Optical Coherence Tomography OCT. 3D Imaging in Medical Technology and Quality Control
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1 Optical Coherence Tomography OCT 3D Imaging in Medical Technology and Quality Control SLN Seminar, EPMT Lausanne, 26. May Ch. Meier 1 / 27 SLN/EPMT, Lausanne, Ch. Meier
2 Outline 1. Introduction 2. OCT Basics Time Domain TD-OCT, Frequency Domain FD-OCT, Full Field OCT 3. OCT: Medical Applications 4. OCT: Industrial Applications 5. Some OptoLab, BFH-TI, Biel-Bienne 2 / 27 SLN/EPMT, Lausanne, Ch. Meier
3 Tomographic Methods in Medical Engineering Tomography = 3D image by sections Greek word tomos = slice, section CT MRI PET X-ray Magnetic Resonance Imaging Positron Emission Tomography 3 / 27 SLN/EPMT, Lausanne, Ch. Meier
4 Tomographic Methods in Medical Engineering UST Ultra Sound Tomography ODT Optical Diffusion Tomography PAT Photoacoustic Tomography 4 / 27 SLN/EPMT, Lausanne, Ch. Meier
5 Tomographic Methods in Medical Engineering Confocal Microscopy OCT Optical Coherence Tomography Stained mitochondrial network Olypus Microscopy Drexler W., Fujimoto J. Science Direct / 27 SLN/EPMT, Lausanne, Ch. Meier
6 Tomographic Methods in Medical Engineering MRI, PET CT Name Speed Hazard CT MRI - - PET UST ++ - DOT - - PAT + - OCT / 27 SLN/EPMT, Lausanne, Ch. Meier
7 3D Imaging by scanning OCT B-scan A-scan, spatial domain A-scan: Depth profile of backscattered or back reflected light B-scan: Cross section obtained by scanning in x direction C-scan: 3D image. Source S(λ) Spectrometer Similar to ultrasonic time of flight measurements Interferometric measurement technique z 0 7 / 27 SLN/EPMT, Lausanne, Ch. Meier
8 OCT: wavelength range Hemoglobin and water have low absorption in near infrared Diagnostic window Commonly used wavelengths: 840nm 1060nm 1310 nm 8 / 27 SLN/EPMT, Lausanne, Ch. Meier
9 Basic principle: Time Domain OCT Michelson Interferometer setup with moving reference mirror The signal envelope represent the reflectivity depth profile 9 / 27 SLN/EPMT, Lausanne, Ch. Meier
10 FD-OCT, basic principle Swept Source Detector z 0 z 1 z Source S(λ) Spectrometer z 0 z 1 z 10 / 27 SLN/EPMT, Lausanne, Ch. Meier
11 Resolution: OCT and Microscopy Lateral resolution Axial resolution Confocal Microscope OCT z 0 Coherence gate 11 / 27 SLN/EPMT, Lausanne, Ch. Meier
12 Scanning OCT Full Field Cam OCT SLED Detector TD OCT Source S(λ) z 0 z SLED Cam SS 0 z FD OCT Swept Source Detector 0 z 12 / 27 SLN/EPMT, Lausanne, Ch. Meier
13 State of the art, retina imaging From Zeiss cyrrus From OptoPol, soct_hr 13 / 27 SLN/EPMT, Lausanne, Ch. Meier
14 State of the art, retina imaging 14 / 27 SLN/EPMT, Lausanne, Ch. Meier
15 Anterior segment of the eye Woitkowsky, AVRO / 27 SLN/EPMT, Lausanne, Ch. Meier
16 Endoscopic OCT and cardiology From LightLab Kume, Assessment of corocary calcification by OCT, PCR online / 27 SLN/EPMT, Lausanne, Ch. Meier
17 Functional OCT, Doppler Bachmann, Leitgeb. OpticExpress, / 27 Leitgeb in Optical Cherence Tomography, Springer 2008 SLN/EPMT, Lausanne, Ch. Meier
18 White Light Interferometry (Full Field time domain OCT) Different Microscope manufacterer provide such systems. Z-Resolution some nm Slow scanning motion Problem: mechanical vibration S 18 / 27 SLN/EPMT, Lausanne, Ch. Meier
19 Full Field OCT: Smart Pixel Technology Phase Sensitive Parallel Optical Coherence Tomography Number of pixels 144 x 90 Vertical resolution 200nm Lateral resolution 2 um May 2011: 300x / 27 SLN/EPMT, Lausanne, Ch. Meier
20 Surface Characterisation (ISO 4287) 20 / 27 SLN/EPMT, Lausanne, Ch. Meier
21 Electronic components I) Solder bumps (BGAs) II) Pads of an integrated circuit 21 / 27 SLN/EPMT, Lausanne, Ch. Meier
22 Spectrometer for OCT (fast and linear-k) Collimator Grating Lens Camera λ=800nm ±60nm Sensitivity: 103dB 1 Camera speed: A-scans/s Measuring range: 4.4 mm Collimator Grating Prism Lens Camera λ=835nm ±25nm Sensitivity: 93 db 1 Camera speed: A-scans/s Measuring range: 6 mm λ=1058nm ±30nm Sensitivity: in progress Camera speed: A-scans/s Measuring range: 6 mm 22 / 27 SLN/EPMT, Lausanne, Ch. Meier
23 OCT Callisto Bern University of Applied Sciences OCT Box Callisto Includes: - Source - Spectrometer - Reference arm - Interferomter Dimensions: 200 x 150 x 70 Axial Scan Resolution: 6.5 μm Measurement range 6.6 mm 23 / 27 SLN/EPMT, Lausanne, Ch. Meier
24 Optical control of bio-printed skin KTI project in collaboration ZHAW and Delta Robotics (KTI ) Integration of OCT into the Delta Robotics engine Control of the quality and thickness homogeneity of the printed skin with OCT 24 / 27 SLN/EPMT, Lausanne, Ch. Meier
25 Miniaturized Swept sources EXALOS 50 khz sweep rate AXSUN Parameter Wavelength Range Output Power Sweep Rate Coherence Length Value nm 20 mw 50 khz 12 mm Sweeping due to tunable Fabry-Perrot filter 25 / 27 SLN/EPMT, Lausanne, Ch. Meier
26 OptoLab BFH TI Biel Master Thesis available Biomedical Master or MSE Master Laser + Photonics Thank you for your attention S. Gloor, P. Steiner, B. Moser, T. von Niederhäusern, F. Andronico, P Stalder, D. Trivun, D. Ernst R. Lehmann, A. Bossen, Ch. Meier 26 / 27 SLN/EPMT, Lausanne, Ch. Meier
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