (): Question: DNA methylation is used by eukaryotes to... Answer 1: inactivate genes Answer 2: cause apoptosis Answer 3: increase transcription Answer 4: terminate transcription Answer 5: facilitate binding of DNA to enzymes Question 5 (): Question: Why is gene expression more likely to be altered post-transcriptionally in eukaryotes than in prokaryotes? Answer 1: prokaryotic genes are expressed as mrnas that are more stable in the cell Answer 2: eukaryotic mrna is capped and contains polya tails Answer 3: prokaryotes use ribosomes of different structure and size Answer 4: eukaryotic exons may be spliced in alternative patterns Answer 5: Eukaryotic polypeptides often require cleaving of signal sequences before localization 1 von :44

2 Quiz Name and Quiz name: Genregulation und Evolution (KK) Enable SOC Question 1 (): Question: Welche Mechanismen sind dabei treibende Kräfte? Question 2 (): Question: In einem Experiment wurde das menschliche Chromosoms 21 in die Maus eingebracht und das Genexpressionsmuster diese Answer 1: Die Maus-DNA und die menschliche DNA sind so homolog, das humane DNA in Mauszellen exprimiert werden kann. Answer 2: Regulatorische Elemente der DNA sind primär für die Genexpression verantwortlich. Answer 3: Epigenetische Effekte regulieren die Expression der Gene auf dem Chromosom 21. Answer 4: Transkriptionsfaktoren der Maus sind verantwortlich für die Regulation der Expression der menschlichen Gene. Answer 5: Elemente auf der Maus-DNA können mit denen auf der menschlichen DNA wechselwirken, um die Genexpression zu regu Question 3 (): Question: The functioning of a CRE is an example of Answer 1: a eukaryotic equivalent of prokaryotic promoter functioning. Answer 2: a post-transcriptional mechanism to regulate mrna. Answer 3: the stimulation of translation by initiation factors. Answer 4: transcriptional control of gene expression. Answer 5: post-translational control that activates certain proteins. Question 4 (): Question: Within a cell, the amount of protein made using a given mrna molecule depends partly on Answer 1: the presence of certain transcription factors. Answer 2: the degree of DNA methylation. Answer 3: the rate at which the mrna is degraded. Answer 4: the number of introns present in the mrna. Answer 5: the types of ribosomes present in the cytoplasm. 1 von :45

3 Quiz Name and Quiz name: Krebsentstehung (KK) Enable SOC Question 1 (): Question: Which of the following would be most likely to lead to cancer? Answer 1: failure of a proto-oncogene to produce a protein and amplification of a tumor-suppressor gene Answer 2: hyperactivity of both a proto-oncogene and a tumor-suppressor gene Answer 3: hyperactivity of a proto-oncogene and activation of a tumor-suppressor gene Answer 4: amplification of a proto-oncogene and inactivation of a tumor-suppressor gene Answer 5: failure of both a proto-oncogene and a tumor-suppressor gene to produce proteins Question 2 (): Question: All your cells contain proto-oncogenes, which can change into cancer-causing genes. Why do cells possess such potential t Answer 1: Proto-oncogenes are necessary for the normal control of cell growth and division. Answer 2: Cells produce proto-oncogenes as a by-product of mitosis. Answer 3: Proto-oncogenes are unavoidable environmental carcinogens. Answer 4: Proto-oncogenes are genetic junk that has not yet been eliminated by natural selection. Answer 5: Proto-oncogenes protect cells from infection by cancer-causing viruses. Question 3 (): Question: Tumor-suppressor genes Answer 1: are frequently overexpressed in cancerous cells. Answer 2: are cancer-causing genes introduced into cells by viruses. Answer 3: often encode proteins that stimulate the cell cycle. Answer 4: can encode proteins that promote DNA repair or cell-cell adhesion. Answer 5: do all of the above. Question 4 (): Question: For a chemotherapeutic drug to be useful for treating cancer cells, which of the following is most desirable? Answer 1: It is safe enough to limit all apoptosis. Answer 2: It interferes with rapidly dividing cells. Answer 3: It interferes with cells entering G0. Answer 4: It only attacks cells that are density dependent. Answer 5: It does not alter metabolically active cells. Question 5 (): Question: You have a series of cells, all of which were derived from tumors, and you first need to find out which ones are malignant. W Answer 1: See which ones are not overproliferating. Answer 2: Measure metastasis. Answer 3: Find out which ones have a higher rate of apoptosis. Answer 4: Time their cell cycles. Answer 5: Karyotype samples to look for unusual size and number of chromosomes Question 6 (): Question: What is true of all cancers? Answer 1: They have escaped normal cell cycle controls. Answer 2: They are caused by chemical carcinogens. Answer 3: They are inherited. Answer 4: Answer 5: Question 7 (): Question: The cell cycle control systems of cancer cells differ from those of normal cells. Select the best explanation for this fact. Answer 1: Genetic changes alter the function of the cancer cell s protein products. Answer 2: Cancer cells divide excessively and invade other tissues. Answer 3: Cancer cells are immortal. Answer 4: Answer 5: 1 von :45

4 Create a quiz using multiple choice and free response questions. Learn more Quiz Name and Quiz name: Entwicklung Mehrzelliger Organismen (KK) Enable SOC Question 1 (): Question: Please enter your last name, first name (ex. West, Michael): Question 2 (): Question: The first stage of embryonic development is. This process produces. Answer 1: ovulation... a zygote Answer 2: parturition... a fetus Answer 3: gastrulation... a three-layered embryo Answer 4: neurulation... a neurula Answer 5: cleavage... a cluster of cells Question 3 (): Question: Cells move to new positions as an embryo establishes its three germ tissue layers during Answer 1: gastrulation. Answer 2: fertilization. Answer 3: cleavage. Answer 4: determination. Answer 5: induction. Question 4 (): Question: From earliest to latest, the overall sequence of early development proceeds in which of the following sequences? Answer 1: organogenesis neurulation cleavage Answer 2: gastrulation organogenesis cleavage Answer 3: cleavage gastrulation organogenesis Answer 4: cleavage organogenesis gastrulation Answer 5: gastrulation blastulation neurulation Question 5 (): Question: How is it possible for a single zygote to give rise to all the cell types in a multicellular organism? Answer 1: Some cells contain maternal chromosomes and some contain paternal chromosomes. Answer 2: The DNA in each cell changes so that the appropriate proteins are produced. Answer 3: Paternal effect genes begin the process of differentiation by providing positional information. Answer 4: They differentiate through the process of mitosis. Answer 5: Different genes are expressed so that different proteins are produced. Question 6 (): Question: Which of the following genes map out the basic subdivisions along the anterior-posterior axis of the Drosophila embryo? Answer 1: homeotic genes Answer 2: egg-polarity genes Answer 3: morphogens Answer 4: inducers Answer 5: segmentation genes Question 7 (): Question: The product of the bicoid gene in Drosophila provides essential information about Answer 1: the anterior-posterior axis. Answer 2: the left-right axis. Answer 3: the dorsal-ventral axis. Answer 4: lethal genes. Answer 5: segmentation. Question 8 (): Question: Mutations in which of the following genes lead to transformations in the identity of entire body parts? Answer 1: homeotic genes Answer 2: egg-polarity genes Answer 3: morphogens Answer 4: inducers Answer 5: segmentation genes Question 9 (): Question: Muscle cells differ from nerve cells mainly because they Answer 1: have different chromosomes. Answer 2: contain different genes. Answer 3: have unique ribosomes. Answer 4: use different genetic codes. Answer 5: express different genes. Question 10 (): Question: Which of the following statements about the DNA in one of your brain cells is true? Answer 1: The majority of genes are likely to be transcribed. Answer 2: It is the same as the DNA in one of your heart cells. Answer 3: Many genes are grouped into operon-like clusters. Answer 4: Each gene lies immediately adjacent to an enhancer. Answer 5: Most of the DNA codes for protein. 1 von :46

5 1 von 1 Quiz Name and Quiz name: Gentechnologie (KK) Enable SOC Question 1 (): Question: Which "ingredients" for PCR and for the dideoxy chain-termination method of DNA sequencing are the same? Answer 1: template DNA, reverse transcriptase, DNA primers Answer 2: free nucleotides, DNA polymerase, DNA primers Answer 3: nucleic acid probes, DNA polymerase, DNA ligase Answer 4: RNA, reverse transcriptase, free nucleotides Answer 5: enucleated eggs, reverse transcriptase, free nucleotides Question 2 (): Question: A gene that contains introns can be made shorter (but remain functional) for genetic engineering purposes by using Answer 1: reverse transcriptase to reconstruct the gene from its mrna. Answer 2: RNA polymerase to transcribe the gene. Answer 3: DNA polymerase to reconstruct the gene from its polypeptide product. Answer 4: DNA ligase to put together fragments of the DNA that code for a particular polypeptide. Answer 5: a restriction enzyme to cut the gene into shorter pieces. Question 3 (): Question: For a particular microarray assay (DNA chip), cdna has been made from the mrnas of a dozen patients' breast tumor biopsies. The researchers will be looking for Answer 1: a group of cdnas that act differently from those on the rest of the grid. Answer 2: a particular gene that is amplified in all or most of the patient samples. Answer 3: a pattern of fluorescence that indicates which cells are overproliferating. Answer 4: a pattern shared among some or all of the samples that indicates gene expression differing from control samples. Answer 5: a group of cdnas that match those in non-breast cancer control samples from the same population. Question 4 (): Question: Which of the following tools of recombinant DNA technology is incorrectly paired with its use? Answer 1: DNA polymerase-polymerase chain reaction to amplify sections of DNA Answer 2: DNA ligase-cutting DNA, creating sticky ends of restriction fragments Answer 3: reverse transcriptase-production of cdna from mrna Answer 4: electrophoresis-separation of DNA fragments Answer 5: restriction enzyme-analysis of RFLPs Question 5 (): Question: Which of the following would not be true of cdna produced using human brain tissue as the starting material? Answer 1: It could be used as a probe to detect genes expressed in the brain. Answer 2: It could be used to create a complete genomic library. Answer 3: It was produced from mrna using reverse transcriptase. Answer 4: It could be amplified by the polymerase chain reaction. Answer 5: It lacks the introns of the human genes. Question 6 (): Question: A principal problem getting an eukarytotic gene expressed in bacteria, is that Answer 1: bacteria translate only mrnas that have multiple messages. Answer 2: bacterial DNA is not found in a membrane-bounded nucleus and is therefore incompatible with mammalian DNA. Answer 3: bacteria cannot remove eukaryotic introns. Answer 4: bacterial RNA polymerase cannot make RNA complementary to mammalian DNA. Answer 5: prokaryotes use a different genetic code from that of eukaryotes. 1 von :22