Global topological features of cancer proteins in the human interactome

Transcription

1 Global topological features of cancer proteins in the human interactome Pall F. Jonsson and Paul A. Bates Protein communities identified by k-clique clustering. KEGG pathway data is provided for proteins where available.

2 k = 3 Community 0 k = 3 NP ACADM METABOLIC Lipid Metabolism Fatty acid metabolism METABOLIC Amino Acid Metabolism Valine, leucine and isoleucine degradation METABOLIC Metabolism of Other Amino Acids beta-alanine metabolism METABOLIC Carbohydrate Metabolism Propanoate metabolism NP PSEN1 REGULATORY Signal Transduction Notch signaling pathway REGULATORY Neurodegenerative Disorders Alzheimer s disease NP SGCA NP ADSL METABOLIC Nucleotide Metabolism Purine metabolism METABOLIC Amino Acid Metabolism Alanine and aspartate metabolism NP AGL METABOLIC Carbohydrate Metabolism Starch and sucrose metabolism NP ALAD METABOLIC Metabolism of Cofactors and Vitamins Porphyrin and chlorophyll metabolism NP ALAS2 METABOLIC Amino Acid Metabolism Glycine, serine and threonine metabolism NP ALDOA METABOLIC Carbohydrate Metabolism Glycolysis / Gluconeogenesis METABOLIC Carbohydrate Metabolism Pentose phosphate pathway METABOLIC Carbohydrate Metabolism Fructose and mannose metabolism METABOLIC Energy Metabolism Carbon fixation NP ALDOB METABOLIC Carbohydrate Metabolism Glycolysis / Gluconeogenesis METABOLIC Carbohydrate Metabolism Pentose phosphate pathway METABOLIC Carbohydrate Metabolism Fructose and mannose metabolism METABOLIC Energy Metabolism Carbon fixation NP APC NP TNFRSF6 REGULATORY Metabolic Disorders Type I diabetes mellitus NP AR NP ARG1 METABOLIC Amino Acid Metabolism Urea cycle and metabolism of amino groups METABOLIC Amino Acid Metabolism Arginine and proline metabolism NP ASL METABOLIC Amino Acid Metabolism Urea cycle and metabolism of amino groups METABOLIC Amino Acid Metabolism Alanine and aspartate metabolism METABOLIC Amino Acid Metabolism Arginine and proline metabolism NP ATM NP BCHE NP BCKDHB METABOLIC Amino Acid Metabolism Valine, leucine and isoleucine degradation NP BLM NP BRCA2 NP BTK REGULATORY Immune System B cell receptor signaling pathway NP C6 REGULATORY Immune System Complement and coagulation cascades NP C8B REGULATORY Immune System Complement and coagulation cascades NP CAPN3 NP CBS REGULATORY Neurodegenerative Disorders Huntington s disease METABOLIC Amino Acid Metabolism Glycine, serine and threonine metabolism METABOLIC Amino Acid Metabolism Methionine metabolism METABOLIC Metabolism of Other Amino Acids Selenoamino acid metabolism NP CDK4 NP CDKN1C NP CDKN2A NP LYST NP ERCC8 NP CNGA1 NP COL4A3 NP COL5A1 REGULATORY Signaling Molecules and Interaction ECM-receptor interaction NP COL7A1 NP COMP

3 NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP DDB2 DLD METABOLIC Carbohydrate Metabolism Glycolysis / Gluconeogenesis METABOLIC Carbohydrate Metabolism Citrate cycle (TCA cycle) METABOLIC Amino Acid Metabolism Glycine, serine and threonine metabolism METABOLIC Carbohydrate Metabolism Pyruvate metabolism DMD DPYD METABOLIC Nucleotide Metabolism Pyrimidine metabolism METABOLIC Metabolism of Other Amino Acids beta-alanine metabolism METABOLIC Metabolism of Cofactors and Vitamins Pantothenate and CoA biosynthesis EPOR ERCC3 METABOLIC Carbohydrate Metabolism Starch and sucrose metabolism METABOLIC Metabolism of Cofactors and Vitamins Folate biosynthesis ERCC5 ERCC6 ESR1 F11 REGULATORY Immune System Complement and coagulation cascades F7 REGULATORY Immune System Complement and coagulation cascades FANCC FBN1 GALT METABOLIC Carbohydrate Metabolism Galactose metabolism METABOLIC Carbohydrate Metabolism Nucleotide sugars metabolism GBA METABOLIC Metabolism of Other Amino Acids Cyanoamino acid metabolism METABOLIC Carbohydrate Metabolism Starch and sucrose metabolism METABOLIC Glycan Biosynthesis and Metabolism Glycosphingolipid metabolism METABOLIC Biosynthesis of Secondary Metabolites Stilbene, coumarine and lignin biosynthesis GBE1 METABOLIC Carbohydrate Metabolism Starch and sucrose metabolism GCDH METABOLIC Lipid Metabolism Fatty acid metabolism METABOLIC Amino Acid Metabolism Lysine degradation METABOLIC Amino Acid Metabolism Tryptophan metabolism METABOLIC Xenobiotics Biodegradation and Metabolism Benzoate degradation via CoA ligation GCH1 METABOLIC Metabolism of Cofactors and Vitamins Folate biosynthesis GHR REGULATORY Signaling Molecules and Interaction Neuroactive ligand-receptor interaction GLA METABOLIC Carbohydrate Metabolism Galactose metabolism METABOLIC Lipid Metabolism Glycerolipid metabolism METABOLIC Glycan Biosynthesis and Metabolism Glycosphingolipid metabolism METABOLIC Glycan Biosynthesis and Metabolism Globoside metabolism NR3C1 REGULATORY Signaling Molecules and Interaction Neuroactive ligand-receptor interaction GSN MSH6 GUCY2D REGULATORY Nervous system Long-term depression METABOLIC Nucleotide Metabolism Purine metabolism HADHA METABOLIC Lipid Metabolism Fatty acid elongation in mitochondria METABOLIC Lipid Metabolism Fatty acid metabolism METABOLIC Amino Acid Metabolism Valine, leucine and isoleucine degradation METABOLIC Amino Acid Metabolism Lysine degradation METABOLIC Amino Acid Metabolism Tryptophan metabolism METABOLIC Metabolism of Other Amino Acids beta-alanine metabolism METABOLIC Xenobiotics Biodegradation and Metabolism Benzoate degradation via CoA ligation METABOLIC Carbohydrate Metabolism Propanoate metabolism METABOLIC Carbohydrate Metabolism Butanoate metabolism METABOLIC Biosynthesis of Secondary Metabolites Limonene and pinene degradation METABOLIC Xenobiotics Biodegradation and Metabolism Caprolactam degradation IF REGULATORY Immune System Complement and coagulation cascades IL2RG INSR REGULATORY Metabolic Disorders Type II diabetes mellitus REGULATORY Neurodegenerative Disorders Dentatorubropallidoluysian atrophy (DRPLA) JAG1 REGULATORY Signal Transduction Notch signaling pathway JAK3 KCNQ1 KIT

4 NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP KRT12 KRT18 KRT9 LAMA3 REGULATORY Signaling Molecules and Interaction ECM-receptor interaction SGCG SGCB LIG1 LPL REGULATORY Neurodegenerative Disorders Alzheimer s disease METABOLIC Lipid Metabolism Glycerolipid metabolism MEN1 MET REGULATORY Development Axon guidance MHC2TA MITF MLH1 MSH2 MYH7 MYL3 MYO5A MYO7A NF2 NME1 METABOLIC Nucleotide Metabolism Purine metabolism METABOLIC Nucleotide Metabolism Pyrimidine metabolism NPC1 OAT METABOLIC Amino Acid Metabolism Urea cycle and metabolism of amino groups METABOLIC Amino Acid Metabolism Arginine and proline metabolism PAH METABOLIC Amino Acid Metabolism Phenylalanine, tyrosine and tryptophan biosynthesis PAX6 REGULATORY Metabolic Disorders Maturity onset diabetes of the young PCCA PDHA1 METABOLIC Carbohydrate Metabolism Glycolysis / Gluconeogenesis METABOLIC Amino Acid Metabolism Valine, leucine and isoleucine biosynthesis METABOLIC Carbohydrate Metabolism Pyruvate metabolism METABOLIC Carbohydrate Metabolism Butanoate metabolism PEX6 PEX7 PFKM METABOLIC Carbohydrate Metabolism Glycolysis / Gluconeogenesis METABOLIC Carbohydrate Metabolism Pentose phosphate pathway METABOLIC Carbohydrate Metabolism Fructose and mannose metabolism METABOLIC Carbohydrate Metabolism Galactose metabolism PGAM2 METABOLIC Carbohydrate Metabolism Glycolysis / Gluconeogenesis PGK1 METABOLIC Carbohydrate Metabolism Glycolysis / Gluconeogenesis METABOLIC Energy Metabolism Carbon fixation PHKG2 PKD1 PKLR REGULATORY Metabolic Disorders Type II diabetes mellitus REGULATORY Metabolic Disorders Maturity onset diabetes of the young METABOLIC Carbohydrate Metabolism Glycolysis / Gluconeogenesis METABOLIC Nucleotide Metabolism Purine metabolism METABOLIC Carbohydrate Metabolism Pyruvate metabolism METABOLIC Energy Metabolism Carbon fixation PKP1 PMM2 METABOLIC Carbohydrate Metabolism Fructose and mannose metabolism PPGB PRNP REGULATORY Neurodegenerative Disorders Prion disease PROS1 REGULATORY Immune System Complement and coagulation cascades RB1 RPGR SGCD SPTB ABCA4 TAT METABOLIC Amino Acid Metabolism Tyrosine metabolism METABOLIC Amino Acid Metabolism Phenylalanine metabolism METABOLIC Amino Acid Metabolism Phenylalanine, tyrosine and tryptophan biosynthesis METABOLIC Biosynthesis of Secondary Metabolites Novobiocin biosynthesis METABOLIC Biosynthesis of Secondary Metabolites Alkaloid biosynthesis I TCOF1

5 NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP THBD REGULATORY Immune System Complement and coagulation cascades TPM1 TSC1 VDR WAS WT1 XPA MID1 METABOLIC Amino Acid Metabolism Tryptophan metabolism ALDH3A2 METABOLIC Carbohydrate Metabolism Glycolysis / Gluconeogenesis METABOLIC Carbohydrate Metabolism Ascorbate and aldarate metabolism METABOLIC Lipid Metabolism Fatty acid metabolism METABOLIC Lipid Metabolism Bile acid biosynthesis METABOLIC Amino Acid Metabolism Valine, leucine and isoleucine degradation METABOLIC Amino Acid Metabolism Lysine degradation METABOLIC Amino Acid Metabolism Arginine and proline metabolism METABOLIC Amino Acid Metabolism Histidine metabolism METABOLIC Amino Acid Metabolism Tryptophan metabolism METABOLIC Metabolism of Other Amino Acids beta-alanine metabolism METABOLIC Lipid Metabolism Glycerolipid metabolism METABOLIC Carbohydrate Metabolism Pyruvate metabolism METABOLIC Carbohydrate Metabolism Propanoate metabolism METABOLIC Carbohydrate Metabolism Butanoate metabolism METABOLIC Biosynthesis of Secondary Metabolites Limonene and pinene degradation APOB BLMH CASR CDKN1A CHM CSF2RB EGR2 ERCC2 METABOLIC Carbohydrate Metabolism Starch and sucrose metabolism METABOLIC Metabolism of Cofactors and Vitamins Folate biosynthesis GPD2 METABOLIC Lipid Metabolism Glycerophospholipid metabolism IFNGR1 IL4R KRT10 KRT17 KRT2A KRT5 LAMA2 REGULATORY Signaling Molecules and Interaction ECM-receptor interaction MAT1A METABOLIC Amino Acid Metabolism Methionine metabolism METABOLIC Metabolism of Other Amino Acids Selenoamino acid metabolism PAFAH1B1 METABOLIC Lipid Metabolism Glycerophospholipid metabolism MYL2 NOTCH3 REGULATORY Signal Transduction Notch signaling pathway PLEC1 PSEN2 REGULATORY Signal Transduction Notch signaling pathway REGULATORY Neurodegenerative Disorders Alzheimer s disease RFX5 STK11 HNF4A REGULATORY Metabolic Disorders Maturity onset diabetes of the young TEK THRB REGULATORY Signaling Molecules and Interaction Neuroactive ligand-receptor interaction BARD1 PEX1 NR0B1 APOA4 APP REGULATORY Neurodegenerative Disorders Alzheimer s disease ATRX COL10A1 FBP1 METABOLIC Carbohydrate Metabolism Glycolysis / Gluconeogenesis METABOLIC Carbohydrate Metabolism Pentose phosphate pathway

6 NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP METABOLIC Carbohydrate Metabolism Fructose and mannose metabolism METABOLIC Energy Metabolism Carbon fixation GNAS REGULATORY Nervous system Long-term depression KRT14 PMS1 PMS2 TPO METABOLIC Amino Acid Metabolism Tyrosine metabolism METABOLIC Amino Acid Metabolism Phenylalanine metabolism METABOLIC Energy Metabolism Methane metabolism METABOLIC Biosynthesis of Secondary Metabolites Stilbene, coumarine and lignin biosynthesis WRN GSTM1 METABOLIC Metabolism of Other Amino Acids Glutathione metabolism METABOLIC Xenobiotics Biodegradation and Metabolism Metabolism of xenobiotics by cytochrome P450 C8A REGULATORY Immune System Complement and coagulation cascades IL5RA IL6R IL15 IL2 REGULATORY Metabolic Disorders Type I diabetes mellitus C7 REGULATORY Immune System Complement and coagulation cascades IL3 IL4 IGFBP1 IGFBP5 IL6 CNTF REGULATORY Nervous system Long-term depression NOS1 REGULATORY Nervous system Long-term depression METABOLIC Amino Acid Metabolism Arginine and proline metabolism IL10RB IFNAR1 SOD2 GSR METABOLIC Amino Acid Metabolism Glutamate metabolism METABOLIC Metabolism of Other Amino Acids Glutathione metabolism IL13RA2 IL11 AGL AGL AGL AGL AGL SELL ACHE METABOLIC Lipid Metabolism Glycerophospholipid metabolism ADH1A METABOLIC Carbohydrate Metabolism Glycolysis / Gluconeogenesis METABOLIC Lipid Metabolism Fatty acid metabolism METABOLIC Lipid Metabolism Bile acid biosynthesis

7 NP NP NP NP NP NP NP NP NP NP NP NP METABOLIC Amino Acid Metabolism Tyrosine metabolism METABOLIC Lipid Metabolism Glycerolipid metabolism METABOLIC Xenobiotics Biodegradation and Metabolism 1- and 2-Methylnaphthalene degradation METABOLIC Xenobiotics Biodegradation and Metabolism Metabolism of xenobiotics by cytochrome P450 ADH1B METABOLIC Carbohydrate Metabolism Glycolysis / Gluconeogenesis METABOLIC Lipid Metabolism Fatty acid metabolism METABOLIC Lipid Metabolism Bile acid biosynthesis METABOLIC Amino Acid Metabolism Tyrosine metabolism METABOLIC Lipid Metabolism Glycerolipid metabolism METABOLIC Xenobiotics Biodegradation and Metabolism 1- and 2-Methylnaphthalene degradation METABOLIC Xenobiotics Biodegradation and Metabolism Metabolism of xenobiotics by cytochrome P450 ADH1C METABOLIC Carbohydrate Metabolism Glycolysis / Gluconeogenesis METABOLIC Lipid Metabolism Fatty acid metabolism METABOLIC Lipid Metabolism Bile acid biosynthesis METABOLIC Amino Acid Metabolism Tyrosine metabolism METABOLIC Lipid Metabolism Glycerolipid metabolism METABOLIC Xenobiotics Biodegradation and Metabolism 1- and 2-Methylnaphthalene degradation METABOLIC Xenobiotics Biodegradation and Metabolism Metabolism of xenobiotics by cytochrome P450 ADH4 METABOLIC Carbohydrate Metabolism Glycolysis / Gluconeogenesis METABOLIC Lipid Metabolism Fatty acid metabolism METABOLIC Lipid Metabolism Bile acid biosynthesis METABOLIC Amino Acid Metabolism Tyrosine metabolism METABOLIC Lipid Metabolism Glycerolipid metabolism METABOLIC Xenobiotics Biodegradation and Metabolism 1- and 2-Methylnaphthalene degradation METABOLIC Xenobiotics Biodegradation and Metabolism Metabolism of xenobiotics by cytochrome P450 ADH5 METABOLIC Carbohydrate Metabolism Glycolysis / Gluconeogenesis METABOLIC Lipid Metabolism Fatty acid metabolism METABOLIC Lipid Metabolism Bile acid biosynthesis METABOLIC Amino Acid Metabolism Tyrosine metabolism METABOLIC Lipid Metabolism Glycerolipid metabolism METABOLIC Xenobiotics Biodegradation and Metabolism 1- and 2-Methylnaphthalene degradation METABOLIC Energy Metabolism Methane metabolism METABOLIC Xenobiotics Biodegradation and Metabolism Metabolism of xenobiotics by cytochrome P450 ADH6 METABOLIC Carbohydrate Metabolism Glycolysis / Gluconeogenesis METABOLIC Lipid Metabolism Fatty acid metabolism METABOLIC Lipid Metabolism Bile acid biosynthesis METABOLIC Amino Acid Metabolism Tyrosine metabolism METABOLIC Lipid Metabolism Glycerolipid metabolism METABOLIC Xenobiotics Biodegradation and Metabolism 1- and 2-Methylnaphthalene degradation METABOLIC Xenobiotics Biodegradation and Metabolism Metabolism of xenobiotics by cytochrome P450 ADH7 METABOLIC Carbohydrate Metabolism Glycolysis / Gluconeogenesis METABOLIC Lipid Metabolism Fatty acid metabolism METABOLIC Lipid Metabolism Bile acid biosynthesis METABOLIC Amino Acid Metabolism Tyrosine metabolism METABOLIC Lipid Metabolism Glycerolipid metabolism METABOLIC Xenobiotics Biodegradation and Metabolism 1- and 2-Methylnaphthalene degradation METABOLIC Xenobiotics Biodegradation and Metabolism Metabolism of xenobiotics by cytochrome P450 AGTR1 REGULATORY Signaling Molecules and Interaction Neuroactive ligand-receptor interaction AHCY METABOLIC Amino Acid Metabolism Methionine metabolism METABOLIC Metabolism of Other Amino Acids Selenoamino acid metabolism ALAS1 METABOLIC Amino Acid Metabolism Glycine, serine and threonine metabolism ALDH1A1 METABOLIC Metabolism of Cofactors and Vitamins Retinol metabolism ALDH2 METABOLIC Carbohydrate Metabolism Glycolysis / Gluconeogenesis METABOLIC Carbohydrate Metabolism Ascorbate and aldarate metabolism METABOLIC Lipid Metabolism Fatty acid metabolism METABOLIC Lipid Metabolism Bile acid biosynthesis METABOLIC Amino Acid Metabolism Valine, leucine and isoleucine degradation METABOLIC Amino Acid Metabolism Lysine degradation METABOLIC Amino Acid Metabolism Arginine and proline metabolism METABOLIC Amino Acid Metabolism Histidine metabolism METABOLIC Amino Acid Metabolism Tryptophan metabolism METABOLIC Metabolism of Other Amino Acids beta-alanine metabolism METABOLIC Lipid Metabolism Glycerolipid metabolism METABOLIC Carbohydrate Metabolism Pyruvate metabolism METABOLIC Carbohydrate Metabolism Propanoate metabolism METABOLIC Carbohydrate Metabolism Butanoate metabolism METABOLIC Biosynthesis of Secondary Metabolites Limonene and pinene degradation ALDH3A1 METABOLIC Carbohydrate Metabolism Glycolysis / Gluconeogenesis METABOLIC Carbohydrate Metabolism Ascorbate and aldarate metabolism METABOLIC Lipid Metabolism Fatty acid metabolism METABOLIC Lipid Metabolism Bile acid biosynthesis METABOLIC Amino Acid Metabolism Valine, leucine and isoleucine degradation METABOLIC Amino Acid Metabolism Lysine degradation METABOLIC Amino Acid Metabolism Arginine and proline metabolism METABOLIC Amino Acid Metabolism Histidine metabolism METABOLIC Amino Acid Metabolism Tyrosine metabolism METABOLIC Amino Acid Metabolism Phenylalanine metabolism METABOLIC Amino Acid Metabolism Tryptophan metabolism METABOLIC Metabolism of Other Amino Acids beta-alanine metabolism

8 NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP METABOLIC Lipid Metabolism Glycerolipid metabolism METABOLIC Carbohydrate Metabolism Pyruvate metabolism METABOLIC Carbohydrate Metabolism Propanoate metabolism METABOLIC Carbohydrate Metabolism Butanoate metabolism METABOLIC Biosynthesis of Secondary Metabolites Limonene and pinene degradation METABOLIC Xenobiotics Biodegradation and Metabolism Metabolism of xenobiotics by cytochrome P450 ALDH1B1 METABOLIC Carbohydrate Metabolism Glycolysis / Gluconeogenesis METABOLIC Carbohydrate Metabolism Ascorbate and aldarate metabolism METABOLIC Lipid Metabolism Fatty acid metabolism METABOLIC Lipid Metabolism Bile acid biosynthesis METABOLIC Amino Acid Metabolism Valine, leucine and isoleucine degradation METABOLIC Amino Acid Metabolism Lysine degradation METABOLIC Amino Acid Metabolism Arginine and proline metabolism METABOLIC Amino Acid Metabolism Histidine metabolism METABOLIC Amino Acid Metabolism Tryptophan metabolism METABOLIC Metabolism of Other Amino Acids beta-alanine metabolism METABOLIC Lipid Metabolism Glycerolipid metabolism METABOLIC Carbohydrate Metabolism Pyruvate metabolism METABOLIC Carbohydrate Metabolism Propanoate metabolism METABOLIC Carbohydrate Metabolism Butanoate metabolism METABOLIC Biosynthesis of Secondary Metabolites Limonene and pinene degradation ALDH1A3 METABOLIC Carbohydrate Metabolism Glycolysis / Gluconeogenesis METABOLIC Carbohydrate Metabolism Ascorbate and aldarate metabolism METABOLIC Lipid Metabolism Fatty acid metabolism METABOLIC Lipid Metabolism Bile acid biosynthesis METABOLIC Amino Acid Metabolism Valine, leucine and isoleucine degradation METABOLIC Amino Acid Metabolism Lysine degradation METABOLIC Amino Acid Metabolism Arginine and proline metabolism METABOLIC Amino Acid Metabolism Histidine metabolism METABOLIC Amino Acid Metabolism Tyrosine metabolism METABOLIC Amino Acid Metabolism Phenylalanine metabolism METABOLIC Amino Acid Metabolism Tryptophan metabolism METABOLIC Metabolism of Other Amino Acids beta-alanine metabolism METABOLIC Lipid Metabolism Glycerolipid metabolism METABOLIC Carbohydrate Metabolism Pyruvate metabolism METABOLIC Carbohydrate Metabolism Propanoate metabolism METABOLIC Carbohydrate Metabolism Butanoate metabolism METABOLIC Biosynthesis of Secondary Metabolites Limonene and pinene degradation METABOLIC Xenobiotics Biodegradation and Metabolism Metabolism of xenobiotics by cytochrome P450 ALDH3B1 METABOLIC Carbohydrate Metabolism Glycolysis / Gluconeogenesis METABOLIC Amino Acid Metabolism Histidine metabolism METABOLIC Amino Acid Metabolism Tyrosine metabolism METABOLIC Amino Acid Metabolism Phenylalanine metabolism METABOLIC Xenobiotics Biodegradation and Metabolism Metabolism of xenobiotics by cytochrome P450 ALDH3B2 METABOLIC Carbohydrate Metabolism Glycolysis / Gluconeogenesis METABOLIC Amino Acid Metabolism Histidine metabolism METABOLIC Amino Acid Metabolism Tyrosine metabolism METABOLIC Amino Acid Metabolism Phenylalanine metabolism METABOLIC Xenobiotics Biodegradation and Metabolism Metabolism of xenobiotics by cytochrome P450 ALDH9A1 METABOLIC Carbohydrate Metabolism Glycolysis / Gluconeogenesis METABOLIC Carbohydrate Metabolism Ascorbate and aldarate metabolism METABOLIC Lipid Metabolism Fatty acid metabolism METABOLIC Lipid Metabolism Bile acid biosynthesis METABOLIC Amino Acid Metabolism Valine, leucine and isoleucine degradation METABOLIC Amino Acid Metabolism Lysine degradation METABOLIC Amino Acid Metabolism Arginine and proline metabolism METABOLIC Amino Acid Metabolism Histidine metabolism METABOLIC Amino Acid Metabolism Tryptophan metabolism METABOLIC Metabolism of Other Amino Acids beta-alanine metabolism METABOLIC Lipid Metabolism Glycerolipid metabolism METABOLIC Carbohydrate Metabolism Pyruvate metabolism METABOLIC Carbohydrate Metabolism Propanoate metabolism METABOLIC Carbohydrate Metabolism Butanoate metabolism METABOLIC Biosynthesis of Secondary Metabolites Limonene and pinene degradation ALOX12 METABOLIC Lipid Metabolism Arachidonic acid metabolism ATP1A1 ATP1A2 BCKDHA METABOLIC Amino Acid Metabolism Valine, leucine and isoleucine degradation CACNB1 CACNB3 CACNB4 CSF2 CSF3R CYP3A7 METABOLIC Xenobiotics Biodegradation and Metabolism gamma-hexachlorocyclohexane degradation METABOLIC Lipid Metabolism Linoleic acid metabolism METABOLIC Xenobiotics Biodegradation and Metabolism Metabolism of xenobiotics by cytochrome P450 CYP3A5 METABOLIC Xenobiotics Biodegradation and Metabolism gamma-hexachlorocyclohexane degradation

9 NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP METABOLIC Lipid Metabolism Linoleic acid metabolism METABOLIC Xenobiotics Biodegradation and Metabolism Metabolism of xenobiotics by cytochrome P450 DDC METABOLIC Amino Acid Metabolism Histidine metabolism METABOLIC Amino Acid Metabolism Tyrosine metabolism METABOLIC Amino Acid Metabolism Phenylalanine metabolism METABOLIC Amino Acid Metabolism Tryptophan metabolism METABOLIC Biosynthesis of Secondary Metabolites Alkaloid biosynthesis I FGF1 FKBP1A GAD1 GAD2 REGULATORY Metabolic Disorders Type I diabetes mellitus METABOLIC Amino Acid Metabolism Glutamate metabolism METABOLIC Amino Acid Metabolism Alanine and aspartate metabolism METABOLIC Metabolism of Other Amino Acids beta-alanine metabolism METABOLIC Metabolism of Other Amino Acids Taurine and hypotaurine metabolism METABOLIC Carbohydrate Metabolism Butanoate metabolism GART METABOLIC Nucleotide Metabolism Purine metabolism METABOLIC Metabolism of Cofactors and Vitamins One carbon pool by folate GRIA2 REGULATORY Signaling Molecules and Interaction Neuroactive ligand-receptor interaction REGULATORY Nervous system Long-term potentiation REGULATORY Nervous system Long-term depression GRIA1 REGULATORY Signaling Molecules and Interaction Neuroactive ligand-receptor interaction REGULATORY Nervous system Long-term potentiation REGULATORY Nervous system Long-term depression GRIA3 REGULATORY Signaling Molecules and Interaction Neuroactive ligand-receptor interaction REGULATORY Nervous system Long-term depression GRIA4 REGULATORY Signaling Molecules and Interaction Neuroactive ligand-receptor interaction GRIK1 REGULATORY Signaling Molecules and Interaction Neuroactive ligand-receptor interaction GRIK3 REGULATORY Signaling Molecules and Interaction Neuroactive ligand-receptor interaction GRIN1 REGULATORY Signaling Molecules and Interaction Neuroactive ligand-receptor interaction REGULATORY Nervous system Long-term potentiation GRIN2A REGULATORY Signaling Molecules and Interaction Neuroactive ligand-receptor interaction REGULATORY Nervous system Long-term potentiation GRIN2B REGULATORY Signaling Molecules and Interaction Neuroactive ligand-receptor interaction REGULATORY Nervous system Long-term potentiation GRIN2C REGULATORY Signaling Molecules and Interaction Neuroactive ligand-receptor interaction REGULATORY Nervous system Long-term potentiation GRIN2D REGULATORY Signaling Molecules and Interaction Neuroactive ligand-receptor interaction REGULATORY Nervous system Long-term potentiation GRM1 REGULATORY Signaling Molecules and Interaction Neuroactive ligand-receptor interaction REGULATORY Nervous system Long-term potentiation REGULATORY Nervous system Long-term depression GRM2 GRM3 REGULATORY Signaling Molecules and Interaction Neuroactive ligand-receptor interaction GRM4 REGULATORY Signaling Molecules and Interaction Neuroactive ligand-receptor interaction GRM6 REGULATORY Signaling Molecules and Interaction Neuroactive ligand-receptor interaction GRM8 REGULATORY Signaling Molecules and Interaction Neuroactive ligand-receptor interaction GSTA2 METABOLIC Metabolism of Other Amino Acids Glutathione metabolism METABOLIC Xenobiotics Biodegradation and Metabolism Metabolism of xenobiotics by cytochrome P450 GSTA3 METABOLIC Metabolism of Other Amino Acids Glutathione metabolism METABOLIC Xenobiotics Biodegradation and Metabolism Metabolism of xenobiotics by cytochrome P450 GSTM2 METABOLIC Metabolism of Other Amino Acids Glutathione metabolism METABOLIC Xenobiotics Biodegradation and Metabolism Metabolism of xenobiotics by cytochrome P450 GSTM3 METABOLIC Metabolism of Other Amino Acids Glutathione metabolism METABOLIC Xenobiotics Biodegradation and Metabolism Metabolism of xenobiotics by cytochrome P450 GSTM4 METABOLIC Metabolism of Other Amino Acids Glutathione metabolism METABOLIC Xenobiotics Biodegradation and Metabolism Metabolism of xenobiotics by cytochrome P450 GSTM5 METABOLIC Metabolism of Other Amino Acids Glutathione metabolism METABOLIC Xenobiotics Biodegradation and Metabolism Metabolism of xenobiotics by cytochrome P450

10 NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP GSTP1 METABOLIC Metabolism of Other Amino Acids Glutathione metabolism METABOLIC Xenobiotics Biodegradation and Metabolism Metabolism of xenobiotics by cytochrome P450 GSTT1 METABOLIC Metabolism of Other Amino Acids Glutathione metabolism METABOLIC Xenobiotics Biodegradation and Metabolism Metabolism of xenobiotics by cytochrome P450 GSTT2 METABOLIC Metabolism of Other Amino Acids Glutathione metabolism METABOLIC Xenobiotics Biodegradation and Metabolism Metabolism of xenobiotics by cytochrome P450 GUK1 METABOLIC Nucleotide Metabolism Purine metabolism HMGCR METABOLIC Lipid Metabolism Biosynthesis of steroids IGF1R REGULATORY Nervous system Long-term depression IL1R1 IL2RB IL5 IL7 IL12A REGULATORY Metabolic Disorders Type I diabetes mellitus IMPDH1 METABOLIC Nucleotide Metabolism Purine metabolism IMPDH2 KCNJ2 KLKB1 REGULATORY Immune System Complement and coagulation cascades LTA4H METABOLIC Lipid Metabolism Arachidonic acid metabolism NR3C2 NPR1 REGULATORY Nervous system Long-term depression METABOLIC Nucleotide Metabolism Purine metabolism NPR2 REGULATORY Nervous system Long-term depression METABOLIC Nucleotide Metabolism Purine metabolism NPR3 OPRD1 OPRK1 REGULATORY Signaling Molecules and Interaction Neuroactive ligand-receptor interaction OPRL1 REGULATORY Signaling Molecules and Interaction Neuroactive ligand-receptor interaction OPRM1 REGULATORY Signaling Molecules and Interaction Neuroactive ligand-receptor interaction P4HB PC METABOLIC Carbohydrate Metabolism Citrate cycle (TCA cycle) METABOLIC Amino Acid Metabolism Alanine and aspartate metabolism METABOLIC Carbohydrate Metabolism Pyruvate metabolism PDHB METABOLIC Carbohydrate Metabolism Glycolysis / Gluconeogenesis METABOLIC Amino Acid Metabolism Valine, leucine and isoleucine biosynthesis METABOLIC Carbohydrate Metabolism Pyruvate metabolism METABOLIC Carbohydrate Metabolism Butanoate metabolism PGR PLAT PLCB3 REGULATORY Signal Transduction Phosphatidylinositol signaling system REGULATORY Nervous system Long-term potentiation REGULATORY Nervous system Long-term depression METABOLIC Carbohydrate Metabolism Inositol phosphate metabolism PLCB4 REGULATORY Signal Transduction Phosphatidylinositol signaling system REGULATORY Nervous system Long-term potentiation REGULATORY Nervous system Long-term depression METABOLIC Carbohydrate Metabolism Inositol phosphate metabolism POLR2A METABOLIC Nucleotide Metabolism Purine metabolism METABOLIC Nucleotide Metabolism Pyrimidine metabolism

11 NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP POLR2B METABOLIC Nucleotide Metabolism Purine metabolism METABOLIC Nucleotide Metabolism Pyrimidine metabolism PPP3CA REGULATORY Development Axon guidance REGULATORY Immune System B cell receptor signaling pathway REGULATORY Nervous system Long-term potentiation REGULATORY Neurodegenerative Disorders Amyotrophic lateral sclerosis (ALS) PPP3R1 REGULATORY Development Axon guidance REGULATORY Immune System B cell receptor signaling pathway REGULATORY Nervous system Long-term potentiation PRIM1 METABOLIC Nucleotide Metabolism Purine metabolism METABOLIC Nucleotide Metabolism Pyrimidine metabolism PRLR REGULATORY Signaling Molecules and Interaction Neuroactive ligand-receptor interaction RARA RARB RARG RPL3 RPL4 RPL5 RPL6 RPL7A RPL8 RPL12 RPL23 RPL18 RPL18A RPL17 RPL31 RPLP1 RPS3 RPS3A RPS4X PRKCSH ATP2B3 NKIRAS2 LMO3 ATP2B4 LOC SMAD5 SMAD5 TNNT2 STX16 REGULATORY Folding, Sorting and Degradation SNARE interactions in vesicular transport ZDHHC13 ATP2C1 ATP2C1 ATP2C1 RORC GRB10 GRB10 GRB10 GGA1 TIMM50 FLJ26175 FLJ16518 NFKBIB REGULATORY Immune System B cell receptor signaling pathway COP1 MGC21382 PIM3 PPARA PPARA PPARA ATP5A1 METABOLIC Energy Metabolism Oxidative phosphorylation METABOLIC Energy Metabolism ATP synthesis ATP5A1 ATP5C1

12 NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP METABOLIC Energy Metabolism Oxidative phosphorylation METABOLIC Energy Metabolism ATP synthesis EXOSC10 RPS7 GMPR2 METABOLIC Nucleotide Metabolism Purine metabolism GMPR2 GMPR2 PFKL METABOLIC Carbohydrate Metabolism Glycolysis / Gluconeogenesis METABOLIC Carbohydrate Metabolism Pentose phosphate pathway METABOLIC Carbohydrate Metabolism Fructose and mannose metabolism METABOLIC Carbohydrate Metabolism Galactose metabolism ANAPC11 REGULATORY Folding, Sorting and Degradation Ubiquitin mediated proteolysis ANAPC11 ANAPC11 ANAPC11 ANAPC11 ANAPC11 SUMO4 GATA3 HIRIP5 SMC4L1 SMC4L1 PDE4DIP PDE4DIP PRKWNK3 MYL4 PIP5K3 REGULATORY Signal Transduction Phosphatidylinositol signaling system METABOLIC Carbohydrate Metabolism Inositol phosphate metabolism KCTD11 H2BFWT RPS8 BICD1 SMAD2 PPP2R2D LEPR REGULATORY Signaling Molecules and Interaction Neuroactive ligand-receptor interaction LEPR SMAD1 BRPF1 RECQL5 RECQL5 LYK5 LYK5 LYK5 RABL2B RBMS3 NHP2L1 SMARCD3 SMARCD3 DLGAP1 HNRPD TRIM6 TRIM6-TRIM34 TRIM34 SP5 PCQAP TSPYL6 OGDH METABOLIC Carbohydrate Metabolism Citrate cycle (TCA cycle) METABOLIC Amino Acid Metabolism Lysine degradation METABOLIC Amino Acid Metabolism Tryptophan metabolism ALAD CAPNS1 FBLN2 DYRK3 REGULATORY Signal Transduction Phosphatidylinositol signaling system METABOLIC Carbohydrate Metabolism Inositol phosphate metabolism METABOLIC Xenobiotics Biodegradation and Metabolism Benzoate degradation via CoA ligation METABOLIC Metabolism of Cofactors and Vitamins Nicotinate and nicotinamide metabolism LRRC29 QSCN6 FLJ43980 FLJ16542 LOC LOC283337

13 NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP FLJ16641 FLJ16353 EPHA10 FLJ16478 LOC MGC61598 UMODL1 FMNL2 FMNL2 FMNL2 PLA2G6 REGULATORY Nervous system Long-term depression METABOLIC Lipid Metabolism Glycerophospholipid metabolism METABOLIC Lipid Metabolism Arachidonic acid metabolism METABOLIC Lipid Metabolism Linoleic acid metabolism MUC17 NCK2 REGULATORY Development Axon guidance PKP2 CHD3 CHD3 SREBF1 DNM1 PKP1 DNM2 DNM2 DNM2 POTE2 FBXL10 ZNF32 FLJ12760 ACTR2 SF3A1 ZWINT H3/o NFKBIZ PKP4 CHEK2 NUMB CACNB4 CACNB4 SUMO1 SUMO1 ADAM9 SUMO2 LOC RYK ERBB2 ERBB3 RPS11 SIAH1 WDR33 WDR33 RAB37 RAB37 ZNF473 WDR35 RPS6KA1 REGULATORY Nervous system Long-term potentiation LRRC18 EPHA8 REGULATORY Development Axon guidance RPS12 DRPLA REGULATORY Neurodegenerative Disorders Dentatorubropallidoluysian atrophy (DRPLA) SDCBP SDCBP SDCBP SDCBP ZNF21 ZNF37A NTRK2 ZNF484 NTRK3 NTRK3 NTRK1 SPOP ERCC8 ERCC8 ZNF599 ZNF599

14 NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP ATP6V1C1 METABOLIC Energy Metabolism Oxidative phosphorylation METABOLIC Energy Metabolism ATP synthesis RFP2 RRP22 SMARCB1 LOC LOC LOC TFG NTRK1 BUB3 TTC6 RPS13 OPTN OPTN OPTN AMY1B METABOLIC Carbohydrate Metabolism Starch and sucrose metabolism UACA CNOT4 METABOLIC Amino Acid Metabolism Tryptophan metabolism TAGLN3 TAGLN3 LOC LOC WDHD1 FLJ16231 TDG KLF6 NEDD5 NEDD5 OPRM1 OPRM1 OPRM1 USP20 NUPL1 NUPL1 TSC1 TCOF1 TCOF1 KAT3 KAT3 TFIP11 IL4R LOC C10orf80 C14orf150 LOC HMG1L1 LOC RAB19B ZNF468 CUL4A PPP2CB REGULATORY Nervous system Long-term depression CDKL4 CLSTN1 RPS15A RPS17 RPS19 RPS20 RPS23 RPS24 RRM1 METABOLIC Nucleotide Metabolism Purine metabolism METABOLIC Nucleotide Metabolism Pyrimidine metabolism RYR2 RYR3 SLC2A4 REGULATORY Metabolic Disorders Type II diabetes mellitus SSTR1 REGULATORY Signaling Molecules and Interaction Neuroactive ligand-receptor interaction SSTR2 REGULATORY Signaling Molecules and Interaction Neuroactive ligand-receptor interaction SSTR3 REGULATORY Signaling Molecules and Interaction Neuroactive ligand-receptor interaction SSTR4 REGULATORY Signaling Molecules and Interaction Neuroactive ligand-receptor interaction SSTR5 REGULATORY Signaling Molecules and Interaction Neuroactive ligand-receptor interaction TBXAS1

15 NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP METABOLIC Lipid Metabolism Arachidonic acid metabolism TKT METABOLIC Carbohydrate Metabolism Pentose phosphate pathway METABOLIC Energy Metabolism Carbon fixation TNFRSF1A TNFRSF1B TOP2A TOP2B TUBB2 TUBG1 ZAP70 ALDH5A1 METABOLIC Amino Acid Metabolism Glutamate metabolism METABOLIC Carbohydrate Metabolism Butanoate metabolism CUBN ABCA3 ABCF1 ACACB ACLY METABOLIC Carbohydrate Metabolism Citrate cycle (TCA cycle) ACO2 METABOLIC Carbohydrate Metabolism Citrate cycle (TCA cycle) METABOLIC Carbohydrate Metabolism Glyoxylate and dicarboxylate metabolism METABOLIC Energy Metabolism Reductive carboxylate cycle (CO2 fixation) ACTB ACTN1 ACTN2 ACTN3 ADAM8 ADARB1 AP1B1 AFG3L1 ANXA4 APAF1 APBA1 ARG2 METABOLIC Amino Acid Metabolism Urea cycle and metabolism of amino groups METABOLIC Amino Acid Metabolism Arginine and proline metabolism ARHGDIB ARHGDIG ARL1 ARNTL REGULATORY Behavior Circadian rhythm ALDH7A1 METABOLIC Carbohydrate Metabolism Glycolysis / Gluconeogenesis METABOLIC Carbohydrate Metabolism Ascorbate and aldarate metabolism METABOLIC Lipid Metabolism Fatty acid metabolism METABOLIC Lipid Metabolism Bile acid biosynthesis METABOLIC Amino Acid Metabolism Valine, leucine and isoleucine degradation METABOLIC Amino Acid Metabolism Lysine degradation METABOLIC Amino Acid Metabolism Arginine and proline metabolism METABOLIC Amino Acid Metabolism Histidine metabolism METABOLIC Amino Acid Metabolism Tryptophan metabolism METABOLIC Metabolism of Other Amino Acids beta-alanine metabolism METABOLIC Lipid Metabolism Glycerolipid metabolism METABOLIC Carbohydrate Metabolism Pyruvate metabolism METABOLIC Carbohydrate Metabolism Propanoate metabolism METABOLIC Carbohydrate Metabolism Butanoate metabolism METABOLIC Biosynthesis of Secondary Metabolites Limonene and pinene degradation ATR BACH1

16 NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP BAPX1 HCN2 BTEB1 C1QBP CALU CAMK2B REGULATORY Nervous system Long-term potentiation CAMK2D REGULATORY Nervous system Long-term potentiation CAMK2G REGULATORY Nervous system Long-term potentiation CASP9 CASQ2 CCNA2 CCNE1 CCNH TNFRSF7 TNFRSF8 ENTPD6 METABOLIC Nucleotide Metabolism Purine metabolism METABOLIC Nucleotide Metabolism Pyrimidine metabolism TNFRSF5 CDC5L CDC6 CDC20 REGULATORY Folding, Sorting and Degradation Ubiquitin mediated proteolysis CDC27 REGULATORY Folding, Sorting and Degradation Ubiquitin mediated proteolysis CDH13 CDK3 CDK6 CDK8 CDK9 CDKN2C CDSN CDX2 CES1 CHC1 CHD1 CHD2 CHD4 CHEK1 CHUK CKAP1 AP2B1 LDB2 CNGA3 CNN1 KLF6 MAPK14 CSE1L CSNK1G2 REGULATORY Signal Transduction Phosphatidylinositol signaling system METABOLIC Carbohydrate Metabolism Inositol phosphate metabolism METABOLIC Xenobiotics Biodegradation and Metabolism Benzoate degradation via CoA ligation METABOLIC Metabolism of Cofactors and Vitamins Nicotinate and nicotinamide metabolism CSNK2B CSTF1 CSTF2 CSTF3 CTBP1 REGULATORY Signal Transduction Notch signaling pathway CTBP2

17 NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP REGULATORY Signal Transduction Notch signaling pathway CTNND1 CTNND2 DGKG REGULATORY Signal Transduction Phosphatidylinositol signaling system METABOLIC Lipid Metabolism Glycerolipid metabolism METABOLIC Lipid Metabolism Glycerophospholipid metabolism DAXX DDX3X DHX9 DHX15 DKC1 DLG2 DLG4 DNAH5 DNAH8 DNCI2 DNMT1 METABOLIC Amino Acid Metabolism Methionine metabolism DOK1 DSCAM DTNA DTNA DTNA DYRK1A REGULATORY Signal Transduction Phosphatidylinositol signaling system METABOLIC Carbohydrate Metabolism Inositol phosphate metabolism METABOLIC Xenobiotics Biodegradation and Metabolism Benzoate degradation via CoA ligation METABOLIC Metabolism of Cofactors and Vitamins Nicotinate and nicotinamide metabolism EEF1A1 EEF1G CELSR3 CELSR2 EGFL3 EGFL4 EIF2B1 EIF2S3 EIF4A1 EIF4G2 ELAVL1 ELF4 ELF5 ENO1 METABOLIC Carbohydrate Metabolism Glycolysis / Gluconeogenesis METABOLIC Amino Acid Metabolism Phenylalanine, tyrosine and tryptophan biosynthesis EP300 REGULATORY Signal Transduction Notch signaling pathway REGULATORY Nervous system Long-term potentiation REGULATORY Neurodegenerative Disorders Huntington s disease EPAS1 EPB41L2 ERN1 FBL ESR2 ESRRG FAT2 FLNA FLNB FLNC ADAM2 G22P1 TADA2L NR6A1 GDI1 GDI2 GRID2 REGULATORY Signaling Molecules and Interaction Neuroactive ligand-receptor interaction REGULATORY Nervous system Long-term depression GSTA4 METABOLIC Metabolism of Other Amino Acids Glutathione metabolism METABOLIC Xenobiotics Biodegradation and Metabolism Metabolism of xenobiotics by cytochrome P450 GTF2B GTF2H2 GTF2H3 GUCY2F REGULATORY Nervous system Long-term depression METABOLIC Nucleotide Metabolism Purine metabolism HDAC2

18 NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP REGULATORY Signal Transduction Notch signaling pathway HGFAC HIF1A HRMT1L1 METABOLIC Lipid Metabolism Androgen and estrogen metabolism METABOLIC Amino Acid Metabolism Histidine metabolism METABOLIC Amino Acid Metabolism Tyrosine metabolism METABOLIC Amino Acid Metabolism Tryptophan metabolism METABOLIC Metabolism of Other Amino Acids Aminophosphonate metabolism METABOLIC Metabolism of Other Amino Acids Selenoamino acid metabolism METABOLIC Xenobiotics Biodegradation and Metabolism Nitrobenzene degradation HRMT1L2 METABOLIC Lipid Metabolism Androgen and estrogen metabolism METABOLIC Amino Acid Metabolism Histidine metabolism METABOLIC Amino Acid Metabolism Tyrosine metabolism METABOLIC Amino Acid Metabolism Tryptophan metabolism METABOLIC Metabolism of Other Amino Acids Aminophosphonate metabolism METABOLIC Metabolism of Other Amino Acids Selenoamino acid metabolism METABOLIC Xenobiotics Biodegradation and Metabolism Nitrobenzene degradation HSPB1 IFIT3 IKBKB REGULATORY Immune System B cell receptor signaling pathway REGULATORY Metabolic Disorders Type II diabetes mellitus IL12RB2 IL13RA1 TNFRSF9 ING1L IRAK1 IRAK2 ACTG1 ADRBK1 AHR AIF1 AK2 METABOLIC Nucleotide Metabolism Purine metabolism AMBP AMPH APEX1 APLP2 APXL ARAF1 ARCN1 TRIM23 ARF1 ARF3 ARF4 ARF4L ARF5 ARF6 RHOA REGULATORY Development Axon guidance RHOG ARL2 ARNT ARVCF ATF3 ATF4 REGULATORY Nervous system Long-term potentiation ATP2A2 ATP2B2 ATP2B4 ATP5B METABOLIC Energy Metabolism Oxidative phosphorylation

19 NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP METABOLIC Energy Metabolism ATP synthesis ATP6V1A METABOLIC Energy Metabolism Oxidative phosphorylation METABOLIC Energy Metabolism ATP synthesis ATP6V1B1 METABOLIC Energy Metabolism Oxidative phosphorylation METABOLIC Energy Metabolism ATP synthesis ATP6V1B2 METABOLIC Energy Metabolism Oxidative phosphorylation METABOLIC Energy Metabolism ATP synthesis ATP6V1C1 ATP6V1E1 METABOLIC Energy Metabolism Oxidative phosphorylation METABOLIC Energy Metabolism ATP synthesis ATP5O METABOLIC Energy Metabolism Oxidative phosphorylation METABOLIC Energy Metabolism ATP synthesis AUH METABOLIC Amino Acid Metabolism Valine, leucine and isoleucine degradation AXL BCL6 BDNF REGULATORY Neurodegenerative Disorders Huntington s disease BICD1 BLK BMX DST BPGM METABOLIC Carbohydrate Metabolism Glycolysis / Gluconeogenesis BRDT C9 REGULATORY Immune System Complement and coagulation cascades CALM2 REGULATORY Signal Transduction Phosphatidylinositol signaling system REGULATORY Nervous system Long-term potentiation REGULATORY Neurodegenerative Disorders Huntington s disease CAMK4 REGULATORY Nervous system Long-term potentiation CANX CAPN2 CAPNS1 CAST CAT REGULATORY Neurodegenerative Disorders Amyotrophic lateral sclerosis (ALS) METABOLIC Amino Acid Metabolism Tryptophan metabolism METABOLIC Energy Metabolism Methane metabolism CCND2 CCND3 CCNF CCT6A CD38 METABOLIC Metabolism of Cofactors and Vitamins Nicotinate and nicotinamide metabolism CDC2 CDC2L1 CDC10 CDC25A CDC25C CDC42 REGULATORY Development Axon guidance CDH2 CDH3

20 NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP NP CDH4 CDH5 CDH8 CDH11 CDK2 CDK7 CDR2 CEL METABOLIC Lipid Metabolism Bile acid biosynthesis METABOLIC Lipid Metabolism Glycerolipid metabolism CENPA CENPE CHML CKB METABOLIC Amino Acid Metabolism Urea cycle and metabolism of amino groups METABOLIC Amino Acid Metabolism Arginine and proline metabolism CKS1B CKS2 CNN3 CNTFR CNTN1 COL4A2 REGULATORY Signaling Molecules and Interaction ECM-receptor interaction COL4A6 REGULATORY Signaling Molecules and Interaction ECM-receptor interaction COL6A1 REGULATORY Signaling Molecules and Interaction ECM-receptor interaction COL9A3 COL19A1 COX6B1 METABOLIC Energy Metabolism Oxidative phosphorylation CPA2 CPA3 CPS1 METABOLIC Amino Acid Metabolism Urea cycle and metabolism of amino groups METABOLIC Amino Acid Metabolism Glutamate metabolism METABOLIC Amino Acid Metabolism Arginine and proline metabolism METABOLIC Energy Metabolism Nitrogen metabolism ATF2 CRYAB CRYZ CSNK1A1 CSNK1D REGULATORY Signal Transduction Hedgehog signaling pathway REGULATORY Behavior Circadian rhythm CSNK1E REGULATORY Signal Transduction Hedgehog signaling pathway REGULATORY Behavior Circadian rhythm CSNK2A1 CSNK2A2 CTNNA1 CTNNB1 CTPS METABOLIC Nucleotide Metabolism Pyrimidine metabolism CTSB CTSD CUTL1 DBT METABOLIC Amino Acid Metabolism Valine, leucine and isoleucine degradation METABOLIC Amino Acid Metabolism Lysine degradation METABOLIC Amino Acid Metabolism Histidine metabolism METABOLIC Amino Acid Metabolism Tyrosine metabolism