Adolescent Brain Development and Effects of Alcohol Use

Size: px
Start display at page:

Download "Adolescent Brain Development and Effects of Alcohol Use"

Transcription

1 Adolescent Brain Development and Effects of Alcohol Use Monica Luciana, Ph.D. Professor and Chair Department of Psychology and Center for Neurobehavioral Development University of Minnesota

2 The Minnesota Adolescent Brain Development Project Longitudinal study initiated in 2004 Healthy children, adolescents and young adults (ages 9-23) recruited for initial assessment; n=203 Baseline assessment = MRI scans (volumetrics; DTI; resting state connectivity); neurobehavioral assessment; personality testing Sample re-assessed at two year intervals; just starting wave 5 End result = comprehensive biologically-based assessment of development from adolescence into young adulthood

3 Aims Characterize aspects of normative brain and behavioral development during typical adolescence Determine neuroplasticity in the context of substance use: is brain development altered as a function of alcohol or other substance use during this period?

4 Normative Changes in the Adolescent Brain Synaptic Pruning: Gray Matter Decline Myelination: White Matter volumetric increases Increased complexity of white matter s directional orientation Changes in functional connectivity, esp involving cortical control networks Changes in neurochemistry: overactivity of reward system?

5 Important to Recognize A developing brain is a malleable and receptive brain Experience impacts further brain development and subsequent behavior; neuroplasticity

6 One type of relevant experience Substance use/misuse Common but not universal

7 Percentages of Past Year Alcohol Dependence or Abuse among Adults Aged 21 or Older, by Age at First Use:

8 Alcohol as Neurotoxin Use in large quantities associated with impaired attention, memory and executive functions; neurotoxicity evident with heavy adult use, exposure during prenatal development, exposure during aging Does use in smaller amounts impact brain development in the adolescent period?

9 Will focus here on three sets of findings. I. Region-of-interest analyses: subcortical brain volumes and individual differences in reward responsivity as predictors of use and outcomes 2. Alcohol use and structural brain development 3. Behavioral changes after alcohol use initiation

10 MRI Acquisition Siemens 3T Tim Trio T1: (MPRAGE) sequence (TR = 2530 msec, TE = 3.65 msec, TI = 1100 msec, flip angle = 7, 240 slices, no gap, voxel size =1.0 x 1.0 x 1.0 mm, FOV = 256 mm). DTI: 12 noncollinear directions, axial plane, dual spin echo, single-shot, pulsed-gradient, echo-planar imaging (EPI) sequence (TR = 12.5 sec, TE = 99 msec, 64 slices, no gap, voxel size = mm, FOV = 256 mm, 2 averages, b value = 1000 sec/mm2). Freesurfer longitudinal analysis suite (v 4.5.0) Diffusion Toolbox (FDT) from the FMRIB software library; FSL s Tract-Based Spatial Statistics (TBSS); SPM8

11 I. Region-of-interest analyses: Subcortical brain volumes and individual differences in reward responsivity as predictors of use and outcomes

12 Age-related Trends in the Typical Development of Executive Function High scores = Poor performance Best Transitioning into best performance when risk-taking is highest

13 The nucleus accumbens is a key node in the brain s reward system

14 BIS/BAS Behavioral Activation: Typical Development Behavior Volume of the L Nucleus Accumbens Adolescent increases in reward sensitivity (left) are paralleled by increases in left nucleus accumbens volume (right); both show a quadratic trend with peaks in late adolescence (ages 15-19) Urosevic, S.. Collins, P.F., Muetzel, R., & Luciana, M. (2012). Longitudinal changes in adolescentbehavioral approach system and behavioral inhibition system sensitivities: associations with OFC and nucleus accumbens volumes. Developmental Psychology. advance on-line publication: doi: /a

15 Behavioral Activation: Prediction of Substance Use Initiation 1. Baseline Predictors Left Nacc Volume, Wald s 2 (1) = 4.13, p =.042, OR =.985, 95% CI = Developmental predictors Increases in BAS Total, Wald s 2 (1) = 3.88, p =.049, OR = 1.34 Increases in BAS Reward Responsiveness, Wald s 2 (1) = 4.20, p =.040, OR = 2.59 No effects for BIS (Behavioral Inhibition System; threat sensitivity) Urosevic, S., Collins, P.F., Muetzel, R., Schissel, A.M., Lim, K.O. & Luciana, M. (2014). Effects of reward sensitivity and regional brain volumes on substance use initiation in adolescence. Social, Cognitive and Affective Neuroscience.

16 2. Alcohol Use and Structural Brain Development Luciana et al., (2013) Am J. of Drug and Alcohol Abuse, 39 (6) (NOV):

17 Analytic Strategy Comparison of developmental trajectories across a two-year span for Adolescents who have never used alcohol Adolescents who transition between baseline and follow-up into a regular pattern of alcohol use Regular pattern of use = more than one drink on more than one occasion per week

18 Two-year change in cortical thickness in non-users versus alcohol use initiators. Initiators have accelerated rates of loss of cortical thickness relative to non-users in the right middle frontal gyrus. This region important for WM and inhibitory control; expected that we would see pruning across normal development Accelerated tissue loss? A more mature brain? X=24, y=26, z=34; max t= 3.54

19 Two-year change in cortical white matter extent in non-users versus alcohol use initiators 4 broad clusters; t-values= 3.62 to 5.47 Non-users show greater increases in white matter volumes over time in the right hemisphere precentral gyrus, lingual gyrus, middle temporal gyrus, and anterior cingulate cortex relative to alcohol use initiators. Alcohol use initiation associated here with a blunting of white matter development.

20 Two-year change in fractional anisotropy in non-users versus alcohol use initiators Upper row: cluster peak near dorsal caudate in left hemisphere (x=-6, y=16, z=8; t=4.51). Lower row: cluster peak in mid-temporal/polar-temporal region of inferior fronto-occipital fasciculus in right hemisphere (x=32, y=0, z=-22 t=4.32).

21 What about patterns of drinking over time?

22 Change in Cortical Thickness and alcohol use frequency Clusterwise threshold p<.05, FWE using Monte Carlo Simulation

23 Change in cortical Thickness and Maximum drinks in 24 hours

24 3. Behavioral changes after alcohol use initiation

25 Could non-use of alcohol represent the more deviant pattern? Don t think so.

26 Self-reported changes in behavioral control (MPQ) p=.06

27 Importance of self-reported control Post-initiation MPQ Control is associated with: Frequency of alcohol use : Maximum drinks in a 24-hour period : r=0.23, p=.027 r=.22, p=.03 (partial corrs controlling for age, sex, baseline Control scores)

28 Also evidence that executive functions are altered with more problematic drinking patterns

29 Summary High levels of reward sensitivity are associated with substance use initiation; baseline integrity of the ventral striatum (Nacc) is also a predictor Deviations from the normative pattern of cortical brain development are apparent after alcohol use initiation These deviations are particularly pronounced for cortical thickness as a function of high frequency of drinking and amounts consumed

30 Longitudinal Cascade Increased Reward Sensitivity (BAS) Volumetric and functional integrity of Ventral striatum Increased Risk Taking (Substance Use Initiation) Changes in Cortical thickness and WM volume, connectivity Failures of Self- Monitoring/ Decreased Control Problematic Use: Substance Use frequency Using in large amounts Binge drinking

31 Acknowledgments Research Associates Paul Collins, Ph.D. Steve Malone, Ph.D. Snezana Urosevic, Ph.D. Ryan Muetzel, M.A. (now at Erasmus University) Graduate Students Ann Schissel Mary Petrosko Becker, M.A. Elizabeth Olson, Ph.D. Dustin Wahlstrom, Ph.D. Jim Porter, Ph.D. Catalina Hooper, Ph.D. Collaborators Tonya White, M.D. (now at Erasmus University, the Netherlands) Kelvin O. Lim, M.D. (U of MN Dept of Psychiatry) Bill Iacono, Ph.D. (U of MN, Psychology) This work was supported by the U of MN s Center for Neurobehavioral Development, by NIDA (grant DA017843), and by NIAAA (AA ), by BTRC grants awarded to the Center for Magnetic Resonance Research, P41 RR008079, P41 EB015894, and 1P30 NS as well as by the Minnesota Supercomputing Institute.

MRI DATA PROCESSING. Compiled by: Nicolas F. Lori and Carlos Ferreira. Introduction

MRI DATA PROCESSING. Compiled by: Nicolas F. Lori and Carlos Ferreira. Introduction MRI DATA PROCESSING Compiled by: Nicolas F. Lori and Carlos Ferreira Introduction Magnetic Resonance Imaging (MRI) is a clinical exam that is safe to the patient. Nevertheless, it s very important to attend

More information

GE Medical Systems Training in Partnership. Module 8: IQ: Acquisition Time

GE Medical Systems Training in Partnership. Module 8: IQ: Acquisition Time Module 8: IQ: Acquisition Time IQ : Acquisition Time Objectives...Describe types of data acquisition modes....compute acquisition times for 2D and 3D scans. 2D Acquisitions The 2D mode acquires and reconstructs

More information

Youth Drug Abuse and Addiction

Youth Drug Abuse and Addiction Youth Drug Abuse and Addiction Ken Winters, Ph.D. Dept. of Psychiatry, U. of Minnesota winte001@umn.edu Summit on Prescription Drug Abuse in Georgia March 2, 2011 1. Epidemiology of Rx Abuse by Youth 4.

More information

The Developing Brain, Adolescence and Vulnerability to Drug Abuse

The Developing Brain, Adolescence and Vulnerability to Drug Abuse Welcome. This presentation is for you to read and to use in your prevention work. We hope you will review it, learn from it and feel comfortable using it in presentations to colleagues that work in prevention,

More information

Structural Brain Changes in remitted Major Depression

Structural Brain Changes in remitted Major Depression Structural Brain Changes in remitted Major Depression Andreas Berger unter der Anleitung von Assoc.Prof. Priv.Doz. Dr. Lukas Pezawas Universitätsklinik für Psychiatrie und Psychotherapie Medizinische Universität

More information

Diffusione e perfusione in risonanza magnetica. E. Pagani, M. Filippi

Diffusione e perfusione in risonanza magnetica. E. Pagani, M. Filippi Diffusione e perfusione in risonanza magnetica E. Pagani, M. Filippi DW-MRI DIFFUSION-WEIGHTED MRI Principles Diffusion results from a microspic random motion known as Brownian motion THE RANDOM WALK How

More information

Learning with Your Brain. Teaching With the Brain in Mind

Learning with Your Brain. Teaching With the Brain in Mind Learning with Your Brain Should what (and how) we teach be associated with what we know about the brain and the nervous system? Jonathan Karp, Ph.D. Dept of Biology 5/20/2004 Teaching With the Brain in

More information

Charles A. Nelson III Children s Hospital Boston/Harvard Medical School Harvard Center on the Developing Child

Charles A. Nelson III Children s Hospital Boston/Harvard Medical School Harvard Center on the Developing Child Charles A. Nelson III Children s Hospital Boston/Harvard Medical School Harvard Center on the Developing Child Presented at NICHD Cognition Workshop, 14-15 March 2011, Bethesda, MD Outline I. Declaration

More information

32-Channel Head Coil Imaging at 3T

32-Channel Head Coil Imaging at 3T 32-Channel Head Coil Imaging at 3T Thomas Benner Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA

More information

Individual Differences in Susceptibility to Investment Fraud! Brian Knutson Stanford University"

Individual Differences in Susceptibility to Investment Fraud! Brian Knutson Stanford University Individual Differences in Susceptibility to Investment Fraud Brian Knutson Stanford University" Gregory Samanez-Larkin" Yale University" April 2014 RESEARCH ON FRAUD SUSCEPTIBILITY 04/2014 1 Overview"

More information

Effects of Achievement Goals on Challenge Seeking and Feedback Processing: Behavioral and fmri Evidence

Effects of Achievement Goals on Challenge Seeking and Feedback Processing: Behavioral and fmri Evidence on Challenge Seeking and Feedback Processing: Behavioral and fmri Evidence Woogul Lee, Sung-il Kim* Department of Education and bmri (Brain and Motivation Research Institute), Korea University, Seoul,

More information

NEURO M203 & BIOMED M263 WINTER 2014

NEURO M203 & BIOMED M263 WINTER 2014 NEURO M203 & BIOMED M263 WINTER 2014 MRI Lab 1: Structural and Functional Anatomy During today s lab, you will work with and view the structural and functional imaging data collected from the scanning

More information

LONI De-Identification Policy

LONI De-Identification Policy The following defines how different file formats are de-identified with LONI tools. Each metadata attribute of each file can have the following operations performed: Operation keep Remove Replace Description

More information

Alcohol and Other Drug Use and Adolescent Brain Development

Alcohol and Other Drug Use and Adolescent Brain Development Alcohol and Other Drug Use and Adolescent Brain Development Ken Winters, Ph.D. Department of Psychiatry University of Minnesota winte001@umn.edu Prevention, Law Enforcement and Coalitions: Developing Lasting

More information

Alcohol Overuse and Abuse

Alcohol Overuse and Abuse Alcohol Overuse and Abuse ACLI Medical Section CME Meeting February 23, 2015 Daniel Z. Lieberman, MD Professor and Vice Chair Department of Psychiatry George Washington University Alcohol OVERVIEW Definitions

More information

Myelinization. THOMAS P. NAIDICH, MD FACR Mt. Sinai Medical Center New York, NY USA

Myelinization. THOMAS P. NAIDICH, MD FACR Mt. Sinai Medical Center New York, NY USA Myelinization THOMAS P. NAIDICH, MD FACR Mt. Sinai Medical Center New York, NY USA ALTERS BRAIN WATER LOCALLY MYELIN CONTAINS: GLYCOLIPIDS PHOSPHOLIPIDS & CHOLESTEROL Maturation of the White Matter Maturation

More information

SITE IMAGING MANUAL ACRIN 6698

SITE IMAGING MANUAL ACRIN 6698 SITE IMAGING MANUAL ACRIN 6698 Diffusion Weighted MR Imaging Biomarkers for Assessment of Breast Cancer Response to Neoadjuvant Treatment: A sub-study of the I-SPY 2 TRIAL Version: 1.0 Date: May 28, 2012

More information

runl I IUI%I/\L Magnetic Resonance Imaging

runl I IUI%I/\L Magnetic Resonance Imaging runl I IUI%I/\L Magnetic Resonance Imaging SECOND EDITION Scott A. HuetteS Brain Imaging and Analysis Center, Duke University Allen W. Song Brain Imaging and Analysis Center, Duke University Gregory McCarthy

More information

MEDIMAGE A Multimedia Database Management System for Alzheimer s Disease Patients

MEDIMAGE A Multimedia Database Management System for Alzheimer s Disease Patients MEDIMAGE A Multimedia Database Management System for Alzheimer s Disease Patients Peter L. Stanchev 1, Farshad Fotouhi 2 1 Kettering University, Flint, Michigan, 48504 USA pstanche@kettering.edu http://www.kettering.edu/~pstanche

More information

5 Factors Affecting the Signal-to-Noise Ratio

5 Factors Affecting the Signal-to-Noise Ratio 5 Factors Affecting the Signal-to-Noise Ratio 29 5 Factors Affecting the Signal-to-Noise Ratio In the preceding chapters we have learned how an MR signal is generated and how the collected signal is processed

More information

Characterizing Structural Neural Networks

Characterizing Structural Neural Networks Characterizing Structural Neural Networks In Major Depressive Disorder using Diffusion Tensor Imaging A Dissertation Presented to The Academic Faculty by Ki Sueng Choi In Partial Fulfillment of the Requirements

More information

Subjects: Fourteen Princeton undergraduate and graduate students were recruited to

Subjects: Fourteen Princeton undergraduate and graduate students were recruited to Supplementary Methods Subjects: Fourteen Princeton undergraduate and graduate students were recruited to participate in the study, including 9 females and 5 males. The mean age was 21.4 years, with standard

More information

ADOLESCENT BRAIN DEVELOPMENT: IMPLICATIONS FOR DRUG USE PREVENTION. Jessie Breyer, B.A. & Ken C. Winters, Ph.D. Center for Substance Abuse Research

ADOLESCENT BRAIN DEVELOPMENT: IMPLICATIONS FOR DRUG USE PREVENTION. Jessie Breyer, B.A. & Ken C. Winters, Ph.D. Center for Substance Abuse Research ADOLESCENT BRAIN DEVELOPMENT: IMPLICATIONS FOR DRUG USE PREVENTION Jessie Breyer, B.A. & Ken C. Winters, Ph.D. Center for Substance Abuse Research Department of Psychiatry, University of Minnesota & Mentor

More information

3/30/2013. Disclosure. Advanced Neuro MRI: Imaging Techniques and Protocol Optimization. MRI, 35 year ago. MRI Today. Outlines

3/30/2013. Disclosure. Advanced Neuro MRI: Imaging Techniques and Protocol Optimization. MRI, 35 year ago. MRI Today. Outlines http://www.magnet.fsu.edu Disclosure Advanced Neuro MRI: Imaging Techniques and Protocol Optimization Research funding provided by Siemens Healthcare. Chen Lin, PhD DABR Indiana University School of Medicine

More information

The Teen Brain: Still Under ConStrUCtion NATIONAL INSTITUTE OF MENTAL HEALTH

The Teen Brain: Still Under ConStrUCtion NATIONAL INSTITUTE OF MENTAL HEALTH The Teen Brain: Still Under ConStrUCtion NATIONAL INSTITUTE OF MENTAL HEALTH One of the ways that scientists have searched for the causes of mental illness is by studying the development of the brain from

More information

What is Adolescence? Three Developmental Tasks. What is the science behind the teen brain? Rollercoaster Highs: Substance Abuse and Adolescence

What is Adolescence? Three Developmental Tasks. What is the science behind the teen brain? Rollercoaster Highs: Substance Abuse and Adolescence Rollercoaster Highs: Substance Abuse and Adolescence Naomi Weinstein, MPH Center on Addiction and the Family Phoenix House 646-505-2061 nweinstein@phoenixhouse.org What is Adolescence? Period of time between

More information

Musculoskeletal MRI Technical Considerations

Musculoskeletal MRI Technical Considerations Musculoskeletal MRI Technical Considerations Garry E. Gold, M.D. Professor of Radiology, Bioengineering and Orthopaedic Surgery Stanford University Outline Joint Structure Image Contrast Protocols: 3.0T

More information

NEUROPHARMACOLOGY AND ADDICTION CHRISTOPHER M. JONES, PHARMD, MPH

NEUROPHARMACOLOGY AND ADDICTION CHRISTOPHER M. JONES, PHARMD, MPH NEUROPHARMACOLOGY AND ADDICTION CHRISTOPHER M. JONES, PHARMD, MPH Disclosures This presentation does not represent the views of the US Public Health Service or the US Food and Drug Administration The majority

More information

Brain Damage & Recovery: The Resilience of the Brain, Addiction Impact & Therapeutic Repair. Michael Fishman, MD Director of Young Adult Program

Brain Damage & Recovery: The Resilience of the Brain, Addiction Impact & Therapeutic Repair. Michael Fishman, MD Director of Young Adult Program Brain Damage & Recovery: The Resilience of the Brain, Addiction Impact & Therapeutic Repair Michael Fishman, MD Director of Young Adult Program How Addiction Takes Hold Large & rapid upsurges in dopamine

More information

Aberrant Frontal and Temporal Complex Network Structure in Schizophrenia: A Graph Theoretical Analysis

Aberrant Frontal and Temporal Complex Network Structure in Schizophrenia: A Graph Theoretical Analysis The Journal of Neuroscience, November 24, 2010 30(47):15915 15926 15915 Behavioral/Systems/Cognitive Aberrant Frontal and Temporal Complex Network Structure in Schizophrenia: A Graph Theoretical Analysis

More information

Youth and Drug Abuse

Youth and Drug Abuse Youth and Drug Abuse Eric F. Wagner, Ph.D. Florida International University United Nations Expert Group Meeting World Programme of Action for Youth 19-21 May 2008 Frequency of Alcohol Use and Drinking

More information

NeuroImage: Clinical xxx (2014) xxx xxx. Contents lists available at ScienceDirect. NeuroImage: Clinical

NeuroImage: Clinical xxx (2014) xxx xxx. Contents lists available at ScienceDirect. NeuroImage: Clinical YNICL-00299; No. of pages: 17; 4C: NeuroImage: Clinical xxx (2014) xxx xxx Contents lists available at ScienceDirect NeuroImage: Clinical journal homepage: www.elsevier.com/locate/ynicl 1 Review 2 The

More information

2. MATERIALS AND METHODS

2. MATERIALS AND METHODS Difficulties of T1 brain MRI segmentation techniques M S. Atkins *a, K. Siu a, B. Law a, J. Orchard a, W. Rosenbaum a a School of Computing Science, Simon Fraser University ABSTRACT This paper looks at

More information

Neurobiology of Depression in Relation to ECT. PJ Cowen Department of Psychiatry, University of Oxford

Neurobiology of Depression in Relation to ECT. PJ Cowen Department of Psychiatry, University of Oxford Neurobiology of Depression in Relation to ECT PJ Cowen Department of Psychiatry, University of Oxford Causes of Depression Genetic Childhood experience Life Events (particularly losses) Life Difficulties

More information

Current Industry Neuroimaging Experience in Clinical Trials Jerome Barakos, M.D.

Current Industry Neuroimaging Experience in Clinical Trials Jerome Barakos, M.D. Current Industry Neuroimaging Experience in Clinical Trials Jerome Barakos, M.D. Melbourne Australia March 28, 2012 Synarc Experience and Expertise Largest imaging service provider dedicated to clinical

More information

The Teen Brain. What s Going on in There? Sion Kim Harris, PhD. Boston Children s Hospital Harvard Medical School

The Teen Brain. What s Going on in There? Sion Kim Harris, PhD. Boston Children s Hospital Harvard Medical School The Teen Brain What s Going on in There? Sion Kim Harris, PhD Boston Children s Hospital Harvard Medical School Center for Adolescent Substance Abuse Research www.ceasar-boston.org Leading Causes of Mortality,

More information

Medicinal Marijuana and the Developing Adolescent Brain

Medicinal Marijuana and the Developing Adolescent Brain Medicinal Marijuana and the Developing Adolescent Brain John R. Knight, MD Associate Professor of Pediatrics Harvard Medical School Associate in Medicine & Psychiatry Children s Hospital Chair in Developmental

More information

University of California San Francisco, CA, USA 4 Department of Veterans Affairs Medical Center, San Francisco, CA, USA

University of California San Francisco, CA, USA 4 Department of Veterans Affairs Medical Center, San Francisco, CA, USA Disrupted Brain Connectivity in Alzheimer s Disease: Effects of Network Thresholding Madelaine Daianu 1, Emily L. Dennis 1, Neda Jahanshad 1, Talia M. Nir 1, Arthur W. Toga 1, Clifford R. Jack, Jr. 2,

More information

MDCT Technology. Kalpana M. Kanal, Ph.D., DABR Assistant Professor Department of Radiology University of Washington Seattle, Washington

MDCT Technology. Kalpana M. Kanal, Ph.D., DABR Assistant Professor Department of Radiology University of Washington Seattle, Washington MDCT Technology Kalpana M. Kanal, Ph.D., DABR Assistant Professor Department of Radiology University of Washington Seattle, Washington ACMP Annual Meeting 2008 - Seattle, WA Educational Objectives Historical

More information

Supplemental Information: Structure of Orbitofrontal Cortex Predicts Social Influence

Supplemental Information: Structure of Orbitofrontal Cortex Predicts Social Influence 1 Supplemental Information: Structure of Orbitofrontal Cortex Predicts Social Influence Daniel K Campbell Meiklejohn, Ryota Kanai, Bahador Bahrami, Dominik R Bach, Raymond J Dolan, Andreas Roepstorff &

More information

Software Packages The following data analysis software packages will be showcased:

Software Packages The following data analysis software packages will be showcased: Analyze This! Practicalities of fmri and Diffusion Data Analysis Data Download Instructions Weekday Educational Course, ISMRM 23 rd Annual Meeting and Exhibition Tuesday 2 nd June 2015, 10:00-12:00, Room

More information

12 Steps to Changing Neuropathways. Julie Denton

12 Steps to Changing Neuropathways. Julie Denton 12 Steps to Changing Neuropathways Julie Denton Review the neurobiology of the brain Understand the basics of neurological damage to the brain from addiction Understand how medications and psychotherapy

More information

The latest in addiction medicine: What every nurse needs to know

The latest in addiction medicine: What every nurse needs to know CNA Webinar Series: Progress in Practice The latest in addiction medicine: What every nurse needs to know Monica Gregory Nurse Practitioner, Crosstown Clinic December 4, 2014 Canadian Nurses Association,

More information

5/28/2015. Medhat Bassiony Samar Abdelgayed Usama M. Youssef

5/28/2015. Medhat Bassiony Samar Abdelgayed Usama M. Youssef Medhat Bassiony Samar Abdelgayed Usama M. Youssef The adolescent is biased by functionally mature subcortical relative to less mature cortical circuitry. With development, the functional connectivity between

More information

Risk Taking in Adolescence

Risk Taking in Adolescence CURRENT DIRECTIONS IN PSYCHOLOGICAL SCIENCE Risk Taking in Adolescence New Perspectives From Brain and Behavioral Science Laurence Steinberg Temple University ABSTRACT Trying to understand why adolescents

More information

NeuroVault and the vision for data sharing in neuroimaging. Chris Gorgolewski Max Planck Research Group: Neuroanatomy & Connectivity Leipzig, Germany

NeuroVault and the vision for data sharing in neuroimaging. Chris Gorgolewski Max Planck Research Group: Neuroanatomy & Connectivity Leipzig, Germany NeuroVault and the vision for data sharing in neuroimaging Chris Gorgolewski Max Planck Research Group: Neuroanatomy & Connectivity Leipzig, Germany Data sharing? Data sharing? Ok, ok so we should share

More information

Etude POPART'MUS MRI Component

Etude POPART'MUS MRI Component TECHNICAL SURVEY Dear Investigators, This document is a Technical Survey which provides the teams of THERALYS and of the Pierre Wertheimer Neurological Hospital of Lyon with an overview of your site s

More information

GE Medical Systems Training in Partnership. Module 12: Spin Echo

GE Medical Systems Training in Partnership. Module 12: Spin Echo Module : Spin Echo Spin Echo Objectives Review the SE PSD. Review the concepts of T, T, and T*. Spin Echo PSD RF Gz Gy 90 80 Gx Spin Echo - SE Spin echo is a standard pulse sequence on Signa MRi/LX and

More information

7 The use of fmri. to detect neural responses to cognitive tasks: is there confounding by task related changes in heart rate?

7 The use of fmri. to detect neural responses to cognitive tasks: is there confounding by task related changes in heart rate? 7 The use of fmri to detect neural responses to cognitive tasks: is there confounding by task related changes in heart rate? This chapter is submitted as: D. van t Ent, A. den Braber, E. Rotgans, E.J.C.

More information

American Society of Addiction Medicine

American Society of Addiction Medicine American Society of Addiction Medicine Public Policy Statement: Definition of Addiction (Long Version) Addiction is a primary, chronic disease of brain reward, motivation, memory and related circuitry.

More information

Chapter Fourteen. Emotion, Reward, Aggression, and Stress

Chapter Fourteen. Emotion, Reward, Aggression, and Stress Chapter Fourteen Emotion, Reward, Aggression, and Stress EMOTIONS! Emotions generally include a Physical component, and a Subjective component or quality, and a Valence Emotions a product of Evolution?

More information

Alcohol and the Adolescent Brain. Ruth Bowles. BS, CPP Executive Director The Rockland Council on Alcoholism and other Drug Dependence, Inc.

Alcohol and the Adolescent Brain. Ruth Bowles. BS, CPP Executive Director The Rockland Council on Alcoholism and other Drug Dependence, Inc. Alcohol and the Adolescent Brain Ruth Bowles. BS, CPP Executive Director The Rockland Council on Alcoholism and other Drug Dependence, Inc. Freedom is that instant between when someone tells you to do

More information

Prevention & Recovery Conference November 28, 29 & 30 Norman, Ok

Prevention & Recovery Conference November 28, 29 & 30 Norman, Ok Prevention & Recovery Conference November 28, 29 & 30 Norman, Ok What is Addiction? The American Society of Addiction Medicine (ASAM) released on August 15, 2011 their latest definition of addiction:

More information

Mani Pavuluri MD PhD Professor and Director Pediatric Brain Research and Intervention Center Berger-Colbeth Endowed Chair in Child Psychiatry

Mani Pavuluri MD PhD Professor and Director Pediatric Brain Research and Intervention Center Berger-Colbeth Endowed Chair in Child Psychiatry Mani Pavuluri MD PhD Professor and Director Pediatric Brain Research and Intervention Center Berger-Colbeth Endowed Chair in Child Psychiatry Focus of the Talk fmri Activity Studies fmri Treatment Studies

More information

FASD in Context: Substance Abuse Treatment. Minnesota Organization on Fetal Alcohol Syndrome (MOFAS) Fetal Alcohol Spectrum Disorders (FASD)

FASD in Context: Substance Abuse Treatment. Minnesota Organization on Fetal Alcohol Syndrome (MOFAS) Fetal Alcohol Spectrum Disorders (FASD) Minnesota Organization on Fetal Alcohol (MOFAS) Our mission is to eliminate disability caused by alcohol consumption during pregnancy and to improve the quality of life for those living with Fetal Alcohol

More information

Your Brain on Google: Patterns of Cerebral Activation during Internet Searching

Your Brain on Google: Patterns of Cerebral Activation during Internet Searching REGULAR RESEARCH ARTICLES Your Brain on Google: Patterns of Cerebral Activation during Internet Searching Gary W. Small, M.D., Teena D. Moody, Ph.D., Prabha Siddarth, Ph.D., Susan Y. Bookheimer, Ph.D.

More information

Medical Image Processing on the GPU. Past, Present and Future. Anders Eklund, PhD Virginia Tech Carilion Research Institute andek@vtc.vt.

Medical Image Processing on the GPU. Past, Present and Future. Anders Eklund, PhD Virginia Tech Carilion Research Institute andek@vtc.vt. Medical Image Processing on the GPU Past, Present and Future Anders Eklund, PhD Virginia Tech Carilion Research Institute andek@vtc.vt.edu Outline Motivation why do we need GPUs? Past - how was GPU programming

More information

The relationship among alcohol use, related problems, and symptoms of psychological distress: Gender as a moderator in a college sample

The relationship among alcohol use, related problems, and symptoms of psychological distress: Gender as a moderator in a college sample Addictive Behaviors 29 (2004) 843 848 The relationship among alcohol use, related problems, and symptoms of psychological distress: Gender as a moderator in a college sample Irene Markman Geisner*, Mary

More information

Update: MRI in Multiple sclerosis

Update: MRI in Multiple sclerosis Nyt indenfor MS ved MR Update: MRI in Multiple sclerosis Hartwig Roman Siebner Danish Research Centre for Magnetic Resonance (DRCMR) Copenhagen University Hospital Hvidovre Dansk Radiologisk Selskabs 10.

More information

Activation neuroimaging studies - GABA receptor function - alcohol cues in alcoholism

Activation neuroimaging studies - GABA receptor function - alcohol cues in alcoholism Activation neuroimaging studies - GABA receptor function A - alcohol cues in alcoholism Professor David Nutt Psychopharmacology Unit, University of Bristol. MRC Clinical Sciences Centre, London. Study

More information

GE 3.0T NPW,TRF,FAST,F R NPW,TRF,FAST,F R

GE 3.0T NPW,TRF,FAST,F R NPW,TRF,FAST,F R GE 3.0T 3.0T WRIST Invivo 8CH Wrist Coil Sequence Ax T2 Cor PD Cor PDFS Cor T1 Cor PD (Small FOV) FOV (mm) 80 80 80 80 40 Matrix 384x224 384x256 320x256 384x320 320x192 Phase Direction RL RL RL RL RL #

More information

Education and the Brain: A Bridge Too Far John T. Bruer. Key Concept: the Human Brain and Learning

Education and the Brain: A Bridge Too Far John T. Bruer. Key Concept: the Human Brain and Learning Education and the Brain: A Bridge Too Far John T. Bruer Key Concept: the Human Brain and Learning John T. Bruer Scholar in cognitivist approaches to human learning and instruction. His argument refers

More information

Development of Chemical Dependency in Adolescents & Young Adults. How to recognize the symptoms, the impact on families, and early recovery

Development of Chemical Dependency in Adolescents & Young Adults. How to recognize the symptoms, the impact on families, and early recovery Development of Chemical Dependency in Adolescents & Young Adults How to recognize the symptoms, the impact on families, and early recovery Tim Portinga, PsyD, LP, Mental Health Clinic Supervisor Tim Portinga

More information

Toshiba Excelart Vantage 1.5T MRI Tech Specs (Technical Specifications)

Toshiba Excelart Vantage 1.5T MRI Tech Specs (Technical Specifications) Toshiba Excelart Vantage 1.5T MRI Tech Specs (Technical Specifications) Excelart Vantage Magnet Configuration: Ultra-short-bore Strength (or W x H): 1.5 T Homogeneity, ppm V-RMS: Dimensions of maximum

More information

From Neurons to Neighborhoods: The Science of Early Childhood Development

From Neurons to Neighborhoods: The Science of Early Childhood Development From Neurons to Neighborhoods: The Science of Early Childhood Development By Jack P. Shonkoff, MD This chapter explains the work of the Committee on Integrating the Science of Early Childhood Development

More information

12-Step Recovery - Making Sense of Adolescent Neuropsychosis

12-Step Recovery - Making Sense of Adolescent Neuropsychosis NEUROPSYCHOLOGICAL EDUCATION AND THE 12 STEPS: RECLAIMING A VIABLE RECOVERY OPTION FOR ADOLESCENTS MAP Challenges to 12 Step Recovery History of 12 Step Recovery Overview of the 12 Steps Alternatives to

More information

Oregon Association of Vocational Special Needs Personnel

Oregon Association of Vocational Special Needs Personnel Oregon Association of Vocational Special Needs Personnel Brain Development and Traumainformed Services for Emerging Adults Hood River, OR February 21, 2015 2015 Conference: Making Connections Julie M.

More information

An fmri study on reading Hangul and Chinese Characters by Korean Native Speakers

An fmri study on reading Hangul and Chinese Characters by Korean Native Speakers 언 어 치 료 연 구, 제14 권 제4호 Journal of Speech & Hearing Disorders 2005, Vol.14, No.4, 29 ~ 36 An fmri study on reading Hangul and Chinese Characters by Korean Native Speakers Hyo-Woon Yoon(Brain Science Research

More information

UCLA Screening and Brief Intervention Training

UCLA Screening and Brief Intervention Training UCLA Screening and Brief Intervention Training For Alcohol Reduction or Cessation Client Centered Care Western Regional Training Center on Fetal Alcohol Spectrum Disorders Materials provided through funding

More information

AMPHETAMINE AND COCAINE MECHANISMS AND HAZARDS

AMPHETAMINE AND COCAINE MECHANISMS AND HAZARDS AMPHETAMINE AND COCAINE MECHANISMS AND HAZARDS BARRY J. EVERITT Department of Experimental Psychology, University of Cambridge Stimulant drugs, such as cocaine and amphetamine, interact directly with dopamine

More information

Internal Medicine Residency, University of Colorado Health Sciences Center. Psychiatry Residency, University of California at San Francisco

Internal Medicine Residency, University of Colorado Health Sciences Center. Psychiatry Residency, University of California at San Francisco Internal Medicine Residency, University of Colorado Health Sciences Center Psychiatry Residency, University of California at San Francisco Addiction Psychiatry Fellowship, University of New Mexico E-mail:

More information

Marijuana: What Does Science Tell Us?

Marijuana: What Does Science Tell Us? Marijuana: What Does Science Tell Us? Jack B. Stein, Ph.D. Director Office of Science Policy and Communications Secretaries Innovation Group November 17, 2015 State Marijuana Policies State Laws related

More information

Novel Pharmacological Treatments for Gambling Addiction Brian L. Odlaug, MPH

Novel Pharmacological Treatments for Gambling Addiction Brian L. Odlaug, MPH Novel Pharmacological Treatments for Gambling Addiction Brian L. Odlaug, MPH Department of Public Health, Faculty of Health & Medical Sciences, University of Copenhagen, Denmark Disclosure Information

More information

Objectives. Cortical thickness over time. Cortical thickness over time. ADHD neurobiology

Objectives. Cortical thickness over time. Cortical thickness over time. ADHD neurobiology The Neuroscience of Attention Deficit Hyperactivity Disorder: Implications for Treatment Steven R., M.D. Professor and Chief Division of Child and Adolescent Psychiatry UTHSCSA Source Purdue Disclosures

More information

New findings on Borderline Personality Disorder : a research update. Associate Professor Brin Grenyer University of Wollongong grenyer@uow.edu.

New findings on Borderline Personality Disorder : a research update. Associate Professor Brin Grenyer University of Wollongong grenyer@uow.edu. New findings on Borderline Personality Disorder : a research update Associate Professor Brin Grenyer University of Wollongong grenyer@uow.edu.au 1 Today What is new - hot topics and studies 2008-9 Current

More information

Why Study Psychology at The University of Western Ontario?

Why Study Psychology at The University of Western Ontario? Why Study Psychology at The University of Western Ontario? The Psychology Department at Western has over 50 faculty members representing seven Areas of Research Excellence. They work with talented graduate

More information

EPIDEMIC 4.6 % OF INDIVIDUALS 18 25 USED PAIN RELIEVERS FOR NON-MEDICAL REASONS. 1.5 MILLION YOUNG ADULTS USED PAIN RELIEVERS IN THE PAST MONTH.

EPIDEMIC 4.6 % OF INDIVIDUALS 18 25 USED PAIN RELIEVERS FOR NON-MEDICAL REASONS. 1.5 MILLION YOUNG ADULTS USED PAIN RELIEVERS IN THE PAST MONTH. Drug Court EPIDEMIC In the 10 years (1997 2007) the per capita retail purchases of Methadone, Hydrocodone and Oxycodone in the United States increased 13-fold, 4-fold and 9-fold, respectively. 4.6 % OF

More information

Underage Drinking. Underage Drinking Statistics

Underage Drinking. Underage Drinking Statistics Underage Drinking Underage drinking is a serious public health problem in the United States. Alcohol is the most widely used substance of abuse among America s youth, and drinking by young people poses

More information

jptrujillo88@hotmail.com 2005 2009 Tulsa Community College (Associate of Arts -Psychology)

jptrujillo88@hotmail.com 2005 2009 Tulsa Community College (Associate of Arts -Psychology) Curriculum Vitae Personal Information Surname: Given Name: Trujillo James Paul Address: Paulinastraat 62 Postal code, city and country: Email: 2595GK, Den Haag, NL jptrujillo88@hotmail.com Date of birth:

More information

Vocabulary & General Concepts of Brain Organization

Vocabulary & General Concepts of Brain Organization Vocabulary & General Concepts of Brain Organization Jeanette J. Norden, Ph.D. Professor Emerita Vanderbilt University School of Medicine Course Outline Lecture 1: Vocabulary & General Concepts of Brain

More information

ParaVision 6. Innovation with Integrity. The Next Generation of MR Acquisition and Processing for Preclinical and Material Research.

ParaVision 6. Innovation with Integrity. The Next Generation of MR Acquisition and Processing for Preclinical and Material Research. ParaVision 6 The Next Generation of MR Acquisition and Processing for Preclinical and Material Research Innovation with Integrity Preclinical MRI A new standard in Preclinical Imaging ParaVision sets a

More information

Drugs and Teens: Current Facts and Recent Trends. Agenda. Adolescent development

Drugs and Teens: Current Facts and Recent Trends. Agenda. Adolescent development Drugs and Teens: Current Facts and Recent Trends Cheryl Houtekamer Youth Addiction Services Calgary Agenda Adolescent Development Brain Development Adolescent Substance Use - Prevalence How does addiction

More information

Neurobiology of Reward and Addiction in the Vulnerable Brain. Alan I. Green, M.D. May 1, 2009

Neurobiology of Reward and Addiction in the Vulnerable Brain. Alan I. Green, M.D. May 1, 2009 Neurobiology of Reward and Addiction in the Vulnerable Brain Alan I. Green, M.D. May 1, 2009 DSM-IV Substance Abuse Maladaptive pattern of substance use leading to significant impairment distress, as indicated

More information

MGH Adult Diffusion Data Scanning Protocols

MGH Adult Diffusion Data Scanning Protocols MGH Adult Diffusion Data Scanning Protocols Structural scans SIEMENS MAGNETOM ConnectomA syngo MR D11 \\USER\INVESTIGATORS\Default\AAHScout_64 TA:0:14 PAT:3 Voxel size:1.6 1.6 1.6 mm Rel. SNR:1.00 :fl

More information

Neuroscience/Psychology M 272 Key Terms & Acronyms

Neuroscience/Psychology M 272 Key Terms & Acronyms http://www.loni.ucla.edu/ccb/training/courses/ns172_2006.shtml I. Basic Terminology 1. LONI Laboratory of Neuro Imaging (www.loni.ucla.edu) 2. CCB Center for Computational Biology (www.ccb.ucla.edu) 3.

More information

Internet and Gaming Addiction: A Systematic Literature Review of Neuroimaging Studies

Internet and Gaming Addiction: A Systematic Literature Review of Neuroimaging Studies Brain Sci. 2012, 2, 347-374; doi:10.3390/brainsci2030347 Review OPEN ACCESS brain sciences ISSN 2076-3425 www.mdpi.com/journal/brainsci/ Internet and Gaming Addiction: A Systematic Literature Review of

More information

Fall 2013 to present Assistant Professor, Department of Psychological and Brain Sciences, Johns Hopkins University

Fall 2013 to present Assistant Professor, Department of Psychological and Brain Sciences, Johns Hopkins University M A R I N A B E D N Y Johns Hopkins University Department of Psychological and Brain Sciences 3400 N. Charles Street, Ames Hall Baltimore, MD 21218 mbedny@mit.edu ACADEMIC POSITIONS Fall 2013 to present

More information

Mapping Brain Changes Over Time during Development: Challenges, Limits and Potential

Mapping Brain Changes Over Time during Development: Challenges, Limits and Potential Mapping Brain Changes Over Time during Development: Challenges, Limits and Potential Guido Gerig University of Utah Scientific Computing and Imaging (SCI) Institute Gerig 09-2008 Outline 1. Imaging Technology

More information

Chapter 3 The Anatomy of the Nervous System

Chapter 3 The Anatomy of the Nervous System Chapter 3 The Anatomy of the Nervous System Systems, Structures, and Cells That Make Up Your Nervous System 1 General Layout of the Nervous System Central Nervous System (CNS) Brain (in the skull) Spinal

More information

Effects of Distance to Treatment and Treatment Type on Alcoholics Anonymous Attendance and Subsequent Alcohol Consumption. Presenter Disclosure

Effects of Distance to Treatment and Treatment Type on Alcoholics Anonymous Attendance and Subsequent Alcohol Consumption. Presenter Disclosure Effects of Distance to Treatment and Treatment Type on Alcoholics Anonymous Attendance and Subsequent Alcohol Consumption Jamie L. Heisey, MA Katherine J. Karriker-Jaffe, PhD Jane Witbrodt, PhD Lee Ann

More information

Trends in Neuroscience and Education

Trends in Neuroscience and Education Trends in Neuroscience and Education ] (]]]]) ]]] ]]] Contents lists available at SciVerse ScienceDirect Trends in Neuroscience and Education journal homepage: www.elsevier.com/locate/tine The effects

More information

Ken C. Winters, Ph.D. Senior Scientist, Treatment Research Institute, Philadelphia, PA Professor, Department of Psychiatry, University of Minnesota

Ken C. Winters, Ph.D. Senior Scientist, Treatment Research Institute, Philadelphia, PA Professor, Department of Psychiatry, University of Minnesota Adolescent Brain Development and Drug Abuse Research indicates that brain development is still in progress during adolescence; immature brain regions may place teenagers at elevated risk to effects of

More information

COST AID ASL post- processing Workshop

COST AID ASL post- processing Workshop COST AID ASL post- processing Workshop This workshop runs thought the post- processing of ASL data using tools from the FMRIB Software Library (www.fmrib.ox.ac.uk.uk/fsl), we will primarily focus on the

More information

Processing Strategies for Real-Time Neurofeedback Using fmri

Processing Strategies for Real-Time Neurofeedback Using fmri Processing Strategies for Real-Time Neurofeedback Using fmri Jeremy Magland 1 Anna Rose Childress 2 1 Department of Radiology 2 Department of Psychiatry University of Pennsylvania School of Medicine MITACS-Fields

More information

Magnetic Resonance Imaging

Magnetic Resonance Imaging Magnetic Resonance Imaging What are the uses of MRI? To begin, not only are there a variety of scanning methodologies available, but there are also a variety of MRI methodologies available which provide

More information

Margaret Rosenbloom, M.A., Edith V. Sullivan, Ph.D., and Adolf Pfefferbaum, M.D.

Margaret Rosenbloom, M.A., Edith V. Sullivan, Ph.D., and Adolf Pfefferbaum, M.D. Using Magnetic Resonance Imaging and Diffusion Tensor Imaging to Assess Brain Damage in Alcoholics Margaret Rosenbloom, M.A., Edith V. Sullivan, Ph.D., and Adolf Pfefferbaum, M.D. Brain imaging using conventional

More information

Temporomandibular Joint Imaging Using CBCT: Technology Now Captures Reality!

Temporomandibular Joint Imaging Using CBCT: Technology Now Captures Reality! Temporomandibular Joint Imaging Using CBCT: Technology Now Captures Reality! Dale A. Miles BA, DDS, MS, FRCD (C) Diplomate, American Board of Oral and Maxillofacial Radiology Diplomate, American Board

More information

Alcohol and Brain Damage

Alcohol and Brain Damage Alcohol and Brain Damage By: James L. Holly, MD O God, that men should put an enemy in their mouths to steal away their brains! That we should, with joy, pleasance, revel, and applause, transform ourselves

More information

MRI SEQUENCES. 1 Gradient Echo Sequence

MRI SEQUENCES. 1 Gradient Echo Sequence 5 An MRI sequence is an ordered combination of RF and gradient pulses designed to acquire the data to form the image. In this chapter I will describe the basic gradient echo, spin echo and inversion recovery

More information