REGISTER TODAY. March 17-19, 2016 Le Royal Hotel Amman, Jordan ASSOCIATION: CONGRESS PORTAL: Hosted by menactrims.

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1 Hosted by ASSOCIATION: REGISTER TODAY CONGRESS PORTAL: In collaboration with menactrims.com March 17-19, 2016 Le Royal Hotel Amman, Jordan

2 Welcome Note Dear Colleagues, On behalf of Middle East North Africa Committee for Research and Treatment in Multiple Sclerosis and its executive committee, it is my pleasure to invite you to participate in the Second MENACTRIMS Congress, which will take place from March 17 th to 19 th, 2016 in Amman, Jordan. The congress aim is to provide a forum of excellence in MS education and research. Building on the collective efforts of the scientific committee, the meeting will deliver state-of-the-art presentations on MS by renowned international and regional keynote speakers. The content of the meeting includes up to date information on the latest treatments, clinical research, therapeutic strategies, imaging, epidemiology, differential diagnosis, risk factors, pregnancy, and much more. The congress will convene over a two-day period to present major updates through plenary sessions, scientific symposia and teaching courses. This year s congress will also feature parallel sessions addressed to nurses in collaboration with the International Organization of MS Nurses (IOMSN) and the Consortium of Multiple Sclerosis Centers (CMSC), and to regional MS societies in collaboration with the MS International Federation (MSIF). In addition, the European Charcot Foundation will participate in the meeting for the first time through a scientific symposium. The congress is also a great opportunity to meet and network with colleagues interested in the field of MS clinical care with more than 500 healthcare professionals from the MENA region expected to attend. We look forward to welcoming participants from all over the world to the lively cosmopolitan city of Amman. Amman is a lively cosmopolitan fascinating city of contrasts a unique blend of old and new, ideally situated on a hilly area between the desert and the fertile Jordan Valley. Jordan is a land steeped in history and has truly world-class sights such as Petra (one of the seven wonders of the world), Wadi Rum, Jerash and the Dead Sea, which form part of the magic that is Jordan. We very much look forward to welcoming you in Amman. Yours Sincerely, Bassem I. Yamout, MD, FAAN MENACTRIMS President

3 MENACTRIMS is an independent non-profit scientific organization that facilitates communication and creates synergies among clinicians and scientists to promote and enhance research and improve clinical outcomes in multiple sclerosis (MS). The main objectives of the organization are as follows: To support and promote basic and clinical research in multiple sclerosis in the Middle East and North Africa regions To act as representative of the multiple sclerosis research community To be actively involved in coordinating initiatives in the field of research both in our region and worldwide in collaboration with national and international MS organizations To establish National and Regional MS registries and to collaborate database in order to formulate a large MS registry To develop regular updated guidelines pertaining to diagnosis and therapy of MS in this region To organize at least bi-annual congresses in the field of treatment and research in multiple sclerosis To encourage young researchers in the field of multiple sclerosis. To collaborate with relevant national and local associations in the region to enhance MENACTRIMS mission. Executive Committee Prof. Bassem I Yamout MENACTRIMS President Lebanon Prof. Riadh Gouider MENACTRIMS Vice President Tunisia Dr. Mohammed Al-Jummah MENACTRIMS Vice President Saudi Arabia Dr. Maurice Dahdaleh MENACTRIMS Treasurer Jordan Dr. Raed Alroughani MENACTRIMS Secretary General Kuwait Prof. Saeed Bohlega MENACTRIMS Member Saudi Arabia Prof. Saher Hashem MENACTRIMS Member Egypt Dr. Jihad Inshasi MENACTRIMS Member United Arab Emirates Dr. Isa Alsharoqi MENACTRIMS Member Bahrain Organizing Committee... Dr. Maurice Dahdaleh- Chair, Consultant Neurologist, Khalidi Hospital and Medical Center, Amman, Jordan Dr. Jihad Inshasi- Co-Chair, Consultant Neurologist, Rashid Hospital & Dubai Medical College, Dubai, United Arab Emirates Prof. Riadh Gouider, Head of Department and Consultant Neurologist, Razi Hospital, Tunis, Tunisia Dr. Isa Alsharoqi, Consultant Neurologist, Salmaniya Medical Complex, Manama, Bahrain Dr. Waleed Batayha, Consultant Neurologist, Ministry of Health, Amman, Jordan Dr. Abdel Rahim Dwairi, Consultant Neurologist, Royal Medical Services, Amman, Jordan About MENACTRIMS Scientific Committee Dr. Saeed Bohlega- Chair, Professor and Senior Consultant Neurologist, Department of Neurosciences, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia Prof. Riadh Gouider- Co-chair, Consultant Neurologist and Head of Department, Razi Hospital, Tunis, Tunisia Dr. Raed Alroughani, Director of MS Clinic, Amiri Hospital & Dasman Research Institute, Kuwait City, Kuwait Dr. Isa Alsharoqi, Consultant Neurologist, Salmaniya Medical Complex, Manama, Bahrain Dr. Saher Hashem, Professor and Consultant Neurologist, Faculty of Medicine, University of Cairo, Cairo, Egypt Dr. Mohamad Sahraian, Associate Professor, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran Dr. Majed Habahbeh, Consultant Neurologist, Royal Medical Services, Amman, Jordan Congress Committees

4 MENACTRIMS Nursing Session MS Organizations Session Day 3 March 19, :30-09:50 Session I 08:30 Role of the MS Nurse J. Massouh 09:00 Clinical Evaluation Tools: MSFC, EDSS, QOL, Fatigue Scale, Hamilton Depression J. Haartsen 09:30 Discussion 09:50-10:20 Coffee Break 10:20-12:30 Session II 10:20 Symptomatic Management of MS Patients: What Nurses Need to Know J. Haartsen 10:50 Safety of DMDs in Pregnancy M. Zeineddine 11:20 Discussion 11:40 Case Discussion M. Dahdaleh J. Inshasi 12:30-13:45 Lunch 13:45-16:40 Satellite Symposia: Managing MS Patients on DMTs 13:45 Managing MS patients on DMTs I (Sponsored by Biologix) 14:25 Managing MS patients on DMTs II (Sponsored by Novartis) 15:05-15:20 Coffee Break 15:20 Managing MS patients on DMTs IV (Sponsored by MerckSerono) Day 3 March 19, :00-15:30 Session I: The Role of MS Organizations 14:00 The MSIF: Who are we and how do we work with Local MS Organizations C. A. Napier 14:20 How are MS Organisations Established and What is their Role? A. Ibrahim 14:50 MS Organizations in the West: How are they organized and what do they do? 15:15 Discussion 15:30-16:00 Coffee Break MSIF Speaker TBA 16:00-17:30 Session II: Working Together: MS Organizations and Healthcare Professionals in the MENA Region 16:00 Cooperation between MS Societies and Healthcare Professionals R. Alroughani 16:30 How can MS Organizations Inform People with MS about available Therapeutic Options I. Alsharoqi 17:15 Discussion International Organization of MS Nurses (IOMSN) and the Consortium of Multiple Sclerosis Centers (CMSC) Multiple Sclerosis International Federation (MSIF)

5 Day 1 March 17, 2016 Neuroradiology of MS MENACTRIMS-WFNRS Symposium 16:30-18:10 Session I 16:30 Lesion Characteristics in Brain and Spinal Cord T. Yusri 16:50 MS Mimickers A. Rovira 17:10 MS Diagnostic Criteria: Past, Present & Future T. Yusri 17:30 Advanced MRI Imaging in MS M. Wattjes 18:10 Discussion 18:10-18:30 Coffee Break 18:30-20:15 Session II 18:30 The Role of MRI in Monitoring Disease Activity A. Rovira 18:50 Brain Atrophy: Its Role in MS S. Schippling 19:10 Progressive Multifocal Leukoencephalopathy T. Yusri 19:30 Neuromyelitis Optica M. Wattjes 19:50 Discussion Day 2 March 18, :00-08:45 Registration 08:45-09:15 Opening Ceremony B. Yamout, President MENACTRIMS A. Younis, President Jordan Neurological Society 09:15-11:15 PS I: Pathogenesis and Natural History of MS 09:15 Immunology of MS S. Khoury 09:40 The Pathology of MS and Other Inflammatory Demyelinating Diseases H. Lassman 10:05 The New MS Phenotypes: Benefits and Pitfalls P. Rieckmann 10:30 The Natural History of MS G. Giovannoni 10:55 Discussion 11:15-13:00 Prayer and Lunch 13:00-13:45 SS I: Satellite Symposium (sponsored by Biologix) 13:00 Treatment Decisions at the Intersection of Clinical Trials and Real Life Practice T. Ziemssen 13:35 Discussion 13:45-15:05 PS II: Treatment of MS 13:45 The Role of Real World Studies in Assessing the Effectiveness of MS Therapies M. Trojano 14:00 MENACTRIMS Treatment Guidelines B. Yamout 14:35 Future Therapies in Relapsing Remitting MS L. Kappos 14:50 Discussion 15:05-15:30 Coffee Break 15:30-16:50 PS III: Special Issues in MS 15:30 Pediatric MS A. Boykov 15:55 Women s Issues in MS S. Ibrahim 16:10 NMO Spectrum Disorders R. Alroughani 16:35 Discussion 16:50-17:20 SS II: Satellite Symposium (sponsored by MerckSerono) 16:50 Optimizing Long-Term Clinical Outcomes in the Management of MS L. Kappos 17:10 Discussion Second Middle East North Africa Committee for Research and Treatment in Multiple Sclerosis Congress

6 Day 3 March 19, :00-09:00 Registration 09:00-10:20 PS IV: Controversies in MS 09:00 Radiologically Isolated Syndrome (RIS): Should we treat? M. Zakaria 09:15 Benign MS: Does it Exist? P. Rieckmann 09:40 Debate: Should we Stop DMTs in Patients with No: G. Comi Long term Control of Disease Activity? Yes: M. Khawaja 10:20-10:40 Coffee Break 10:40-12:00 PS V: European Charcot Foundation Symposium Progressive MS: Where Do We Stand Today? 10:40 Pathological Mechanisms of Progressive MS H. Lassman 11:00 Disease Modifying Treatments in Progressive MS G. Comi 11:20 Future Therapies in Progressive MS L. Kappos 11:40 Electric and Magnetic Neuromodulation L. Leocani 12:00-12:45 SS III: Satellite Symposium (sponsored by Novartis) 12:00 NEDA 4 impacting early in MS: Time is Brain J. S. Garriga 12:20 Integrating MRI Reading into Practice M. Nagels 12:35 Discussion Day 3 March 19, :45-13:45 Lunch 13:45-15:05 PS VI: Clinical Issues in MS 13:45 Genetic and Environmental Risk Factors in MS M. Etamedifar 14:05 The Role of Optical Coherence Tomography in MS C. Guevara 14:20 The Differential Diagnosis of MS S. Daoudi 14:35 Defining Suboptimal Response to Treatment in MS G. Giovannoni 14:50 Discussion 15:05-15:35 SS IV: Satellite Symposium (sponsored by Genpharm/Genzyme) 15:05 Optimizing the Patient s Journey in Relapsing Remitting Multiple Sclerosis P. Rieckmann 15:25 Discussion 15:35-16:00 Coffee Break 16:00-17:30 PS VII: Clinical Management of MS: Case Studies Panelists: P. Rieckman, S. Bohlega, M. Aljumah 16:00 When to Switch or Escalate? R. Goueider 16:25 CIS: To Treat or not to Treat R. Obeid 16:50 The Dilemma of NMOSD E. Slassi 17:15 PML and MS in the MENA Region J. Saaedi 17:30-18:00 Closing Ceremony Second Middle East North Africa Committee for Research and Treatment in Multiple Sclerosis Congress

7 Target Audience: Healthcare professionals and researchers involved in MS clinical care or research. Congress Overview: Full congress plenary sessions and symposia Symposium on neuroradiology in MS European Charcot Foundation Symposium Half-day parallel session in collaboration with the International Organization of MS Nurses (IOMSN) aimed at nurses Half-day parallel session in collaboration with the MS International Federation (MSIF) aimed at MENA region MS societies. Congress Highlights: Recent advances in MS therapy MS and the Environment Update review of MRI in MS Immunology of MS Epidemiology of MS Differential Diagnosis of MS Update on Secondary Progressive MS Neuromyelitis Optica Pediatric MS MS and pregnancy Symptomatic Management of MS CME Accreditation: CME Accredited by the Jordan Medical Council. Under process. Registration Schedule: Pass Early Bird Jan. 15 Standard Mar. 12 Group Registration: Onsite Doctors USD 400 USD 450 USD 500 Non Doctors USD 200 USD 250 USD 300 The registration fee will cover tuition, symposium literature, certificate of attendance, lunch & coffee breaks for the Congress only. Non-sponsoring companies that would like to purchase a group of delegates passes attending the congress may do so by using the special group registration fee. A group consists of a minimum of 10 persons as such: Category Early Bird Jan. 15 Standard Mar. 12 Doctors USD 3600 USD 4000 Non Doctors USD 2000 USD 2500 Le Royal Hotel: Le Royal Hotel is an ultra-modern complex atop Jebal Amman that stands out as the city s loftiest structure, lending importance to all the streets adjoining it. The hotel is located just 30 minutes away from the airport and offers its guests unequaled services and facilities. Accommodation: Sponsors can book and pay for their hotel accommodation(s) through a direct online link that will provide the best group rates from the congress organisers. The following room options are provided: Type Single Double Deluxe USD 180 USD 195 Grand USD 265 USD 280 Rooms include morning breakfast and are price inclusive of 10% service charge and 16% government tax. Prices quoted above are subject to change. 1 JOD= USD, 1 USD = JOD Address: Le Royal Hotels & Resorts Amman Post: Al Mutanabbi, Third Circle P.O. Box 52 Amman,11118 Jordan Tel Fax Web: Congress Information

8 Speakers Prof. Saeed Bohlega, Professor and Senior Consultant Neurologist, King Faisal Specialist Hospital and Research Center, Riyadh, KSA Prof. Alexey N. Boyko, Professor of Neurology, Director of the MS Center, Pirogov s Russian National Research Medical University, MS Center at the Neuroclinica of Usupov s Hospital, Moscow, Russia PCO: Diaedu LOCAL AGENT: Jordan Valley Prof. Giancarlo Comi, Professor of Neurology, Department of Neurology and INSPE, Scientific Institute San Raffaele, Milan, Italy Dr. Guy Nagels, Consultant Neurologist, MS, UZ Leuven, Brussels, Belgium Mrs. Ceri Angood Napier, Director of Programmes, MS International Federation (MSIF), London, UK Dr. Suzan Noori, Senior Consultant Neurologist, Assistant Professor of Neurology, University Hospital Sharjah, Sharjah, UAE Dr. Rajaie Obaid, Consultant Neurologist, Private Practice, Indiana, USA Dr. Maurice Dahdale, Consultant Neurologist, Khalidi Hospital and Medical Center, Amman, Jordan Dr. Celia Oreja-Guevara, Consultant Neurologist,Chief of Clinical Research at the Multiple Sclerosis Unit, University Hospital San Carlos, Madrid, Spain Dr. Smail Daoudi, Consultant Neurologist and Head of Neurology Department, University Hospital of Tizi Ouzou, Algiers, Algeria Prof. Peter Rieckmann, Professor of Neurology, Director of the Neurological Clinic, Department of Neurology, Sozialstiftung Bamberg Hospital, Bamberg, Germany Prof. Masoud Etamedifar, Professor of Neurology and Director, Isfahan MS Clinic, Isfahan, Iran Dr. Raed Alroughani, Consultant Neurologist and Director of MS Clinic, Amiri Hospital & Dasman Research Institute, Kuwait City, Kuwait Prof. Gavin Giovannoni, Professor of Neurology, Royal London Hospital, Blizard Institute, London, UK Dr. Alejandro Rovira, Consultant Neuroradiologist, Head of the Unit for RMI Neuroradiology, Vall d Hebron University Hospital, Barcelona, Spain Prof. Riadh Gouider, Consultant Neurologist and Head of Department, Razi Hospital, Tunis, Tunisia Mrs. Jodi Haartsen, MS Nurse Consultant, Manager, Eastern Health MS Service, Melbourne, Australia Mr. Abdelfatah Ibrahim, Regional Capacity Building Manager, MS International Federation (MSIF), London, UK Prof. Jihad Inshasi, Consultant Neurologist, Rashid Hospital, Dubai, United Arab Emirates Dr. Mohammed Al-Jummah, Professor and Consultant Neurologist, King Abdullah International Medical Research Center, Riyadh, KSA Prof. Ludwig Kappos, Chair of Neurology, University Hospital Basel, Basel, Switzerland Dr. Mona Al Khawajah, Consultant Neurologist, Assistant Professor, Al Faisal University, King Faisal Specialist Hospital & Research Center, Riyadh, KSA Prof. Samia Khoury, Professor of Neurology, Director of Abou Haidar Neuroscience Institute and Multiple Sclerosis Center, American University of Beirut Medical Center, Beirut, Lebanon Prof. Hans Lassmann, Professor of Neuroimmunology, Head of Department, Center for Brain Research, Vienna, Austria Dr. Jameelah Saeedi, Professor of Neurology, King Fahad Medical City, Riyadh, KSA Dr. Jaume Sastre-Garriga, Clinical Neurologist, Department of Neurology/ Neuroimmunology, MS Centre of Catalonia, Hospital Vall d Hebron, Barcelona, Spain Dr. Sven Schippling, Deputy Head of Department of Neuroimmunology and Clinical MS Research, University Medical Center Zurich, Zurich, Switzerland Dr. Isa Alsharoqi, Consultant Neurologist, Salmaniya Medical Complex, Manama, Bahrain Prof. Ilham Slassi, Professor of Neurology, Ibn Rochd Hospital, Casablanca, Morocco Prof. Maria Trojano, Professor of Neurology, Chair of Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari, Bari, Italy Dr. Mike Wattjes, Consultant Neuroradiologist, Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, Netherlands Prof. Bassem I. Yamout, Professor of Clinical Neurology, Director, Multiple Sclerosis Center Clinical Research, American University of Beirut Medical Center, Beirut, Lebanon Prof. Tarek Yousry, Professor of Neuroradiology, University College of London Hospitals, London, UK Prof. Magd Zakaria, Professor of Neurology, Ain Shams University, Cairo, Egypt Prof. Letizia Leocani, Professor of Neurology, Scientific Institute San Raffaele, Milan, Italy Dr. Maya Zeineddine, Pharmacist, MS Specialist, American University of Beirut Medical Center, Beirut, Lebanon Ms. Joelle Massouh, MS Nurse Specialist, American University of Beirut Medical Center, Beirut, Lebanon Dr. Tjalf Ziemssen, Director, Center of Clinical Neuroscience, Carl Gustav Carus University Hospital, Dresden, Germany