Undergraduate Biomedical Engineering Curriculum University of North Carolina at Chapel Hill,

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1 Undergraduate Biomedical Engineering Curriculum University of North Carolina at Chapel Hill, First two years Fall: BMME 101 Frontiers of Biomedical Engineering (strongly recommended but not required; see note 1) 1 BMME 160 Statics 3 Spring: BMME 150 Introduction to Material Sciences 3 Either semester, or in the summer: *BMME 210 BME Design and Manufacturing I 2 BIOL 101, 101L Principles of Biology with Lab 4 BIOL 202 Molecular Biology and Genetics 4 CHEM 101, 101L General Chemistry I and Lab 4 CHEM 102, 102L General Descriptive Chemistry II and Lab 4 *COMP Introductory Programming Elective (COMP 116 highly 3 recommended, but you can choose from COMP 110, 116, 401, or PHYS 331) ENGL 105 / 105I English Composition and Rhetoric 3 Foreign Language 3 3 MATH 231 Calculus of Functions of One Variable 3 MATH 232 Calculus of Functions of One Variable II 3 MATH 233 Calculus of Functions of Several Variables 3 *MATH 383, 383L Linear Algebra and Differential Equations (lab section is 3 mandatory for the class of 2018 and beyond) PHYS 116/118 Mechanics 4 *PHYS 117/119 Electromagnetism and Optics 4 Approaches class #1 (note #2) 3 Approaches class #2 (note #2) 3 Approaches class #3 (note #2) 3 Lifetime Fitness 1 * It is particularly important to finish these classes in the first two years, as they are pre-requisites for several courses taken in the junior year.

2 Junior year Fall: BMME 350 Fundamentals of Biomedical Electronics (replaces PHYS 351 for BME students) 4 Spring: BMME 351 Human Physiology and Biological Measurements 4 (replaces PHYS 352 for BME students) BMME 465 Biomedical Instrumentation 4 BMME 410 Signals and Systems (reduces to 3 cr. hrs. in spring 2017) 4 Either semester: BMME 310 BME Design and Manufacturing II 2 BIOL 252 Fund. Of Hum. Anatomy and Physiol. 4 MATH 528 Mathematical Methods for the Physical Sciences I (lab 3 section is optional) Approaches class #4 (note #2) 3 BME Specialty Elective 1 3 Senior year Fall: BMME 697 Senior Design Project 3 Spring: BMME 698 Senior Design Project 3 Courses available either semester: Choose one of the following (take more than one, and it counts as one of your BME electives): BMME 341 Thermodynamics (fall) 3 BMME 455 BioFluid Mechanics (fall) 3 BMME 475 Transport Processes (spring) 3 You must take each of the following courses: BME Specialty Elective 2 3 BME Specialty Elective 3 3 BME Specialty Elective 4 3 Statistics Elective (choose from STOR 435, 455 or BIOS 600) 3 Approaches class #5 (note #2) 3 Approaches class #6 (note #2) 3

3 Notes: 1. While this is NOT a required class, we strongly urge you to take this one credit class in your first year or sophomore year. This will provide you with an introduction to the groundbreaking tools and topics of BME. It will also provide you with information about the BME curriculum, and it is a great opportunity to meet the other BME students. 2. The 6 Approaches classes must satisfy all UNC General Education requirements in Social and Behavioral Sciences and Humanities/Fine Arts (the Physical and Life Sciences requirements will be satisfied by the other required courses in BME) 3. If you have completed prerequisites, you may take any class earlier than what is recommended here. BME electives offered fall (this list is subject to change): BMME 445: Systems Neuroscience (Tommerdahl) BMME 485: Biotechnology (Macdonald) BMME 505 Biomechanics (Bateman) BMME 510 Biomaterials (Banes) BMME 550 Medical Imaging (enrollment is limited, contact Dr. Gallippi) BMME 580 Microcontroller Applications I PHYS 405 Biological Physics (Superfine) PHYS 660 Fluid dynamics BME electives offered spring (this list is subject to change): BMME 460 Analytical Microscopy (Taylor) BMME 470 Tissue Engineering (Dennis) BMME xxx Biomechanics I (Franz) new class in spring 2016 that will be the start of a two semester biomechanics sequence CHEM 449 Microfabricated Chemical Measurement Systems CHEM 441 Intermediate Analytical Chemistry COMP Introduction to Robotics (Alterovitz)

4 BME UNDERGRADUATE COURSE SCHEDULE FALL 2015 Sections are 001 unless otherwise noted. Introductory Class for First-Year Students & Sophomores: BMME 101: Frontiers of Biomedical Engineering (1 cr.) An introduction to the groundbreaking tools and topics of BME including: Medical Imaging, Medical Robotics, Rehabilitative Engineering, Regenerative Medicine, and Medical Device Design. While this is NOT a required class, we strongly urge you to take this one credit class in your first year or sophomore year. (Class will be available late April for enrollment on Connect Carolina.) Hubbard; Lecture: M 3:35pm- 4:25pm; TBA Required Courses: BMME 160: Statics (3 cr.) Prerequisites, MATH 232 and PHYS 116. The resolution, distribution, and transfer of forces in rigid structural bodies. Taylor; T/TH 2:00pm- 3:15pm; TBA BMME 210: BME Design & Manufacturing I (2 cr.) Students will learn to use design software: SolidWorks and support/analysis programs such as COSMOS. Basic techniques for directly measuring solid objects using digital calipers, gauges, and identification of standard components to reverse-engineer the dimensions of the object. Specific topics covered: generation of designed solid model, three-view drawings, dimensions, tolerances, etc. Donnelly; M 12:20pm- 2:15pm; classroom TBA, lab Phillips 114B/116B BMME 310: BME Design & Manufacturing II (2 cr.) Prerequisite, APPL 210. Students learn basic tools and procedures of modern design practice traditional and modern rapid manufacturing technologies/techniques. Laboratory exercises and Web-based instructional content. Donnelly; M 2:30pm- 4:25pm; classroom TBA, lab Phillips 114B/116B 1

5 BMME 350: Fundamentals of Biomedical Electronics (4 cr.) Prerequisites, PHYS 117. Fundamentals of analog and digital circuit analysis and design as applied to biomedical instrumentation and measurement of biological potentials. Class will consist of lectures and problem solving of analog and digital circuits. In lab, students will design, develop, and test circuits. Goldberg; Lecture: M/W 11:15AM- 12:30PM; TBA Lab 1: T 2pm- 4:50pm; Phillips 114/116 Lab 2: W 2pm- 4:50pm; Phillips 114/116 BMME 697: Senior Design Project I (3 cr.) Prerequisite, APPL 310. Conceptual prelude and preparation to BMME 698, in which the theoretical and practical knowledge acquired during the undergraduate tenure is applied to develop a solution to a realworld problem. Hubbard; Lecture [Section 002]: T 9:30am- 10:45am; TBA Hubbard Lab: TH 8am- 9:30am; TBA Goldberg; Lecture [Section 001]: TH 9:30am- 10:45am; TBA Goldberg Lab: various times (no need to signup for lab) Electives: BMME / PHYS 341: Thermodynamics and Kinetics Applied to Solids (3 cr.) Prerequisites, APPL 150, MATH 383, and PHYS 117. The elements of thermodynamics and phenomenological kinetics of diffusion appropriate to solids are examined. Topics include equations of state, heat capacity, polyphase equilibria, phase transitions, diffusion, and interfaces. TBA; Lecture: TBA; TBA BMME 445: Systems Neuroscience (3 cr.) Introduction to methodologies used to characterize a) the aggregate behavior of living neural networks and b) the changes in that behavior that occur as a function of stimulus properties, pharmacological manipulations, and other factors that dynamically modify the functional status of the network. Tommerdahl; W 3:35pm- 6:35pm; TBA 2

6 BMME 455: BioFluid Mechanics (3 cr.) Fluid mechanics is a broad area that can describe the transport of materials in biological systems, such as the flow of blood circulation, or airflow through the lungs, but also covers the transport of materials through mechanical systems, such as micro- and nanochannels. Interestingly, fluid transport can be driven either hydrodynamically, chemically or electrokinetically. This course will start with a basic survey of the governing principles that describe transport, both turbulent and laminar, in mechanical and biological systems, present the governing equations at different length-scales and show examples of their usage. Examples will clearly show the applications of fluid mechanics to biomedical engineering. A section of experimental techniques to monitor fluid dynamics, such as particle image velocity, will provide a springboard for future research efforts in this subject area. Soper; M/W 9:05am- 10:20am; TBA BMME 485: Biotechnology (3 cr.) This course is designed to prepare a biomedical engineering student with the survey tools to understand key concepts in modern biotechnologies. The principles in this course will be taught with reference to diseases of relevance to biomedical engineering and to engineering principles where appropriate. Fundamental concepts, theory, design, operation, and analysis of the most common biotechnologies in bioengineering will be presented. Students will learn the four main technologies of the -omics sciences and pattern recognition algorithms used for analysis of the omics data, hardware technologies for imaging live animals or bioreactors (MRI, MRS), bioreactors and tissue engineering principles, and microfabricated devices (lab-on-a-chip), BioMEMS). Macdonald; T/TH 3:30pm- 4:45pm; TBA BMME 505: Biomechanics (3 cr.) Biomechanics is the application of mechanics to biological systems and medical problems. A firm understanding of the principles of mechanics is an important foundation to biomechanics. This course will address both the mechanics of materials with applications to the strength of bone, implant analysis, and dynamic function of the body. Bateman; M/W 11:15am- 12:30pm; TBA BMME 510: Biomaterials (3 cr.) Prerequisite, BIOL 101. Chemical, physical engineering and biocompatibility aspects of materials, devices or systems for a implantation in or interfering with the body cells or tissues. Food and Drug Administration and legal aspects. TBA; T/TH 9:30am- 10:45am; TBA 3

7 BMME 550: Medical Imaging: Ultrasound, MRI and Optical (3 cr.) Prerequisites, BIOS 550 and 430, and PHYS 128. Physical and mathematical foundations of ultrasonic, optical, and magnetic resonance imaging systems in application to medical diagnostics. Each imaging modality is examined, highlighting critical system characteristics: underlying physics of the imaging system, including mechanisms of data generation and acquisition; image creation; and relevant image processing methods, such as noise reduction. Gallippi; TBA; TBA. BMME 580: Microcontroller Applications (3 cr.) Introduction to digital computers for online, real-time processing and control of signals and systems. Programming analog and digital input and output devices using C and assembly language is stressed Case studies are used as vehicles to present software design strategies for real-time laboratory systems. Dennis; T/TH 11:00am- 12:15pm; Phillips 114/116 PHYS 405: Biological Physics (3 cr.) Prerequisites, PHYS 116 and 117. How diffusion, entropy, electrostatics, and hydrophobicity generate order and force in biology. Topics include DNA manipulation, intracellular transport, cell division, molecular motors, single molecule biophysics techniques, nerve impulses, neuroscience. TBA; T/TH 12:30pm-1:45pm; TBA Research & Independent Study Courses: BMME 395: Research in Applied Sciences and Engineering for Undergraduates (1-3 cr.) At least six hours of independent work a week. May be repeated for elective credit. In order to enroll in this class, you must turn in a research proposal and research contract to the department of Biomedical Engineering before the end of the drop/add period. Further details are available from the department office. Goldberg; TBA BMME 396: Independent Study in Applied Sciences (1-3 cr.) Permission of the Director of Undergraduate Studies. Independent study under a member of the Biomedical Engineering faculty. In order to enroll in this class, you must turn in a proposal and contract to the department of Biomedical Engineering before the end of the drop/add period. Further details are available from the department office. Goldberg; TBA 4

8 BMME 691H: Honors Thesis (3 cr.) First semester of a two semester sequence for honors thesis research. You must have the minimum GPA, you must complete all requirements of the UNC honors program and you must apply for an honors thesis research grant from UNC honors office. In order to enroll in this class, you must turn in a research proposal and research contract to the department of Biomedical Engineering before the end of the drop/add period. Further details are available from the department office and at Goldberg; TBA 5