AGGRESSIVE LYMPHOMAS WORKSHOP

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1 ALMA MATER STUDIORUM Università di Bologna Dipartimento di Ematologia e Scienze Oncologiche L. e A. Seragnoli AGGRESSIVE LYMPHOMAS WORKSHOP PROGRAM Bologna, November , 2010 Presidents: Michele Baccarani Stefano Pileri Pier Luigi Zinzani Honorary President: Sante Tura

2 REQUESTED AUSPICIES UNIVERSITÀ DEGLI STUDI DI BOLOGNA REGIONE EMILIA-ROMAGNA Presidents Michele Baccarani Stefano Pileri Pier Luigi Zinzani Honorary President Sante Tura AZIENDA OSPEDALIERO-UNIVERSITARIA DI BOLOGNA AIL ASSOCIAZIONE ITALIANA CONTRO LE LEUCEMIE LINFOMI E MIELOMA (Sezione di Bologna) SIE - SOCIETÀ ITALIANA DI EMATOLOGIA Scientific Committee Michele Baccarani Stefano Pileri Pier Luigi Zinzani Paolo Corradini Gianluca Gaidano Maurizio Martelli Umberto Vitolo Scientific Secretariat Vittorio Stefoni Istituto di Ematologia L. e A. Seràgnoli Via Massarenti, Bologna, Phone Fax Organizing Secretariat Studio E.R. Congressi - Triumph Group Via Marconi, Bologna, Phone Fax ercongressi@triumphgroup.it

3 FACULTY 3 AGGRESSIVE LYMPHOMAS WORKSHOP Bologna, November , 2010 James O. Michele Lodovico Alberto Elias Antonino Franco Bruce D. Bertrand Paolo Myron S. Riccardo Martin Fabio Brunangelo Renato Richard I. Gianluca Christian Marco Anthony H. Mary Ulrich Issa Philip M. Thierry John P. Pietro Ian T. Alberto M. Maurizio Thomas P. Franck Owen Michael Pier Paolo Stefano Aaron Alessandro Michael J. Andreas Laurie H. Margaret A. Michele Louis M. Herald Corrado Hervé Lorenz Gustaaf W. Giuseppe Umberto Julie M. Wyndham H. Thomas E. Anas Alfonso Pier Luigi ARMITAGE BACCARANI BALDUCCI BOSI CAMPO CARBONE CAVALLI CHESON COIFFIER CORRADINI CZUCZMAN DALLA FAVERA DREYLING FACCHETTI FALINI FANIN FISHER GAIDANO GISSELBRECHT GOBBI GOLDSTONE GOSPODAROWICZ JAEGER KHOURI KLUIN LAMY LEONARD LEONI MAGRATH MARMONT MARTELLI MILLER MORSCHHAUSER O CONNOR PFREUNDSCHUH PICCALUGA PILERI POLLIACK RAMBALDI ROBERTSON ROSENWALD SEHN SHIPP SPINA STAUDT STEIN TARELLA TILLY TRUMPER VAN IMHOFF VISANI VITOLO VOSE WILSON WITZIG YOUNES ZACCARIA ZINZANI Spain Switzerland France Germany France United Kingdom Canada Austria The Netherlands France France Germany Israel Germany Canada Germany France Germany The Netherlands

4 November 15, p.m. Welcome and Introduction 2.30 p.m. Histopathology Chairmen: A. Carbone, F. Facchetti Diffuse Large B Cell Lymphoma (DLBCL) A. Rosenwald Aggressive Follicular Lymphoma P.P. Piccaluga Primary Mediastinal Large B Cell Lymphoma B. Falini Mantle Cell Lymphoma E. Campo Burkitt Lymphoma H. Stein Peripheral T Cell Lymphoma Unspecified S. Pileri

5 p.m. Biology and Prognosis in DLBCL Chairmen: G. Gaidano, S. Pileri Cytogenetic P. Kluin Biopathology R. Dalla Favera Gene Expression Profiling Studies L.M. Staudt Molecular Signatures Define New Treatment Rationales M.A. Shipp Prognostic Value of FDG-PET B.D. Cheson 6.15 p.m. The Long Story of Clinical Prognostic Factor in DLBCL L.H. Sehn 6.45 p.m. Systemic Lupus Erythematosus and DLBCL. Dichotomy of Therapeutical Response A.M. Marmont AGGRESSIVE LYMPHOMAS WORKSHOP Bologna, November , 2010

6 November 16, a.m. Chairmen: M. Gobbi, P.L. Zinzani Role of Radiotherapy in DLBCL M. Gospodarowicz 9.00 a.m. DLBCL: Front-line Treatment in Adult (<60 years, IPI 0-1) The German Experience L. Trumper The French Experience H. Tilly The American Experience T.P. Miller a.m. Coffee break a.m. DLBCL: Front-line Treatment in Adult (<60 years, IPI 2) Chairmen: B.D. Cheson, C. Tarella The American Experience R.I. Fisher The French Experience C. Gisselbrecht The German Experience L. Trumper The Italian Experience U. Vitolo The Hovon Experience G.W. van Imhoff

7 p.m. DLBCL: Specific Regimens Chairman: A. Polliack High Dose Sequential A. Rambaldi EPOCH W.H. Wilson 1.00 p.m. Lunch 2.30 p.m. DLBCL: Front-line Treatment in Elderly Patients Chairmen: L. Balducci, P. Leoni The German Experience M. Pfreundschuh The French Experience B. Coiffier The American Experience R.I. Fisher Unfit Patients Regimens L. Balducci 4.00 p.m. Coffee break AGGRESSIVE LYMPHOMAS WORKSHOP Bologna, November , 2010

8 p.m. Role of Transplant in DLBCL Chairmen: A. Bosi, R. Fanin Autologous as Consolidation Phase: European Perspectives A.H. Goldstone American Perspectives J.O. Armitage Allogenic: American Perspectives I. Khouri European Perspectives P. Corradini 5.45 p.m. Is there a Role for Maintenance Treatment in DLBCL? Chairman: F. Cavalli Enzastaurin M.J. Robertson Bevacizumab T.P. Miller Rituximab U. Jaeger Everolimus F. Cavalli

9 9 November 17, a.m. New Drugs in DLBCL Chairmen: M. Baccarani, J.P. Leonard RAD001 T.E. Witzig Lenalidomide J.M. Vose Y 90 Ibritumomab Tiuxetan P.L. Zinzani Ofatumumab B. Coiffier Veltuzumab F. Morschhauser Galiximab M.S. Czuczman Anti-CD40 A.Younes Bortezomib J.P. Leonard GA101 T. Lamy Non Pegylated Liposomial Doxorubicin G. Visani AGGRESSIVE LYMPHOMAS WORKSHOP Bologna, November , 2010

10 a.m. Other Aggressive Entities Chairmen: O. O Connor, A. Zaccaria Burkitt Lymphoma I.T. Magrath Peripheral T Cell Lymphoma Unspecified O. O Connor Mantle Cell Lymphoma M. Dreyling DLBCL Transformed from CLL G. Gaidano HIV+ DLBCL M. Spina Primary Mediastinal Large B Cell Lymphoma M. Martelli

11 11 GENERAL INFORMATION Meeting venue Via Montebello, Bologna, Phone Fax AGGRESSIVE LYMPHOMAS WORKSHOP HOW TO GET THERE By car From the motorway, turn into the ring road ("Tangenziale") Exit 7 Fiera and follow direction city center and railway station. By taxi From the airport about 20 minutes. By bus Bus 91 and Aerobus BLQ from the airport. From the railway station walking distance. OFFICIAL LANGUAGE English. REGISTRATION FEE Euro 350,00 The registration fee includes: Conference Kit Partecipation in the Scientific Sessions Proceedings Book Attendance Certificate Coffee breaks Lunches Bologna, November , 2010 REGISTRATION Registrations can only be accepted and confirmed after the registration form and fee have been received by the Organizing Secretariat, Studio E.R. Congressi. All payments must be done in Euro net of all bank charges and made out to Studio E.R. Congressi S.r.l. Please pay by: * Bank transfer made out to Studio E.R. Congressi S.r.l. CASSA DI RISPARMIO DI CESENA - Agenzia n 29, Largo Caduti del Lavoro 1/A, Bologna Swift code: CECRIT 2C - Iban code: IT49L CC * Credit Card Please send a copy of the bank transfer with the registration form. In case of written cancellation before September 1, 2010, 80% of the registration fee will be refunded.

12 TRAVEL AGENCY Viaggi Salvadori S.r.l. Via Ugo Bassi, Bologna Phone Fax HOTEL RESERVATION Hotel RATES (Breakfast & tax incl.) Double Single Use / Double / Twin MillennHotel 3* 69,00 / 79,00 / 79,00 Hotel Regina 3* 73,00 / 73,00 / 73,00 Hotel Europa 4* 83,00 / 83,00 / 83,00 Hotel Tre vecchi 4* 83,00 / 83,00 / 83,00 Hotel Internazionale 4* 88,00 / 102,00 / 102,00 Hotel Roma 3* sup 100,00 / 125,00 / 125,00 Hotel NH De La Gare 4* 110,00 / 120,00 / 120,00 These prices are per night, per room and included breakfast. Please fill in the hotel reservation form and send it to the official travel agency Viaggi Salvadori S.r.l. before September 1, When Viaggi Salvadori will receive this registration form, it will provide to send by the reservation along with the total Bank Statement of the reservation, which will be confirmed only after receiving the deposit, within 2 days. Payments must be done in Euro net of all bank charges and made out to Viaggi Salvadori S.r.l. Please pay by: * Bank transfer made out to Viaggi Salvadori S.r.l. Monte dei Paschi AG 8, Via Zamboni, 11 - Bologna - BO / IBAN - IT 07 J BIC - PASCITM1006 * Credit card In case of written cancellation please see conditions at cancellation policy. No hotel reservation fee will be refunded.

13 13 SCIENTIFIC INFORMATION AGGRESSIVE LYMPHOMAS WORKSHOP Slides Slides must be in English. Computer videoprojection will be available in Power Point. Other requirements should be communicated to the Organizing Secretariat as soon as possible. Slides should be handed to the slide center one hour before the beginning of the session and collected at the end. Badge All registered participants, speakers and exhibitors will be given a badge which they must wear to be admitted to the scientific sessions. Bologna, November , 2010 Attendance certificate A certificate will be given to all participants at the end of the Meeting. CME Application for italian CME credits will be made. Changes Parts of the program may be changed if necessary without notice.

14 14 AGGRESSIVE LYMPHOMAS WORKSHOP Presidents: Michele Baccarani Stefano Pileri Pier Luigi Zinzani Honorary President: Sante Tura Bologna, November , 2010

15 REGISTRATION FORM Please, return this form by September 1, 2010 to: Studio E.R. Congressi - Triumph Group Via Marconi Bologna, Phone Fax ercongressi@triumphgroup.it Vat Number/ Tax Payer s Number: LAST NAME AGGRESSIVE LYMPHOMAS WORKSHOP Bologna, November , 2010 FIRST NAME ISTITUTION /DEPARTMENT PROFESSION DISCIPLINE ADDRESS STATE/PROVINCE ZIP CITY COUNTRY TELEPHONE MOBILE PHONE FAX TAX PAYER S NUMBER (COD. FISCALE) FOR THE INVOICE: LAST NAME FIRST NAME PRIVATE ADDRESS CITY STATE/PROVINCE ZIP COUNTRY VAT NUMBER (P. IVA) TAX PAYER S NUMBER (COD. FISCALE)

16 REGISTRATION FORM 16 REGISTRATION FEE (in Euro - VAT included): Euro 350,00 PAYMENT Bank Transfer made out to Studio E.R. Congressi S.r.l. CASSA DI RISPARMIO DI CESENA - Agenzia n 29, Largo Caduti del Lavoro 1/A, Bologna Swift code: CECRIT 2C - Iban code: IT49L CC Credit Card: Number Cvv (security number) Expiry date Owner Date of birth VISA MASTERCARD AMERICAN EXPRESS I enclose a copy of the bank transfer with the registration form. Registrations can only be accepted and confirmed when the registration form and fee have been received by the Organizing Secretariat Studio E.R. Congressi. In case of written cancellation before September 1, 2010, 80% of the registration fee will be refunded. Information on Legislative Decree N. 196/2003 ( Personal data processing ) Signing this form and well informed on the Legislative Decree n.196/2003 concerning Personal data processing, I authorize Studio E.R. Congressi Srl, until written revocation, to process and divulge my personal data within the limits of the above-mentioned law and in accordance with the procedure laid down by the law. I gave my assent provided that Studio E.R. Congressi Srl complies with the regulations in force. I do not want that my personal data are divulged to third parties. DATE SIGNATURE

17 HOTEL RESERVATION FORM Please, return this form within September 1, 2010 to the Travel Agency: Viaggi Salvadori S.r.l. - Via Ugo Bassi, Bologna, Phone Fax aggressive@viaggisalvadori.it AGGRESSIVE LYMPHOMAS WORKSHOP Bologna, November , 2010 LAST NAME FIRST NAME INSTITUTE ADDRESS ZIP CODE CITY STATE/PROVINCE TELEPHONE FAX MOBILE PHONE FOR THE INVOICE: INSTITUTE/CORPORATE NAME TAX RESIDENCE ZIP CODE CITY STATE/PROVINCE TELEPHONE FAX MOBILE PHONE COMPULSORY VAT NUMBER (P. IVA) TAX PAYER S NUMBER (COD. FISCALE) Invoice sending address (if different from the tax residence) ZIP CODE CITY STATE/PROVINCE TELEPHONE FAX MOBILE PHONE COMPULSORY 3* MILLENNHOTEL Located in Bologna Downtown A well established Bolognese hotel which opened in January 2002; a 3 stars hotel situated near the railway station and the business fair area with easy access to the. Its 60 rooms, including 4 suites, are all stylish furnished. For this reason the Millennhotel is the best solution for both business and leisure travellers. 3* HOTEL REGINA Located in Bologna Downtown Situated in Via Indipendenza and closed to the railway station at only 15 minutes from the airport (by taxi), the hotel invites you to enjoy your vacancy in Bologna, starting, for example, from the celebrated "Piazzola" open air weekly Market. 4* HOTEL EUROPA Located in Bologna Downtown Hotel Europa is located in the city centre and may be conveniently reached by those travelling by car or train. The 101 Guest rooms are elegantly decorated in a classic imperial style design, all with self controlled air conditioning system, direct dial telephone, mini bar, digital safety box, radio, WI-FI Internet connection, PAY TV, satellite and SKY TV, hairdryer and confort kit in the bathroom. 4* HOTEL TRE VECCHI Located in Bologna Downtown Zanhotel Tre Vecchi is located on the main street of Bologna in an old building with a characteristic portico. Zanhotel Tre Vecchi is in the heart of the city centre and it is easily reached by any means: a short walk from the railway station,15 minutes by taxi from the airport, 1.5 kilometres from exit no. 7 on the motorway bypass (Trade fair district). 4* HOTEL INTERNAZIONALE Located in Bologna Downtown The Hotel Internazionale is located in a historic building in Via Indipendenza, in the heart of Bologna, just a short distance from the railway station. Recent renovation has further enhanced the quality features that distinguish its decor, creating a reserved and elegant atmosphere where guests feel distinctly at home. 3* SUP HOTEL ROMA Located in Bologna INNER Downtown Few Steps from Maggiore Square Hotel Roma has a long tradition of having a refined and welcoming atmosphere. Situated in the historical centre of the city, just beside Piazza Maggiore, it is easy to access. Located on Via d Azeglio, the shopping and walking street of Bologna. 4* NH DE LA GARE Located in Bologna Downtown The NH Bologna De La Gare can be defined by its central location, just a few steps from the train station, the main historical monument and the cities business district.

18 HOTEL RESERVED rates FOR AGGRESSIVE (per night per room) Your priority of Double single Double Twin (Breakfast & tax incl.) choice (1 to 4) use (1 pers.) (2 pers.) (2 beds) Double Single Use / Double / Twin MillennHotel 3* 69,00 / 79,00 / 79,00 Hotel Regina 3* 73,00 / 73,00 / 73,00 Hotel Europa 4* 83,00 / 83,00 / 83,00 Hotel Tre vecchi 4* 83,00 / 83,00 / 83,00 Hotel Internazionale 4* 88,00 / 102,00 / 102,00 Hotel Roma 3* sup 100,00 / 125,00 / 125,00 Hotel NH De La Gare 4* 110,00 / 120,00 / 120,00 These prices are per night, per room and include breakfast. 18 DELEGATES GROUP: In case of reservation of 5 rooms, please contact us direcly and we will arrange a tailor made offer for your group. Date of arrival Date of departure In case of double room, indicate the name of your room-mate When Viaggi Salvadori will receive this registration form, it will provide to send by the reservation along with the total Bank Statement of the reservation, which will be confirmed only after receiving the deposit, within 2 days. PAYMENT: 25% at confirmation. Settlement a month before arrival. Hotel reservation charges 20,00 p/room Credit transfer VIAGGI SALVADORI S.R.L. - MONTE DEI PASCHI AG 8 BOLOGNA - VIA ZAMBONI 11 - BOLOGNA / ITALY IBAN - IT 07 J BIC - PASCITM1006 PAYMENT USING CREDIT CARDS: Payment by credit cards counts a surtax of 3% for bank charges. Credit Card: Visa Mastercard American Express Owner: Number: Expiry date: CVV I authorize Viaggi Salvadori S.r.l. to charge on this card the following amount: Signature For payment by credit cards, please send a copy of the front and of the back of your card and a copy of the identity card of the owner to the fax CANCELLATION POLICY: In case of cancellation please, communicate in writing to Viaggi Salvadori to the aggressive@viaggisalvadori.it or to the fax A) Group: by request. B) In case of individual reservation cancellation the following fines will be applied: For cancellation carried out within 60 days before arrival, no penalty will be applied / For cancellation carried out from 59 till 30 days before arrival, 30% penalty of the total stay will be applied / For cancellation carried out from 29 till 15 days before arrival, 50% penalty of the total stay will be applied / For cancellation carried out from 14 till 8 days before arrival, 75% penalty of the total stay will be applied / For cancellation carried out 7 days before arrival, 100% penalty of the total stay will be applied No hotel reservation fee will be refunded. Information on Legislative Decree N. 196/2003 ( Personal data processing ) Viaggi Salvadori treats the client's personal data following the rules of the legislative decree dated 30 June 2003 n.196 of the Italian law. Viaggi Salvadori, through the booking of the services, treats the personal data only to accomplish its commercial duties towards the client. In order to accomplish these duties Viaggi Salvadori and its suppliers must have access to its client's personal data, the first as responsible of these data, the second as charged of their treatment Viaggi Salvadori informs that these data will be treated only for the above mentioned purposes.

19 INFORMATION ON LEGISLATIVE DECREE N. 196/2003 According to art. 13, Legislative decree no. 196/2003, and in relation to the processing of personal data, Studio E.R. Congressi S.r.l inform you of the following: l. Data processing purposes Your personal data will be processed by Studio E.R. Congressi S.r.l for managing, accounting, statistical, commercial, marketing and/or promoting purposes and this by processing, comparing, divulging or employing these very data. 2. Data Processing modality Data will be processed by appropriate devices ensuring their security and confidentiality. Data could be also processed by automatic machines employed to process, store and transmit the very data. 3. Obligatoriness of personal data bestowal To be registered in the congresses we organize, you are obligated to give your data. 4. Data communication, diffusion and transfer Your data can be given to organizers of the congress and to the companies sponsoring the event as well as to other companies, authorities, consortia or associations that could divulge these data to their members, users and other related people within the limits of their institutional purposes. The only objective is to inform the person concerned about the existence of similar initiatives or to supply him with other information that could be deemed interesting. Furthermore, the above mentioned data can be given/divulged to companies, authorities, consortia and association working in or in the EC countries having the same objectives as stated before. 5. Rights of interested parties You have the right to know, consulting the register specified in the art. 154 sub-section 1 letter l) of the legislative decree 196/2003, the existence of data processing; you can partially or entirely oppose, for legitimate reasons, the processing of your data, even if these data are relevant to the objective of data collection. Furthermore you can prevent his data from being used for commercial purposes, market surveys, advertisement for direct selling or interactive commercials. You are acknowledged exercise of rights as per art. 7, Legislative decree 196/2003, the complete text of which is given in the enclosure. 6. The owner of the data processing The owner of the data processing is Studio E.R. Congressi S.r.l Via Marconi, Bologna. The list of the people responsible of the processing itself is kept updated, and you can easily consult it sending a written communication to the above address. Data will be held into the Studio E.R. Congressi S.r.l building, as long as the law prescribes. Article 7 of the legislative decree 196/ right of access to personal data and other rights 1. The person concerned has the right to obtain confirmation of the existence of personal data and information regarding him/her - even though not recorded yet - and their disclosure under an intelligible form. 2. The person concerned is entitled to be informed of: a) the origin of personal data and information; b) data treatment purposes and ways; c) the logic followed in the event of data treatment being carried out with electronic tools; d) the details to identify the owner, the persons in charge and the representative appointed under article 5, paragraph 2; e) the people or groups of people to whom personal data and information can be disclosed or who may come to know them in their capacity as representative appointed in the State territory or persons in charge. 3. The person concerned has the right to obtain: a) updating, correction or - where interested in this process - supplementation of data; b) cancellation, turning into anonymous data or the block of data treated by infringing the law, including data and information which need not be kept in relation to the purposes for which data and information were collected or subsequently treated; c) a certificate stating that the operations under sub-paragraphs a) and b) - including their content - have been communicated to those to whom data and information were provided or disclosed, except the case when this proves to be impossible or entails the use of such an amount of means which is overtly non commensurate with the right which is protected. 4. The person concerned has to right to wholly or partially refuse: a) treatment of personal data and information regarding him/her for legitimate reasons, even though they are relevant to the aim of collection; b) treatment of personal data regarding him/her for the purposes of sending advertising material, direct sale or performance of market studies or commercial communications.

20 Scientific Secretariat Vittorio Stefoni Istituto di Ematologia L. e A. Seràgnoli Via Massarenti, Bologna, Phone Fax Organizing Secretariat Studio E.R. Congressi - Triumph Group Via Marconi, Bologna, Phone Fax ercongressi@triumphgroup.it

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