PRELIMINARY PROGRAM. Hotel Le Saint-Paul NICE, FRANCE. International Mouse Models of Skin Cancer symposium.

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PRELIMINARY PROGRAM www.canceropole-paca.fr

EDITORIAL Skin cancer is a widely spread disease, which causes patient death and arises from both epithelial and nonepithelial cells. Deciphering the molecular mechanisms of skin cancers development will allow discovery of new molecular targets for therapeutic intervention. To this aim, researchers have developed, during the last decades, innovative mouse models of skin cancers that bring new insights in many aspects of this life threatening disease. This symposium will bring together internal multidisciplinary experts, including biologists, clinicians and physicians, in skin cancers and will provide latest discovery using innovative mouse models of skin cancers development and corroborate their finding with the corresponding human diseases. INVITED SPEAKERS D. Hanahan (EPFL, Switzerland) F. Calvo (CRUK, United Kingdom) P. Coulombe (Jonhs Hopkins, USA) E. Farge (Curie Institute, France) M-D. Galibert (IGDR, France) E. Hoste (VIB, Belgium) G. J. Inman (University of Dundee, United Kingdom) T. S. Kupper (Brigham and Woman s Hospital, USA) L. Larue (Curie Institute, France) B. Lichtenberger (KCL, United Kingdom) R. Marais (Cancer Research UK, United Kingdom) J. C. Marine (VIB, Belgium) R-M. Mège (IJM, France) C. Niessen (CECAD, Germany) T. Passeron (CHU Nice, France) V. Sanz-Moreno (KCL, United Kingdom) B. Weigelin (RIMLS, The Netherlands) S. Wickstrom (Max Planck Institute for Biology of Aging, Germany)

PRELIMINARY PROGRAM 17:00 Registration 18:00 Opening SUNDAY OCTOBER 2 ND XX:00 XX:00 Keynote lecture: TBA. D. Hanahan (EPFL, Switzerland) Welcome reception MONDAY OCTOBER RD 09:00 12:0 I CARCINOMAS Chairman: L. Le Cam TBA. B. Lichtenberger (KCL, United Kingdom) Regulation of cell and tissue architecture in skin barrier function, inflammation and cancer. C. Niessen (CECAD, Germany) Selected talk 1 Selected talk 2 10:0 Coffee break TBA. G. J Inman (University of Dundee, United Kingdom) Selected talk Selected talk 4 Selected talk 5 12:0 Lunch 14:00 17:0 II Chairmen: S. Tartare-Deckert & R. Marais What can we learn about melanomagenesis from mice? R. Marais (Cancer Research UK, England) Relevance to humans of mouse models for the melanocyte lineage. L. Larue (Curie Institute, France) TBA. V. Sanz-Moreno (KCL, England) Selected talk 6 Selected talk 7 16:00 Coffee break Integrative genomic analysis of genetically-induced mouse melanoma lesions identifies novel melanoma tumor suppressors. J-C. Marine (VIB, Belgium) 17:0 19:00 MELANOMA Selected talk 8 Selected talk 9 POSTER & Drinks 19:0 Gala Dinner

PRELIMINARY PROGRAM TUESDAY OCTOBER 4 TH 09:00 SKIN MICROENVIRONMENT, 14:00 12:0 INFLAMMATION & IMMUNITY 15:0 Chairmen: E. Hoste & C. Gaggioli III 15:0 Mechanisms of wound-induced skin tumor formation. XX:XX E. Hoste (VIB, Belgium) Keratins regulate inflammation and immunity in skin epithelia: relevance IV to cancer and related diseases. P. Coulombe (Johns Hopkins, USA) Selected talk 10 Selected talk 11 10:0 Coffee break TBA. TS. Kupper (Brigham and Woman s Hospital, USA) Selected talk 12 Selected talk 1 Selected talk 14 12:0 Lunch XX:00 POSTER PHYSICS OF MICROENVIRONMENT Chairman: XXXXX Intravital imaging of melanoma cell invasion: principles of interface guidance along tissue highways. B. Weigelin (RIMLS, The Netherlands) Biomechanical regulation of cell fate. S. Wickstrom (Max Planck Institute for Biology of Aging, Germany) Mechanobiology of cancer-associated fibroblasts. F. Calvo (CRUK, United Kingdom) Mechanosensitivity of junctional beta-catenin: from mesoderm mechanotransductive evolutionary origins to tumorigenic mechanical induction. E. Farge (Curie Institute, France) Influence of the mechanical properties of the environment on cell migration and wound healing. R-M. Mège (IJM, France) Selected talk 15 Selected talk 16 Free evening WEDNESDAY OCTOBER 5 TH 09:00 12:0 V HUMAN SKIN PHYSIOPATHOLOGY Chairmen: T. Passeron & G. Meneguzzi TBA. T. Passeron (CHU Nice, France) TBA. TBA. M-D. Galibert (IGDR, Rennes, France) Selected talk 17 Selected talk 18 12:0 Lunch XX:00 End of the meeting

SCIENTIFIC COMMITTEE Chloé Feral, IRCAN, Nice Cédric Gaggioli, IRCAN, Nice Laurent Le Cam, IRCM, Montpellier Sophie Tartare-Deckert, CM, Nice Ariane Leroy, Cancéropôle PACA Marseille, France Tel.: + (0)4 91 2 47 00 ariane.leroy@univ-amu.fr Photo Jean-Marc BEREDER ORGANIZING COMMITTEE GENERAL INFORMATION Congress venue 29, Bd Franck Pilatte 0600 Nice, France Tel.: + (0)4 9 89 9 57 Contact & organization Com&Co, Rodolphe Bayle 15, Bd Grawitz 1016 Marseille, France Tel.: + (0)6 5 2 75 57 / + (0)4 91 09 70 5 Fax: + (0)4 96 15 08 Email: rodolphe@comnco.com www.canceropole-paca.fr

REGISTRATION FORM Title: Prof Dr Mr Ms Last Name... First Name... Institution / Company... Department... Address...... Post Code... City... Country... Phone... Email... REGISTRATION FEES BEFORE AUGUST 1ST RETURN TO COM&CO BY: Post 15, Bd Grawitz 1016 Marseille, France Fax + (0)4 96 15 08 Email rodolphe@comnco.com Online www.canceropole-paca.fr Students Docs / Post-docs Gala dinner 150 AFTER AUGUST 1ST 180 25 25 250 280 Researchers 50 50 Gala dinner 50 90 Industrials 90 90 Gala dinner PAYMENT By credit ca (Visa / Masterca / no other ca) On protected payment Paybox online form, directly on the website www.comnco.com. Please indicate your Name + MMSC 2016 in the part: Additional details By check enclosed (make check in euros payable in France to Com&Co) By bank transfer to Com&Co Bank Chaix - 41/4, Bd Peytral 1006 Marseille IBAN FR76 1017 8000 2600 2626 880 80 BIC CCBPFRPPCHX