Brains Unlimited, UHF MRI, 3T, 7T, 9.4T

Transcription

1 Brains Unlimited, UHF MRI, 3T, 7T, 9.4T Erik van den Bergh, Siemens Nederland 2e Hans Boter symposium 1 november 2013 siemens.com/answers Komende 40 minuten o De bouw van een geavanceerd scannerlab o 3T o 7T o 9.4T o Motivatie UHF MRI voor Brains Unlimited o f-mri o Anatomie o Diffusion tensor tractography o Scannexus o Open scanning facility o Educational program o Vragen? Handout 1

2 Officiele opening 29 Oktober 2013 Foto: Arjen Schmitz Brains Unlimited project 9.4T 7T 3T Turnkey solution Scannerlab Handout 2

3 Responsible - The scanner lab The Consortium Partners Handout 3

4 T 7T 3T 9.4T ruimte, Ruimte voor de 9.4T magneet L x B x H 17.35m x 11.20m x 9.80m Handout 4

5 MAGNETOM Prisma 3T Power to outperform Unmatched 3T magnet T/m/s gradient performance Parallel transmit architecture Tim 4G integrated coil technology 2e systeem world wide Handout 5

6 MAGNETOM 7T, MAGNETOM 7T 7T 830 Active Shielded Magnet 5 Gauss at 6m 570km wire, 255 A 69MJ stored energy Operating temperature 4.2K kg SC72 gradient set 200T/m/s 1 st, 2 nd and 3 rd order shims Multinuclear TxRx capabilities. Tim RF receive chain 32 channels with Dedicated coils: Head Knee Occipital Auditory 35e 7T, 4e active shielded Eerste resultaten 7T Handout 6

7 9.4T Preparation, RF Shielding, T Preparation, Steel Shielding, Handout 7

8 9.4T Preparation, Steel Shielding, T Preparation, Steel Shielding, Handout 8

9 9.4T Preparation, Steel Shielding, T MAGNET Delivery, Handout 9

10 MAGNETOM 9.4T MAGNETOM 9.4T 9.4T 820 Passive Shielded Magnet 5 Gauss at 25m contained with kg passive steel shielding! 460km wire, 260A 126MJ stored energy Operating temperature 4.2K kg AC84 head gradient set 400T/m/s 1 st, 2 nd, 3 rd and 4 th order shims 8 channel ptx setup Tim RF receive chain 32 channels with Dedicated coils: 8TxRx Head Several coils under development 4e 9.4T system world wide First Images 9.4T 0.5x0.15x0.15mm Handout 10

11 3 rd Human subject Dedicated Occipital Coil SWI MIP Motivatie scanners o Hoge resolutie Anatomische scans o Hoge spatiele en temporele resolutie functionele-mri o Hoge resolutie diffusion tensor imaging Handout 11

12 MS patient 3T versus 7T 63-year-old female with primary progressive multiple sclerosis (MS) with an Expanded Disability Status Score (EDSS) of approximately 6.0. A 7 T MRI scan was performed for the detection of possible cortical lesions. 7T 3D-FLAIR 0.8 mm isotropic resolution; 3T FLAIR 1.1 mm isotropic. 9.4T versus 3T 9.4T 3T Handout 12

13 The Story of Phineas Gage, arbeidsongeval 13 september Phineas Gage : Cognitieve neurowetenschappen hersen letsel dysfunctioneren (post mortem) deductie functie van aangetaste hersengebied Probleem: geen controle over het experiment Handout 13

14 Time delay between neuronal activity and BOLD respons f-mri Blood Oxygen Level Dependent PET EEG MEG Techniques for brain research EEG MEG PET(CT) f-mri TMS + speed - localization + speed - localization + localization - radioactive tracers + localization - slow + localization - invasive Handout 14

15 start stimulus end stimulus f-mri visual experiment 10 volumes baseline 5 volumes stimulus volume Tr=2s 25 slices, not all shown Inline t-test evaluation roi t-test data signal intensity 550 ROI 1 bas. ROI 1 act. ROI 2 bas. ROI 2 act. 525 ROI 1 bas. ROI 1 act. ROI 2 bas. ROI 2 act. Handout 15

16 T-test result Result T-test Using BOLD card 3D view event related average activation Handout 16

17 Stimuli o visual o auditory o somatosensory (touch, pressure and temperature) o olfactory o gustatory Reaction recording o button response box o joystick/mouse/trackball o eye tracker o EEG o ECG o respiration o skin temparature Handout 17

18 Complex visual stimulus: polar angle Primary motor cortex: Homunculus Handout 18

19 Flatmaps Motor Homunculus, on flatmap Handout 19

20 Motor Homunculus, activation Realtime feedback MRI Siemens MRI: EPI, 25 slices, TR = 2 s Feedback Presenter Turbo-BrainVoyager Real-time fmri Network drive mapping Image Reconstruction Scanner Console B. Sorger, R. Goebel, Universiteit Maastricht Handout 20

21 Realtime feedback MRI Subjects control vertical position of racket by the amplitude of the BOLD response in modulated brain area Subject 1 Subject 2 B. Sorger, R. Goebel, Universiteit Maastricht Alfabet codering B. Sorger, R. Goebel, Universiteit Maastricht Handout 21

22 Realtime encoding B. Sorger, R. Goebel, Universiteit Maastricht Brain functions map Welk deel van het brein zal van groot belang zijn voor musici? Handout 22

23 Grijze en Witte hersenmassa Heschl s Gyrus * * Auditieve cortex: Heschl s Gyrus Dominante zijde Dominante zijde Handout 23

24 P. Schneider, Ann. N.Y. Acad. Sci. 1060: (2005) Muzikaliteit & grijze massa volume P. Schneider, nature neuroscience volume 5 no 7 july 2002 Handout 24

25 Talent of Training? Vraag blijft of genetische aanleg (talent) of vroege blootstelling en oefening het anatomische verschil veroorzaken tussen muzikanten en niet-muzikanten? Wat doet u? Handout 25

26 Highly organized tissue: Nerve Fibers Kissing / Crossing fibers and tensors, tracking Handout 26

27 Diffusion in tissue Two important measures: diffusion constant (ADC) diffusion direction (anisotropy) Diffusion Imaging RF excitation Gradient Signal dephasing TE/2 rephasing TE Echo acquisition Handout 27

28 Diffusion Imaging RF excitation Gradient Signal dephasing TE/2 rephasing Signal loss! acquisition Echo Diffusion Imaging: diffusion direction RF Gradient excitation dephasing TE/2 rephasing Gradient direction Spin movement direction Handout 28

29 Diffusion Imaging: diffusion direction RF excitation TE/2 Signal loss! Gradient dephasing rephasing Gradient direction Spin movement direction Directional encoding spin movement direction X (or X) diffusion gradient direction y y y z z z x x x X (or X) Y (or Y) Z (or Z) Signal LOSS! No signal loss No signal loss Y (or Y) No signal loss Signal LOSS! No signal loss Z (or Z) No signal loss No signal loss Signal LOSS! Handout 29

30 Diffusion weighting g g S 0 S Attenuation S = S 0 e -bd b = 2 2 /3) g 2 D : The Apparent Diffusion Coefficient (ADC) b : The b-value (or b-factor), amount of diffusion weighting : The gyromagnetic ratio (42 MHz/T for H + ) g : Amplitude of the diffusion gradients : Length of the diffusion gradients : Time between onset of the diffusion gradients DTI phantoom Proton density TSE 0.18 x 0.18 x 3mm pixels Handout 30

31 Diffusion direction & b-value: phantoom b = 500 b = 1000 b = 2000 ADC, FA, direction: phantoom ADC-map FA-map Direction Color Coded-map Handout 31

32 Diffusion direction & b-value: brain b = 0 b = 500 b = 2000 T1 MPRAGE ADC, FA, direction: brain ADC-map FA-map Direction Color Coded Handout 32

33 Brain: nerve tracking Complex nerve architecture: optisch chiasma Handout 33

34 Scannexus Scannexus provides: Access to world-leading ultra-high-field (3T, 7T, 9.4T) MRI scanners and operational support and clinical and technical networks Facilitate development of projects matchmaking Organisation dealing with project delivery Advanced-level training in MR development & application Programme Outline o Part-time, Post-graduate Master s programme typically 1 week in Maastricht every 2 months o Consists of 17 modules o Modules can be taken as stand-alone courses or... o Combined to tailor Master study for different needs and background o A Master student follows eleven modules, and writes a Master s thesis o All taught in English o Setup in collaboration: Handout 34

35 Dank u! VRAGEN? Dank aan: Prof. dr. R. Goebel, University Maastricht Dr. A. Roebroeck, University Maastricht Dr. B. Sorger, University Maastricht Dr. F. Demartino, University Maastricht Dr. C. Wiggins, Scannexus Dr. R. McLennan, Scannexus Dr. F. Demartino, University Maastricht Ing. S. van der Pouw, Siemens Handout 35