Encephalopathy with Electrical Status Epilepticus during Slow Sleep Linking epilepsy, sleep disruption and cognitive impairment March 2014
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1 International Conference on Encephalopathy with Electrical Status Epilepticus during Slow Sleep Linking epilepsy, sleep disruption and cognitive impairment March 2014 Sorø (Denmark)
2 Encephalopathy with Electrical Status Epilepticus during Sleep (ESES) was described more than 40 years ago, however its clinical spectrum and its boundaries, the diagnostic criteria, the pathophysiology and the therapeutic management are still a matter of debate. In the last years, clinical data, neurophysiological and imaging investigations, and genetic studies have renewed the interest on ESES. In addition, experimental findings from sleep research have opened fascinating perspectives on some possible pathophysiological mechanisms involved in this condition. The aim of this conference is to bring together clinicians and scientists, who have been working on ESES and sleep physiology to create a better overall understanding of this special syndrome in the light of recent research. In addition we would want to reach an international consensus on diagnostic inclusion and exclusion criteria and clinical management of ESES. Scientific Committee Guido Rubboli Marina Nikanorova Helle Hjalgrim Carlo Alberto Tassinari Organizing Committee Rikke Møller Elena Gardella Elena Pavlidis Alice Bøjlund Lyseen Faculty Aldenkamp A (The Netherlands) Alving J (Denmark) Arzimanoglou A (France) Beniczky S (Denmark) Cantalupo G (Italy), Caraballo R (Argentina) Cross H (UK), Dalla Bernardina B (Italy) Hirsch E (France) Hjalgrim H (Denmark) Huber R (Switzerland) Jansen F (The Netherlands) Larsson P (Norway), Loddenkemper T (USA) Møller R (Denmark), Nikanorova M (Denmark), Nobili L (Italy), Peltola M (Finland), Rubboli G (Denmark), Siniachtkin M (Germany), Szepetowski P (France), Tassinari CA (Italy), Van Bogaert P (Belgium).
3 14 March :00-9:10 Opening: G Rubboli (Denmark), M Nikanorova (Denmark) 9:10-9:30 Historical background and current knowledge. CA Tassinari (Italy) Epilepsy Chairs: E Hirsch (France), H Hjalgrim (Denmark) 9:30-10:10 Clinical pictures: - the spectrum. T Loddenkemper (USA) 10:10-10:30 EEG features. B Dalla Bernardina (Italy) - evolution and prognosis. R Caraballo (Argentina) 10:30-11:10 EEG analysis: - what to analyze? G Cantalupo (Italy) 11:10-11:25 Coffee break - how to quantify? P Larsson (Norway) 11:25-12:25 Genetics: - overview. E Hirsch (France) - GRIN2A mutations and the spectrum of encephalopathies with speech and language dysfunctions. P Szepetowski (France) - future research perspectives. R Møller (Denmark) 12:25-12:45 Neuroimaging. M Siniachtkin (Germany) 12:45-13:15 General discussion 13:15-14:30 LUNCH
4 14 March 2014 Sleep Chairs: J Alving (Denmark), S Beniczky (Denmark) 14: Lecture. The synaptic homeosthasis hypothesis and ESES. R Huber (Switzerland) 15:15-15:35 Sleep EEG synchronization mechanisms and activation of interictal epileptic spikes. L Nobili (Italy) 15:35-15:55 Sleep-enhanced epileptiform activity in other conditions. P Van Bogaert (Belgium) 15:55-16:15 General discussion on role of sleep-enhanced epileptiform activity and sleep derangement on cognitive performances and development 16:15-16:30 Coffee Break 16:30-17:30 Symposium: "Identifying gaps in management of acute seizures in pre-hospital setting" (sponsored by Viropharma) Chair: Helle Hjalgrim (Denmark) - PERFECT initiative. H Cross (UK) - Swedish data on the PERFECT initiative phase II. T Hallbook (Sweden) 17:30-18:30 Science Talenter Lecture. How do we handle the talented and gifted young people in Denmark Guided tour at Science Talenter
5 15 march 2014 Cognition Chairs: H.Cross (UK), A.Arzimanoglou (France) 9:00-9:20 Spike-related cognitive dysfunction. G Rubboli (Denmark) 9:20-9:40 Cognitive impairment in ESES and diagnostic assessment. A Arzimanoglou (France) 9:40-10:00 Cognitive impairment in other epilepsy conditions with increased spike-related activity during sleep. A Aldenkamp (The Netherlands) 10:00-10:20: Cognitive and behavioural outcome. H Cross (UK) Coffee break 10:20-10:35 Treatment Chairs: M Nikanorova (Denmark), F Jansen (The Netherlands) 10:35-11:55 AEDs, ketogenic diet, tdcs. M.Nikanorova (Denmark) Steroids. F Jansen (The Netherlands) Surgery. M Peltola (Finland) Synopsis 11:55-12:15. CA Tassinari (Italy) 12:15-12:55 General discussion with all participants on a consensus on definition and diagnostic assessment of ESES: all participants Chairs: CA Tassinari (Italy), G Rubboli (Denmark) 12:55-13:00 Closure of the Conference 13:00-14:00 LUNCH
6 REGISTRATION FEE: 100 euro (750 DKK) to be paid on bank account: Danske Bank Address: Torvet 6, 4100 Ringsted (Denmark) Account n IBAN: DK SWIFT-BIC: DABADKKK Please report in the payment your name and the title of the conference. Please send the filled registration form to Alice Bøjlund Lyseen: Registration form and further information can be downloaded at: For information please contact Alice Bøjlund Lyseen: GENERAL INFORMATION The venue of the conference is SCIENCE TALENTER - Mærsk Mc-Kinney Møller Videncenter which is located in Akademigrunden 18, Sorø. Science Talenter is about 1 km distant from Sorø railway station. Sorø is directly connected by train to Slagelse (about 15 minutes) and to Ringsted (about 15 minutes). Public bus are also available. Highway E20 connects Sorø to Copenhagen (about 1 hour drive), Slagelse (about 20 minutes drive), Ringsted (about 20 minutes drive).
7 With the kind support of
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