Effect of Electrical Stimulation on Bacterial Growth
|
|
- Justin Norris
- 8 years ago
- Views:
Transcription
1 Effct of Elctrical Stimulation on Bactrial Growth By Jrrold Ptrofsky Ph D Michal Laymon DPTSc* Wndy Chung DPTSc Klly Collins BS* Tin-Ning Yang BS* Dpts. of Physical Thrapy Loma Linda Univrsity Loma Linda, California and Azusa PACific Univrsity* Azusa California Snd rprint rqusts to: Dr. Jrrold Ptrofsky Profssor and Dirctor of Rsarch Dpartmnt of Physical Thrapy Loma Linda Univrsity Loma Linda California, (909) jptrofsky@llu.du
2 Abstract Background; Elctrical stimulation has bn usd as a modality for many yars for wound haling. On of th mchanisms proposd for why it works is that lctrical stimulation is blivd to b bactria static. Howvr, arly studis making this claim usd much gratr than normal stimulation voltags and currnts. Mthods and procdurs; In th prsnt invstigation, 3 typs of bactria, Eschrichia coli, Psudomonas aruginosa, and Staphylococcus aurus wr xamind with physiological lvls of AC (5 and 20 ma) and DC lctrical stimulation to s if ths sam currnts that travrs through tissu during normal lctrical stimulation for wound tratmnt could impair bactrial growth. Rsults; DC micro currnt did not altr bactria growth for any of th thr bactria studid. Psudomonas aruginosa showd significantly rducd growth with both (5 and 20 ma) AC currnt intnsitis (p<0.05) whras th othr bactria showd no consistnt rductions in growth with AC currnt; ach showing som snsitivity to AC stimulation. Whil thr wr significant diffrncs btwn th ph of th culturs with AC stimulation in th xprimntal vs. th control groups in som conditions, thr was no consistncy in any corrlation btwn ph and growth. Thus, whil psudomonas was inhibitd with AC stimulation, thr was no vidnc from ths studis that lctrical stimulation had a consistnt bactria static ffct on th othr bactria. Evn in psudomonas, bactria growth was only slowd and not stoppd with 30 minuts of stimulation. Conclusions; whil thr was som snsitivity at last in on bactrium to AC stimulation, largly th bactria static ffct of lctrical stimulation undr th conditions usd hr was d minimis. Ky words: wounds, lctrical stimulation, bactria, haling
3 Introduction Wound haling, spcially in popl with diabtic nuropathis, can b xtrmly difficult to accomplish. 1 For xampl, of popl who hav diabtic ulcrs on thir ft, inability of wounds to hal causs an avrag amputation rat to b about 25% 2,3. Many 2, 3, 4 diabtic ulcrs and vn dcubitus ulcrs can tak months, yars, or nvr hal at all. This inability of convntional mdical practic to hal wounds has bn trmd a failur of th halth car systm. 5 Evn nwr thrapis such as myocutanous flaps, watr dbridmnt, and othr tchniqus hav not incrasd th haling rat apprciably in th past fifty yars or th rat of roccurrnc. 5 On modality that has bn studid is lctrical stimulation. 6 Many paprs point to th us of lctrical stimulation across wounds to incras wound haling. 7, 8 Howvr, vn this tchnology dos not always work. Som paprs show wound haling with DC micro currnts whil othrs show only haling with strong AC currnts. 9, 10, 11 Som paprs rport that in th arly stags of wound haling th polarity nds to b positiv nar th wound and ngativ away from th wound and othr paprs rport th opposit. 12, 13, 14 In fact, in a summary of diffrnt studis on wound haling, Yarkony rportd nothing conclusiv in stting th intnsity of currnts, whthr it was DC or AC stimulation or th frquncy of lctrical stimulation in th ability of lctrical stimulation to hal wounds. 12 Rcnt vidnc, howvr, links this disparity to possibly bing linkd to room tmpratur. Vasoconstriction of th circulation during tratmnt du to a cool or cold xamination room blocks th blood flow incras du to lctrical stimulation of th wound. If th room is warmd, blood flow incrass and wounds hal 15, 16 wll with lctrical stimulation.
4 Numrous mchanisms hav bn suggstd on why lctrical stimulation promots wound haling including incrasd circulation, 1,17 18, 19, 20 incrasd angiognsis incrasd prolifration of pidrmal tissu, and a bactria static ffct of lctrical stimulation. 21 Th possibl bactria static ffct of lctrical stimulation was first rportd ovr 30 yars ago by Rowly & McKnna. 22, 23 Using high voltag lctrical stimulation (300 volts), bactria (E. coli) did aftr a brif sssion of lctrical stimulation. Whil a fw studis hav usd similar voltags for clinical lctrical stimulation of wounds 11, 24 most studis that rport haling us a fraction of ths voltags and currnts. 12, 13, 25, 17 Th stimulation voltags usd by Rowly t al. would b xtrmly painful for th patint. Furthr, sinc DC micro currnt has bn shown, in som studis, to aid in haling of wounds, whn th voltags usd by Rowly and collagus ar compard to DC micro currnts, thy ar thousands of tims highr. Thus, th currnts usd in ths studis wr not clinically rlvant and, thrfor, th application of ths studis to ral lif situations is qustionabl. Th prsnt invstigation was conductd to study th ffct of lctrical stimulation on bactrial growth in thr common bactria that ar sn in wounds, Eschrichia coli, Psudomonas aruginosa, and Staphylococcus Aurus. 23, 26 Ths bactria wr grown in cultur and thn xposd to ithr DC microcurrnt (100 µamps) or biphasic sin wav stimulation at 5 or 20 ma for 30 minuts. Ths currnts ar normal currnts usd in wound haling. 16, 15 Bactrial growth was thn assssd aftr 24 hours of incubation to s if th normal currnts that ar usd with lctrical stimulation clinically to hal wounds can altr bactrial growth.
5 Mthods Bactria- Bactria wr grown in a soy broth (tryptic soy broth, soyban- casin digst) from Hardy Diagnostics (Cat # C7141, Santa Monica, CA). Th bactria usd wr Eschrichia coli, Psudomonas aruginosa, and Staphylococcus aurus. Ths bactria wr obtaind from stock concntrations (Micro biologics, ST Cloud, Minnsota). Bactria wr grown in broth at a tmpratur of 37 o C until th concntration of bactria was btwn 4-5 on th McFarland Scal. 27 All bactria wr grown and tstd for activity by standard microbiological light microscopy. Th broth was tstd for growth in an absorption spctromtr at a wavlngth of 580 nanomtrs; th rlationship btwn bactrial dnsity and broth absorption was stablishd. Onc this was stablishd, stock broth culturs wr placd btwn two 2 X 2 cm carbonizd rubbr lctrods, so that thy could b subjctd to lctrical stimulation for a priod of thirty minuts. Th sparation distanc btwn th lctrods was 10.3cm. Th covrd cultur siz was 10.3 X 8.5 cm and 6.75 cm dp. Th volum was 400ml. Using ths lctrods and lctrod sizs, th impdanc of th broth was 1280 ohms during lctrical stimulation, a valv similar to that rcordd across wounds. 15 Th siz of th broth holdr was slctd so that if currnt was masurd ovr a 0.5 cm distanc in th broth, th rcordd currnt was 15, 16 similar to that rcordd in human wounds.
6 Elctrical Stimulation- AC lctrical stimulation was providd by a challng 8000 powrd muscl stimulator (MPTS Tustin, CA). This stimulator providd 4 channls of currnt controlld output with a biphasic sin wav at 250 µsc puls width and a frquncy of 30 Hz. DC stimulation was providd at a currnt of 1 ma by a battry with a rgulatd currnt controlld output. ph- Th ph was masurd with an Accrumnt Basic AB15 ph mtr (Fishr Scintific, Singapor).
7 Procdurs Using th stock broth bactrial culturs dscribd abov, ach of th 3 bactria wr placd in a bactrial broth in th rctangular culturs. Aftr th broth had bn culturd, lctrical stimulation was applid for thirty minuts. AC currnt was dlivrd with biphasic lctrical stimulation (sin wav) at a frquncy of 30 Hz and a puls width of 250 microsconds at intnsitis of ithr 5 or 20 ma for a priod of 30 minuts. Th stimulation output was currnt controlld. DC stimulation was also applid for 30 minuts. Th bactrial cultur along with culturs whr no stimulation was applid, wr thn placd back into th incubator for anothr 24 hours and growth was assssd. Th procss was rpatd on 8 culturs for ach bactrium. Statistical Analysis- Statistical analysis involvd th calculation of mans, standard dviations, and t tsts. Valus in th txt ar shown as th man+/-sd. Th lvl of significanc was p < 0.05.
8 Rsults Initially, th McFarland Scal was calculatd at a frquncy of 580 nanomtrs for ach of th bactria. Absorbncy at this frquncy was plottd against st concntrations of bactria to obtain a calibration curv. Th corrlation btwn th concntrations of bactria to th absorbncy was This yildd an R 2 of and, th quation rlatd concntration to absorbncy was Y = x. Givn th calibration on th McFarland Scal, broth was mixd and th studis wr compltd as dscribd undr procdurs. Th rsults for ach bactrium ar listd blow. Eschrichia coli - Th rsults showing growth in Eschrichia coli ar shown in figur 1, panl A and B. Panl A, in figur 1, shows th bactrial colony growth from th bginning to th nd of th study (24 hours aftr th initial incubation). As shown in panl A of figur 1, with a currnt of 5 milliamps, th incras in bactrial colony growth ovr 24 hours was 365 +/- 57 x 10 6 bactria pr millilitr whras for 20 milliamps stimulation th incras in growth was 366 +/- 16 x 10 6 bactria pr millilitr. For th controls, whr no stimulation was accomplishd, bactrial colony growth incrasd by 401 +/- 7.5 X 10 6 bactria pr millilitr ovr th 24 hours. Thr was no statistical diffrnc btwn growth in th 5 and 20 ma and control groups (p < 0.01). Bactrial colony growth for DC stimulation was 460 +/- 74 x 10 6 bactria pr millilitr. Th only significant growth rduction compard to th controls was for stimulation at 20 ma (p<0.01). Hr, howvr, th rduction in growth was only 9.8%.
9 ph was also masurd at th bginning and at th nd of studis. For th control bactria colonis (no stimulation) ph startd at / At th nd of th 24 hour priod, ph avragd /- 0.18, a rduction of an avrag of 1.22 ph units. For bactrial stimulation at 5 and 20 milliamps, thr was a significantly gratr rduction in ph ovr th 24 hours compard to th control colonis (p > 0.01). Th chang in ph was small, avraging 0.4 ph units. For DC stimulation, th chang in ph, ovr th 24 hour priod was not significantly diffrnt than that of th controls (p > 0.05). Thr was no corrlation for any group in ph and bactrial growth (p>0.05). Psudomonas aruginosa- As shown in th top panl of figur 2, undr all four conditions, thr was an incras in bactrial growth ovr th 24 hour priod for ths colonis. As shown in panl A of figur 2, th incras in bactrial growth with 5 milliamps of stimulation avragd 204 +/- 116 x 10 6 pr millilitr, for 20 milliamps stimulation avragd 228 +/- 121 x 10 6 bactria pr millilitr and aftr DC stimulation avragd 331 +/- 161 x 10 6 bactria pr millilitr ovr th 24 hour priod. Th growth for all conditions was significantly lowr than growth for E. coli (p< 0.05). Compard to th control group, th bactrial growth ovr th 24 hour priod was significantly lss for th AC stimulation than for th control group (p<0.05). Bactrial growth avragd a 38% rduction in growth with AC stimulation. For DC stimulation, thr was no significant diffrnc to th growth of th control group (p>0.05). As shown in th bottom panl of figur 2, th ovrall chang in ph was lss than that obsrvd for E. coli (p < 0.01). Howvr, th rduction in ph, which avragd /- 0.5 in th control group, was only statistically lss with stimulation at DC and 20 ma
10 AC (p<0.05). Thr was a significant corrlation btwn ph and growth only for stimulation at 20ma. (p<0.01) Staphylococcus aurus- Figur 3 shows th rsults of th Staphylococcus xprimnts. As shown in th top panl of figur 3, th avrag chang in growth for ths bactria was 358 +/- 8 x 10 6 bactria pr millilitr aftr stimulation with currnts of 5 milliamps, 376 +/- 20 x 10 6 bactria pr millilitr aftr stimulation at 20 milliamps and 405 +/- 69 x 10 6 aftr DC stimulation. Only th growth aftr 5ma AC stimulation was diffrnt than that of th controls (p < 0.01). Howvr, th rduction in growth was only 3.9% compard to th control group. As shown in th bottom of th panl, th ph was diffrnt in th 5ma group compard to th control group (p<0.01). Thr was no diffrnc btwn th DC and AC 20 ma groups compard to th control groups (p>0.05). Thr was a significant corrlation btwn ph and growth in th 20ma and DC groups (p<0.01).
11 Discussion On of th mchanisms causing wounds to not hal is bactrial invasion. 21 Bactria ruptur cll mmbrans and maintain chronic inflammation to prvnt wound haling 27 Many studis show that ithr DC microcurrnt or low currnt AC stimulation has th ability to incras wound haling. 6, 9, 10, 17 In arlir studis, Rowly and collagus publishd data showing that lctrical stimulation has a bactria static ffct on Eschrichia coli and svral othr bactria. Barranco t al. 28 showd inhibition in Staphylococcus aurus growth with 400µA DC stimulation. But th lctrods wr mtal and at 400 µamps, corrosion was notd. Othr in vitro studis with 100 µa DC stimulation also showd a bactria static ffct but hr silvr lctrods wr also usd. 29, 30 Othr studis showd a bactria static ffct of DC at 1, 5, or 10 ma but not AC 22, 23 stimulation. 31 Ths studis showd larg changs in ph with DC stimulation, probably du to th fact that, unlik clinical situations whr stimulation is a 30 minut modality, th currnt was lft on for hours. 32 This ph chang was sn also with AC stimulation at 500 volts. 33 But ths studis wr conductd in vitro with a small sparation distanc btwn th lctrods. Thus th currnt pr mm of distanc on th bactrial culturs wr larg. Furthr, mtal ions lik silvr can kill bactria in thmslvs. In addition, ths studis wr conductd at vry high stimulation voltags (ovr 300 volts). In wounds, nrv ndings ar snsitizd by th rlas of cytokins. 34 Evn mild lctrical stimulation can thrfor b painful. In prvious studis, 16, 1, 15 th currnt usd to hal wounds was lss than 20 ma. Thrfor this was th currnt usd in ths studis.
12 In th prsnt invstigations, th dnsity of th broth, siz of th chambr and siz of lctrods wr adjustd so that th lctrods wr sparatd by th distanc sn in a typical wound tratmnt. 15, 16 Th impdanc of th broth matchd that of a human wound, about 1200 ohms btwn th lctrods. This, in itslf, is diffrnt than prvious studis whr larg currnt dnsitis wr sn du to high voltags bing applid to small bactria culturs. Whil w usd a larg chambr for th broth, th currnt dnsity may hav still bn somwhat highr thn in a limb du to th highr volum in a limb. Howvr, whil currnt dnsity may hav bn somwhat highr than in a wound hr, arlir in vitro studis usd a fraction of th volum usd hr btwn th lctrods and lctrods wr closr togthr making currnt dnsity in.g. Rowly t al 22, 23 much highr than in wounds. Whn currnts wr applid in th prsnt xprimnts for a 30 minut stimulation priod, similar to a standard tratmnt priod for wound haling, DC stimulation had no ffct on bactria growth. AC had som ffct on ach of th bactria but th only ral ffct on growth with lctrical stimulation was on psudomonas. Any ffct sn on Eschrichia coli and Staphylococcus aurus was small. For psudomonas, th growth rduction at ithr AC currnt was larg. Howvr, bactria can still b dstroyd by lctrical stimulation through anothr mchanism in wounds. Elctrical stimulation and, lctrical stimulation of wounds causs th rlas of prostaglandins and othr cytokins. 35, 36, 37, 38 Ths prostaglandins and othr cytokins attract macrophags to th ara whr lctrical stimulation is applid. 31 Thrfor, although lctrical stimulation may not hav a dirct ffct on bactria in wounds, thr is som vidnc that whit blood clls such as macrophags
13 ar attractd as a scondary ffct of th lctrical stimulation, this may xplain why lctrical stimulation may b associatd with bactrial dath. Th prsnt studis still rmain in dirct contradiction to th studis by Rowly t al showing a dirct ffct of lctrical stimulation on inhibiting growth in Eschrichia coli. Howvr, whil Eschrichia coli and Staphylococcus aurus showd ithr a statistically insignificant chang in growth or an insignificant clinical chang in growth with lctrical stimulation, this is not to say that lctrical currnt dos not altr bactrial bhavior. Bactrial motility and attachmnt to substrats appars to b impaird by stimulation with lctric currnts (39). This is spcially tru for psudomonas whr flaglla ar ndd for mobility (40). Th fact that psudomonas hr did hav som impaird growth may b du to th fact that thr ar two flaglla protins involvd in its mobility and attachmnt- if ithr is impaird, growth is rducd 41. Hr, ths flaglla, sinc thy us contractil protins and ion channls for movmnt, may b impaird with lctric currnt. This maks ths bactria diffrnt from th othr 2 which do not mov by this mchanism. 22, 23 Howvr, thr ar conditions whr lctrical stimulation will inhibit growth in all 3 bactria. Whil currnts of up to 20ma in thmslvs with ths sam bactria did not rduc bactrial growth 39,42, in combination with antibiotics, th rducd ability of th bactria to attach to substrats mad thm mor suscptibl to attack by th antibiotics. Thus whil antibiotics alon or lctrical stimulation alon did not kill ths bactria, th combination of th two did 39,42. Thus, lctrical stimulation with ithr DC or wak AC currnts may hav an unsn ffct which may kill bactria in vivo but not undr ths circumstancs in vitro. Furthr invstigation is warrantd. Hr, for xampl, currnt
14 was usd for 30 minuts, a standard tratmnt modality. Prhaps longr xposur to currnt would hav a mor dramatic ffct in vivo.
15 Rfrncs 1. Ptrofsky, J.S. Schwab, E., Lo, T., Cuno, M., Gorg, J., Kim, J., & AlMarty, A. (2005). Effcts of Elctrical stimulation on Skin Blood Flow in Controls and in and around Stag III and IV Wounds in Hairy and Non Hairy Skin. Md Sci Monit, 11, Knndy, E.J. (1999). Spinal cord injury; th facts and figurs. Th Univrsity at Alabama Prss: Birmingham, Alabama. 3. Snt, P., & Maum, S. (1999). Dcubitus sors in griatric mdicin. Local and gnral tratmnt of prssur sors in th agd. Prss Md, 28, D Astis, V., Corblla, A., Bafico, F., Spinlli, E., Porcu, G., Bottari, L., Ptrini, M., & Madddu, V. (1999). Dcubitus lsions in patints rfrrd to acut and post-acut hom nursing car for th ldrly in Gnova. Assist Infrm Ric, 18, Mhan, M. (2000). Byond th prssur ulcr blam gam: rflctions for th futur. Ostomy Wound Manag, 46, Kloth, L.C. (2005). Elctrical stimulation for wound haling: a rviw of vidnc from in vitro studis, animal xprimnts, and clinical trials. Int J Low Extrm Wounds, 4, 1, Ennis WJ, L C, Mnss P. (2007) A biochmical approach to wound haling through th us of modalitis. Clin Drmatol, 25(1): Bogi KM, Triolo RJ (2003) Effcts of rgular us of nuromuscular lctrical stimulation on tissu halth. J Rhabil Rs Dv. 40(6): Fdar, J., Kloth, L., & Gntzkow, G. (1992). Chronic drmal ulcr haling nhancd with monophasic pulsd lctrical stimulation. Phys Thr, 72, Frank, A., Frank, E., & Grzsik, J. (1999). Elctrically nhancd damagd tissus haling. Part II: dirct and puls currnt in soft tissu haling. Pol Mrkuriusz Lk, 40, Houghton, P.E., Kincaid, C.B., Lovll, M., Cambll, K.E., Kast, D.H., Woodbury, M.G., & Harris, K.A. (2003). Effct of lctrical stimulation on chronic lg ulcr siz and apparanc. Phys Thr, 83, 1,
16 12. Yarkony, G.M. (1994). Prssur ulcrs: a rviw. Arch Phys Md Rhabil, 75, Bogi, K.M., Rgr, S.I., Lvin, S.P, & Sahgal, V. (2000). Elctrical stimulation for prssur sor prvntion. J Assist Tchnol, 12, Dmir, H., Balay, H., & Kirnap, M. (2004). A comparison study of th ffcts of lctrical stimulation and lasr tratmnt on xprimntal wound haling in rats. J Rhabil Rs Dv, 42, 2, Ptrofsky, J.S., Schwab, E., Cuno, M., Gorg, J., Kim, J., AlMarty, A., & Lawson, D. (2007). Intraction btwn rsting skin blood flow and th blood flow rspons to lctrical stimulation in normal and woundd skin. Submittd Md Sci Monit 16. Lawson, D., Ptrofsky, J.S., (2007). A randomizd control study of th ffct of biphasic lctrical stimulation in a warm room on blood flow and haling rats in chronic wounds of patints with and without diabts. Md Sci Monit 17. Kloth, L.C. (2002). How to us lctrical stimulation for wound haling. Nursing, 32, 12, Bai H, McCaig C.D, Forrstr J.V, & Zhao M. (2004). DC lctrical filds induc distinct prangiognic rsponss in microvascular and macrovascular clls. Artriosclr Thromb Vasc Biol, 24, 7, Zhao, M., Bai, H., Wang, E., Forrstr, J.V., & McCaig, C.D. (2004). Elctrical stimulation dirctly inducs pr-angiognic rsponss in vascular ndothlial clls by signaling through VEGF rcptors. J Cll Sci, 117, Ojingwa, J.C., & Issroff, R.R. (2003). Elctrical stimulation in wound haling. J Invst Drmatol, 121, 1, Rowly BA, McKnna JM, Chas GR, Wolcott LE: (1974) Th influnc of lctrical currnt on an infcting microorganism in wounds. Ann NY ACad Sci 1974b 238: Rowly BA, McKnna JM, Wolocott LE (1974) Procdings: Th us of low lvl lctrical currnt for nhancmnt of tissu haling. Biomd Sci Instrum, 10: Rowly BA (1972) Elctrical currnt ffcts on E. coli growth rats. Proc Soc Exp Biol Md 139(3): Polak, A., Frank, A., Hunka-Zurawinska, W., Kucharzwski, M., & Swist, D. (2000). High voltag stimulation in lg ulcr s tratmnt. Wiad Lk, 53, 7-8,
17 25. Spilholz, N.I., & Kloth, L.C. (2000). Elctrical stimulation and pulsd lctromagntic nrgy: diffrncs in opinion. Ostomy Wound Manag, 5, Hossini SV, Tanidh N, Kohantb J, Ghodrati Z, Mhrabani D, Yarmohammadi H. (2007) Comparision btwn Alpha and silvr sulfadiazin ointmnts in tratmnt of Psudomonas infctions in 3 rd dgr burns. Int J Surg, 5(1): Nubaur T, Bayr GS, Wagnr M. (2006) Opn fracturs and infction. ACta Chir Orthop Traumotol Cch. 73(5): Barranco S, Spadro J, Brgr T (1974) In vitro ffct of wak dirct currnt on Staphylococcus aurus. ClinOrthop 100: Ong P, Laatsch L, Kloth L. (1994) Antibatrial ffcts of a silvr lctrod carrying microamparag dirct currnt in vitro. J Clin Elctrophysiol 6(1): Laatsch L, Ong P, Kloth L. (1995) In vitro ffcts of two silvr lctrods on slct wound pathogns. J Clin Elctrophysiol 7(1): Guffy J, Asmussn M. (1989) In vitro bactricidal ffcts of high voltag pulsd currnt vrsus dirct currnt against Staphylococcus aurus. J Clin Elctrophysiolo 1: Nwton R, Karslis T. (1983) Skin ph following high voltag pulsd galvanic stimulation. Phys Thr 63(10): Szuminsky N, Albrs A, Ungr P (1994). Effct of narrow, pulsd high voltags on bactrial viability. Phys Thr 74: Hrnandz R (2006). Th us of systmic antibiotics in th tratmnt of chronic wounds. Drmatol Thr. 19(6): Hofbaur R, Mosr D, Kay AD, Knapp S, Gminr B, Kapiotis S, Wagnr O, Frass M. (2000) Prostaglandin E(1) is abl to incras migration of lukocyts through ndothlial cll monolayrs. Microvasc Rs, 59(3): Andrson SI, Hudlicka O, Brown MD. (1997) Capillary rd blood cll flow and ACtivation of whit blood clls in chronic muscl ischmia in th rat. Am J Physiol. 272(6 Pt 2): H McLoughlin TJ, Mylona E, Hornbrgr TA, Essr KA, Pizza FX. (2003) Inflammatory clls in rat skltal muscl ar lvatd aftr lctrically stimulatd contractions. J Appl Physiol, 94(3):
18 38. Dustrhoft S, Putman CT, Ptt D. (1999) Changs in FGF and FGF rcptor xprssion in low frquncy-stimulatd rat muscls and rat satllit cll culturs. Diffrntiation 65(4): Jass J, Costrton JW, Lappin-Scott HM. Th ffct of lctrical currnts and tobramycin on Psudomonas aruginosa biofilms. J Ind Microbiol Sp;15 (3): Murray TS, Kazmirczak BI. FlhF is rquird for swimming and swarming in Psudomonas aruginosa. J Bactriol Oct;188(19): Toutain CM, Zgans ME, O'Tool GA. Evidnc for two flagllar stators and thir rol in th motility of Psudomonas aruginosa. J Bactriol Jan;187(2): Costrton JW, Ellis B, Lam K, Johnson F, Khoury AE. Mchanism of lctrical nhancmnt of fficacy of antibiotics in killing biofilm bactria. Antimicrob Agnts Chmothr Dc;38(12): Figur 1
19 A B
20 Figur 2 A B
21 Figur 3 A B
FACULTY SALARIES FALL 2004. NKU CUPA Data Compared To Published National Data
FACULTY SALARIES FALL 2004 NKU CUPA Data Compard To Publishd National Data May 2005 Fall 2004 NKU Faculty Salaris Compard To Fall 2004 Publishd CUPA Data In th fall 2004 Northrn Kntucky Univrsity was among
More informationQUANTITATIVE METHODS CLASSES WEEK SEVEN
QUANTITATIVE METHODS CLASSES WEEK SEVEN Th rgrssion modls studid in prvious classs assum that th rspons variabl is quantitativ. Oftn, howvr, w wish to study social procsss that lad to two diffrnt outcoms.
More informationTraffic Flow Analysis (2)
Traffic Flow Analysis () Statistical Proprtis. Flow rat distributions. Hadway distributions. Spd distributions by Dr. Gang-Ln Chang, Profssor Dirctor of Traffic safty and Oprations Lab. Univrsity of Maryland,
More informationEcon 371: Answer Key for Problem Set 1 (Chapter 12-13)
con 37: Answr Ky for Problm St (Chaptr 2-3) Instructor: Kanda Naknoi Sptmbr 4, 2005. (2 points) Is it possibl for a country to hav a currnt account dficit at th sam tim and has a surplus in its balanc
More informationLG has introduced the NeON 2, with newly developed Cello Technology which improves performance and reliability. Up to 320W 300W
Cllo Tchnology LG has introducd th NON 2, with nwly dvlopd Cllo Tchnology which improvs prformanc and rliability. Up to 320W 300W Cllo Tchnology Cll Connction Elctrically Low Loss Low Strss Optical Absorption
More informationGold versus stock investment: An econometric analysis
Intrnational Journal of Dvlopmnt and Sustainability Onlin ISSN: 268-8662 www.isdsnt.com/ijds Volum Numbr, Jun 202, Pag -7 ISDS Articl ID: IJDS20300 Gold vrsus stock invstmnt: An conomtric analysis Martin
More informationThe example is taken from Sect. 1.2 of Vol. 1 of the CPN book.
Rsourc Allocation Abstract This is a small toy xampl which is wll-suitd as a first introduction to Cnts. Th CN modl is dscribd in grat dtail, xplaining th basic concpts of C-nts. Hnc, it can b rad by popl
More informationby John Donald, Lecturer, School of Accounting, Economics and Finance, Deakin University, Australia
Studnt Nots Cost Volum Profit Analysis by John Donald, Lcturr, School of Accounting, Economics and Financ, Dakin Univrsity, Australia As mntiond in th last st of Studnt Nots, th ability to catgoris costs
More informationLong run: Law of one price Purchasing Power Parity. Short run: Market for foreign exchange Factors affecting the market for foreign exchange
Lctur 6: Th Forign xchang Markt xchang Rats in th long run CON 34 Mony and Banking Profssor Yamin Ahmad xchang Rats in th Short Run Intrst Parity Big Concpts Long run: Law of on pric Purchasing Powr Parity
More informationEFFECT OF GEOMETRICAL PARAMETERS ON HEAT TRANSFER PERFORMACE OF RECTANGULAR CIRCUMFERENTIAL FINS
25 Vol. 3 () January-March, pp.37-5/tripathi EFFECT OF GEOMETRICAL PARAMETERS ON HEAT TRANSFER PERFORMACE OF RECTANGULAR CIRCUMFERENTIAL FINS *Shilpa Tripathi Dpartmnt of Chmical Enginring, Indor Institut
More informationDehumidifiers: A Major Consumer of Residential Electricity
Dhumidifirs: A Major Consumr of Rsidntial Elctricity Laurn Mattison and Dav Korn, Th Cadmus Group, Inc. ABSTRACT An stimatd 19% of U.S. homs hav dhumidifirs, and thy can account for a substantial portion
More informationBasis risk. When speaking about forward or futures contracts, basis risk is the market
Basis risk Whn spaking about forward or futurs contracts, basis risk is th markt risk mismatch btwn a position in th spot asst and th corrsponding futurs contract. Mor broadly spaking, basis risk (also
More informationAdverse Selection and Moral Hazard in a Model With 2 States of the World
Advrs Slction and Moral Hazard in a Modl With 2 Stats of th World A modl of a risky situation with two discrt stats of th world has th advantag that it can b natly rprsntd using indiffrnc curv diagrams,
More informationLecture 3: Diffusion: Fick s first law
Lctur 3: Diffusion: Fick s first law Today s topics What is diffusion? What drivs diffusion to occur? Undrstand why diffusion can surprisingly occur against th concntration gradint? Larn how to dduc th
More informationWORKERS' COMPENSATION ANALYST, 1774 SENIOR WORKERS' COMPENSATION ANALYST, 1769
08-16-85 WORKERS' COMPENSATION ANALYST, 1774 SENIOR WORKERS' COMPENSATION ANALYST, 1769 Summary of Dutis : Dtrmins City accptanc of workrs' compnsation cass for injurd mploys; authorizs appropriat tratmnt
More informationQuestion 3: How do you find the relative extrema of a function?
ustion 3: How do you find th rlativ trma of a function? Th stratgy for tracking th sign of th drivativ is usful for mor than dtrmining whr a function is incrasing or dcrasing. It is also usful for locating
More informationIntermediate Macroeconomic Theory / Macroeconomic Analysis (ECON 3560/5040) Final Exam (Answers)
Intrmdiat Macroconomic Thory / Macroconomic Analysis (ECON 3560/5040) Final Exam (Answrs) Part A (5 points) Stat whthr you think ach of th following qustions is tru (T), fals (F), or uncrtain (U) and brifly
More informationAbstract. Introduction. Statistical Approach for Analyzing Cell Phone Handoff Behavior. Volume 3, Issue 1, 2009
Volum 3, Issu 1, 29 Statistical Approach for Analyzing Cll Phon Handoff Bhavior Shalini Saxna, Florida Atlantic Univrsity, Boca Raton, FL, shalinisaxna1@gmail.com Sad A. Rajput, Farquhar Collg of Arts
More informationUniversal, Family-based Substance Abuse Prevention for Youth
www.ccsa.ca www.cclt.ca Novmbr 2014 Rapid Rviw Univrsal, Family-basd Substanc Abus Prvntion for Youth Ky Mssags Univrsal, family-basd substanc abus prvntion programs can b ffctiv for fmals, whthr dsignd
More informationRural and Remote Broadband Access: Issues and Solutions in Australia
Rural and Rmot Broadband Accss: Issus and Solutions in Australia Dr Tony Warrn Group Managr Rgulatory Stratgy Tlstra Corp Pag 1 Tlstra in confidnc Ovrviw Australia s gographical siz and population dnsity
More informationC H A P T E R 1 Writing Reports with SAS
C H A P T E R 1 Writing Rports with SAS Prsnting information in a way that s undrstood by th audinc is fundamntally important to anyon s job. Onc you collct your data and undrstand its structur, you nd
More informationCARE QUALITY COMMISSION ESSENTIAL STANDARDS OF QUALITY AND SAFETY. Outcome 10 Regulation 11 Safety and Suitability of Premises
CARE QUALITY COMMISSION ESSENTIAL STANDARDS OF QUALITY AND SAFETY Outcom 10 Rgulation 11 Safty and Suitability of Prmiss CQC Rf 10A 10A(1) Lad Dirctor / Lad Officr Rspons Impact Liklihood Lvl of Concrn
More informationAdsorption of Malachite Green Dye onto Activated Carbon Derived from Durian Peel
Adsorption of Malachit Grn Dy onto Activatd Carbon Drivd from Durian Pl SARAWUT SRIKHUN, SAMORN HIRUNPRADITKUN, KAMCHAI NUITHITIKUL* Dpartmnt of Chmical Enginring King Mongkut s Univrsity of Tchnology
More informationFree ACA SOLUTION (IRS 1094&1095 Reporting)
Fr ACA SOLUTION (IRS 1094&1095 Rporting) Th Insuranc Exchang (301) 279-1062 ACA Srvics Transmit IRS Form 1094 -C for mployrs Print & mail IRS Form 1095-C to mploys HR Assist 360 will gnrat th 1095 s for
More informationA Theoretical Model of Public Response to the Homeland Security Advisory System
A Thortical Modl of Public Rspons to th Homland Scurity Advisory Systm Amy (Wnxuan) Ding Dpartmnt of Information and Dcision Scincs Univrsity of Illinois Chicago, IL 60607 wxding@uicdu Using a diffrntial
More informationIBM Healthcare Home Care Monitoring
IBM Halthcar Hom Car Monitoring Sptmbr 30th, 2015 by Sal P. Causi, P. Eng. IBM Halthcar Businss Dvlopmnt Excutiv scausi@ca.ibm.com IBM Canada Cloud Computing Tigr Tam Homcar by dfinition 1. With a gnsis
More information5 2 index. e e. Prime numbers. Prime factors and factor trees. Powers. worked example 10. base. power
Prim numbrs W giv spcial nams to numbrs dpnding on how many factors thy hav. A prim numbr has xactly two factors: itslf and 1. A composit numbr has mor than two factors. 1 is a spcial numbr nithr prim
More information(Analytic Formula for the European Normal Black Scholes Formula)
(Analytic Formula for th Europan Normal Black Schols Formula) by Kazuhiro Iwasawa Dcmbr 2, 2001 In this short summary papr, a brif summary of Black Schols typ formula for Normal modl will b givn. Usually
More informationLecture 20: Emitter Follower and Differential Amplifiers
Whits, EE 3 Lctur 0 Pag of 8 Lctur 0: Emittr Followr and Diffrntial Amplifirs Th nxt two amplifir circuits w will discuss ar ry important to lctrical nginring in gnral, and to th NorCal 40A spcifically.
More informationCategory 7: Employee Commuting
7 Catgory 7: Employ Commuting Catgory dscription This catgory includs missions from th transportation of mploys 4 btwn thir homs and thir worksits. Emissions from mploy commuting may aris from: Automobil
More informationCategory 1: Purchased Goods and Services
1 Catgory 1: Purchasd Goods and Srvics Catgory dscription T his catgory includs all upstram (i.., cradl-to-gat) missions from th production of products purchasd or acquird by th rporting company in th
More informationLecture notes: 160B revised 9/28/06 Lecture 1: Exchange Rates and the Foreign Exchange Market FT chapter 13
Lctur nots: 160B rvisd 9/28/06 Lctur 1: xchang Rats and th Forign xchang Markt FT chaptr 13 Topics: xchang Rats Forign xchang markt Asst approach to xchang rats Intrst Rat Parity Conditions 1) Dfinitions
More informationhttp://www.wwnorton.com/chemistry/tutorials/ch14.htm Repulsive Force
ctivation nrgis http://www.wwnorton.com/chmistry/tutorials/ch14.htm (back to collision thory...) Potntial and Kintic nrgy during a collision + + ngativly chargd lctron cloud Rpulsiv Forc ngativly chargd
More informationthe so-called KOBOS system. 1 with the exception of a very small group of the most active stocks which also trade continuously through
Liquidity and Information-Basd Trading on th Ordr Drivn Capital Markt: Th Cas of th Pragu tock Exchang Libor 1ÀPH³HN Cntr for Economic Rsarch and Graduat Education, Charls Univrsity and Th Economic Institut
More informationCPU. Rasterization. Per Vertex Operations & Primitive Assembly. Polynomial Evaluator. Frame Buffer. Per Fragment. Display List.
Elmntary Rndring Elmntary rastr algorithms for fast rndring Gomtric Primitivs Lin procssing Polygon procssing Managing OpnGL Stat OpnGL uffrs OpnGL Gomtric Primitivs ll gomtric primitivs ar spcifid by
More informationInternational Association of Scientific Innovation and Research (IASIR) (An Association Unifying the Sciences, Engineering, and Applied Research)
Intrnational Association of Scintific Innovation and Rsarch (IASIR) (An Association Unifing th Scincs, Enginring, and Applid Rsarch) ISSN (Print): 79-000 ISSN (Onlin): 79-009 Intrnational Journal of Enginring,
More informationSPREAD OPTION VALUATION AND THE FAST FOURIER TRANSFORM
RESEARCH PAPERS IN MANAGEMENT STUDIES SPREAD OPTION VALUATION AND THE FAST FOURIER TRANSFORM M.A.H. Dmpstr & S.S.G. Hong WP 26/2000 Th Judg Institut of Managmnt Trumpington Strt Cambridg CB2 1AG Ths paprs
More information81-1-ISD Economic Considerations of Heat Transfer on Sheet Metal Duct
Air Handling Systms Enginring & chnical Bulltin 81-1-ISD Economic Considrations of Hat ransfr on Sht Mtal Duct Othr bulltins hav dmonstratd th nd to add insulation to cooling/hating ducts in ordr to achiv
More informationSeeking Safety: The Benefits of Gender-specific versus Co-Educational Therapy
www.ccsa.ca www.cclt.ca Octobr 2014 Rapid Rviw Sking Safty: Th Bnfits of Gndr-spcific vrsus Co-Educational Thrapy Ky Mssags Sking Safty programming is an approach for addrssing co-occurring substanc us
More informationCurrent and Resistance
Chaptr 6 Currnt and Rsistanc 6.1 Elctric Currnt...6-6.1.1 Currnt Dnsity...6-6. Ohm s Law...6-4 6.3 Elctrical Enrgy and Powr...6-7 6.4 Summary...6-8 6.5 Solvd Problms...6-9 6.5.1 Rsistivity of a Cabl...6-9
More informationA copy of the Consultation Paper is in the Members Library and further details are available at www.scotland~qov.umpublications/2012/12/5980
To: CORPORATE SERVICES COMMITTEE NORTH LANARKSHIRE COUNCIL REPORT Subjct: CONSULTATION: CIVIL LAW OF DAMAGES - ISSUES IN PERSONAL INJURY From: HEAD OF LEGAL SERVICES Dat: 30 JANUARY 2013 Rf: AL LE CSN
More informationEssays on Adverse Selection and Moral Hazard in Insurance Market
Gorgia Stat Univrsity ScholarWorks @ Gorgia Stat Univrsity Risk Managmnt and Insuranc Dissrtations Dpartmnt of Risk Managmnt and Insuranc 8--00 Essays on Advrs Slction and Moral Hazard in Insuranc Markt
More information[ ] These are the motor parameters that are needed: Motor voltage constant. J total (lb-in-sec^2)
MEASURING MOOR PARAMEERS Fil: Motor paramtrs hs ar th motor paramtrs that ar ndd: Motor voltag constant (volts-sc/rad Motor torqu constant (lb-in/amp Motor rsistanc R a (ohms Motor inductanc L a (Hnris
More informationAP Calculus AB 2008 Scoring Guidelines
AP Calculus AB 8 Scoring Guidlins Th Collg Board: Conncting Studnts to Collg Succss Th Collg Board is a not-for-profit mmbrship association whos mission is to connct studnts to collg succss and opportunity.
More informationNAVAL POSTGRADUATE SCHOOL
NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA MBA PROFESSIONAL REPORT Th Survivor Bnfit Plan: A Cost-Bnfit Analysis By: Advisors: Scott E. Batty, and Tho Kang Dcmbr 2007 William R. Gats, Raymond E. Franck
More informationRemember you can apply online. It s quick and easy. Go to www.gov.uk/advancedlearningloans. Title. Forename(s) Surname. Sex. Male Date of birth D
24+ Advancd Larning Loan Application form Rmmbr you can apply onlin. It s quick and asy. Go to www.gov.uk/advancdlarningloans About this form Complt this form if: you r studying an ligibl cours at an approvd
More informationSPECIAL VOWEL SOUNDS
SPECIAL VOWEL SOUNDS Plas consult th appropriat supplmnt for th corrsponding computr softwar lsson. Rfr to th 42 Sounds Postr for ach of th Spcial Vowl Sounds. TEACHER INFORMATION: Spcial Vowl Sounds (SVS)
More informationSTATEMENT OF INSOLVENCY PRACTICE 3.2
STATEMENT OF INSOLVENCY PRACTICE 3.2 COMPANY VOLUNTARY ARRANGEMENTS INTRODUCTION 1 A Company Voluntary Arrangmnt (CVA) is a statutory contract twn a company and its crditors undr which an insolvncy practitionr
More informationUse a high-level conceptual data model (ER Model). Identify objects of interest (entities) and relationships between these objects
Chaptr 3: Entity Rlationship Modl Databas Dsign Procss Us a high-lvl concptual data modl (ER Modl). Idntify objcts of intrst (ntitis) and rlationships btwn ths objcts Idntify constraints (conditions) End
More informationTheoretical approach to algorithm for metrological comparison of two photothermal methods for measuring of the properties of materials
Rvista Invstigación Cintífica, ol. 4, No. 3, Nuva época, sptimbr dicimbr 8, IN 187 8196 Thortical approach to algorithm for mtrological comparison of two photothrmal mthods for masuring of th proprtis
More informationLogo Design/Development 1-on-1
Logo Dsign/Dvlopmnt 1-on-1 If your company is looking to mak an imprssion and grow in th marktplac, you ll nd a logo. Fortunatly, a good graphic dsignr can crat on for you. Whil th pric tags for thos famous
More informationRelationship between Cost of Equity Capital And Voluntary Corporate Disclosures
Rlationship btwn Cost of Equity Capital And Voluntary Corporat Disclosurs Elna Ptrova Eli Lilly & Co, Sofia, Bulgaria E-mail: ptrova.lnaa@gmail.com Gorgios Gorgakopoulos (Corrsponding author) Amstrdam
More informationEthanolic Extraction of Soybean Oil: Oil Solubility Equilibria and Kinetic Studies
Ethanolic Extraction of Soyban Oil: Oil Solubility Equilibria and Kintic Studis Christiann E. C. Rodrigus*, Natália M. Longo, Cibl C. Silva, Kila K.. Aracava, Bruna R. Garavazo Sparation Enginring Laboratory
More informationIncomplete 2-Port Vector Network Analyzer Calibration Methods
Incomplt -Port Vctor Ntwork nalyzr Calibration Mthods. Hnz, N. Tmpon, G. Monastrios, H. ilva 4 RF Mtrology Laboratory Instituto Nacional d Tcnología Industrial (INTI) Bunos irs, rgntina ahnz@inti.gov.ar
More informationHigh Interest Rates In Ghana,
NO. 27 IEA MONOGRAPH High Intrst Rats In Ghana, A Critical Analysis IEA Ghana THE INSTITUTE OF ECONOMIC AFFAIRS A Public Policy Institut High Intrst Rats In Ghana, A Critical Analysis 1 by DR. J. K. KWAKYE
More informationCategory 11: Use of Sold Products
11 Catgory 11: Us of Sold Products Catgory dscription T his catgory includs missions from th us of goods and srvics sold by th rporting company in th rporting yar. A rporting company s scop 3 missions
More informationCloud and Big Data Summer School, Stockholm, Aug., 2015 Jeffrey D. Ullman
Cloud and Big Data Summr Scool, Stockolm, Aug., 2015 Jffry D. Ullman Givn a st of points, wit a notion of distanc btwn points, group t points into som numbr of clustrs, so tat mmbrs of a clustr ar clos
More informationForeign Exchange Markets and Exchange Rates
Microconomics Topic 1: Explain why xchang rats indicat th pric of intrnational currncis and how xchang rats ar dtrmind by supply and dmand for currncis in intrnational markts. Rfrnc: Grgory Mankiw s Principls
More informationMathematics. Mathematics 3. hsn.uk.net. Higher HSN23000
hsn uknt Highr Mathmatics UNIT Mathmatics HSN000 This documnt was producd spcially for th HSNuknt wbsit, and w rquir that any copis or drivativ works attribut th work to Highr Still Nots For mor dtails
More informationNatural Gas & Electricity Prices
Click to dit Mastr titl styl Click to dit Mastr txt styls Scond lvl Third lvl Natural Gas & Elctricity Prics Fourth lvl» Fifth lvl Glnn S. Pool Manufacturing Support Mgr. Enrgy April 4, 2013 Click Vrso
More informationMajor Portions in Climate Change: Physical Approach
Intrnational Rviw of Physics (I.R.E.PHY.), Vol. 5, N. 5 Octobr 20 Major Portions in Climat Chang: Physical Approach Jyrki Kauppinn, Jorma. Hinonn, Pkka J. Malmi Abstract h dstroying of rainforsts can warm
More informationNew Basis Functions. Section 8. Complex Fourier Series
Nw Basis Functions Sction 8 Complx Fourir Sris Th complx Fourir sris is prsntd first with priod 2, thn with gnral priod. Th connction with th ral-valud Fourir sris is xplaind and formula ar givn for convrting
More informationIMES DISCUSSION PAPER SERIES
IMES DISCUSSIN PAPER SERIES Th Choic of Invoic Currncy in Intrnational Trad: Implications for th Intrnationalization of th Yn Hiroyuki I, Akira TANI, and Toyoichirou SHIRTA Discussion Papr No. 003-E-13
More informationJune 2012. Enprise Rent. Enprise 1.1.6. Author: Document Version: Product: Product Version: SAP Version: 8.81.100 8.8
Jun 22 Enpris Rnt Author: Documnt Vrsion: Product: Product Vrsion: SAP Vrsion: Enpris Enpris Rnt 88 88 Enpris Rnt 22 Enpris Solutions All rights rsrvd No parts of this work may b rproducd in any form or
More informationFleet vehicles opportunities for carbon management
Flt vhicls opportunitis for carbon managmnt Authors: Kith Robrtson 1 Dr. Kristian Stl 2 Dr. Christoph Hamlmann 3 Alksandra Krukar 4 Tdla Mzmir 5 1 Snior Sustainability Consultant & Lad Analyst, Arup 2
More informationMicro Satellite System
4-226-697-71(1) Micro Satllit Systm Oprating instructions GB CS SA-V315 SA-V312 2000 Sony Corporation WARNING To prvnt fir or shock hazard, do not xpos th unit to rain or moistur. To avoid lctrical shock,
More informationB-285141. April 21, 2000. The Honorable Charles B. Rangel Ranking Minority Member Committee on Ways and Means House of Representatives
Unit Stats Gnral Accounting Offic Washington, DC 20548 Halth, Eucation, an Human Srvics Division B-285141 April 21, 2000 Th Honorabl Charls B. Rangl Ranking Minority Mmbr Committ on Ways an Mans Hous of
More informationWAVELENGTH SCALING OF LITHIUM-LIKE RECOMBINATION SCHEME FOR X-UV GAIN PRODUCTION
WAVELENGTH SCALING OF LITHIUM-LIKE RECOMBINATION SCHEME FOR X-UV GAIN PRODUCTION A. Carillon, F. Gadi, B. GauthÉ, H. Gunnou, P. Jaglé, G. Jamlot, A. Klisnick, C. Möllr, A. Surau To cit this vrsion: A.
More informationDevelopment of Financial Management Reporting in MPLS
1 Dvlopmnt of Financial Managmnt Rporting in MPLS 1. Aim Our currnt financial rports ar structurd to dlivr an ovrall financial pictur of th dpartmnt in it s ntirty, and thr is no attmpt to provid ithr
More informationElectronic Commerce. and. Competitive First-Degree Price Discrimination
Elctronic Commrc and Comptitiv First-Dgr Pric Discrimination David Ulph* and Nir Vulkan ** Fbruary 000 * ESRC Cntr for Economic arning and Social Evolution (ESE), Dpartmnt of Economics, Univrsity Collg
More informationGlobal Sourcing: lessons from lean companies to improve supply chain performances
3 rd Intrnational Confrnc on Industrial Enginring and Industrial Managmnt XIII Congrso d Ingniría d Organización Barclona-Trrassa, Sptmbr 2nd-4th 2009 Global Sourcing: lssons from lan companis to improv
More informationPACKINGHOUSE NEWSLETTER
Cooprativ Extnsion Srvic Institut of Food and Agricultural Scincs PACKINGHOUSE NEWSLETTER Mark Ritnour Packinghous Nwslttr No. 192 Indian Rivr REC Dcmbr 29, 2000 2199 South Rock Road Ft. Pirc, FL 34945-3138
More informationwetenschap I.J. de Raat i, R. van den Boom i, ii M. van Poppel i and M.M. Sloet van Oldruitenborgh-Oosterbaan i
Th ffct of a topical inscticid containing prmthrin on th numbr of Culicoids midgs caught nar horss with and without insct bit hyprsnsitivity in th Nthrlands I.J. d Raat i, R. van dn Boom i, ii M. van Poppl
More informationA Note on Approximating. the Normal Distribution Function
Applid Mathmatical Scincs, Vol, 00, no 9, 45-49 A Not on Approimating th Normal Distribution Function K M Aludaat and M T Alodat Dpartmnt of Statistics Yarmouk Univrsity, Jordan Aludaatkm@hotmailcom and
More informationTheoretical aspects of investment demand for gold
Victor Sazonov (Russia), Dmitry Nikolav (Russia) Thortical aspcts of invstmnt dmand for gold Abstract Th main objctiv of this articl is construction of a thortical modl of invstmnt in gold. Our modl is
More informationSci.Int.(Lahore),26(1),131-138,2014 ISSN 1013-5316; CODEN: SINTE 8 131
Sci.Int.(Lahor),26(1),131-138,214 ISSN 113-5316; CODEN: SINTE 8 131 REQUIREMENT CHANGE MANAGEMENT IN AGILE OFFSHORE DEVELOPMENT (RCMAOD) 1 Suhail Kazi, 2 Muhammad Salman Bashir, 3 Muhammad Munwar Iqbal,
More informationEntity-Relationship Model
Entity-Rlationship Modl Kuang-hua Chn Dpartmnt of Library and Information Scinc National Taiwan Univrsity A Company Databas Kps track of a company s mploys, dpartmnts and projcts Aftr th rquirmnts collction
More informationMDMA (Ecstasy, Molly)
www.ccsa.ca www.cclt.ca Spring 2015 Canadian Drug Summary MDMA (Ecstasy, Molly) Ky points Th prvalnc of past-yar cstasy us is lss than 1% and has dcrasd by half sinc 2008. 1 in 25 Canadian youth in grads
More informationKidde International, Mathisen Way, Colnbrook, Slough, SL3 OHB UK Tel: +44 1753 683245 Fax: +44 1753 683810
Th Dvlopmnt of a Small Scal Class A Fir Tst A Chattawayt, G G Cox, S R Prc & D J Spring Kidd Intrnational, Mathisn Way, Colnbrook, Slough, SL3 OHB UK Tl: +44 1753 683245 Fax: +44 1753 683810 1. Introduction
More informationIntroduction to Finite Element Modeling
Introduction to Finit Elmnt Modling Enginring analysis of mchanical systms hav bn addrssd by driving diffrntial quations rlating th variabls of through basic physical principls such as quilibrium, consrvation
More informationGovernment Spending or Tax Cuts for Education in Taylor County, Texas
Govrnmnt Spnding or Tax Cuts for Education in Taylor County, Txas Ian Shphrd Abiln Christian Univrsity D Ann Shphrd Abiln Christian Univrsity On Fbruary 17, 2009, Prsidnt Barack Obama signd into law th
More information5.4 Exponential Functions: Differentiation and Integration TOOTLIFTST:
.4 Eponntial Functions: Diffrntiation an Intgration TOOTLIFTST: Eponntial functions ar of th form f ( ) Ab. W will, in this sction, look at a spcific typ of ponntial function whr th bas, b, is.78.... This
More informationKeywords Cloud Computing, Service level agreement, cloud provider, business level policies, performance objectives.
Volum 3, Issu 6, Jun 2013 ISSN: 2277 128X Intrnational Journal of Advancd Rsarch in Computr Scinc and Softwar Enginring Rsarch Papr Availabl onlin at: wwwijarcsscom Dynamic Ranking and Slction of Cloud
More informationArchitecture of the proposed standard
Architctur of th proposd standard Introduction Th goal of th nw standardisation projct is th dvlopmnt of a standard dscribing building srvics (.g.hvac) product catalogus basd on th xprincs mad with th
More informationParallel and Distributed Programming. Performance Metrics
Paralll and Distributd Programming Prformanc! wo main goals to b achivd with th dsign of aralll alications ar:! Prformanc: th caacity to rduc th tim to solv th roblm whn th comuting rsourcs incras;! Scalability:
More informationFar Field Estimations and Simulation Model Creation from Cable Bundle Scans
Far Fild Estimations and Simulation Modl Cration from Cabl Bundl Scans D. Rinas, S. Nidzwidz, S. Fri Dortmund Univrsity of Tchnology Dortmund, Grmany dnis.rinas@tu-dortmund.d stphan.fri@tu-dortmund.d Abstract
More informationCHAPTER 4c. ROOTS OF EQUATIONS
CHAPTER c. ROOTS OF EQUATIONS A. J. Clark School o Enginring Dpartmnt o Civil and Environmntal Enginring by Dr. Ibrahim A. Aakka Spring 00 ENCE 03 - Computation Mthod in Civil Enginring II Dpartmnt o Civil
More informationCPS 220 Theory of Computation REGULAR LANGUAGES. Regular expressions
CPS 22 Thory of Computation REGULAR LANGUAGES Rgular xprssions Lik mathmatical xprssion (5+3) * 4. Rgular xprssion ar built using rgular oprations. (By th way, rgular xprssions show up in various languags:
More informationOnline Price Competition within and between Heterogeneous Retailer Groups
Onlin Pric Comptition within and btwn Htrognous Rtailr Groups Cnk Kocas Dpartmnt of Markting and Supply Chain Managmnt, Michigan Stat Univrsity kocas@msu.du Abstract This study prsnts a modl of pric comptition
More informationReal-Time Evaluation of Email Campaign Performance
Singapor Managmnt Univrsity Institutional Knowldg at Singapor Managmnt Univrsity Rsarch Collction L Kong Chian School Of Businss L Kong Chian School of Businss 10-2008 Ral-Tim Evaluation of Email Campaign
More informationProceedings of the 6th WSEAS International Conference on Simulation, Modelling and Optimization, Lisbon, Portugal, September 22-24, 2006 246
Procdings of th 6th WSEAS Intrnational Confrnc on Simulation, Modlling and Optimization, Lisbon, Portugal, Sptmbr 22-24, 2006 246 Larg dformation modling in soil-tillag tool intraction using advancd 3D
More informationSurface wave accelerator based on silicon carbide (SWABSiC)
Surfac wav acclrator basd on silicon carbid (SWABSiC) V. Khudi, S. Trndafilov, Kamil B. Alici P.I. Gnnady Shvts Th Univrsity of Txas at Austin V. Yaimno, M. Babzin, M. Fdurin, K. Kusch BNL/ATF Lasr Bam
More informationOver-investment of free cash flow
Rv Acc Stud (2006) 11:159 189 DOI 10.1007/s11142-006-9012-1 Ovr-invstmnt of fr cash flow Scott Richardson Publishd onlin: 23 Jun 2006 Ó Springr Scinc+Businss Mdia, LLC 2006 Abstract This papr xamins th
More informationFACILITY MANAGEMENT SCHEMES FOR SCHOOLS IN THE UK:A STUDY OF VARIATIONS IN SUPPORT SERVICES COSTS AND CAPITAL EFFICIENCY RATIOS
FACILITY MANAGEMENT SCHEMES FOR SCHOOLS IN THE UK:A STUDY OF VARIATIONS IN SUPPORT SERVICES COSTS AND CAPITAL EFFICIENCY RATIOS By Rui PdroPrira Magalhas 1 Sptmbr 2013 A Dissrtation submittd in part fulfilmnt
More informationSection 7.4: Exponential Growth and Decay
1 Sction 7.4: Exponntial Growth and Dcay Practic HW from Stwart Txtbook (not to hand in) p. 532 # 1-17 odd In th nxt two ction, w xamin how population growth can b modld uing diffrntial quation. W tart
More informationLift Selection Guide
Lift Slction Guid Hlping you choos th right lifts to kp your staff and rsidnts saf Th Dirct Supply diffrnc Kp your community saf DIRECT SUPPLY MAKES EQUIPMENT SELECTION EASY BENEFITS OF SAFE LIFTING PRACTICES
More informationPlanning and Managing Copper Cable Maintenance through Cost- Benefit Modeling
Planning and Managing Coppr Cabl Maintnanc through Cost- Bnfit Modling Jason W. Rup U S WEST Advancd Tchnologis Bouldr Ky Words: Maintnanc, Managmnt Stratgy, Rhabilitation, Cost-bnfit Analysis, Rliability
More informationBMJ Open. For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml. Journal: BMJ Open. Manuscript ID: bmjopen-2015-008649
BMJ Opn Forcasting and Control Policy Assssmnt for th Ebola Virus Disas (EVD) Epidmic in Sirra Lon Using Small- World Ntworkd Modl Simulations Journal: BMJ Opn Manuscript ID: bmjopn-0-00 Articl Typ: Rsarch
More informationEffects of Fuel Prices on Air Transportation Performance at New York and San Francisco Airports
Effcts of Ful Prics on Air Transportation Prformanc at Nw York and San Francisco Airports John Frguson; Karla Hoffman; Lanc Shrry; Abdul Qadar Kara Cntr for Air Transportation Systms Rsarch, Gorg Mason
More information