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1 Scientific Committee Paolo Rossi (President, Rome, Italy); Marco Cappa (Chair, Rome, Italy); Stefano Cianfarani (Rome, Italy); George P. Chrousos (Athens, Greece); Lucia Ghizzoni (Turin, Italy) Sandro Loche (Cagliari, Italy); Mohamad Maghnie (Genoa, Italy), Paul Saenger (New York, USA) Monday 27 th October ,00-14,00 Registration 12,30-14,00 Welcome Buffet ,30 Welcome G Profiti (It), B Dallapiccola (It), M Raponi (It) 14,30-15,15 Chair: M Maghnie (It) Introductive lecture Pharmacology Research in Pediatrics P Rossi (It) 15,15-16,45 Chair: P Pozzilli (It) New therapeutic strategies for type 1 Diabetes Artificial pancreas M Phillip (Isr) Pancreatic islet transplantation F Bertuzzi (It) 16,45-17,15 Coffee Break 17,15-18,15 Chair: S Loche (It) Approaches for obesity and metabolic syndrome GLp1-Receptor antagonist AS Kelly (USA) DHA and its role in GRP 120 receptor activation in children affected by NAFLD V Nobili (It) Tuesday 28th October Lecture - Chair: L Ghizzoni (It) CAH:Non-Invasive Prenatal Diagnosis M.I. New (USA) 9,00-11,00 Adrenal and Gonads Chair: GP Chrousos (Gr), L Ghizzoni (It) Recent advances in hydrocortisone replacement treatment M Debono (UK) Histrelin implants in pediatrics EA Eugster (USA) Very early therapy of Congenital Hypogonadotropic Hypogonadism P Bougneres (Fr) Different medications for Hypogonadotropic Hypogonadism M Maggi (It)

2 11,00-11,30 Coffee Break 11,30-12,30 Growth Chair: S Cianfarani (It) Long Acting GH therapy P Saenger (USA) C-Type natriuretic peptide analog as therapy for achondroplasia L Legeai-Mallet (Fr) 12,30-14,30 Lunch 14,30-16,30 Puberty Chair: G Radetti (It), M Salerno (It) GnRH, kisspeptin and neurokinin B analog RP Millar (UK) Aromatase inhibitors in pediatrics Hero M (UK) New therapeutic approaches for pediatric osteoporosis N Di Iorgi (It) 16,30-17,00 Coffee Break 17,00-18,00 Neurological disorders. Chair: E Bertini (It) Gene therapy in CNS disorders P Aubourg (Fr) Oxidative stress blocker as therapy for X-linked adrenoleukodystrophy A Pujol Onofre (Sp) 18,00-18,15 Wrap up and closing remarks M Cappa (It)

3 WELCOME Dear Friends, It is a great pleasure to welcome you to the workshop on Advanced Therapies in Paediatric Endocrinology and Diabetology. This is the sixth of a series of workshop started in 2007 on Congenital Endocrinopathies and continued every two years in Italy in different cities (Genoa, Rome, Cagliari, Turin). The sixth workshop will be held in Rome and the intent is to provide an updating on new therapies focus on endocrine disorders. As you can see from the program, the workshop will cover several topics, and there will be thematic sessions as well as plenary lectures. We will have the privilege of hosting outstandig experts who have accepted our invitation to jointly discuss issue including advanced therapy for DM1, new approaches for obesity and metabolic syndrome, new therapies for adrenal and gonads disorders, advances in growth promoter drugs, new approaches for delayed puberty, osteoporosis and gene therapy and oxidative stress blocker for neurological disease. We hope that the quality of the scientific program, the venue and the environment will make this workshop a successful event. Welcome to Rome Paolo Rossi President Marco Cappa On Behalf of the Scientific Planning Committee LOCAL ORGANIZING COMMITTEE Paola Cambiaso Antonino Crinò Armando Grossi Patrizia Patera Ospedale Pediatrico Bambino Gesù, Roma (Italy) REGISTRATION INFORMATION Registration fee includes: Participation in the Scientific Program, Congress kit, Welcome Lunch, Coffee Breaks, Working Lunch, Certificate of attendance. You can register using the following registration form or by visiting the website at the page Corsi e Congressi, choosing the workshop and following the indications. CONGRESS VENUE Ospedale Bambin Gesù Viale F. Baldelli, Roma Meeting Room: Auditorium

4 REGISTRATION FORM Send to fax number or Family Name Name Address Town Zip Code Country Phone Fax Mobile Fiscal code (Italian only) Job Specialization Institution/Company Department If invoice requested with different data, please fill in the following fields: Company Address Town Zip Code Country Vat Number Fiscal code (Italian only) Registration fees (VAT included) Before August, 31 st From September 1 st Participant 500,00 550,00 Student 120,00 120,00 Registration fee includes: Participation in the Scientific Program, Congress kit, Welcome Lunch, Coffee Breaks, Working Lunch, Certificate of attendance.

5 PAYMENT On line: through credit card payment (Visa, Mastercard,Eurocard), visiting Off line, following the below methods: 1) Credit card Visa Eurocard Mastercard Card number Exp. Date / CVV Card holder s Name Date Signature 2) Bank transfer* to Centro Congressi Internazionale S.r.l. IBAN: IT 24 Q SWIFT CODE: UNCRITMMON2 Purpose of payment: ADVANCED THERAPIES C65/14 family name-name * Participants should pay any service fee charged by the bank on their money transfer. CANCELLATION POLICY Up to 28 September, 2014 After 28 September, % Fee Refund No Refund Privacy - Italian Law n. 196/2003: We warrant complete privacy on personal data. They will be kept and used only for communications regarding the meeting organization. Date Signature

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