IV INTERNATIONAL CONFERENCE ON FUTURE TRENDS IN THE TREATMENT OF BRAIN TUMORS February 22-23, Aula Magna S. Lucia, Bologna (Italy)

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1 Under the auspices of CHAIRPERSON Alba A. Brandes G Gruppo I Italiano C Cooperativo N Neuro O Oncologia

2 REQUESTED AUSPICES: Ministero della Salute Provincia di Bologna Alma Mater Studiorum Università di Bologna Treatment of brain tumors is a challenge. After a dark age of poor options in diagnosis, biological knowledge and treatments, characterized by the feeling that this field of medical oncology might remain motionless, recent years have seen new improvements that have consistently changed the landscape. These advances have been the fruit of the efforts of many clinicians and biologists that, both individually and together, have led to the organization and realization of clinical studies providing new therapeutic standards and, more importantly, the increased survival of patients with brain tumors. Thanks to the foresight and experience of these colleagues, clinical research has been flanked by molecular biology studies enabling us to understand and fight our common enemy, and its intrinsic characteristics, with an enhanced response to treatments and new instruments for developing targeted and selective strategies. It is my pleasure to welcome to this bi-annual Meeting taking place in Bologna for the first time many friends and colleagues who, throughout the years, have contributed to the development of Neuro-Oncology. I hope that this Meeting will provide a clear picture of the state of the art in this field, but that it will also stimulate new research and further international collaboration. Comune di Bologna Alba A. Brandes 2 3

3 SCIENTIFIC PROGRAM FRIDAY, FEBRUARY FACULTY L. Abrey (NewYork) D. Amadori (Forlì) A. Andreoli (Bologna) B. Baumert (Maastricht) A.A. Brandes (Bologna) G. Broggi (Milan) J. Buckner (Rochester) F. Calbucci (Bologna) P. Casali (Milan) F. Colombo (Vicenza) R. Delfini (Roma) F. Dhermain (Paris) V. Esposito (Pozzilli) V. Eusebi (Bologna) D. Farci (Cagliari) F. Ferrarese (Treviso) G. Finocchiaro (Milan) E. Franceschi (Bologna) M. Frattarelli (Cesena) G. Frezza (Bologna) S.M. Gaini (Milan) E. Galanis (Rochester) R. Galzio (L'Aquila) F. Giangaspero (Roma) M. Gilbert (Houston) M. Hegi (Lausanne) R. Kortmann (Leipzig) D. Lacombe (Brussels) N. Laperriere (Toronto) M. Leonardi (Bologna) P. Longatti (Treviso) N. Magrini (Modena) F. Maiuri (Naples) W. Mason (Toronto) R.O. Mirimanoff (Lausanne) B. Neyns (Brussels) G. Oliveri (Siena) G. Pavanato (Rovigo) J.R. Perry (Toronto) G. Pinna (Modena) E. Pozzati (Bologna) R. Rampling (Glasgow) D. Reardon (Durham) M. Reni (Milan) U. Ricardi (Turin) M. Sanson (Paris) A. Silvestro (Bologna) M. Skrap (Udine) R. Stupp (Lausanne) A. Talacchi (Verona) M. Taphoorn (The Hague) F. Tomasello (Messina) A. Tosoni (Bologna) S. Turazzi (Verona) M.J van den Bent (Rotterdam) C. Vecht (The Hague) S. Villa (Barcelona) M. Weller (Zurich) P. Wen (Boston) H. Zwinkels (The Hague) 08:30 a.m. Welcome address and introductory remarks: A.A. Brandes (Bologna) SESSION I EPIDEMIOLOGY - SURGERY - DIAGNOSIS AND PROGNOSIS Moderators: R. Delfini (Rome) - V. Eusebi (Bologna) 09:00 a.m. Translational research in brain tumors: how to incorporate MGMT and 1p19q in the clinical decision M. Hegi (Lausanne) 09:15 a.m. Targeting stem cells in the treatment of glioma G. Finocchiaro (Milan) 09:30 a.m. Neuroradiological possibilities of the differential diagnosis of brain tumors M. Leonardi (Bologna) 09:45 a.m. The new boundaries of neurosurgery in the treatment of brain tumors F. Calbucci (Bologna) Moderators: A. Andreoli (Bologna) - F. Giangaspero (Rome) - S. Turazzi (Verona) 10:00 a.m. Clinical case n 1: A. Talacchi (Verona) 10:10 a.m. Clinical case n 2: E. Pozzati (Bologna) 10:20 a.m. Discussion SESSION II SCIENTIFIC PROGRAM FRIDAY, FEBRUARY GLIOBLASTOMA BEYOND EORTC/ NCIC TRIAL Moderators: G. Broggi (Milan) - M.J. van den Bent (Rotterdam) 10:30 a.m. Pseudoprogression and MGMT: friend or foe? A.A. Brandes (Bologna) 10:45 a.m. Long term follow-up and RPA of the EORTC chemo-irradiation study with Temozolomide R.O. Mirimanoff (Lausanne) 4 5

4 SCIENTIFIC PROGRAM FRIDAY, FEBRUARY :00 a.m. Strategies for treatment and new frontiers in elderly patients N. Laperriere (Toronto) 11:15 a.m. Dose dense regimen: a new challenge M. Gilbert (Houston) 11:30 a.m. Target therapy in combination with other modalities: the next step R. Stupp (Lausanne) Moderators: M. Frattarelli (Cesena) - F. Maiuri (Naples) - G. Pinna (Modena) 11:45 a.m. Clinical case n 3: F. Dhermain (Paris) 11:55 a.m. Clinical case n 4: F. Ferrarese (Treviso) 12:05 p.m. Discussion SESSION III Moderators: N. Magrini (Modena) - M.J. van den Bent (Rotterdam) 12:15 p.m. Challenges and opportunities for non profit clinical oncological research in Italy P. Casali (Milan) 12:30 p.m. EORTC: challenges and opportunities for a European wide non profit clinical oncological research organization D. Lacombe (Brussels) 12:45 p.m. LUNCH 02:45 p.m. Alternative schedules of Temozolomide and rechallenge B. Neyns (Brussels) 03:15 p.m. Does chemotherapy still have a role as a second line treatment? Fotemustine: a phase II GICNO study M. Reni (Milan) Moderators: R. Galzio (L'Aquila) - S.M. Gaini (Milan) - M. Skrap (Udine) 03:30 p.m. Clinical case n 5: G. Pavanato (Rovigo) 03:40 p.m. Clinical case n 6: E. Franceschi - A. Tosoni (Bologna) 03:50 p.m. Clinical case n 7: D. Farci (Cagliari) 04:00 p.m. Discussion SESSION V TARGETED THERAPIES Moderators: J.R. Perry (Toronto) - R. Stupp (Lausanne) 04:15 p.m. Integrins inhibitor: Cilengitide D. Reardon (Durham) 04:30 p.m. Small molecules VEGFr inhibitors: Cediranib and Vandetanib P. Wen (Boston) 04:45 p.m. Anti VEGF antibodies: Bevacizumab M. Sanson (Paris) 05:00 p.m. Histone deacetylase inhibitor: Vorinostat E. Galanis (Rochester) 05:15 p.m. Enzastaurin and radiotherapy R. Rampling (Glasgow) 05:30 p.m. Multikinase inhibitor: Sorafenib M. Gilbert (Houston) 05:45 p.m. Discussion SCIENTIFIC PROGRAM FRIDAY, FEBRUARY SESSION IV 06:00 p.m. Conclusion RECURRENT BRAIN TUMORS Moderators: L. Abrey (New York) - D. Amadori (Forlì) - G. Oliveri (Siena) 02:30 p.m. Recurrent gliomas: practical aspects of management, assessment of efficacy and progression J. Buckner (Rochester) 6 7

5 SCIENTIFIC PROGRAM SATURDAY, FEBRUARY SESSION I LOW GRADE GLIOMAS Moderators: V. Esposito (Pozzilli) - P. Longatti (Treviso) - R.O. Mirimanoff (Lausanne) 08:45 a.m. Pre- and post-treatment factors predicting survival for patients with low-grade glioma B. Baumert (Maastricht) 09:00 a.m. Chemotherapy for low-grade gliomas: emerging consensus on its benefits P. Wen (Boston) 09:15 a.m. Delayed radiation toxicity after focal or whole brain radiotherapy and effects on cognitive function in patients with low-grade glioma M. Taphoorn (The Hague) 09:30 a.m. Discussion 09:40 a.m. NURSES LECTURE Moderators: M. Sanson (Paris) - A. Silvestro (Bologna) 10:00 a.m. Discussion The role of the nurse in both clinical and research Neuro-Oncology H. Zwinkels (The Hague) 10:40 a.m. Discussion SESSION III THE STATE OF THE ART AND FUTURE TRENDS IN THE TREATMENT Moderators: R.O. Mirimanoff (Lausanne) - U. Ricardi (Turin) 11:00 a.m. Anaplastic Astrocytoma M. Weller (Zurich) 11:15 a.m. Oligodendroglioma W. Mason (Toronto) 11:30 a.m. Meningioma S. Villa (Barcelona) 11:45 a.m. Pineal Tumors R. Kortmann (Leipzig) 12:00 p.m. Primary Central Nervous System Lymphoma L. Abrey (New York) 12:15 p.m. Discussion 12:30 p.m. Closing Remarks: A.A. Brandes (Bologna) SCIENTIFIC PROGRAM SATURDAY, FEBRUARY SESSION II BRAIN METASTASES Moderators: F. Colombo (Vicenza) - G. Frezza (Bologna) - F. Tomasello (Messina) 10:10 a.m. Innovation in the management of CNS metastases C. Vecht (The Hague) 10:25 a.m. Radio-chemotherapy for brain metastases: how to define a role for Temozolomide M. Weller (Zurich) 8 9

6 SCIENTIFIC INFORMATION OFFICIAL LANGUAGE English. SLIDES Only computer videoprojection will be available. Other requirements should be communicated to the Organizing Secretariat as soon as possible. The presentations should be handed in to the Slide Center on cd-rom or pen drive one hour before the beginning of the session, and collected at the end. BADGE All registered participants, speakers and attendants will be given a badge which they must wear to be admitted to the scientific sessions. ATTENDANCE CERTIFICATE A certificate will be given to all attendants at the end of the conference. ECM Accreditation has been requested for MDs working in oncology, neurology and neurosurgery departments for the whole meeting and for Nurses only for Saturday. GENERAL INFORMATION CONFERENCE VENUE AULA MAGNA S. LUCIA VIA CASTIGLIONE BOLOGNA ITALY HOW TO REACH THE CONFERENCE VENUE By bus: from Bologna railway station: bus C (15 minutes). By taxi: 10 minutes from Bologna railway station, 20 minutes from Bologna Airport. By car: exit from the motorway at Bologna Casalecchio or Arcoveggio, enter the Tangenziale until exit n 7 city center. The venue is in a limited traffic area, leave the car in the nearest parking Ex Staveco Viale Panzacchi, 10 and parking VIII AGOSTO - Piazza VIII Agosto / Via Menotti. Walking distance. REGISTRATION The registration is free of charge. Preference will be given to pre-registered attendants. Please return the pre-registration form to the Organizing Secretariat Studio ER Congressi - Gruppo Triumph Via Marconi, Bologna, Italy Phone Fax ercongressi@gruppotriumph.it TRAVEL AGENCY Bononia Viaggi S.r.l. Piazza dei Martiri, Bologna Phone Fax congressi@bononiaviaggi.it 10 11

7 REGISTRATION FORM The registration is free of charge Please return this form to the Organizing Secretariat: STUDIO ER CONGRESSI-GRUPPO TRIUMPH VIA MARCONI, BOLOGNA - ITALY PHONE FAX: ercongressi@gruppotriumph.it P. IVA / CODICE FISCALE HOTEL RESERVATION FORM To be sent to: BONONIA VIAGGI - BT&I P.za dei Martiri, Bologna - Italy Phone Fax congressi@bononiaviaggi.it LAST NAME FIRST NAME POSITION TITLE INSTITUTION PRIVATE ADDRESS ZIP CODE CITY STATE/PROVINCE COUNTRY PHONE FAX MOBILE PHONE TAX PAYER S NUMBER (COD. FISCALE) LAST NAME FIRST NAME POSITION TITLE INSTITUTION ADDRESS ZIP CODE CITY STATE/PROVINCE COUNTRY PHONE FAX FOR THE INVOICE: LAST NAME FIRST NAME Signing this form and well informed on the Legislative Decree n. 196/2003 concerning Personal data processing, I authorize Studio ER Congressi S.r.l. - Gruppo Triumph until written revocation, to process and divulge my personal data within the limits of the above-mentioned law and in accordance with the procedure laid down by the law. I give my assent provided that Studio ER Congressi S.r.l. - Gruppo Triumph complies with the regulations in force. I do not want that my personal data are divulged to third parties. ADDRESS CITY ZIP VAT NUMBER ( P. IVA) STATE/PROVINCE COUNTRY TAX PAYER S NUMBER (COD. FISCALE) Date Signature NAME OF THE ACCOMPANYING PERSON 12 13

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9 SCIENTIFIC SECRETARIAT Raffaele Agati Antonella Bacci Stefania Bartolini Enrico Franceschi Annalisa Pession Eugenio Pozzati Franca Ruggeri Federica Spagnolli Giovanni Tallini Alicia Tosoni ORGANIZING SECRETARIAT Studio E.R. Congressi - Gruppo Triumph Via Marconi, Bologna, Italy Tel.: Fax: ercongressi@gruppotriumph.it GICNO Gruppo Italiano Cooperativo Neuro-Oncologia Piazza Eremitani, Padova, Italy alba.brandes@yahoo.it