Svenska nätverket för

Transcription

1 Swedish Bioimaging Svenska nätverket för biomedicinsk i avbildning i Seminar at VR, Stockholm, 11 March 2010 Örjan Smedby Dept. of Radiology (IMH) / CMIV Linköping University, Linköping, Sweden

2 Imaging chain Making targets visible Acquisition & image generation Image analysis & description Visualization, modelling & simulation Biomedical research question

3 Morphological Levels of study Physiological Metabolic Molecular

4 Molecular imaging Weissleder, Radiology 1999

5 Resolution and sensitivity EM tracer advanced STED CT light micro radio- graphy CT M mm μm nm pm MRI scintigraphy tracer SPECT optical PET MRI macro nm μm mm cm

6 Swedish examples Tracer chemistry at UU Uppsala PET Centre (Bengt Långström et al.) >300 tracers, >100 tracers in human use KI, UmU involved in tracer evaluation Invited by Euro- Bioimaging i i to form node for tracer development elopment Endocrine pancreas tumour 68 Ga-DOTA-TOC-PET/CT A. Sundin, UU/KI

7 Swedish examples National 7 T MRI facility at LU (planned) First Swedish human 7 T scanner National group of applicants (Freddy Ståhlberg et al.) Planning grant from VR 2009 DSC perfusion MRI L Knutsson, LU Diffusion MRI M. Nilsson, LU

8 Swedish examples EPRI at LiU (P. Hammarström, H. Gustafsson) Electron Paramagnetic Resonance Imaging (analog to MRI using electrons and not nuclei) First Swedish scanner being installed Small animal studies of protein folding defects (e.g. Alzheimer) NO formation in ischemic rat heart J. L. Zweier Nitric i Oxide 2010

9 Swedish examples Advanced Light Microscopy Science for Facility for Bioimaging for Life Lab, KI/KTH/SU (Hj. Brismar) Non-Linear Microscopy, CTH infection biology, UmU (R. Rosqvist) high-throughput cell imaging, tissue imagingi and in vivo imaging g Artificial tissue: Muscle cells (CARS) in a cellulose scaffold A. Enejder, CTH (A. Enejder) High lighted in April issue of Nature Methods, 2010 sub-wavelength, label- free imaging (CARS, SHG, THG) live-cell imaging, CCD and confocal microscopy for host-parasite interaction

10 Swedish examples Post-processing at LiU Center for Medical Image Science and Visualization (CMIV) Connection to National Supercomputer Centre Integrates image processing and visualization into imaging g chain Virtual autopsy table A. Persson, LiU

11 Swedish process Summer 2009: informal network formed (Örjan Smedby + Annika Enejder) Sept. 2009: Network members join EBI stakeholders meeting (Heidelberg) Oct Nov 2009: Participation i in writing of EU proposal Nov. 2009: First national meeting (Stockholm) 21 participants from 10 universities

12 Swedish process Steering group appointed Freddy Ståhlberg, LU Annika Enejder, CTH/GU Örjan Smedby, LiU Hjalmar Brismar, KI/KTH/SU Bengt Långström, UU Katrine Riklund Åhlström, UmU Currently 45 members Website established (bioimaging.se)

13 Website

14 Planned activities 1. Participation in Euro-Bioimaging 2. Coordination of Swedish national infrastructures 3. Coordination of training 4. National meetings

15 Resources needed Research coordinator 50% Researcher with PhD IT support 10% Web page, mailing lists, course info National meetings Travel expenses Participation in European meetings Possibly travel support for courses

16 Possible role European infrastructure Funding Swedish Bioimaging National infrastructure t Research groups Research training