National Workshop of Hematology The TP53 Workshop

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1 National Workshop of Hematology The TP53 Workshop Bologna, 10 th May 2013 Aemilia Hotel Via G. Zaccherini Alvisi, 16 Bologna PROMOTED BY

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3 Workshop Presidents Michele Cavo Giovanni Martinelli Pier Luigi Zinzani Department of Experimental, Diagnostic and Specialty Medicine Institute of Hematology L. e A. Seràgnoli, University of Bologna Honorary Presidents Sante Tura BolognAIL Onlus, Italian Association for Leukemias, Lymphomas, and Myeloma Domenico Russo Chair of Hematology and Unit of Blood Diseases and Stem Cell Transplantation, Department of Clinical and Experimental Sciences, University of Brescia - Brescia, Italy Scientific Secretariat Ilaria Iacobucci Cristina Papayannidis Vittorio Stefoni Carolina Terragna Elena Zamagni Simona Soverini Nicoletta Testoni Francesca Palandri Department of Experimental, Diagnostic and Specialty Medicine Institute of Hematology L. e A. Seràgnoli, University of Bologna I Bologna(Italy) Phone Fax Under the Auspices of AIRC Associazione Italiana per la Ricerca sul Cancro AIL Associazione Italiana contro le Leucemie- Linfomi e Mieloma Azienda Ospedaliero-Universitaria di Bologna - Policlinico S. Orsola-Malpighi BolognAIL Onlus Fondazione Cassa di Risparmio in Bologna Fondazione del Monte di Bologna e Ravenna Next Generation Sequencing for Targeted Personalized Therapy of Leukemia SIE Società Italiana di Ematologia SIES Società Italiana di Ematologia Sperimentale Regione Emilia-Romagna UNIBO Alma Mater Studiorum - Università di Bologna PROGRAMME OVERVIEW TP53 gene mapped on 17p13.1 is one of the most important tumor suppressor in humans. It encodes a nuclear p53 protein of 393 amino acids, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, DNA repair, apoptosis, senescence or changes in metabolism. Tumour-associated alterations in TP53 are a hallmark of over 50% of human cancers and cause dramatic defects in p53 function promoting the accumulation of DNA damage. MDM2, a p53-inducible phosphoprotein, binds to the N-terminus of the p53 and negatively regulates its transcriptional activity. New MDM2 antagonists are now available for Phase I/II clinical development to reactive wild-type p53 function. National Workshop of Hematology The TP53 Workshop

4 SCIENTIFIC PROG Friday, 10 th May Participants registration Welcome address Introduction and Workshop purpose 1 st session - Structure and function of p53 wild-type and mutated Chairmen: Gianluca Gaidano (Novara, Italy) - Pier-Luigi Lollini (Bologna, Italy) Introduced by: Giovanni Perini (Bologna, Italy) TP53 mutation in human cancer: lessons learned from the UMD_TP53 database Thierry Soussi (Paris, France) P53 and chromosomal aberrations Ilaria Iacobucci (Bologna, Italy) Oncogenic Transcriptional activity of mutant p53 and its pathway disruption Giulia Fontemaggi (Roma, Italy) Coffee break 2 nd session - Detection and role of mutations in TP53 in hematologic malignancies Chairmen: Domenico Russo (Brescia, Italy) - Antonio Bonati (Parma, Italy) Introduced by: Elena Zamagni (Bologna, Italy) TP53 Mutations in Multiple Myeloma Carolina Terragna (Bologna, Italy) Recommendations on TP53 mutational analysis in chronic lymphocytic leukemia (CLL) Sarka Pospisilova (Brno, Czech Republic) TP53 disruption in transformation from CLL to aggressive lymphoma Davide Rossi (Novara, Italy) TP53 Mutations in Acute Lymphoblastic Leukemia Sabina Chiaretti (Roma, Italy) TP53 Mutations in AML/MDS Matteo Della Porta (Pavia, Italy) Lunch

5 RAMME 3 rd session - Novel cancer therapy by targeting the p53 pathway Chairmen: Giovanni Tallini (Bologna, Italy) New drugs for TP53 reactivation Cristina Papayannidis (Bologna, Italy) Introduced by: Giovanni Martinelli (Bologna, Italy) P53 and stem cells Pier Giuseppe Pelicci (Milano, Italy) 4 th session - Sequencing and targeting the p53 pathway Chairmen: Giovanna Cenacchi (Bologna, Italy) How I seq TP53 in solid tumor for diagnostic purpose Luca Morandi (Bologna, Italy) TP53: prognostic and predictive factor in solid tumor? Giovanni Brandi (Bologna, Italy) Discussion Conclusions Workshop session * LECTURE: MDM2 inhibitors: the past, the present and the future Gwen Nichols (San Francisco, USA) National Workshop of Hematology The TP53 Workshop

6 FACULTY Antonio Bonati Department of Clinical and Experimental Medicine, University of Parma - Parma, Italy Giovanni Brandi Department of Experimental, Diagnostic and Speciality Medicine, University of Bologna, Bologna, Italy Giovanna Cenacchi Department of Biomedical and Neuromotoric Sciences, University of Bologna, Bologna, Italy Sabina Chiaretti Department of Cellular Biotechnologies and Hematology, Sapienza University of Rome - Roma, Italy Matteo Della Porta Section of Hematology, University of Pavia, Policlinico San Matteo - Pavia, Italy Giulia Fontemaggi Department of Experimental Oncology, Regina Elena National Cancer Institute IRCCS - Roma, Italy Gianluca Gaidano Division of Hematology, Department of Translational Medicine Amedeo Avogadro University of Eastern Piedmont - Novara, Italy Ilaria Iacobucci Pier-Luigi Lollini Giovanni Martinelli Luca Morandi Department of Biomedical and Neuromotor Sciences - DIBINEM, Bellaria Hospital- Bologna, Italy Gwen Nichols Roche - San Francisco, USA

7 Cristina Papayannidis Pier Giuseppe Pelicci European Institute of Oncology - Milano, Italy Giovanni Perini Department of Pharmacy and Biotechnologies FaBit, University of Bologna - Bologna, Italy Sarka Pospisilova Head of Centre for Molecular Medicine, Masaryk University Ceitec - Brno, Czech Republic Davide Rossi Division of Hematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont - Novara, Italy Domenico Russo Chair of Hematology and Unit of Blood Diseases and Stem Cell Transplantation, Department of Clinical and Experimental Sciences, University of Brescia Brescia, Italy Thierry Soussi Department of Life Science, University P.M. Curie of Paris Paris, France Department of Oncology-Pathology, Karolinska Institutet Stockholm, Sweden Giovanni Tallini Carolina Terragna Elena Zamagni

8 A cura di MEC&PARTNERS VENUE Aemilia Hotel Sala Archiginnasio Via G. Zaccherini Alvisi, 16 Bologna OFFICIAL LANGUAGE The official Congress language is English. No translation will be provided. C.M.E. ACCREDITATION The Congress (ECM CODE 58487) has been credited at the Italian Ministry of Health for the categories of Physician, Biologist, Pharmacist, Health and Biomedical Laboratory Technician. Disciplines accredited Physician: Clinical Biochemistry, Hematology, Clinical Pharmacology and Toxicology, Medical Genetics, Geriatrics, Internal Medicine, Oncology, Clinical Pathology. Discipline accredited Pharmacist: Hospital Pharmacy. Please note that credits for the Workshop session are not required. The pre-assigned ECM credits are 5,3 Please note that, in order to obtain the CME credits, it is NECESSARY the 100% of attendance to the congress work, the 75% of correct answers to the learning questionnaire and the compiling of the evaluating form. No exceptions to this requirements will be considered. ORGANIZING SECRETARIAT AND PROVIDER (891) Via Orefici, Bologna Tel Fax THANKS TO Roche SpA Roche Diagnostics SpA.

National Workshop of Hematology The TP53 Workshop

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