May 18, 2013 Sheraton Delfina Santa Monica, California

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1 3rd International Symposium on Lung-Sparing Therapies for Malignant Pleural Mesothelioma May 18, 2013 Sheraton Delfina Santa Monica, California

2 Malignant pleural mesothelioma (MPM) is an unusual cancer because it grows throughout the chest cavity as a diffuse process rather than a typical solid nodule or mass. Because of this unique characteristic, it has very specific treatment issues. MPM also is an unusual tumor with less than 3000 new cases annually, and therefore, most physicians, even pulmonologists and medical oncologists, may only see these patients infrequently. Despite this, it is critical that all physicians involved in the care of MPM patients be familiar with the important issues in this disease and possess a thorough understanding regarding the tumor itself, its evaluation process, staging, treatment and the role of multidisciplinary management of these patients. This includes the role and extent of surgery as well as radiation, chemotherapy and newer targeted therapies. Robert B. Cameron, MD, the course organizer and the Director of the UCLA Comprehensive Mesothelioma Program, has had over 19 years of experience with treating patients with MPM and, in particular, lung-sparing therapies, including pleurectomy and decortication surgical procedures and a number of complementary adjuvant therapies with the goal of treating this deadly disease like a chronic illness, similar to hypertension and diabetes. Course Objectives At the completion of this course, participants should be able to: understand the role of each modality in multidisciplinary therapies, including surgery, radiation, and chemotherapy understand the indications and contra-indications for surgery understand the pros and cons of lung-sparing surgery for MPM understand the need for chronic treatment for MPM understand the role for thermal and photodynamic therapy Target Audience Pulmonary physicians who are frequently involved in patient workups Medical Oncologists who are frequently involved in patient therapy Mesothelioma experts who want to learn/share experiences about lung-sparing therapies Patients, family, friends who desire to learn more about the disease

3 Course Chair Professor of Clinical Cardiothoracic Surgery and Surgical Oncology Director, Comprehensive Mesothelioma Program Chief, Thoracic Surgery West Los Angeles VA Medical Center International and Distinguished Faculty Michael J. Becich, MD, PhD Chair and Professor, Department of Biomedical Informatics University of Pittsburgh Pittsburgh, PA Joseph S. Friedberg, MD Chief of Thoracic Surgery Penn Presbyterian Medical Center Co-Director, Penn Mesothelioma & Pleural Program University of Pennsylvania Philadelphia, PA Raffit Hassan, MD Senior Investigator Laboratory of Molecular Biology Head, solid Tumor Immunotherapy Section National Cancer Institute National Institutes of Health Bethesda, MD Marco Trovo, MD Centro di Riferimento Oncologico CRO- Aviano Department of Radiation Oncology Aviano, Italy Faculty Clare Cameron Executive Director Pacific Heart, Lung, & Blood Institute Savannah Cline, RN, BSN Medical Liason Pacific Meso Center Pacific Heart, Lung, & blood Institute Marko Kostic, PhD Post-Doctoral Research Fellow Department of Bioengineering UCLA School of Engineering Olga Olevsky, MD Assistant Professor of Medical Oncology Linda Reinstein President/CEO and Co-Founder Asbestos Disease Awareness Organization (ADAO) Manhattan Beach, CA Raymond Wong, PhD Research Scientist Pacific Meso Center Pacific Heart, Lung, & Blood Institute

4 Program Schedule Saturday, May 18, :00 am Welcome Morning Session I: Lung-Sparing Surgical Techniques Moderator: 8:15 am Treatment of Mesothelioma as a Sarcoma: Implications for Surgical Timing and Techniques 8:45 am Pleurectomy and Decortication with Intraoperative Photodynamic Therapy Joseph S. Friedberg, MD 9:15 am Discussion 9:30 am Break Morning Session II: Lung-Sparing Adjuvant Therapies Moderator: Olga Olevsky, MD 9:45 am New Results and Concepts in Systemic Treatment of Mesothelioma Olga Olevsky, MD 10:15 am Anti-Mesothelin Agents for Mesothelioma Therapy Raffit Hassan, MD 10:45 am Postoperative Adjuvant Radiation: The Role of IMRT and Tomotherapy Following Lung-Sparing Surgery Marco Trovo, MD 11:15 am Thermal Therapy for Malignant Pleural Mesothelioma: Hot or Cold? 11:45 am Discussion 12:00 Lunch

5 Afternoon Session I: Potential Future Adjuvant Therapies Moderator: 1:00 pm Creating a National Network of Biospecimen Banks to Catalyze Mesothelioma Research Michael Becich, MD 1:30 pm Investigating the Tumor Microenvironment Using Multicellular Mesothelioma Spheroids Raymond Wong, PhD 2:00 pm Theoretical Modeling and Experimental Results: Implications of the Design of a Clinical Cryosprayer for the Treatment of Mesothelioma Marko Kostic, PhD 2:30 pm Discussion 2:45 pm Break Afternoon Session II: Supportive Therapies Moderator: Clare Cameron 3:00 pm Palliative Therapy and Mesothelioma: When is it NOT Palliation? 3:15 pm Unique Opportunities Offered by a Non-Profit Research Organization Clare Cameron 3:30 pm Mesothelioma Information on the Internet: How do you Find the Truth? Savannah Cline, RN, BSN 3:45 pm The Global Asbestos Struggle: Progress and Challenges Linda Reinstein 4:00 pm Navigating the Healthcare System for Patients with Mesothelioma 4:30 pm Concluding Remarks 4:45 pm Adjourn

6 General Information Conference Location The Sheraton Delfina 530 Pico Blvd., Santa Monica, CA Accommodations If you wish to stay at the hotel you can call reservations at and ask for the Social Rate, SET Number: Parking Hotel self parking is complimentary Valet parking is $15 per day Fees Pre-registration fee: (Deadline May 15) Physicians: $150 Nurses: $100 Family &Patients: $50 Students: $25 Legal Profession: $250 On-site registration fee: Physicians: $300 Nurses: $200 Family & Patients: $100 Students: $50 Legal Profession: $500 Refunds Cancellations must be received in writing by April 19, 2013 and will be subject to a $75 processing fee. A full refund will be provided if for any reason the course must be cancelled or rescheduled. Enrollment Online Go to to enroll online using your American Express, Discover, MasterCard or Visa. Click on 3rd International Symposium on Lung- Sparing Therapies for Malignant Pleural Mesothelioma. By Mail Enroll by mail with your Discover, MasterCard or Visa by using the form attached. Mail to the Office of Continuing Medical Education,, Wilshire Blvd., Suite 1060, Los Angeles, CA By Fax Enroll by fax with your Discover, MasterCard or Visa by sending the completed enrollment form with credit card information and authorizing signature. Fax to By Phone Use your Discover, MasterCard or Visa to enroll over the phone. Call Accreditation The Office of Continuing Medical Education, is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The Office of Continuing Medical Education, designates this live activity for a maximum of 7.25 AMA PRA Category 1 Credits. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Disclosure The FDA has issued a concept paper which classifies commercial support of scientific and educational programs as promotional unless it can be affirmed that the program is truly independent and free of commercial influence. In addition to independence, the FDA requires that non-promotional, commercially supported education be objective, balanced, and scientifically rigorous. The policy further states that all potential conflicts of interest of the CME staff and faculty be fully disclosed to the program s participants. In addition, Accreditation Council for Continuing Medical Education policy now mandates that the provider adequately manage all identified potential conflicts of interest prior to the program. We, at UCLA, fully endorse the letter and spirit of these concepts. Please visit our website for other UCLA CME offerings ww.cme.ucla.edu

7 Mail Application for Enrollment (please print) Course Title & Number Amount 3rd International Symposium on Lung-Sparing Therapies for Malignant Pleural Mesothelioma M Pre-registration fee: (Deadline May 15) On-site registration fee: Physicians: $150 Physicians: $300 Nurses: $100 Nurses: $200 Family & Patients: $50 Family & Patients: $100 Students: $25 Students: $50 Legal Profession: $250 Legal Profession: $500 LAST FOUR DIGITS OF SOCIAL SECURITY NUMBER NAME (FIRST, MIDDLE, LAST) u MALE u FEMALE DEGREE PREFERRED MAILING ADDRESS CITY/STATE/ZIP specialty AREA CODE/DAYTIME PHONE AREA CODE/FAX ADDRESS CHECK enclosed, payable to Regents of the University of California CHARGE u Discover u MasterCard u Visa Card Number Authorizing Signature Expiratioin Date (Mo/Yr) / Mail to: UCLA Office of Continuing Medical Education Mesothelioma Wilshire Blvd., Suite

8 UCLA Office of Continuing Medical Education 405 Hilgard Avenue Los Angeles, California rd International Symposium on Lung-Sparing Therapies for Malignant Pleural Mesothelioma May 18, 2013 Sheraton Delfina Santa Monica, California Non-Profit Org. U.S. Postage PAID UCLA

May 18, 2013 Sheraton Delfina Santa Monica, California

May 18, 2013 Sheraton Delfina Santa Monica, California 3rd International Symposium on Lung-Sparing Therapies for Malignant Pleural Mesothelioma May 18, 2013 Sheraton Delfina Santa Monica, California Malignant pleural mesothelioma (MPM) is an unusual cancer

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