Nutrition support in neurodegenerative diseases
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1 ESPEN Congress Leipzig 2013 The ESPEN Guidelines session Nutrition support in neurodegenerative diseases R. Burgos (ES)
2 ESPEN GUIDELINES ON NUTRITION SUPPORT IN NEURODEGENERATIVE DISORDERS Dr. Rosa Burgos Nutritional Support Unit University Hospital Vall d Hebron Barcelona, Spain
3 GUIDELINES ESPEN GUIDELINES ON NUTRITION SUPPORT IN NEURODEGENERATIVE DISORDERS Dr. Rosa Burgos Nutritional Support Unit University Hospital Vall d Hebron Barcelona, Spain
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6 Professionals involved in the Guidelines: Clinical Nutrition doctors, Dietitian, Nurse, Speach language therapists, Neurologists, Radiologist.
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8 Society involved in the Guideline development European Society for Swallowing Disorders
9 ESPEN GUIDELINES ON NUTRITION IN NEURODEGENERATIVE DISORDERS GUIDELINE DEVELOPMENT GROUP Chairperson: Rosa Burgos Members of the GDG: Laurence Genton Graf Clinical Nutrition, University Hospital Geneva, Switzerland. Jean Claude Desport Nutrition Unit. ALS Center. University Hospital Limoges, France. Suzanne Yates Senior dietitian specialist in neurology. The National Hospital for Neurology and Neurosurgery. London. UK. Marjolein A van der Marck Dept Neurology. Radboud University Nijmegen Medical Centre. Netherlands.
10 ESPEN GUIDELINES ON NUTRITION IN NEURODEGENERATIVE DISORDERS GUIDELINE DEVELOPMENT GROUP Maurizio Muscaritoli Head, Clinical Nutrition Management Unit. Dept. of Clinical Medicine. Sapienza University of Roma, Italy. Adriano Chió ALS Center. Dept of Neurosciences. University of Torino. Italy. Olle Ekberg Professor of Diagnostic Radiology Lund University. Dept of Clinical Sciences / Medical Radiology. Skane University Hospital. Malmö. Sweden. Pere Clavé Associated Professor of Surgery. Universitat Autónoma de Barcelona. Hospital de Mataró. Barcelona, Spain. Chairman of ESSD.
11 ESPEN GUIDELINES ON NUTRITION IN NEURODEGENERATIVE DISORDERS GUIDELINE DEVELOPMENT GROUP Mette Holst. RN Centre for Nutrition and Bowel Disease. Dept of Gastroenterolgy. Aalborg University Hospital. Denmark. Margareta Bülow SLT Diagnostic Centre of Imaging and Functional Medicine, Skäne University. Hospital Malmö. Sweden. Renee Speyer. SLT HAN University of Applied Sciences. Institute of Healt Studies. Netherlands.
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13 ESPEN GUIDELINES ON NUTRITION IN NEURODEGENERATIVE DISORDERS KEY DISEASES Classification of Neurodegenerative Disorders with Nutritional implications (ICD-10 based) Systemic atrophies primarily affecting the central nervous system (G10-13) Huntington s disease Hereditary ataxia Spinal muscular atrophy and related syndromes Motor neuron disease (G 12.2)» Amyotrophic lateral sclerosis (ALS) Extrapyramidal and movement disorders (G 20-26) Parkinson s disease Other degenerative diseases of basal ganglia (Progressive supranuclear palsy) Demyelinating diseases of the central nervous system (G 35-37) Multiple sclerosis (MS) WHO International Classification of Diseases (ICD) ( / www. who. int/ classifications/ icd/ en/ )
14 ESPEN GUIDELINES ON NUTRITION IN NEURODEGENERATIVE DISORDERS RELEVANT ISSUES TO BE ADDRESSED IN THE GUIDELINES ON NUTRITION IN NEURODEGENERATIVE DISORDERS 1. Nutritional support in neuromuscular disorders (with special attention to Amyotrophic Lateral Sclerosis). 2. Nutritional support in extrapyramidal (Parkinson s Disease) and movement disorders. 3. Nutritional support in demyelinating diseases (with special attention to Multiple Sclerosis) 4. Global issues for oropharyngeal dysphagia in patients with neurodegenerative diseases. 5. Ethical issues.
15 ESPEN GUIDELINES ON NUTRITION IN NEURODEGENERATIVE DISORDERS RELEVANT ISSUES TO BE ADDRESSED IN THE GUIDELINES ON NUTRITION IN NEURODEGENERATIVE DISORDERS 1. Nutritional support in neuromuscular disorders (with special attention to Amyotrophic Lateral Sclerosis). 2. Nutritional support in extrapyramidal (Parkinson s Disease) and movement disorders. 3. Nutritional support in demyelinating diseases (with special attention to Multiple Sclerosis, MS) Common issues
16 ESPEN GUIDELINES ON NUTRITION IN NEURODEGENERATIVE DISORDERS RELEVANT ISSUES TO BE ADDRESSED IN THE GUIDELINES ON NUTRITION IN NEURODEGENERATIVE DISORDERS Common issues to the 3 main groups of pathologies: Prevalence of malnutrition. Nutritional status as a prognostic factor for survival. Nutritional requirements. Prevalence and natural history of oropharyngeal dysphagia.
17 ESPEN GUIDELINES ON NUTRITION IN NEURODEGENERATIVE DISORDERS RELEVANT ISSUES TO BE ADDRESSED IN THE GUIDELINES ON NUTRITION IN NEURODEGENERATIVE DISORDERS Common issues to the 3 main groups of pathologies: At what stage of the disease do we need to screen for dysphagia? Are there specific methods for screening and clinical diagnosis of OD? What are the therapeutic effects of behavioral, rheological and rehabilitation treatments for OD in patients?
18 1. Nutritional support in neuromuscular disorders (with special attention to Amyotrophic Lateral Sclerosis) Specific issues
19 NUTRITIONAL SUPPORT IN NEUROMUSCULAR DISORDERS (with special attention to ALS) Nutritional requirements in MND-ALS patients. Non-ventilated patients Ventilated patients What is the timing for gastrostomy tube in MND-ALS patients? Relationship between survival and respiratory function at the time of gastrostomy. What is the best approach for gastrostomy in MND-ALS patients: percutaneous endoscopic gastrostomy or radiologic gastrostomy?
20 NUTRITIONAL SUPPORT IN NEUROMUSCULAR DISORDERS (with special attention to ALS) Does enteral nutrition improve quality of life in MND-ALS patients? Does enteral nutrition improve survival in MND-ALS patients? Is there a role for long term parenteral nutrition (home PN or in rehab facilities) in ALS patients? Specific characteristics of OD and Malnutrition in other NM diseases: Myastenia Gravis Muscular dystrophies: Myotonic Dystrophy and Oculopharyngeal Muscular Dystrophy
21 2. Nutritional support in extrapyramidal (Parkinson s Disease) and movement disorders. Specific issues
22 NUTRITIONAL SUPPORT IN EXTRAPYRAMIDAL (PARKINSON S DISEASE) AND MOVEMENT DISORDERS. Side effects of drugs that influence nutritional status in PD. Is there a role for protein redistribution diet in PD patients on dopaminergic treatment? Does nutritional support improves QoL / survival of PD patients? What is the clinical relevance and natural history of OD in other movement disorders (PSP, Chorea, etc)
23 3. Nutritional support in demyelinating diseases (with special attention to Multiple Sclerosis, MS) Specific issues
24 NUTRITIONAL SUPPORT IN DEMYELINATING DISEASES (WITH SPECIAL ATTENTION TO MULTIPLE SCLEROSIS, MS) Is there a role for a dietary prevention of MS? (list of specific nutrients involved in MS to facilitate retrieval of articles) Can nutritional support decrease the rate and severity of relapses in MS patients? Does nutritional intervention improve nutritional status in MS patients? Can nutritional support improve QoL / survival in MS patients?
25 4. Global issues for oropharyngeal dysphagia in patients with neurodegenerative disease.
26 GLOBAL ISSUES FOR OROPHARYNGEAL DYSPHAGIA IN PATIENTS WITH NEURODEGENERATIVE DISEASE What are the most appropriated dysphagia screening tools for patients with neurodegenerative diseases? Diagnosis of dysphagia. What is the role of clinical methods in the diagnosis of dysphagia in neurodegenerative patients? What is the role of videofluoroscopy in the diagnosis of dysphagia in neurodegenerative patients? What is the role of fiberoptic endoscopic evaluation in the diagnosis of dysphagia in neurodegenerative patients?
27 GLOBAL ISSUES FOR OROPHARYNGEAL DYSPHAGIA IN PATIENTS WITH NEURODEGENERATIVE DISEASE Treatment of dysphagia What is the role of dietary treatment of neurogenic dysphagia? Modified consistency diets (solids and fluids, rheology, consistencies and viscosity) Oral nutritional supplementation. Enteral nutrition. Can tube feeding prevent aspiration pneumonia in neurodegenerative patients? What is the role of swallowing therapy in the treatment of neurogenic dysphagia in neurodegenerative patients? Specific aims for specific diseases. New neurorehabilitation methods (surface electrical stimulation, magnetic stimulation, etc)
28 5. Ethical issues
29 ETHICAL ISSUES Role of advanced care directives in nutrition support in ND diseases. Ethical concerns about withdrawal or withholding SNS in advanced patients.
30 WHERE ARE WE NOW?
31 THANK YOU FOR YOUR ATTENTION SEE YOU IN GENEVA
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