Hematology. Drugs. New. Bologna, Bologna, Palazzo della Cultura e dei Congressi. Palazzo della Cultura e dei Congressi PROGRAM

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1 PROGRAM Under the Auspices of: Società Italiana di Ematologia ALMA MATER STUDIORUM Università di Bologna ISTITUTO DI EMATOLOGIA ED ONCOLOGIA MEDICA L. E A. SERÀGNOLI SERVIZIO SANITARIO REGIONALE EMILIA-ROMAGNA Azienda Ospedaliero-Universitaria di Bologna Presidents: Michele Baccarani Giovanni Martelli Pier Luigi Zzani Honorary President: Sante Tura Bologna, Palazzo della Cultura e dei Congressi October 5-7, 2008 Bologna, Palazzo della Cultura e dei Congressi

2 Scientific Secretariat Istituto di Ematologia e Oncologia Medica L. e A. Seràgnoli Via Massarenti, Bologna, Italy Tel Fax Organizg Secretariat Studio E.R. Congressi - Gruppo Triumph Via Marconi, Bologna, Italy Tel Fax ercongressi@gruppotriumph.it Requested Auspices MINISTERO DELLA SALUTE ISTITUTO SUPERIORE DELLA SANITA UNIVERSITÀ DEGLI STUDI DI BOLOGNA REGIONE EMILIA-ROMAGNA ASSOCIAZIONE ITALIANA CONTRO LE LEUCEMIE - LINFOMI E MIELOMA Sezione di Bologna FONDAZIONE CASSA DI RISPARMIO IN BOLOGNA FACULTY Sergio Amadori Roma Emanuele Angelucci Cagliari Chalid Assaf Berl, D Michele Baccarani Bologna Mario Boccadoro Toro Priscille Bourquelot Basel, CH Alan K. Burnett Cardiff, UK John C. Byrd Columbus, USA Federico Caligaris Cappio Milano Maria Domenica Cappelli Milano Michele Cavo Bologna Mario Cazzola Pavia Bruce D. Cheson Washgton, USA Paolo Corradi Milano Antonio Cuneo Ferrara Myron S. Czuczman Buffalo, USA Fabrizio De Ponti Bologna Claire Dearden London, UK John F. DiJoseph Pearl River, USA Mart H. Dreylg Munich, D Madelee Duvic Houston, USA Andreas Engert Koln, D Renato Fan Ude Pierre Fenaux Bobigny, F Rob Foà Roma Gianluca Gaidano Novara Guillermo Garcia-Manero Houston, USA Filippo Gherlzoni Treviso Athos Gianella-Borradori Geneva, CH Francis J. Giles San Antonio, USA Marco Gobbi Genova Andre Goy Hackensack, USA François Guilhot Poitiers, F Anton Hagenbeek Utrecht, NL Jean-Luc Harousseau Nantes, F Sandra J. Horng Stanford, USA Jean-Pierre Issa Houston, USA Francesco Lauria Siena John P. Leonard York, USA Pietro Leoni Ancona Maurizio Martelli Roma Giovanni Martelli Bologna Patrizio Mazza Taranto Susan O Brien Houston, USA Owen A. O Connor York, USA Antonio Palumbo Toro Fabrizio Pane Napoli Ronald Paquette Los Angeles, USA Paul Parren Utrecht, NL Stefano Pileri Bologna Giovanni Pizzolo Verona Pierluigi Porcu Columbus, USA Alessandro Rambaldi Bergamo Paul Richardson Boston, USA Alfredo Romano Basel, CH Gianantonio Rosti Bologna Domenico Russo Brescia Giuseppe Saglio Orbassano Jesus F. San Miguel Salamanca, E Neil P. Shah San Francisco, USA Lewis R. Silverman York, USA Ayalew Tefferi Rochester, USA Giuseppe Torelli Modena Patrizia Tosi Bologna Umberto Vitolo Toro Thomas E. Witzig Rochester, USA Anas Younes Houston, USA Alfonso Zaccaria Ravenna Pier Luigi Zzani Bologna BOLOGNA Bologna, Palazzo della Cultura e dei Congressi 3

3 Day 1 October 5, Welcome and Introduction Session I Chairmen: F. Lauria, G. Torelli Myelodisplastic Syndromes M. Cazzola Organ Damage and Iron Overload E. Angelucci Progress the Management of Iron Overload: - Erythrocyte Disorders M. D. Cappelli - Myelodisplastic Syndrome A. Tefferi Session III Chairmen: G. Gaidano, A. Zaccaria Peripheral T-Cell Lymphoma: From Bench to Bed Strategy S. Pileri Histone Deacetylases Inhibitors: SAHA M. Duvic LBH589 P. Bourquelot MS275 P. Porcu Lunch Session II Chairmen: F. Pane, G. Saglio Ph Positive Leukemias F. Guilhot Tyrose Kase Inhibitors: Imatib M. Baccarani Nilotib G. Rosti Dasatib N.P. Shah Bosutib G. Martelli BOLOGNABologna, Palazzo della Cultura e dei Congressi 5

4 Day 2 October 6, Session IV Chairmen: P. Corradi, A. Cuneo Chronic Lymphocytic Leukemia F. Caligaris Cappio Monoclonal Antibodies (update): CD20, Rituximab A. Hagenbeek CD20-90 Y, Ibritumomab P.L. Zzani CD52, Alemtuzumab C. Dearden CD22, Epratuzumab J.P. Leonard CD33-Calicheamic, Gemtuzumab Ozogamic S. Amadori Coffee break Session VI Chairmen: G. Pizzolo, D. Russo Individualizg Therapy for the Hematologic Malignancies: the Stuff of Genes and Dreams B.D. Cheson Aurora Kase Inhibitors: MK-0457 F.J. Giles AS A. Gianella-Borradori PHA R. Paquette Session VII Chairmen: F. De Ponti, M. Martelli Session V Chairmen: A. Rambaldi, U. Vitolo Monoclonal Antibodies (novel): CD40 A. Younes CD80, Galiximab M.S. Czuczman CD22-Calicheamic, Inotuzumab Ozogamic J.F. DiJoseph HuMax CD4, Zanolimumab C. Assaf HuMax CD20, Ofatumumab A. Hagenbeek CD23, Lumiliximab S. O Brien Bevacizumab (Anti-VEGF) S.J. Horng HuMax CD38 P. Parren From Cell Biology to Therapy: Lenalidomide: - Untreated Multiple Myeloma A. Palumbo - Relapsed/Refractory Multiple Myeloma P. Richardson - Myelodisplastic Syndrome P. Fenaux Forodese M. Duvic Praletrexate O. O Connor Flavopiridol, Alvocidib J.C. Byrd CCI-779, Temsirolimus T.E. Witzig MGCD 0103 G. Garcia-Manero Bendamuste M.H. Dreylg HSP90 R. Foà Lunch BOLOGNA Bologna, Palazzo della Cultura e dei Congressi 7

5 Day 3 October 7, Session VIII Chairmen: M. Boccadoro, M. Gobbi Multiple Myeloma J.F. San Miguel Proteasome Inhibitors: Bortezomib : - Multiple Myeloma M. Cavo - Lymphoma A. Goy - Bortezomib- Beyond NFkB Inhibition Alone and the Emergg Role of Combation Therapy P. Richardson - Novel Proteasome Inhibitors P. Tosi Session X Chairmen: R. Fan, P. Mazza Is there a Role for Immunotherapy Hodgk's Disease? A. Engert FTL3 Inhibitors: PKC412 S. Amadori CEP701, Lestaurtib A.K. Burnett CHIR258 and FTL3 Targeted Therapy A. Romano Coffee break Session IX Chairmen: F. Gherlzoni, P. Leoni Lunch MethilDNA and FTI Inhibitors: Decitabe J.P. Issa 5-Azacitide L.R. Silverman Tipifarnib J.L. Harousseau BOLOGNA Bologna, Palazzo della Cultura e dei Congressi 9

6 GENERAL INFORMATION Meetg venue Palazzo dei Congressi Piazza Costituzione 4 - Bologna, Italy Phone HOW TO GET THERE By car From the motorway, turn to the rg road ("Tangenziale") - Exit no. 7 Fiera. By taxi From the railway station (about 10 mutes). From the airport (about 20 mutes). By bus Buses no. 10, 35 and 38 from the railway station. Aerobus BLQ from the airport. OFFICIAL LANGUAGE English. REGISTRATION FEE SIE associates Others Euro 300,00 (VAT cluded) Euro 400,00 (VAT cluded) The registration fee cludes: Conference kit Partecipation the scientific sessions Proceedgs Book Attendance Certificate Coffee breaks Lunches REGISTRATION Registrations can only be accepted and confirmed after the registration form and fee have been received by the Organizg Secretariat, Studio E.R. Congressi. All payments must be done Euro net of all bank charges and made out to Studio E.R. Congressi S.r.l. Please pay by: * Eurocheque or Foreign Cheque * Bank transfer made out to Studio E.R. Congressi S.r.l. Account n Cassa di Risparmio di Cesena - Agenzia n 29, Largo Caduti del Lavoro 1/A Bologna, Italy - Swift code: CECRIT IBAN IT36J ABI CAB CIN J * Credit Card Please send a copy of the bank transfer with the registration form. In case of written cancellation before August 31th, % of the registration fee will be refunded. 11

7 TRAVEL AGENCY Bononia Viaggi Piazza Martiri, Bologna Italy Phone Fax HOTEL RESERVATION Category Double Sgle Use Double MIN. MAX. MIN. MAX. 4 STARS Euro 130,00 Euro 140,00 Euro 160,00 Euro 170,00 3 STARS Euro 120,00 Euro 150,00 Reservation fee: 20,00 per room. Prices are clusive of tax service and breakfast, per room per night. Please fill the hotel reservation form and send it to the official travel agency Bononia Viaggi before September 5th, Hotel reservation can only be accepted and confirmed when the form and the confirmatory deposit (the price of one night per room the selected hotel category plus 20,00 for agency rights) have been received by Bononia Viaggi. Payments must be done Euro net of all bank charges and made out to Bononia Viaggi S.r.l. Please pay by: * Eurocheque or Foreign Cheque * Bank transfer made out to Bononia Viaggi S.r.l. - Banca Popolare dell Emilia Romagna - c/c ABI CAB CIN Z - IBAN IT80Z SWIFT BPMOIT22XXX * Credit card Please send a copy of the bank transfer with the hotel reservation form. In case of written cancellation before September 15th, 2008, 80% of the fee will be refunded. SCIENTIFIC INFORMATION SLIDES Slides must be English. Computer videoprojection will be available a Microsoft Power Pot extention. Other requirements should be communicated to the Organizg Secretariat as soon as possible. Slides should be handed to the slide center one hour before the begng of the session and collected at the end. BADGE All registered participants, speakers and exhibitors will be given a badge which they must wear to be admitted to the scientific sessions. ATTENDANCE CERTIFICATE A certificate will be given to all participants at the end of the meetg. ITALIAN CME Application for Italian CME credits will be made for physicians and biologists. EHA CME Application for EHA CME credits will be made for physicians and biologists. CHANGES Parts of the program may be changed if necessary without notice. 13

8 REGISTRATION FORM Please, return this form by September 5th, 2008 to: Studio E.R. Congressi - Gruppo Triumph Via Marconi Bologna - Italy Phone Fax ercongressi@gruppotriumph.it Vat Number/ Tax Payer s Number: Bologna, Palazzo della Cultura e dei Congressi October 5-7, 2008 LAST NAME FIRST NAME ISTITUTION /DEPARTMENT PROFESSION ADDRESS DISCIPLINE STATE/PROVINCE ZIP CITY COUNTRY TELEPHONE MOBILE PHONE FAX TAX PAYER S NUMBER (COD. FISCALE) FOR THE INVOICE: LAST NAME FIRST NAME POSITION TITLE PRIVATE ADDRESS CITY STATE/PROVINCE ZIP COUNTRY VAT NUMBER (P. IVA) TAX PAYER S NUMBER (COD. FISCALE) BOLOGNA Bologna, Palazzo della Cultura e dei Congressi 15

9 REGISTRATION FORM REGISTRATION FEE SIE associates Others Euro 300,00 (VAT cluded) Euro 400,00 (VAT cluded) HOTEL RESERVATION FORM Please, return this form by September 5th, 2008 to: Bononia Viaggi Piazza Martiri, Bologna Italy Phone Fax Bologna, Palazzo della Cultura e dei Congressi October 5-7, 2008 PAYMENT I enclose Eurocheque or Foreign Cheque LAST NAME of Euro Number FIRST NAME Bank made out to Studio E.R. Congressi S.r.l. INSTITUTION Bank Transfer made out to Studio E.R. Congressi S.r.l. Account n CASSA DI RISPARMIO DI CESENA Agenzia n 29, Largo Caduti del Lavoro 1/A, Bologna I - Swift code: CECRIT 2C Iban code: IT36J ABI CAB CIN J Credit Card: Number Owner Expiry date VISA MASTERCARD DINERS AMERICAN EXPRESS I enclose a copy of the bank transfer with the registration form. ADDRESS CITY ZIP TELEPHONE NAME OF THE ACCOMPANYING PERSON STATE/PROVINCE COUNTRY FAX Registrations can only be accepted and confirmed when the registration form and fee have been received by the Organizg Secretariat Studio E.R. Congressi. In case of written cancellation before August 31th, 2008, 80% of the registration fee will be refunded. Signg this form and well formed on the Legislative Decree n. 196/2003 concerng Personal data processg, I authorize Studio E.R. Congressi S.r.l., until written revocation, to process and divulge my personal data with the limits of the above-mentioned law and accordance with the procedure laid down by the law. I give my assent provided that Studio E.R. Congressi complies with the regulations force. I do not want that my personal data are divulged to third parties. FOR THE INVOICE: PRIVATE ADDRESS CITY ZIP TELEPHONE STATE/PROVINCE COUNTRY DATE SIGNATURE VAT NUMBER (IVA) TAX PAYER S NUMBER (COD. FISCALE) 17

10 HOTEL RESERVATION FORM HOTEL RESERVATION Category Double Sgle Use Double MIN. MAX. MIN. MAX. 4 STARS Euro 130,00 Euro 140,00 Euro 160,00 Euro 170,00 3 STARS Euro 120,00 Euro 150,00 These prices are per night per room and clude bed, breakfast and taxes. Reservation fee: 20,00 4 stars Double Sgle Use 3 stars Double Date of arrival Date of departure Night: no. In case of double room, dicate the name of your room-mate PAYMENT I enclose Eurocheque or Foreign Cheque of: Euro Number Bank made out to Bononia Viaggi S.r.l. Bank Transfer made out to Bononia Viaggi S.r.l. - Banca Popolare dell Emilia Romagna c/c ABI CAB CIN Z IBAN IT80Z SWIFT BPMOIT22XXX Credit Card: Number Owner Expiry date VISA MASTERCARD DINERS AMERICAN EXPRESS I enclose a copy of the bank transfer with the hotel reservation form. Hotel reservation can only be accepted and confirmed when the form and the confirmatory deposit (the price of one night per room the selected hotel category plus Lit. Euro for agency rights) have been received by Bononia Viaggi. In case of written cancellation before September 15th, 2008, 80% will be refunded. Signg this form and well formed on the Legislative Decree n. 196/2003 concerng Personal data processg, I authorize Bononia Viaggi S.r.l., until written revocation, to process and divulge my personal data with the limits of the above-mentioned law and accordance with the procedure laid down by the law. I give my assent provided that Bononia Viaggi complies with the regulations force. I do not want that my personal data are divulged to third parties. INFORMATION ON LEGISLATIVE DECREE N. 196/2003 Accordg to art. 13, Legislative decree no. 196/2003, and relation to the processg of personal data, Studio E.R. Congressi S.r.l form you of the followg: l. Data processg purposes Your personal data will be processed by Studio E.R. Congressi S.r.l for managg, accountg, statistical, commercial, marketg and/or promotg purposes and this by processg, comparg, divulgg or employg these very data. 2. Data Processg modality Data will be processed by appropriate devices ensurg their security and confidentiality. Data could be also processed by automatic maches employed to process, store and transmit the very data. 3. Obligatoress of personal data bestowal To be registered the congresses we organize, you are obligated to give your data. 4. Data communication, diffusion and transfer Your data can be given to organizers of the congress and to the companies sponsorg the event as well as to other companies, authorities, consortia or associations that could divulge these data to their members, users and other related people with the limits of their stitutional purposes. The only objective is to form the person concerned about the existence of similar itiatives or to supply him with other formation that could be deemed terestg. Furthermore, the above mentioned data can be given/divulged to companies, authorities, consortia and association workg Italy or the EC countries havg the same objectives as stated before. 5. Rights of terested parties You have the right to know, consultg the register specified the art. 154 sub-section 1 letter l) of the legislative decree 196/2003, the existence of data processg; you can partially or entirely oppose, for legitimate reasons, the processg of your data, even if these data are relevant to the objective of data collection. Furthermore you can prevent his data from beg used for commercial purposes, market surveys, advertisement for direct sellg or teractive commercials. You are acknowledged exercise of rights as per art. 7, Legislative decree 196/2003, the complete text of which is given the enclosure. 6. The owner of the data processg The owner of the data processg is Studio E.R. Congressi S.r.l Via Marconi, Bologna. The list of the people responsible of the processg itself is kept updated, and you can easily consult it sendg a written communication to the above address. Data will be held to the Studio E.R. Congressi S.r.l buildg, as long as the law prescribes. Article 7 of the legislative decree 196/ right of access to personal data and other rights 1. The person concerned has the right to obta confirmation of the existence of personal data and formation regardg him/her - even though not recorded yet - and their disclosure under an telligible form. 2. The person concerned is entitled to be formed of: a) the orig of personal data and formation; b) data treatment purposes and ways; c) the logic followed the event of data treatment beg carried out with electronic tools; d) the details to identify the owner, the persons charge and the representative appoted under article 5, paragraph 2; e) the people or groups of people to whom personal data and formation can be disclosed or who may come to know them their capacity as repre-sentative appoted the State territory or persons charge. 3. The person concerned has the right to obta: a) updatg, correction or - where terested this process - supplementation of data; b) cancellation, turng to anonymous data or the block of data treated by frgg the law, cludg data and formation which need not be kept relation to the purposes for which data and formation were collected or subsequently treated; c) a certificate statg that the operations under sub-paragraphs a) and b) - cludg their content - have been communicated to those to whom data and formation were provided or disclosed, except the case when this proves to be impossible or entails the use of such an amount of means which is overtly non commensurate with the right which is protected. 4. The person concerned has to right to wholly or partially refuse: a) treatment of personal data and formation regardg him/her for legitimate reasons, even though they are relevant to the aim of collection; b) treatment of personal data regardg him/her for the purposes of sendg advertisg material, direct sale or performance of market studies or com-mercial communications. DATE SIGNATURE 19

11 Scientific Secretariat Istituto di Ematologia e Oncologia Medica L. e A. Seràgnoli Via Massarenti, Bologna, Italy Tel Fax Organizg Secretariat Studio E.R. Congressi Gruppo Triumph Via Marconi, Bologna, Italy Tel Fax ercongressi@gruppotriumph.it