IPMSC First Scientific Conference Daily Program

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1 IPMSC First Scientific Conference Daily Program February 6 th :30 Welcome dinner at the NH Milano 2 Hotel February 7 th 2013 Meeting Venue: San Raffaele Congress Centre - Caravella Santa Maria Room 8.15 & 8.30 Hostess to walk attendees from the Walking direction and map NH Milano 2 Hotel to the San available at hotel front desk Raffaele Congress Centre Shuttle bus from NH Milano 2 Hotel to San Raffaele Congress Centre REGISTRATION Welcome from Italian MS Society Mario A. Battaglia A call for Action John Golding Timothy Coetzee Welcome, introduction and aims Alan Thompson of the meeting Ongoing initiatives in progressive MS Giancarlo Comi Session I Chairperson: Wolfgang Bruck Target identification and Wolfgang Bruck repurposing in progressive MS 15

2 st Keynote speaker Genetic profile st Keynote speaker Immunologic aspects of progressive MS Stephen Sawcer Sergio Baranzini Scott Zamvil Marco Salvetti Coffee break Study group II report Peter Goodfellow General Discussion Sum up of the Session I Wolfgang Bruck Lunch Session II Chairperson: Anne Cross Experimental models for improved Anne Cross understanding of progressive MS and preclinical evaluation of novel therapies st Keynote speakers Clues from degenerative aspects of progressive MS pathology Clues from inflammatory aspects of progressive MS pathology Bruce Trapp Hans Lassmann Discussion of pathology and pathophysiology of progression st Keynote speaker Pitfalls and problems with animal models David Baker Marco Prinz 16

3 Discussion of the animal models Study group I report Peter Stys General discussion Sum up of the Session II Anne Cross Coffee break Session III Chairperson: Giancarlo Comi Proof-of-concept clinical trial strategies Giancarlo Comi st Keynote speaker Study design and biomarkers for disease modifying treatment phase II clinical trials st Keynote speaker Phase II trial design: including single-arm multi-arm, adaptive Gavin Giovannoni Massimo Filippi Jeremy Chataway Jerry Wolinsky Study Group III report Raj Kapoor General Discussion Sum up of the Session III Giancarlo Comi Shuttle bus from San Raffaele Congress Centre to NH Milano 2 Hotel Shuttle bus from NH Milano 2 Hotel to Ciborio Hall Walking instructions and map available at hotel front desk Gala Dinner at Ciborio Hall OSR DIBIT Shuttle bus from Ciborio Hall to NH Milano 2 Hotel 17

4 February 8 th 2013 Meeting Venue: San Raffaele Congress Centre - Caravella Santa Maria Room 8.15 & 8.30 Hostess to walk attendees from the Walking direction and map NH Milano 2 Hotel to the San available at hotel front desk Raffaele Congress Centre Shuttle bus from NH Milano 2 Hotel to San Raffaele Congress Centre Session IV Chairperson: Chris Polman Clinical outcome measures Chris Polman and phase III trial designs st Keynote speaker Phase III trials of DMTs in progressive MS: Jeffrey Cohen endpoints and other aspects of trial design st Keynote speaker Phase III trials in progressive MS: biomarkers of information, axonal damage demyelination and remyelination Ludwig Kappos Per Solberg Sorensen Robert Fox Study group IV report Jeremy Hobart General discussion Sum up of the Session IV Chris Polman Coffee break 18

5 Session V Chairperson: Alan Thompson Symptom management therapies Alan Thompson and rehabilitation strategies st Keynote speaker Congnitive rehabilitation and progressive MS st Keynote speaker Exercise therapy and multiple sclerosis John De Luca Maria Pia Amato Ulrik Dalgas Chris Heesen Study group V report Peter Feys General discussion Sum up of the Session V Alan Thompson Lunch Session VI Chairperson: Monica Di Luca Challenges that together we can Steve Buchsbaum address to bring new medicines Sarah Tabrizi to patients: non-profit, Paul Matthews academia and pharma views Panel discussion Moderated by Heather Brown Steve Buchsbaum Sarah Tabrizi Paul Matthews Coffee break 19

6 Session VII Moderator: Timothy Coetzee Facing progressive MS Collaborative Progressive MS Research Alan Thompson Program: IPMSC proposal and Antonella Moretti next key actions Open Forum with IPMSC Giancarlo Comi Scientific Leadership Anthony Feinstein Bob Fox Raj Kapoor Marco Salvetti Alan Thompson Conclusion and perspective Weyman Johnson Shuttle bus from San Raffaele Congress Centre to NH Milano 2 Hotel 20

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