Corso Integrato di Metodi per Immagini bio-mediche e Chirurgia Assistita MIMCAS. Metodi per bioimmagini Prof. G. Baselli Seminario 24/04/2012

Size: px
Start display at page:

Download "Corso Integrato di Metodi per Immagini bio-mediche e Chirurgia Assistita MIMCAS. Metodi per bioimmagini Prof. G. Baselli Seminario 24/04/2012"

Transcription

1 Corso Integrato di Metodi per Immagini bio-mediche e Chirurgia Assistita MIMCAS Metodi per bioimmagini Prof. G. Baselli Seminario 24/04/2012 DTI Applications Maria Giulia Preti

2 Summary DTI and Tractography main applications Tractographic Atlas construction fmri-driven tractography

3 Tractography in dementias Why? Evaluation of WM damage patterns in dementias Analysis of subjects showing a Mild Cognitive Impairment (MCI, pre-dementia stage) to early predict a possible conversion to dementia Study of structural connections underlying functional activations White matter damages compromised tractographic reconstruction E.g. Alzheimer s Disease (AD) Healthy subject AD patient Healthy subject atrophy

4 Tractpgraphy and Multiple Sclerosis MULTIPLE SCLEROSIS demyelinating pathology causing: 1. White matter lesions: macroscopical areas in which tissue is damaged 2. Cerebral Atrophy 3. Microscopical damages both in white and gray matter o Not visible with conventional MR o Assessable with Diffusion Weighted Imaging Immagine pesata in DP di un paziente con CL=29.61 ml e EDSS = 6. Immagine pesata in T2 di un soggetto sano Immagine pesata in T2 di un paziente con EDSS = 6.5

5 Tractography in Multiple Sclerosis MULTIPLE SCLEROSIS LESIONS: LOW FA Interruption of tractographic reconstruction Possible solutions - Lower AF threshold - Compute indexes by a normal atlas soggetto sano paziente SM (EDSS=6.5) paziente SM (EDSS=6.5)

6 Tractography and brain tumor: deviated fibers A: T2 weighted; B: T1 weighted; C: Directional map, axial plane D: D. map, coronal plane E: WM tracts deviated by the tumor

7 Tractography and brain tumor: interrupted fibers A : T2 weighted B: T1 weighted C: FA map D: Directional map

8 Tractographic Atlases Why an atlas? Study of anatomy Study of patients when individual tractography is not possible Tractographic Atlas: a template of a specific bundle, obtained from the mean of healthy subjects Optimisation of atlas construction - Different approaches are possible - Coregistration is fundamental

9 Regisitration AFFINE registration: 12 DOF in 3D space Rotation, traslation, sharing, scaling ELASTIC registration : control points grid overimposed to the original image, different deformation for every different point Rotation Scaling Higher precision in the registration of morphologically different structures

10 Tractographic Atlases Atlas 1: mean DWI, affine registration Atlas 2: mean DWI, elastic registration Atlas 1 Atlas 2 Atlas 3: mean DTI, affine registration Atlas 4: mean DTI, elastic registration Atlas 3 Atlas 4

11 Tractographic Atlases Atlas 1 IFOF ILF Erroneous terminations Atlas 2 IFOF Erroneous termination of tractography IFOF ILF

12 Tractographic Atlases T=360 L=123.5 (14.06) FA=0,353 (0,102) T=215 L=54.25 (15.94) FA=0,336 (0,123) T=1123 L=71.87 (28.17) FA=0,308 (0,103) IFOF ILF ARCUATE T=787 L=52.92 (18.65) FA=0,375 (0,111) T=693 L=64.22 (22.63) FA=0,349 (0,108) T=812 L=54.07 (20.89) FA=0,356 (0,111) IFOF ILF ARCUATE

13 Tractographic Atlases CC Probabilistic Atlas -Inidivdual tractography for healthy subjects: CC divided in 7 regions - Tract density maps - Binarisation - Average -Threshold (0.9)

14 Tractographic Atlases Example of atlases: ILF UNCINATE IFOF GENU BODY SPLENIUM

15 Atlas-based tractography Atlas-based approach: Evaluation of individual FA values in the positions given by a probabilistic atlas 1)Atlas construction 2) Atlas application to patients FA maps REG within the atlas locations: Mean FA weighted for the probability given by the atlas Individual FA maps Template FA Masking of FA maps (FA>0.2) with the atlas ANOVA test (Bonferroni corr.) for between group comparisons

16 fmri-driven Tractography Exploring brain anatomy and function with MRI Study of anatomical connectivity: atlas-based tractography Study of brain functionality: fmri Integration between fmri and tractography

17 fmri-driven Tractography Functional activation areas = seed points for tractography reconstruction of the bundles recruited for a certain cortical activation Evaluation of anatomical and functional connectivity Example Healthy control activation areas with motor task (right foot movement) Cortico-spinal tract reconstruction

18 fmri-driven Tractography Which anatomical connections are recruited in a particular functional activation? Healthy elderly subject fmri Activations (Categorial task) fmri-guided tractography: arcuate fasciuculus

19 fmri-driven Tractography MCI patient Use of different circuits in MCI? fmri Activations (Categorial task) fmri-guided tractography: arcuate and IFOF

20 fmri-driven Tractography Case report: Cortico-basal degeneration (right ehmisphere) Normal tractography Left CST (healthy): More tracts fmri-guided tractography Left CST(healthy): More focused activation fmri Activations (hand movement)

21 fmri-driven Tractography 2 STEP: GROUP ANALYSIS Seed for every subject from mean group activation Find the tracts which are involved in average in one group We can apply the same approach of atlas construction, to consider average tracts of one group

22 Thank you

Neuroimaging module I: Modern neuroimaging methods of investigation of the human brain in health and disease

Neuroimaging module I: Modern neuroimaging methods of investigation of the human brain in health and disease 1 Neuroimaging module I: Modern neuroimaging methods of investigation of the human brain in health and disease The following contains a summary of the content of the neuroimaging module I on the postgraduate

More information

Advanced MRI methods in diagnostics of spinal cord pathology

Advanced MRI methods in diagnostics of spinal cord pathology Advanced MRI methods in diagnostics of spinal cord pathology Stanisław Kwieciński Department of Magnetic Resonance MR IMAGING LAB MRI /MRS IN BIOMEDICAL RESEARCH ON HUMANS AND ANIMAL MODELS IN VIVO Equipment:

More information

Mapping Brain Changes Over Time during Development: Challenges, Limits and Potential

Mapping Brain Changes Over Time during Development: Challenges, Limits and Potential Mapping Brain Changes Over Time during Development: Challenges, Limits and Potential Guido Gerig University of Utah Scientific Computing and Imaging (SCI) Institute Gerig 09-2008 Outline 1. Imaging Technology

More information

DTI Fiber Tract-Oriented Quantitative and Visual Analysis of White Matter Integrity

DTI Fiber Tract-Oriented Quantitative and Visual Analysis of White Matter Integrity DTI Fiber Tract-Oriented Quantitative and Visual Analysis of White Matter Integrity Xuwei Liang, Ning Cao, and Jun Zhang Department of Computer Science, University of Kentucky, USA, jzhang@cs.uky.edu.

More information

Software Packages The following data analysis software packages will be showcased:

Software Packages The following data analysis software packages will be showcased: Analyze This! Practicalities of fmri and Diffusion Data Analysis Data Download Instructions Weekday Educational Course, ISMRM 23 rd Annual Meeting and Exhibition Tuesday 2 nd June 2015, 10:00-12:00, Room

More information

University of California San Francisco, CA, USA 4 Department of Veterans Affairs Medical Center, San Francisco, CA, USA

University of California San Francisco, CA, USA 4 Department of Veterans Affairs Medical Center, San Francisco, CA, USA Disrupted Brain Connectivity in Alzheimer s Disease: Effects of Network Thresholding Madelaine Daianu 1, Emily L. Dennis 1, Neda Jahanshad 1, Talia M. Nir 1, Arthur W. Toga 1, Clifford R. Jack, Jr. 2,

More information

Requirements for Complex Interactive Workflows in Biomedical Research. Jeffrey S. Grethe, BIRN-CC University of California, San Diego

Requirements for Complex Interactive Workflows in Biomedical Research. Jeffrey S. Grethe, BIRN-CC University of California, San Diego Requirements for Complex Interactive Workflows in Biomedical Research Jeffrey S. Grethe, BIRN-CC University of California, San Diego e-science Workflow Services December 3, 2003 Scientific Workflows Laboratory

More information

Myelinization. THOMAS P. NAIDICH, MD FACR Mt. Sinai Medical Center New York, NY USA

Myelinization. THOMAS P. NAIDICH, MD FACR Mt. Sinai Medical Center New York, NY USA Myelinization THOMAS P. NAIDICH, MD FACR Mt. Sinai Medical Center New York, NY USA ALTERS BRAIN WATER LOCALLY MYELIN CONTAINS: GLYCOLIPIDS PHOSPHOLIPIDS & CHOLESTEROL Maturation of the White Matter Maturation

More information

Quantitative Assessment of MRI Features in Patients with Relapsing-Remitting Multiple Sclerosis

Quantitative Assessment of MRI Features in Patients with Relapsing-Remitting Multiple Sclerosis BIOSCIENCES BIOTECHNOLOGY RESEARCH ASIA, August 2014. Vol. 11(2), 863-868 Quantitative Assessment of MRI Features in Patients with Relapsing-Remitting Multiple Sclerosis Babak Shekarchi 1, Samaneh Fartook

More information

Automatic Morphological Analysis of the Medial Temporal Lobe

Automatic Morphological Analysis of the Medial Temporal Lobe Automatic Morphological Analysis of the Medial Temporal Lobe Neuroimaging analysis applied to the diagnosis and prognosis of the Alzheimer s disease. Andrea Chincarini, INFN Genova Clinical aspects of

More information

runl I IUI%I/\L Magnetic Resonance Imaging

runl I IUI%I/\L Magnetic Resonance Imaging runl I IUI%I/\L Magnetic Resonance Imaging SECOND EDITION Scott A. HuetteS Brain Imaging and Analysis Center, Duke University Allen W. Song Brain Imaging and Analysis Center, Duke University Gregory McCarthy

More information

Magnetic Resonance Imaging

Magnetic Resonance Imaging Magnetic Resonance Imaging What are the uses of MRI? To begin, not only are there a variety of scanning methodologies available, but there are also a variety of MRI methodologies available which provide

More information

Alzheimer s disease. What is Alzheimer s disease?

Alzheimer s disease. What is Alzheimer s disease? Alzheimer s disease What is Alzheimer s disease? What we know about dementia and Alzheimer s disease Alzheimer s disease is the most common of a large group of disorders known as dementias. It is an irreversible

More information

Diffusion MRI imaging for brain connectivity analysis

Diffusion MRI imaging for brain connectivity analysis Diffusion MRI imaging for brain connectivity analysis principles and challenges Prof. Jean-Philippe Thiran EPFL - http://lts5www.epfl.ch - jp.thiran@epfl.ch From Brownian motion to Diffusion MRI - Motivation

More information

Brain Extraction, Registration & EPI Distortion Correction

Brain Extraction, Registration & EPI Distortion Correction Brain Extraction, Registration & EPI Distortion Correction What use is Registration? Some common uses of registration: Combining across individuals in group studies: including fmri & diffusion Quantifying

More information

2. MATERIALS AND METHODS

2. MATERIALS AND METHODS Difficulties of T1 brain MRI segmentation techniques M S. Atkins *a, K. Siu a, B. Law a, J. Orchard a, W. Rosenbaum a a School of Computing Science, Simon Fraser University ABSTRACT This paper looks at

More information

NEURO M203 & BIOMED M263 WINTER 2014

NEURO M203 & BIOMED M263 WINTER 2014 NEURO M203 & BIOMED M263 WINTER 2014 MRI Lab 1: Structural and Functional Anatomy During today s lab, you will work with and view the structural and functional imaging data collected from the scanning

More information

ORDER. DISTRICT COURT, JEFFERSON COUNTY, COLORADO 100 Jefferson County Parkway Golden, Colorado 80401-6002. MARION WHILDEN AND MARY WHLDEN Plaintiff,

ORDER. DISTRICT COURT, JEFFERSON COUNTY, COLORADO 100 Jefferson County Parkway Golden, Colorado 80401-6002. MARION WHILDEN AND MARY WHLDEN Plaintiff, DISTRICT COURT, JEFFERSON COUNTY, COLORADO 100 Jefferson County Parkway Golden, Colorado 80401-6002 MARION WHILDEN AND MARY WHLDEN Plaintiff, v. KIMBERLY CLINE, ELMER DUDDEN and COLORADO CAB COMPANY, L.L.C.

More information

Chapter 10. Summary & Future perspectives

Chapter 10. Summary & Future perspectives Summary & Future perspectives 123 Multiple sclerosis is a chronic disorder of the central nervous system, characterized by inflammation and axonal degeneration. All current therapies modulate the peripheral

More information

MRI DATA PROCESSING. Compiled by: Nicolas F. Lori and Carlos Ferreira. Introduction

MRI DATA PROCESSING. Compiled by: Nicolas F. Lori and Carlos Ferreira. Introduction MRI DATA PROCESSING Compiled by: Nicolas F. Lori and Carlos Ferreira Introduction Magnetic Resonance Imaging (MRI) is a clinical exam that is safe to the patient. Nevertheless, it s very important to attend

More information

Diffusione e perfusione in risonanza magnetica. E. Pagani, M. Filippi

Diffusione e perfusione in risonanza magnetica. E. Pagani, M. Filippi Diffusione e perfusione in risonanza magnetica E. Pagani, M. Filippi DW-MRI DIFFUSION-WEIGHTED MRI Principles Diffusion results from a microspic random motion known as Brownian motion THE RANDOM WALK How

More information

Temporomandibular Joint Imaging Using CBCT: Technology Now Captures Reality!

Temporomandibular Joint Imaging Using CBCT: Technology Now Captures Reality! Temporomandibular Joint Imaging Using CBCT: Technology Now Captures Reality! Dale A. Miles BA, DDS, MS, FRCD (C) Diplomate, American Board of Oral and Maxillofacial Radiology Diplomate, American Board

More information

Why do we have so many brain coordinate systems? Lilla ZölleiZ WhyNHow seminar 12/04/08

Why do we have so many brain coordinate systems? Lilla ZölleiZ WhyNHow seminar 12/04/08 Why do we have so many brain coordinate systems? Lilla ZölleiZ WhyNHow seminar 12/04/08 About brain atlases What are they? What do we use them for? Who creates them? Which one shall I use? Brain atlas

More information

Quantitative Analysis of White Matter Fiber Properties along Geodesic Paths

Quantitative Analysis of White Matter Fiber Properties along Geodesic Paths Quantitative Analysis of White Matter Fiber Properties along Geodesic Paths 1,3 Pierre Fillard, 2 John Gilmore, 2 Joseph Piven, 4 Weili Lin, 1,2 Guido Gerig 1 Department of Computer Science, 2 Department

More information

Cognitive rehabilitation in MS

Cognitive rehabilitation in MS 14th MS Nurse International Workshop Lyon, France, October 9th 2012 Cognitive and psychological issues in MS Cognitive rehabilitation in MS Psychological Unit Neurological Department San Raffaele Hospital

More information

DRIVER REHABILITATION OVERVIEW

DRIVER REHABILITATION OVERVIEW DRIVER REHABILITATION OVERVIEW What is included in a Driving Evaluation? The purpose of the evaluation is to determine if the individual s medical condition, medications, functional limitations and/ or

More information

CREATIVE DEMONSTRATIVE EVIDENCE: ADDING THE MIDAS TOUCH. We all know that the use of demonstrative evidence can be crucial to the jury s ability to

CREATIVE DEMONSTRATIVE EVIDENCE: ADDING THE MIDAS TOUCH. We all know that the use of demonstrative evidence can be crucial to the jury s ability to CREATIVE DEMONSTRATIVE EVIDENCE: ADDING THE MIDAS TOUCH A. Introduction We all know that the use of demonstrative evidence can be crucial to the jury s ability to understand complex issues at trial. There

More information

The File-Card-Browser View for Breast DCE-MRI Data

The File-Card-Browser View for Breast DCE-MRI Data The File-Card-Browser View for Breast DCE-MRI Data Sylvia Glaßer 1, Kathrin Scheil 1, Uta Preim 2, Bernhard Preim 1 1 Department of Simulation and Graphics, University of Magdeburg 2 Department of Radiology,

More information

Cervical Spine Surgery. Orthopaedic Nursing Seminar. Dr Michelle Atkinson. Friday October 21 st 2011. Cervical Disc Herniation

Cervical Spine Surgery. Orthopaedic Nursing Seminar. Dr Michelle Atkinson. Friday October 21 st 2011. Cervical Disc Herniation Cervical Spine Surgery Dr Michelle Atkinson The Sydney and Dalcross Adventist Hospitals Orthopaedic Nursing Seminar Friday October 21 st 2011 Cervical disc herniation The most frequently treated surgical

More information

Clinical Applications of Imaging to Drug Development

Clinical Applications of Imaging to Drug Development Clinical Applications of Imaging to Drug Development Novartis Research: Disease Areas Massachusetts: Diabetes Infectious diseases Cardiovascular Oncology Great Britain: Chronic pain Respiratory New Jersey:

More information

OHTAC Recommendation

OHTAC Recommendation OHTAC Recommendation Multiple Sclerosis and Chronic Cerebrospinal Venous Insufficiency Presented to the Ontario Health Technology Advisory Committee in May 2010 May 2010 Issue Background A review on the

More information

3/30/2013. Disclosure. Advanced Neuro MRI: Imaging Techniques and Protocol Optimization. MRI, 35 year ago. MRI Today. Outlines

3/30/2013. Disclosure. Advanced Neuro MRI: Imaging Techniques and Protocol Optimization. MRI, 35 year ago. MRI Today. Outlines http://www.magnet.fsu.edu Disclosure Advanced Neuro MRI: Imaging Techniques and Protocol Optimization Research funding provided by Siemens Healthcare. Chen Lin, PhD DABR Indiana University School of Medicine

More information

Opening perspective: A user- friendly web portal for neuro- imaging research

Opening perspective: A user- friendly web portal for neuro- imaging research Technical Report: neugrid Portfolio - Page 1 / 17 N Contrat : n.a. Opening perspective: A user- friendly web portal for neuro- imaging research Dr.David Manset & Prof.Giovanni Frisoni, CEOs cerebro GmbH

More information

Update: MRI in Multiple sclerosis

Update: MRI in Multiple sclerosis Nyt indenfor MS ved MR Update: MRI in Multiple sclerosis Hartwig Roman Siebner Danish Research Centre for Magnetic Resonance (DRCMR) Copenhagen University Hospital Hvidovre Dansk Radiologisk Selskabs 10.

More information

A Binary Entropy Measure to Assess Nonrigid Registration Algorithms

A Binary Entropy Measure to Assess Nonrigid Registration Algorithms A Binary Entropy Measure to Assess Nonrigid Registration Algorithms Simon K. Warfield 1, Jan Rexilius 1, Petra S. Huppi 2, Terrie E. Inder 3, Erik G. Miller 1, William M. Wells III 1, Gary P. Zientara

More information

Norbert Schuff Professor of Radiology VA Medical Center and UCSF Norbert.schuff@ucsf.edu

Norbert Schuff Professor of Radiology VA Medical Center and UCSF Norbert.schuff@ucsf.edu Norbert Schuff Professor of Radiology Medical Center and UCSF Norbert.schuff@ucsf.edu Medical Imaging Informatics 2012, N.Schuff Course # 170.03 Slide 1/67 Overview Definitions Role of Segmentation Segmentation

More information

Discogenic Low Backache A clinical and MRI correlative study A DISSERTATION SUBMITTED TO UNIVERSITY OF SEYCHELLES AMERICAN INSTITUTE OF MEDICINE

Discogenic Low Backache A clinical and MRI correlative study A DISSERTATION SUBMITTED TO UNIVERSITY OF SEYCHELLES AMERICAN INSTITUTE OF MEDICINE Discogenic Low Backache A clinical and MRI correlative study A DISSERTATION SUBMITTED TO UNIVERSITY OF SEYCHELLES AMERICAN INSTITUTE OF MEDICINE IN PARTIAL FULFILLMENT OF THE REGULATIONS FOR THE AWARD

More information

Neuroimaging Big Data Challenges and Computational Workflow Solutions

Neuroimaging Big Data Challenges and Computational Workflow Solutions euroimaging Big Data Challenges and Computational Workflow Solutions Organizers: Ivo D. Dinov, UCLA, Los Angeles, CA, United States Jack D. Van Horn, UCLA, Los Angeles, CA, United States There are Peta

More information

Between session reproducibility and between subject variability of diffusion MR and tractography measures

Between session reproducibility and between subject variability of diffusion MR and tractography measures www.elsevier.com/locate/ynimg NeuroImage 33 (2006) 867 877 Between session reproducibility and between subject variability of diffusion MR and tractography measures E. Heiervang, a,b T.E.J. Behrens, a

More information

MEDIMAGE A Multimedia Database Management System for Alzheimer s Disease Patients

MEDIMAGE A Multimedia Database Management System for Alzheimer s Disease Patients MEDIMAGE A Multimedia Database Management System for Alzheimer s Disease Patients Peter L. Stanchev 1, Farshad Fotouhi 2 1 Kettering University, Flint, Michigan, 48504 USA pstanche@kettering.edu http://www.kettering.edu/~pstanche

More information

Integration and Visualization of Multimodality Brain Data for Language Mapping

Integration and Visualization of Multimodality Brain Data for Language Mapping Integration and Visualization of Multimodality Brain Data for Language Mapping Andrew V. Poliakov, PhD, Kevin P. Hinshaw, MS, Cornelius Rosse, MD, DSc and James F. Brinkley, MD, PhD Structural Informatics

More information

Cognitive Neuroscience. Questions. Multiple Methods. Electrophysiology. Multiple Methods. Approaches to Thinking about the Mind

Cognitive Neuroscience. Questions. Multiple Methods. Electrophysiology. Multiple Methods. Approaches to Thinking about the Mind Cognitive Neuroscience Approaches to Thinking about the Mind Cognitive Neuroscience Evolutionary Approach Sept 20-22, 2004 Interdisciplinary approach Rapidly changing How does the brain enable cognition?

More information

Current Industry Neuroimaging Experience in Clinical Trials Jerome Barakos, M.D.

Current Industry Neuroimaging Experience in Clinical Trials Jerome Barakos, M.D. Current Industry Neuroimaging Experience in Clinical Trials Jerome Barakos, M.D. Melbourne Australia March 28, 2012 Synarc Experience and Expertise Largest imaging service provider dedicated to clinical

More information

NEUROIMAGING in Parkinsonian Syndromes

NEUROIMAGING in Parkinsonian Syndromes NEUROIMAGING in Parkinsonian Syndromes (Focus on Structural Techniques: CT and MRI) Dr. Roberto Cilia Parkinson Institute, ICP, Milan, Italy OUTLINE Primary Parkinsonism Idiopathic Parkinson s Disease

More information

2016 Programs & Information

2016 Programs & Information Mayo Alzheimer s Disease Research Clinic Education Center 2016 Programs & Information BROCHURE TITLE FLUSH RIGHT for Persons & Families impacted by Mild Cognitive Impairment Alzheimer s Disease Dementia

More information

Biomarkers and treatments for mild traumatic brain injury: from bench to fieldside

Biomarkers and treatments for mild traumatic brain injury: from bench to fieldside Biomarkers and treatments for mild traumatic brain injury: from bench to fieldside Sandy R Shultz, PhD Department of Medicine The University of Melbourne Australian Rules Football Rugby Findings from

More information

Saturation Biopsy vs. 3D Spatial Biopsy vs. Free Hand Ultrasound biopsy for Targeted Prostate Cancer Therapies

Saturation Biopsy vs. 3D Spatial Biopsy vs. Free Hand Ultrasound biopsy for Targeted Prostate Cancer Therapies Saturation Biopsy vs. 3D Spatial Biopsy vs. Free Hand Ultrasound biopsy for Targeted Prostate Cancer Therapies John F. Ward, MD Assistant Professor University of Texas M. D. Anderson Cancer Center Ablation

More information

Predicting the future progression of dementia. Ashish Raj, PhD

Predicting the future progression of dementia. Ashish Raj, PhD Business Presentation Predicting the future progression of dementia Ashish Raj, PhD Founder and CEO Associate Professor of Computer Science in Radiology Director, IDEAL Laboratory Associate Professor of

More information

advancing magnetic resonance imaging and medical data analysis

advancing magnetic resonance imaging and medical data analysis advancing magnetic resonance imaging and medical data analysis INFN - CSN5 CdS - Luglio 2015 Sezione di Genova 2015-2017 objectives Image reconstruction, artifacts and noise management O.1 Components RF

More information

NeuroImage 46 (2009) 762 774. Contents lists available at ScienceDirect. NeuroImage. journal homepage: www.elsevier.

NeuroImage 46 (2009) 762 774. Contents lists available at ScienceDirect. NeuroImage. journal homepage: www.elsevier. NeuroImage 46 (2009) 762 774 Contents lists available at ScienceDirect NeuroImage journal homepage: www.elsevier.com/locate/ynimg Non-diffeomorphic registration of brain tumor images by simulating tissue

More information

Uusinta tietoa liikunnan ja terveyden välisestä yhteydestä

Uusinta tietoa liikunnan ja terveyden välisestä yhteydestä Uusinta tietoa liikunnan ja terveyden välisestä yhteydestä Urho Kujala Liikuntalääketieteen professori Terveystieteiden laitos Jyväskylän yliopisto urho.m.kujala@jyu.fi Health and motor skills/functioning

More information

First Year. PT7040- Clinical Skills and Examination II

First Year. PT7040- Clinical Skills and Examination II First Year Summer PT7010 Anatomical Dissection for Physical Therapists This is a dissection-based, radiographic anatomical study of the spine, lower extremity, and upper extremity as related to physical

More information

The WalkOn Range. Dynamic Lower Leg Orthoses. NeW. Information for physicians, orthotists and physiotherapists

The WalkOn Range. Dynamic Lower Leg Orthoses. NeW. Information for physicians, orthotists and physiotherapists The WalkOn Range Dynamic Lower Leg Orthoses NeW Information for physicians, orthotists and physiotherapists One Range Many Different Applications The WalkOn product range allows you to address the specific

More information

Network Analysis I & II

Network Analysis I & II Network Analysis I & II Dani S. Bassett Department of Physics University of California Santa Barbara Outline Lecture One: 1. Complexity in the Human Brain from processes to patterns 2. Graph Theory and

More information

Running Head: THE DETECTION OF ALZHEIMER S DISEASE: A LITERATURE 1. The Detection of Alzheimer s Disease: A Literature Review and Case Study

Running Head: THE DETECTION OF ALZHEIMER S DISEASE: A LITERATURE 1. The Detection of Alzheimer s Disease: A Literature Review and Case Study Running Head: THE DETECTION OF ALZHEIMER S DISEASE: A LITERATURE 1 The Detection of Alzheimer s Disease: A Literature Review and Case Study November 15, 2012 Detection of Alzheimer s Disease 2 Abstract

More information

University of California, Irvine. (December 4, 2010, Sapporo, Japan)

University of California, Irvine. (December 4, 2010, Sapporo, Japan) University of California, Irvine 1 2 (December 4, 2010, Sapporo, Japan) This article is an invaluable record of an interview with Prof. Ruth Mulnard, who is a nursing scientist as well as a clinician in

More information

Linguistic Ability in Early Life and the Neuropathology of Alzheimer s Disease and Cerebrovascular Disease

Linguistic Ability in Early Life and the Neuropathology of Alzheimer s Disease and Cerebrovascular Disease Linguistic Ability in Early Life and the Neuropathology of Alzheimer s Disease and Cerebrovascular Disease Findings from the Nun Study D.A. SNOWDON, a,b L.H. GREINER, a AND W.R. MARKESBERY a,c a Sanders-Brown

More information

Machine Learning for Medical Image Analysis. A. Criminisi & the InnerEye team @ MSRC

Machine Learning for Medical Image Analysis. A. Criminisi & the InnerEye team @ MSRC Machine Learning for Medical Image Analysis A. Criminisi & the InnerEye team @ MSRC Medical image analysis the goal Automatic, semantic analysis and quantification of what observed in medical scans Brain

More information

Wallerian Degeneration and Myelin Loss Secondary to Neuronal and Axonal Degeneration

Wallerian Degeneration and Myelin Loss Secondary to Neuronal and Axonal Degeneration Chapter 105 Wallerian Degeneration and Myelin Loss Secondary to Neuronal and Axonal Degeneration 105.1 Introduction There are basically two causes of wallerian degeneration in our definition: neuronal

More information

MedINRIA : Medical Image Navigation and Research Tool by INRIA

MedINRIA : Medical Image Navigation and Research Tool by INRIA MedINRIA : Medical Image Navigation and Research Tool by INRIA Nicolas Toussaint 1, Jean-Christophe Souplet 1, and Pierre Fillard 1 Asclepios Research Team, INRIA Sophia Antipolis, France. {Nicolas.Toussaint,

More information

Dr. A.M. van Cappellen van Walsum (Anne-Marie), MD, PhD.

Dr. A.M. van Cappellen van Walsum (Anne-Marie), MD, PhD. Dr. A.M. van Cappellen van Walsum (Anne-Marie), MD, PhD. Assistant Professor Anatomy Anatomist, specialised in Neuroanatomy in relation to Imaging. Principal Investigator MIRA-Neuro Imaging (NIM)-Neuroanatomy,

More information

Medical Image Processing on the GPU. Past, Present and Future. Anders Eklund, PhD Virginia Tech Carilion Research Institute andek@vtc.vt.

Medical Image Processing on the GPU. Past, Present and Future. Anders Eklund, PhD Virginia Tech Carilion Research Institute andek@vtc.vt. Medical Image Processing on the GPU Past, Present and Future Anders Eklund, PhD Virginia Tech Carilion Research Institute andek@vtc.vt.edu Outline Motivation why do we need GPUs? Past - how was GPU programming

More information

ATLAS-BASED FIBER CLUSTERING FOR MULTI-SUBJECT ANALYSIS OF HIGH ANGULAR RESOLUTION DIFFUSION IMAGING TRACTOGRAPHY

ATLAS-BASED FIBER CLUSTERING FOR MULTI-SUBJECT ANALYSIS OF HIGH ANGULAR RESOLUTION DIFFUSION IMAGING TRACTOGRAPHY ATLAS-BASED FIBER CLUSTERING FOR MULTI-SUBJECT ANALYSIS OF HIGH ANGULAR RESOLUTION DIFFUSION IMAGING TRACTOGRAPHY Gautam Prasad, Neda Jahanshad, Iman Aganj, Christophe Lenglet, Guillermo Sapiro, Arthur

More information

MCDB 4777/5777 Molecular Neurobiology Lecture 38 Alzheimer s Disease

MCDB 4777/5777 Molecular Neurobiology Lecture 38 Alzheimer s Disease MCDB 4777/5777 Molecular Neurobiology Lecture 38 Alzheimer s Disease Outline of Today s Lecture Why is Alzheimer s disease a problem? What is Alzheimer s Disease? What causes Alzheimer s disease? How can

More information

MULTIMODAL THERAPY FOR MS- ASSOCIATED COGNITIVE DYSFUNCTION

MULTIMODAL THERAPY FOR MS- ASSOCIATED COGNITIVE DYSFUNCTION MULTIMODAL THERAPY FOR MS- ASSOCIATED COGNITIVE DYSFUNCTION Michael K. Racke, MD Professor and Chairman in Neurology The Helen C. Kurtz Chair in Neurology Department of Neurology Ohio State University

More information

MRI Brain Tumor Segmentation Using Improved ACO

MRI Brain Tumor Segmentation Using Improved ACO International Journal of Electronic and Electrical Engineering. ISSN 0974-2174, Volume 7, Number 1 (2014), pp. 85-90 International Research Publication House http://www.irphouse.com MRI Brain Tumor Segmentation

More information

J/601/2874. This unit must be assessed in accordance with Skills for Care and Development s QCF Assessment Principles.

J/601/2874. This unit must be assessed in accordance with Skills for Care and Development s QCF Assessment Principles. Unit 13: Dementia Awareness Unit code: DEM 201 Unit reference number: J/601/2874 QCF level: 2 Credit value: 2 Guided learning hours: 17 Unit summary The aim of the unit is to enable learners to gain knowledge

More information

Diffusion Tensor Imaging in Mild Traumatic Brain Injury Litigation

Diffusion Tensor Imaging in Mild Traumatic Brain Injury Litigation REGULAR ARTICLE Diffusion Tensor Imaging in Mild Traumatic Brain Injury Litigation Hal S. Wortzel, MD, Marilyn F. Kraus, MD, Christopher M. Filley, MD, C. Alan Anderson, MD, and David B. Arciniegas, MD

More information

Depression in MS: Is brain imaging helpful?

Depression in MS: Is brain imaging helpful? Depression in MS: Is brain imaging helpful? Anthony Feinstein Professor, Department of Psychiatry Sunnybrook Health Sciences Centre & the University of Toronto Disclosures MS Society of Canada Canadian

More information

MRI for Paediatric Surgeons

MRI for Paediatric Surgeons MRI for Paediatric Surgeons Starship David Perry Paediatric Radiologist Starship Children s Hospital CHILDREN S HEALTH What determines the brightness of a pixel in MRI? i.e. What determines the strength

More information

COMMENTS AND CONTROVERSIES Why Voxel-Based Morphometry Should Be Used

COMMENTS AND CONTROVERSIES Why Voxel-Based Morphometry Should Be Used NeuroImage 14, 1238 1243 (2001) doi:10.1006/nimg.2001.0961, available online at http://www.idealibrary.com on COMMENTS AND CONTROVERSIES Why Voxel-Based Morphometry Should Be Used John Ashburner 1 and

More information

Virtual 3D Model of the Lumbar Spine

Virtual 3D Model of the Lumbar Spine LSNA Virtual 3D Model of the Lumbar Spine Alberto Prats-Galino 1, Miguel Angel Reina 2, Marija Mavar Haramija 1, Anna Puigdellivol-Sánchez 1, Joan San Molina 3 and José Antonio De Andrés 4. 1 Laboratory

More information

Abnormalities of Cortical Thickness, Subcortical Shapes, and White Matter Integrity in Subcortical Vascular Cognitive Impairment

Abnormalities of Cortical Thickness, Subcortical Shapes, and White Matter Integrity in Subcortical Vascular Cognitive Impairment r Human Brain Mapping 35:2320 2332 (2014) r Abnormalities of Cortical Thickness, Subcortical Shapes, and White Matter Integrity in Subcortical Vascular Cognitive Impairment Jamie Yu Jin Thong, 1 Jia Du,

More information

Relapsing Remitting Multiple Sclerosis Treated with Interferon Beta-1a: Immunological and Short-Term Brain Volume Changes

Relapsing Remitting Multiple Sclerosis Treated with Interferon Beta-1a: Immunological and Short-Term Brain Volume Changes Relapsing Remitting Multiple Sclerosis Treated with Interferon Beta-1a: Immunological and Short-Term Brain Volume Changes MG Dwyer, 1 R Zivadinov, 1 Y Tao, 2 X Zhang, 2 C Kennedy, 1 N Bergsland, 1 D Ramasamy,

More information

Cognitive impairment (CI) in Multiple Sclerosis

Cognitive impairment (CI) in Multiple Sclerosis Multiple Sclerosis and Mild Cognitive Impairment What are the cognitive impairments in MS and why are the terms dementia and Mild Cognitive Impairment (MCI) rarely used? By Ronald Devere, MD Cognitive

More information

Rational basis for early treatment in MS. Bonaventura Casanova Estruch Unitat d Esclerosi Múltiple Hospital Universitari la Fe València

Rational basis for early treatment in MS. Bonaventura Casanova Estruch Unitat d Esclerosi Múltiple Hospital Universitari la Fe València Rational basis for early treatment in MS Bonaventura Casanova Estruch Unitat d Esclerosi Múltiple Hospital Universitari la Fe València Bonaventura Casanova Department of Neurology University Hospital La

More information

POLITECNICO DI MILANO DIPARTIMENTO DI ELETTRONICA, INFORMAZIONE E BIOINGEGNERIA (DEIB) DOCTORAL PROGRAMME IN BIOENGINEERING

POLITECNICO DI MILANO DIPARTIMENTO DI ELETTRONICA, INFORMAZIONE E BIOINGEGNERIA (DEIB) DOCTORAL PROGRAMME IN BIOENGINEERING POLITECNICO DI MILANO DIPARTIMENTO DI ELETTRONICA, INFORMAZIONE E BIOINGEGNERIA (DEIB) DOCTORAL PROGRAMME IN BIOENGINEERING MODEL-BASED ANALYSIS OF DIFFUSION MAGNETIC RESONANCE: STUDY OF MICROSTRUCTURAL

More information

Social Security Disability Insurance and young onset dementia: A guide for employers and employees

Social Security Disability Insurance and young onset dementia: A guide for employers and employees Social Security Disability Insurance and young onset dementia: A guide for employers and employees What is Social Security Disability Insurance? Social Security Disability Insurance (SSDI) is a payroll

More information

DKE Fiber Tractography Module: User s Guide Version 1 Release Date: July 2015

DKE Fiber Tractography Module: User s Guide Version 1 Release Date: July 2015 DKE Fiber Tractography Module: User s Guide Version 1 Release Date: July 2015 Author: G. Russell Glenn, B.S., B.A. Medical Scientist Training Program (MD / PhD) Department of Neurosciences Department of

More information

High Resolution Line Scan Diffusion Tensor MRI of White Matter Fiber Tract Anatomy

High Resolution Line Scan Diffusion Tensor MRI of White Matter Fiber Tract Anatomy MS#00195 01 High Resolution Line Scan Diffusion Tensor MRI of White Matter Fiber Tract Anatomy Hatsuho Mamata, MD, PhD 1, 3, Yoshiaki Mamata, MD, PhD 1, Carl Fredrik Westin, PhD 1, Martha E. Shenton, PhD

More information

Supplementary Online Content

Supplementary Online Content Supplementary Online Content Burt RK, Balabanov R, Han X, et al. Association of nonmyeloablative hematopoietic stem cell transplantation with neurological disability in patients with relapsing-remitting

More information

Pradeep Redddy Raamana

Pradeep Redddy Raamana Pradeep Redddy Raamana Research Scientist at Simon Fraser University pkr1@sfu.ca Summary Highlights 8 years of experience in machine learning, data mining and statistical modelling. 6 years of experience

More information

FastTest. You ve read the book... ... now test yourself

FastTest. You ve read the book... ... now test yourself FastTest You ve read the book...... now test yourself To ensure you have learned the key points that will improve your patient care, read the authors questions below. The answers will refer you back to

More information

UPDATES TO NEUROCOGNITIVE DISORDERS IN DSM-5 and DSM-5 DESK REFERENCE UPDATED 10-18-13

UPDATES TO NEUROCOGNITIVE DISORDERS IN DSM-5 and DSM-5 DESK REFERENCE UPDATED 10-18-13 UPDATES TO NEUROCOGNITIVE DISORDERS IN DSM-5 and DSM-5 DESK REFERENCE UPDATED 10-18-13 SUMMARY: These coding changes ensure that insurance reimbursement can be obtained when the specifier With behavioral

More information

WHEN observing a medical image it is relatively easy

WHEN observing a medical image it is relatively easy 28 IEEE TRANSACTIONS ON MEDICAL IMAGING, VOL. 16, NO. 1, FEBRUARY 1997 Graphical Shape Templates for Automatic Anatomy Detection with Applications to MRI Brain Scans Yali Amit Abstract A new method of

More information

2012 Medical School for Actuaries Nov. 6-7, 2012 Session #1: Alzheimer s Disease

2012 Medical School for Actuaries Nov. 6-7, 2012 Session #1: Alzheimer s Disease 2012 Medical School for Actuaries Nov. 6-7, 2012 Session #1: Alzheimer s Disease Dylan Wint, M.D. ALZHEIMER DISEASE Dylan Wint, M.D. Lou Ruvo Center for Brain Health DEFINITIONS Cognitive related to thinking,

More information

Functional properties of fructans and their potential role in management of intestinal inflammatory pathologies

Functional properties of fructans and their potential role in management of intestinal inflammatory pathologies Functional properties of fructans and their potential role in management of intestinal inflammatory pathologies Dr.ssa Valentina Pasqualetti Unità di Ricerca di Scienze degli Alimenti e della Nutrizione

More information

PHYSICAL THERAPY ASSISTANT PROGRAM (Associate in Applied Science, AAS)

PHYSICAL THERAPY ASSISTANT PROGRAM (Associate in Applied Science, AAS) PHYSICAL THERAPY ASSISTANT PROGRAM (Associate in Applied Science, AAS) ADMISSION PROCEDURES To be admitted to the Physical Therapy Assistant Program (AAS), a prospective student must be interviewed by

More information

Neuroanatomy of developmental dyslexia. Franck Ramus CNRS Institut d Etude de la Cognition, Ecole Normale Supérieure, Paris

Neuroanatomy of developmental dyslexia. Franck Ramus CNRS Institut d Etude de la Cognition, Ecole Normale Supérieure, Paris Neuroanatomy of developmental dyslexia Franck Ramus CNRS Institut d Etude de la Cognition, Ecole Normale Supérieure, Paris Environment Causal modelling of dyslexia Genetic difference Brain structure difference

More information

Margaret Rosenbloom, M.A., Edith V. Sullivan, Ph.D., and Adolf Pfefferbaum, M.D.

Margaret Rosenbloom, M.A., Edith V. Sullivan, Ph.D., and Adolf Pfefferbaum, M.D. Using Magnetic Resonance Imaging and Diffusion Tensor Imaging to Assess Brain Damage in Alcoholics Margaret Rosenbloom, M.A., Edith V. Sullivan, Ph.D., and Adolf Pfefferbaum, M.D. Brain imaging using conventional

More information

Fiber consistency measures on brain tracts from digital streamline, stochastic and global tractography

Fiber consistency measures on brain tracts from digital streamline, stochastic and global tractography Universidad de Valladolid Escuela Técnica Superior de Ingenieros de Telecomunicación Tesis de Máster Máster Universitario en Investigación en Tecnologías de la Información y las Comunicaciones Fiber consistency

More information

Diagnosis and Initial Management of Cognitive Disorders

Diagnosis and Initial Management of Cognitive Disorders Diagnosis and Initial Management of Cognitive Disorders January 29, 2016 Kelly Garrett, PhD Cathleen Obray, MD, MHS Neurosciences Clinical Program Cognitive Care Team None Disclosures Neurosciences Clinical

More information

Short Courses in Imaging Sciences

Short Courses in Imaging Sciences Short Courses in Imaging Sciences The Centre for In Vivo Imaging Science (CIVIS) is delighted to offer online Continuing Professional Education to support your educational objectives, career goals and

More information

NEURO MRI PROTOCOLS TABLE OF CONTENTS

NEURO MRI PROTOCOLS TABLE OF CONTENTS TABLE OF CONTENTS NEURO MRI PROTOCOLS BRAIN...2 Brain 1 Screen... 2 Brain 2 Brain Tumor... 2 Brain 3 Brain Infection / Meningitis... 2 Brain 4 Trauma... 3 Brain 5 Hemorrhage... 3 Brain 6 Demyelinating

More information

Name Date Hour. Nerve Histology Microscope Lab

Name Date Hour. Nerve Histology Microscope Lab Name Date Hour Nerve Histology Microscope Lab PRE-LAB: Answer the following questions using your reading and class notes before starting the microscope lab. 1. What is the difference between the functions

More information

09/05/2014. Painting pictures of the brain with numbers. Overview

09/05/2014. Painting pictures of the brain with numbers. Overview Painting pictures of the brain with numbers Neurology for Insurers Dr Ian Cox & Adele Groyer (Gen Re) Overview Critical Illness Product Background Why should we be interested in neurology? Consult our

More information

Small vessel disease, microbleeds and intracerebral haemorrhage

Small vessel disease, microbleeds and intracerebral haemorrhage Small vessel disease, microbleeds and intracerebral haemorrhage Andreas Charidimou Clinical Research Fellow UCL Institute of Neurology Queen Square London The clinical question What is the best anticoagulation

More information

How To Write Long Term Care Insurance

How To Write Long Term Care Insurance By Lori Boyce, AVP Risk Management and R&D Underwriting long term care insurance: a primer Every day Canadians die, are diagnosed with cancer, have heart attacks and become disabled and our insurance solutions

More information

Fuld Skolerapport for Søhusskolen, i Odense kommune, for skoleår 2013/2014 for klassetrin(ene) 9. med reference Tilsvarende klassetrin i kommunen

Fuld Skolerapport for Søhusskolen, i Odense kommune, for skoleår 2013/2014 for klassetrin(ene) 9. med reference Tilsvarende klassetrin i kommunen Side 1 af 41 Side 2 af 41 Side 3 af 41 Side 4 af 41 Side 5 af 41 Side 6 af 41 Side 7 af 41 Side 8 af 41 Side 9 af 41 Side 10 af 41 Side 11 af 41 Side 12 af 41 Side 13 af 41 Side 14 af 41 Side 15 af 41

More information