Diagnosis, Mechanisms, and Management of Cancer Treatment-Induced Neurotoxicities: Neuropathy, Fatigue and Cognitive Impairment

Transcription

1 Diagnosis, Mechanisms, and Management of Cancer Treatment-Induced Neurotoxicities: Neuropathy, Fatigue and Cognitive Impairment January 22-23, 2016 MD Anderson Cancer Center Mid Campus Building 1 (1MC) Floor 3, Conference Center 7007 Bertner Ave Houston, Texas Call for Abstracts Deadline for abstract submissions is Sunday, December 20, Please submit abstracts via to neurotoxicities@mdanderson.org STRATTON HILL FOUNDATION Department of

2 Diagnosis, Mechanisms, and Management of Cancer Treatment-Induced Neurotoxicities: Neuropathy, Fatigue and Cognitive Impairment GOAL This two-day scientific conference is to convene internationally highly recognized researchers specialized in pre-clinical and clinical research on cancer treatment-induced neurotoxicities and its pathological consequences to discuss experimental, translational and clinical cutting edge data on the identification, mechanisms and treatment of neurotoxicities of the peripheral and central nervous system with a focus on chemotherapyinduced neuropathy (CIPN), cognitive impairment, fatigue and depression. TARGET AUDIENCE This program should be of interest to: Physicians Students Post-Docs Basic Scientists Residents Fellows Nurses

3 CALL FOR ABSTRACTS Abstracts may be submitted for the Poster Session, and must be received no later than Sunday, December 20, Please submit via to Limit poster abstracts to half page, plain 8.5 x 11 inch paper, 250 words max, typed single-spaced, font Georgia 11pt. Organize the Aim, Methods, Results, and Conclusions. Define all abbreviations, and provide three to five keywords describing the nature and content of the abstract. Please include the name of the conference, title of your presentation, author s full name, highest degree, and institutional affiliation. Also, please include author s telephone, fax, and information. The conference Executive Committee will select abstracts for poster on the basis of their scientific merit and content quality. Participants will be notified of their posters acceptance by by Tuesday, January 5, Registration for the conference is required. If your abstract is accepted you will receive the poster guidelines. MD ANDERSON PLANNING COMMITTEE Charles Cleeland, PhD Co-Chair McCullough of Cancer Research Cobi J. Heijnen, PhD Co-Chair Neuroimmunology Laboratory Annemieke Kavelaars, PhD Director Neuroimmunology Laboratory CAO Robert Dantzer, PhD, DVM CAO Jeffrey Wefel, PhD Chief, Section of Neuropsychology Associate Neuro-Oncology Lori Williams, PhD, MSN Assistant CAO Xin Shelly Wang, MD, MPH CAO David Grosshans, MD, PhD Associate Radiation Oncology Shelli Kesler, PhD Associate Neuro-Oncology Felisha Estelle Logistics Coordinator CME/Conference Management Kristin L. VanHouten, CPS Executive Assistant

4 PROGRAM Friday, January 22, :00 pm Registration 12:45 Opening Remarks Thomas A. Buchholz, MD Clinical Aspects of Neurotoxicities Chair: Salahadin Abdi, MD, PhD 1:00 Patient Assessment of Neurotoxicities Charles Cleeland, PhD 2:00 Clinical Manifestation and Management of CIPN Salahadin Abdi, MD, PhD 2:30 Self Report and Objective Measurements of CIPN Xin Shelley Wang, MD, MPH 3:00 Break Mechanisms of Chemotherapy-Induced Peripheral Neuropathy Chairs: Annemieke Kavelaars, PhD and Patrick Dougherty, PhD 3:30 Mitotoxicity as the Cause of CIPN Gary J. Bennett, PhD 4:00 TLR and CIPN Patrick Dougherty, PhD 4:30 Resolution and Treatment of CIPN Annemieke Kavelaars, PhD 5:00 Sphingolipids and CIPN Daniela Salvemini, PhD 5:30 Travel to the Hotel ZaZa 6:30 Poster Session Hotel ZaZa Including NIH Discussion/Presentation (subject to change) Ann O Mara, PhD, RN, FAAN Paige Green-McDonald, PhD, MPH

5 Saturday, January 23, :30 am Registration and Continental Breakfast Cognitive Deficits and Cancer Treatment Chairs: Jeffrey Wefel, PhD and Cobi J. Heijnen, PhD 8:30 Clinical Therapeutic Approaches to Minimize Cognitive Dysfunction Associated with Radiation Jing Li, MD, PhD 9:00 Cognitive Effects of Radiation Jeffrey Wefel, PhD 9:30 Connectome, Cognition and Chemotherapy Shelli Kesler, PhD 10:00 Break 10:15 Regenerative Therapy for Cancer Treatment-induced Cognitive Dysfunction Charles Limoli, PhD 10:45 Mitochondrial Damage, Treatment and Cognitive Function Cobi J. Heijnen, PhD 11:15 Novel Drug Development for Cognitive Dysfunction - Forecast Future Drug Development and New Treatments Jim Ray, PhD 11:45 Lunch Fatigue and Cancer Treatment Chairs: Robert Dantzer, PhD, DVM and Andrew H. Miller, MD 12:30 pm Clinical Aspects of Cancer-Induced Fatigue Carmelita Escalante, MD 1:00 The Neuroimmune Basis of Fatigue Robert Dantzer, PhD, DVM 1:30 Neural Mechanisms of Effort and Motivation Michael Treadway, PhD 2:00 Immune Responses in Relation to Persistent Fatigue in Breast Cancer Survivors Julienne Bower, PhD 2:30 CNS Mechanisms of Fatigue and Associated Symptoms: Role of Inflammation Andrew H. Miller, MD 3:00 Closing Remarks 3:15 Adjourn

6 GUEST FACULTY Gary J. Bennett, PhD & Canada Senior Research Chair McGill University Montreal, Quebec, Canada Julienne Bower, PhD Associate UCLA Departments of Psychology and Psychiatry/Biobehavioral Sciences Director, Mind-Body Research Lab Research Scientist Cousins Center for Psychoneuroimmunology Member Jonsson Comprehensive Cancer Center Los Angeles, California Paige Green-McDonald, PhD, MPH Chief, BBPSB/BRP/DCCPS/NCI Basic Biobehavioral and Psychological Sciences Branch (BBPSB) Behavioral Research Program (BRP) Division of Cancer Control and Population Sciences (DCCPS) National Cancer Institute (NCI) Bethesda, Maryland Charles Limoli, PhD, Radiation Oncology School of Medicine University of California, Irvine Irvine, California Andrew H. Miller, MD William P. Timmie of Psychiatry and Behavioral Sciences Research Director, Psychiatric Oncology Winship Cancer Institute Director, Adult Psychiatry Outpatient Division Emory University School of Medicine Atlanta, Georgia Ann O Mara, PhD, RN, FAAN Head, Palliative Care Research Division of Cancer Prevention National Cancer Institute (NCI) Bethesda, Maryland Daniela Salvemini, PhD Pharmacological & Physiological Science Saint Louis University School of Medicine St. Louis, Missouri Michael Treadway, PhD Assistant Lab Director-Translation Research in Affective Disorders Clinical Psychologist and Neuroscientist Atlanta, Georgia A REMINDER: Meeting room temperatures and personal comfort ranges vary widely. Since meeting rooms always seem cold, please bring either a sweater or jacket.

7 MD ANDERSON FACULTY Salahadin Abdi, MD, PhD and Chair Pain Medicine Helen Buchanan & Stanley Joseph Seeger Endowed Research Thomas A. Buchholz, MD Executive Vice President & Physician-in-Chief Hubert L. Olive Stringer Distinguished Chair in Oncology in Honor of Sue Gribble Stringer, Radiation Oncology Division of Radiation Oncology Charles Cleeland, PhD McCullough of Cancer Research Division of Internal Medicine Robert Dantzer, PhD, DVM Division of Internal Medicine Patrick Dougherty, PhD, Pain Medicine Division of Anesthesiology and Critical Care Carmelita Escalante, MD Department Chair, General Internal Medicine Division of Internal Medicine Cobi J. Heijnen, PhD Neuroimmunology Laboratory Division of Internal Medicine Annemieke Kavelaars, PhD Director Neuroimmunology Laboratory President Elect Psychoneuroimmunology Research Society Shelli Kesler, PhD Associate Neuro-Oncology, Section of Neuropsychology Division of Cancer Medicine Jing Li, MD, PhD Assistant CNS Section Radiation Oncology Jim Ray, PhD Head of Research for Neurodegeneration Consortium Applied Cancer Science Institute Neuroscience Xin Shelley Wang, MD, MPH Division of Internal Medicine Jeffrey Wefel, PhD Chief Section of Neuropsychology Associate Neuro-Oncology Please let us know what specific topics, issues, or questions you wish to see addressed or emphasized in this activity. Fax or CME/Conference Management. All responses will be forwarded to the Program Chairs for consideration. Photographing, audio taping, and videotaping are prohibited.

8 REGISTRATION INFORMATION On-site registration opens at 12:00 p.m. on Friday, January 22, 2016 at The University of Texas MD Anderson Cancer, Mid Campus Building 1 (1MC), Floor 3 Conference Center, Houston, Texas. The opening session of the conference will begin at 12:45 p.m. on Friday, January 22 nd and the conference will adjourn at 3:00 p.m. on Saturday, January 23 rd. Advanced registration is encouraged as space and materials are limited. Please see the registration form for applicable fees. Parking will be validated at the conference site. The deadline for advanced registration is Monday, December 28, There are three ways to register: On-line: register online at By Mail: mail registration form to CME/Conference Management Unit 1781, The University of Texas MD Anderson Cancer Center, P. O. Box , Houston, TX By Fax: fax completed form to

9 Telephone registrations are not accepted. We accept the following forms of payment: Check (payable through U.S. banks only) Money order Credit cards (MasterCard, VISA, and American Express) Cash (on-site registration only) When registering online a receipt/confirmation letter will be automatically ed to the address you list on the registration form. If you register by fax or mail a receipt/confirmation letter will be sent to you within ten working days of receipt of your fee. REFUND/CANCELLATION POLICY The registration fee, minus a $50 administrative handling fee, is refundable if a written request is received on or before Monday, December 28, No refunds will be granted after that date. The request for a registration refund must include the tax identification number of the company or institution if registration was paid by a company or institution check. For additional information, contact CME/Conference Management at or toll free at The Department of CME/Conference Management reserves the right to cancel activities prior to the scheduled date, if low enrollment or other circumstances make it necessary. Each registrant will be notified by mail, , or at the phone or fax numbers given on the registration form. In case of activity cancellation, the liability of the Department of CME/Conference Management is limited to the registration fee. CME/Conference Management will refund the full registration fee. The Department of CME/Conference Management reserves the right to limit the number of participants in a program and is not responsible for any expenses incurred by an individual whose registration is not confirmed and for whom space is not available. Please check the website.

10 SPECIAL ASSISTANCE Contact the Department of CME/Conference Management at if you have any special dietary or ADA accommodation needs. ACCOMMODATIONS A block of rooms has been reserved for conference attendees at the Hotel ZaZa, 5701 Main Street, Houston, Texas. Early reservation is suggested. The Hotel ZaZa phone number is The toll free number is When you make reservations be sure to mention MD Anderson Room Block; Code: MD CONF to be assured of receiving the special meeting rate of $ single or double occupancy. Please add 17% Texas state and local taxes. Click on the reservation link below to make online reservations. Reservations and deposits received after Tuesday, December 22, 2015, will be confirmed if space is available and at the current hotel published guest room rates. Transportation from hotel to meeting site will be provided. GROUND TRANSPORTATION (prices are subject to change) Houston is served by two airports, George Bush Intercontinental (IAH) and William P. Hobby (HOU). Taxicabs are available at an estimated cost of $50-$60 to or from William P. Hobby Airport or George Bush Intercontinental Airport. SuperShuttle operates a shuttle bus between George Bush Intercontinental Airport and the Hotel ZaZa for $27 one-way and $53 round-trip. For more information, call or toll free at , or online at SuperShuttle operates a shuttle bus between William P. Hobby Airport and the Hotel ZaZa for $23 one-way and $43 round-trip. For more information, call or toll-free at , or online at Access wayfind map at

11 CONFERENCE REGISTRATION - X Diagnosis, Mechanisms, and Management of Cancer Treatment-Induced Neurotoxicities: Neuropathy, Fatigue and Cognitive Impairment Last Name First MI Highest Degree Department (include unit no.) Specialty Institution MD Anderson Employee ID No. (required for all MDACC employees): Physician Street Yes No City State/Foreign Country/Zip or Mail Code Daytime Phone (with area code) Cell Phone (with area code) Fax (with area code) Address (please print) Emergency Contact Phone (with area code) Charge the following: VISA MasterCard American Express Credit Card Holder Name (First/Last) Credit Card Holder Billing Address & ZIP Code Credit Card Number Expiration Date MD Anderson Interdepartmental Transfer (IDT) No.: *Fund Group 90 will not be accepted Business Unit Department Fund Group* Fund Fund Type Authorized Signature REQUIRED for credit card or IDT IDT Approver Name (First/Last) please print THIS IS NOT A SELF-MAILER - Address to: Diagnosis, Mechanisms, and Management of Cancer Treatment-Induced Neurotoxicities: Neuropathy, Fatigue and Cognitive Impairment Department of CME/Conference Management Unit 1781 The University of Texas MD Anderson Cancer Center PO Box , Houston, TX or fax to Make check or money order payable to: The University of Texas MD Anderson Cancer Center REGISTRATION FEES Physicians, Scientists o Postmarked on or before 12/28/15...$ o Postmarked after 12/28/15...$ Students/Fellows/Residents/Post-docs/ Basic Scientists/Nurses o Postmarked on or before 12/28/15... $50.00 o Postmarked after 12/28/15...$75.00 o MD Anderson... $50.00 Attending the Poster Session...o Yes o No

12 The University of Texas MD Anderson Cancer Center Department of CME/Conference Management - Unit /30/115522/41 P.O. Box Houston, Texas Non-Profit Org. U.S. Postage P A I D Houston, TX Permit No. 7052