Hormones & Chemical Signaling
|
|
- Heather Snow
- 5 years ago
- Views:
Transcription
1 Hormones & Chemical Signaling Part 2 modulation of signal pathways and hormone classification & function How are these pathways controlled? Receptors are proteins! Subject to Specificity of binding Competition for binding site» Agonists and antagonists Saturation of ligand» Up regulation and down regulation of receptors Pathways are mechanisms under homeostasis guidelines Specificity of Binding & Competition Receptors have specific binding sites Different compounds with similar molecular regions may bind to same site = competition Ex. Epinephrine & norepinephrine have similar ligand structure and bind to a class of receptors called adrenergic receptors Adrenergic receptors exhibit specificity Adrenergic receptors are influence by competition 1
2 Advances in medicines Due to study of active sites and their properties Slightly changing the non-binding areas may change the duration of action Agonists vs. Antagonists Agonists bind and cause activation Antagonists bind and stop or prevent activation progesterone progesterone binding area (green) progesterone agonists (used in birth control medications) : Deadly Effects Muscarinic receptors Bind acetylcholine (Ach) in the autonomic nervous system (ANS) Also binds muscarine (a mushroom toxin) that Mimics Ach (agonistic action) and can cause a severe parasympathomimetic to the point of death Nicotinic receptors Bind Ach at neuromuscular junctions Also binds curare (poison arrow frog toxin) and blocks the receptor (antagonistic action) Causes paralysis and very potentially death Up and Down-Regulation Why? To allow cells the ability to control the extent of signal pathway effect depending on The concentration of signal in the ECF The needs of the cell Which form of diabetes would result in up and down regulation of insulin receptors? Down-regulation vs desensitization Down regulation is slower as cell needs to remove receptors from membrane Desensitization is quicker as a binding agent can deactivate the receptor» For ex. adding a phosphate can deactivate a receptor (β adrenergic receptors) 2
3 When the process has to stop Enzymatic degradation of ligand Removal of ligand by re-uptake Endocytosis of receptor-ligand complex Receptors can be reinserted into the membrane Why do we care about this process? Disease & Disorders Pathways Pathways Controlled by homeostatic mechanisms regardless of type of pathway and resulting transduction of signal. What are the options for getting the signal to the cell for transduction? 3
4 Pathways Similarities between neural and endocrine pathways? Pathways The homeostatic pathways are Hormones Hormones What are they? Chemical messengers secreted by specialized cells from isolated endocrine cells which makes up the diffuse endocrine system from neurons from immune system cells producing cytokines Where do they go? Into blood (most) Into environment (ectohormones or pheromones) Involved in Growth Development Metabolism Reproduction Act by 1. Altering rates of enzyme mediated reactions 2. Control the movement of molecules across the plasma membrane 3. Regulating the rate of gene expression (& therefore protein production) 4
5 Hormones How do hormones get from point A to B? To be classified as hormone & not a paracrine or autocrine hormone Travel in blood May require water soluble (protein) transport mechanism if hormone is lipid soluble Hormones act by binding to receptor on target cells Hormones have to have a mechanism for ending the effect Stop/reduce production of hormone Degrate hormones Enzymatic removal from receptor Endocytosis of receptor-hormone complex Hormones are mainly classified by Source Structure Hormones classified by source Hormones classified by source 5
6 Hormones classified by structure Peptide/protein hormones Steroid hormones Amino acid based hormones Derived from tyrosine and may be Catecholamines Thyroid hormones Peptide/protein hormones Classification that includes most hormones If a hormone is not a steroid hormone or an amino acid derived hormone, then it is a protein/peptide hormone! Concerns with these hormones How they are made, stored and released How they are transported in blood The mechanism of action How long they last Peptide/protein hormones & how they are made, stored and released PreproTSH (thyrotropin releasing Examples of hormone processing hormone) has six copies of the 3-amino acid hormones TRH Prohormones may contain several peptide sequences that have biological activity The peptide chain of insulin s prohormone folds back and is cleaved into insulin & C-peptide 6
7 Peptide/protein hormones Cellular action mechanism Lipophobic must bind to receptors on membrane s ECF surface Most work via camp messenger system Some via receptor-enzyme complexes Enzyme attached and activated by binding is tyrosine kinase (recall these enzymes phosphorylate various substrates)» Insulin binds, tyrosine kinase activated and phosphorylates glucose to glucose 6-phosphate Peptide/protein hormones Duration Depends on method of hormone action termination Depends on molecule (some synthetic hormones have been modified to last longer) Steroid Hormones Lipophilic creates problems No storage Production is on an as needed basis Can have the precursors in cytoplasm ready to go Require protein transports in blood prolongs duration of hormone Blocks entrance into cell it must disengage from carrier this follows law of mass action Steroid hormones Based on cholesterol Produced using SER in the Adrenal cortex Gonads Placenta Secretion is by simple diffusion 7
8 New(er) research indicates that some steroid hormones have membrane receptors and signal transduction pathways similar in process to peptide/protein hormones Nongenomic actions also attributed to aldosterone and estrogen Steroid Hormones Cellular mechanism of action Diffuses into cytosol and or into the nucleus Acts as a transcription factors in the nucleus to alter gene activity by Repressing or activating rates of transcription Lag period due to the processes that have to occur Transcription factors have DNA binding domains (DBDs) that tells them where to bind on the DNA (there are approx known human transcription factors with specific DBDs How are they regulated? Negative feedback loop increased transcription factors cause a decrease in production Phosphorylation may stop transcription Ligand binding to transcription factors or cofactors that regulate the transcription factors Steroid Hormone Action Amino acid derived hormones may be Derived from tyrosine Produces T 3 & T 4 Epinephrine & norepinephrine 8
9 Amino acid derived hormones may be Derived from tyrptophan Produces Melatonin Serotonin* Hormone Controls Hormones are controlled by reflex pathways most utilizing negative feedback loops! May have multiple controls though *serotonin is classified as a neurohormone as it is synthesized and secreted by neurons of the GI tract for regulation of motility and CNS 9
Hormones: Classification. Hormones: Classification. Peptide Hormone Synthesis, Packaging, and Release
Hormones: Classification Hormones: Classification Be able to give types and example. Compare synthesis, half-life and location of receptor 1. Peptide or protein hormones Insulin from amino acids 2. Steroid
INTRODUCTION TO HORMONES
INTRODUCTION TO HORMONES UNIVERSITY OF PNG SCHOOL OF MEDICINE AND HEALTH SCIENCES DISCIPLINE OF BIOCHEMISTRY & MOLECULAR BIOLOGY PBL MBBS II SEMINAR VJ Temple What are hormones? Cells in multi-cellular
Chapter-21b: Hormones and Receptors
1 hapter-21b: Hormones and Receptors Hormone classes Hormones are classified according to the distance over which they act. 1. Autocrine hormones --- act on the same cell that released them. Interleukin-2
Actions of Hormones on Target Cells Page 1. Actions of Hormones on Target Cells Page 2. Goals/ What You Need to Know Goals What You Need to Know
Actions of Hormones on Target Cells Graphics are used with permission of: Pearson Education Inc., publishing as Benjamin Cummings (http://www.aw-bc.com) Page 1. Actions of Hormones on Target Cells Hormones
regulation of ECF composition and volume regulation of metabolism thyroid hormones, epinephrine, growth hormone, insulin and glucagon
Hormonal Effects regulation of ECF composition and volume ADH, aldosterone, ANF regulation of metabolism thyroid hormones, epinephrine, growth hormone, insulin and glucagon regulation of muscle contraction
CELL MEMBRANES, TRANSPORT, and COMMUNICATION. Teacher Packet
AP * BIOLOGY CELL MEMBRANES, TRANSPORT, and COMMUNICATION Teacher Packet AP* is a trademark of the College Entrance Examination Board. The College Entrance Examination Board was not involved in the production
Describe how these hormones exert control quickly by changes in phosphorylation state of enzyme, and more slowly by changes of gene expression
Section VIII. Section VIII. Tissue metabolism Many tissues carry out specialized functions: Ch. 43 look at different hormones affect metabolism of fuels, especially counter-insulin Ch. 44 Proteins and
Chapter 18. An Introduction to the Endocrine System. Hormone Chemistry
Chapter 18 An Introduction to the Endocrine System Hormone Chemistry Endocrine System Components endocrine system - glands, tissues, and cells that secrete hormones Copyright The McGraw-Hill Companies,
Drugs, The Brain, and Behavior
Drugs, The Brain, and Behavior John Nyby Department of Biological Sciences Lehigh University What is a drug? Difficult to define Know it when you see it Neuroactive vs Non-Neuroactive drugs Two major categories
Mechanism of hormone action
Mechanism of hormone action ผศ.ดร.พญ.ส ว ฒณ ค ปต ว ฒ ภาคว ชาสร รว ทยา คณะแพทยศาสตร ศ ร ราชพยาบาล Aims What is hormone receptor Type of hormone receptors - cell surface receptor - intracellular receptor
Diabetes and Insulin Signaling
Diabetes and Insulin Signaling NATIONAL CENTER FOR CASE STUDY TEACHING IN SCIENCE by Kristy J. Wilson School of Mathematics and Sciences Marian University, Indianapolis, IN Part I Research Orientation
Endocrine Responses to Resistance Exercise
chapter 3 Endocrine Responses to Resistance Exercise Chapter Objectives Understand basic concepts of endocrinology. Explain the physiological roles of anabolic hormones. Describe hormonal responses to
Chapter 4. The Adrenal Medulla
Chapter 4 The Adrenal Medulla Introduction Induction of cortisol production requires several minutes, and full elaboration of cortisol action requires several hours. In contrast, the adrenal medullary
The Endocrine System
Essentials of Human Anatomy & Physiology Elaine N. Marieb Seventh Edition Chapter 9 The Endocrine System Slides 9.1 9.48 Lecture Slides in PowerPoint by Jerry L. Cook The Endocrine System Second messenger
Mechanisms of Hormonal Action Bryant Miles
Mechanisms of ormonal Action Bryant Miles Multicellular organisms need to coordinate metabolic activities. Complex signaling systems have evolved using chemicals called hormones to regulate cellular activities.
The diagram below summarizes the effects of the compounds that cells use to regulate their own metabolism.
Regulation of carbohydrate metabolism Intracellular metabolic regulators Each of the control point steps in the carbohydrate metabolic pathways in effect regulates itself by responding to molecules that
Endocrine Glands and the General Principles of Hormone Action
Endocrine Glands and the General Principles of Hormone Action Cai Li, Ph.D. Assistant professor Touchstone Center for Diabetes Research Departments of Physiology and Internal Medicine The University of
Endocrine System: Practice Questions #1
Endocrine System: Practice Questions #1 1. Removing part of gland D would most likely result in A. a decrease in the secretions of other glands B. a decrease in the blood calcium level C. an increase in
Keystone Review Practice Test Module A Cells and Cell Processes. 1. Which characteristic is shared by all prokaryotes and eukaryotes?
Keystone Review Practice Test Module A Cells and Cell Processes 1. Which characteristic is shared by all prokaryotes and eukaryotes? a. Ability to store hereditary information b. Use of organelles to control
3) There are different types of extracellular signaling molecules. 4) most signaling molecules are secreted by exocytosis
XIV) Signaling. A) The need for Signaling in multicellular organisms B) yeast need to signal to respond to various factors C) Extracellular signaling molecules bind to receptors 1) most bind to receptors
Chapter 45: Hormones and the Endocrine System
Name Period Overview 1. What is a hormone? 2. Why does a hormone elicit a response only with target cells? 3. The body has two long-distance regulating systems. Which involves chemical signals by hormones?
Lecture 8. Protein Trafficking/Targeting. Protein targeting is necessary for proteins that are destined to work outside the cytoplasm.
Protein Trafficking/Targeting (8.1) Lecture 8 Protein Trafficking/Targeting Protein targeting is necessary for proteins that are destined to work outside the cytoplasm. Protein targeting is more complex
7 Answers to end-of-chapter questions
7 Answers to end-of-chapter questions Multiple choice questions 1 B 2 B 3 A 4 B 5 A 6 D 7 C 8 C 9 B 10 B Structured questions 11 a i Maintenance of a constant internal environment within set limits i Concentration
AP BIOLOGY 2008 SCORING GUIDELINES
AP BIOLOGY 2008 SCORING GUIDELINES Question 1 1. The physical structure of a protein often reflects and affects its function. (a) Describe THREE types of chemical bonds/interactions found in proteins.
D.U.C. Assist. Lec. Faculty of Dentistry General Physiology Ihsan Dhari. The Autonomic Nervous System
The Autonomic Nervous System The portion of the nervous system that controls most visceral functions of the body is called the autonomic nervous system. This system helps to control arterial pressure,
PSK171 STRESS MANAGEMENT
PSK171 STRESS MANAGEMENT Chapter 2 Systems that control stress arousal Controlling Stress & Tension Girdano, Dusek & Everly Ligands Ligands (amino acid molecules) Biochemicals that carry information Neurohormones
Chetek-Weyerhaeuser High School
Chetek-Weyerhaeuser High School Anatomy and Physiology Units and Anatomy and Physiology A Unit 1 Introduction to Human Anatomy and Physiology (6 days) Essential Question: How do the systems of the human
BSc in Medical Sciences with PHARMACOLOGY
BSc in Medical Sciences with PHARMACOLOGY Course Director Dr Christopher John Module Leaders Dr Robert Dickinson (Module 1) Dr Anabel Varela Carver (Module 2) Dr Sohag Saleh (Module 3) Course Administrator
Hormonal Cycles. 1. Briefly describe each component of an endocrine feedback loop: Stimulus. Production Cell. Hormone. Target Cell. Target Cell Action
Hormonal Cycles Directions: a. Click the Contents button. b. Open the Endocrine System File. c. Click Animations. d. Click Hormonal Cycles. 1. Briefly describe each component of an endocrine feedback loop:
Copyright 2000-2003 Mark Brandt, Ph.D. 93
Signal transduction In order to interact properly with their environment, cells need to allow information as well as molecules to cross their cell membranes. Information in many single-celled and all multicellular
Chapter 15. The Autonomic Nervous. The Autonomic Nervous System. Autonomic Motor Pathways. ANS vs. SNS
The Autonomic Nervous System Chapter 15 The subconscious involuntary nervous system Regulates activity of smooth muscle, cardiac muscle & certain glands The Autonomic Nervous System 1 2 ANS vs. SNS Somatic
NO CALCULATORS OR CELL PHONES ALLOWED
Biol 205 Exam 1 TEST FORM A Spring 2008 NAME Fill out both sides of the Scantron Sheet. On Side 2 be sure to indicate that you have TEST FORM A The answers to Part I should be placed on the SCANTRON SHEET.
Activity 7.21 Transcription factors
Purpose To consolidate understanding of protein synthesis. To explain the role of transcription factors and hormones in switching genes on and off. Play the transcription initiation complex game Regulation
PART I: Neurons and the Nerve Impulse
PART I: Neurons and the Nerve Impulse Identify each of the labeled structures of the neuron below. A. B. C. D. E. F. G. Identify each of the labeled structures of the neuron below. A. dendrites B. nucleus
Response to Stress Graphics are used with permission of: Pearson Education Inc., publishing as Benjamin Cummings (http://www.aw-bc.
Response to Stress Graphics are used with permission of: Pearson Education Inc., publishing as Benjamin Cummings (http://www.aw-bc.com) Page 1. Introduction When there is an overwhelming threat to the
Control of Gene Expression
Home Gene Regulation Is Necessary? Control of Gene Expression By switching genes off when they are not needed, cells can prevent resources from being wasted. There should be natural selection favoring
1.1.2. thebiotutor. AS Biology OCR. Unit F211: Cells, Exchange & Transport. Module 1.2 Cell Membranes. Notes & Questions.
thebiotutor AS Biology OCR Unit F211: Cells, Exchange & Transport Module 1.2 Cell Membranes Notes & Questions Andy Todd 1 Outline the roles of membranes within cells and at the surface of cells. The main
Course Curriculum for Master Degree in Medical Laboratory Sciences/Clinical Biochemistry
Course Curriculum for Master Degree in Medical Laboratory Sciences/Clinical Biochemistry The Master Degree in Medical Laboratory Sciences /Clinical Biochemistry, is awarded by the Faculty of Graduate Studies
Anatomy and Physiology Placement Exam 2 Practice with Answers at End!
Anatomy and Physiology Placement Exam 2 Practice with Answers at End! General Chemical Principles 1. bonds are characterized by the sharing of electrons between the participating atoms. a. hydrogen b.
PHC 313 The 7 th. Lecture. Adrenergic Agents
PHC 313 The 7 th. Lecture Adrenergic Agents Introduction Introduction Adrenergic agents are a broad class of agents employed in the treatment of many disorders. They are those chemical agents that exert
Stress & Catecholamines - Overview
Stress & Catecholamines - Overview UNIVERSITY OF PNG SCHOOL OF MEDICINE AND HEALTH SCIENCES DISCIPLINE OF BIOCHEMISTRY AND MOLECULAR BIOLOGY PBL MBBS YEAR II SEMINAR VJ Temple Stress can due to: What is
Chapter 18 Regulation of Gene Expression
Chapter 18 Regulation of Gene Expression 18.1. Gene Regulation Is Necessary By switching genes off when they are not needed, cells can prevent resources from being wasted. There should be natural selection
FIGURE 2.18. A. The phosphate end of the molecule is polar (charged) and hydrophilic (attracted to water).
PLASMA MEMBRANE 1. The plasma membrane is the outermost part of a cell. 2. The main component of the plasma membrane is phospholipids. FIGURE 2.18 A. The phosphate end of the molecule is polar (charged)
Biological cell membranes
Unit 14: Cell biology. 14 2 Biological cell membranes The cell surface membrane surrounds the cell and acts as a barrier between the cell s contents and the environment. The cell membrane has multiple
The Neuron and the Synapse. The Neuron. Parts of the Neuron. Functions of the neuron:
The Neuron and the Synapse The Neuron Functions of the neuron: Transmit information from one point in the body to another. Process the information in various ways (that is, compute). The neuron has a specialized
Todays Outline. Metabolism. Why do cells need energy? How do cells acquire energy? Metabolism. Concepts & Processes. The cells capacity to:
and Work Metabolic Pathways Enzymes Features Factors Affecting Enzyme Activity Membrane Transport Diffusion Osmosis Passive Transport Active Transport Bulk Transport Todays Outline -Releasing Pathways
Molecular Genetics. RNA, Transcription, & Protein Synthesis
Molecular Genetics RNA, Transcription, & Protein Synthesis Section 1 RNA AND TRANSCRIPTION Objectives Describe the primary functions of RNA Identify how RNA differs from DNA Describe the structure and
Complex multicellular organisms are produced by cells that switch genes on and off during development.
Home Control of Gene Expression Gene Regulation Is Necessary? By switching genes off when they are not needed, cells can prevent resources from being wasted. There should be natural selection favoring
glucose and fatty acids to raise your blood sugar levels.
Endocrine & Cell Communication Part IV: Maintaining Balance (Homeostasis) TEACHER NOTES needs coding 1 Endocrine & Cell Communication Part IV: Maintaining Balance (Homeostasis) 2 AP Biology Curriculum
Cell and Membrane Practice. A. chromosome B. gene C. mitochondrion D. vacuole
Name: ate: 1. Which structure is outside the nucleus of a cell and contains N?. chromosome. gene. mitochondrion. vacuole 2. potato core was placed in a beaker of water as shown in the figure below. Which
Chapter 25: Metabolism and Nutrition
Chapter 25: Metabolism and Nutrition Chapter Objectives INTRODUCTION 1. Generalize the way in which nutrients are processed through the three major metabolic fates in order to perform various energetic
The tissues and organs of the vertebrate body cooperate
56 The Endocrine System Concept Outline 56.1 Regulation is often accomplished by chemical messengers. Types of Regulatory Molecules. Regulatory molecules may function as neurotransmitters, hormones, or
Version 1 2015. Module guide. Preliminary document. International Master Program Cardiovascular Science University of Göttingen
Version 1 2015 Module guide International Master Program Cardiovascular Science University of Göttingen Part 1 Theoretical modules Synopsis The Master program Cardiovascular Science contains four theoretical
BSC 2010 - Exam I Lectures and Text Pages. The Plasma Membrane Structure and Function. Phospholipids. I. Intro to Biology (2-29) II.
BSC 2010 - Exam I Lectures and Text Pages I. Intro to Biology (2-29) II. Chemistry of Life Chemistry review (30-46) Water (47-57) Carbon (58-67) Macromolecules (68-91) III. Cells and Membranes Cell structure
Unit 2: Cells, Membranes and Signaling CELL MEMBRANE. Chapter 5 Hillis Textbook
Unit 2: Cells, Membranes and Signaling CELL MEMBRANE Chapter 5 Hillis Textbook HOW DOES THE LAB RELATE TO THE NEXT CHAPTER? SURFACE AREA: the entire outer covering of a cell that enables materials pass.
Class time required: Two 40-minute class periods + homework. Part 1 may be done as pre-lab homework
Diagnosing Diabetes Teacher information Summary: Students analyze simulated blood plasma samples collected during a glucose tolerance test for diabetes. They test glucose and insulin levels to determine
Engage: Brainstorming Body Systems. Record the structures and function of each body system in the table below.
Engage: Brainstorming Body s Record the structures and function of each body system in the table below. Body Nervous Circulatory Excretory Immune Digestive Respiratory Skeletal Muscular Endocrine Integumentary
Disaccharides consist of two monosaccharide monomers covalently linked by a glycosidic bond. They function in sugar transport.
1. The fundamental life processes of plants and animals depend on a variety of chemical reactions that occur in specialized areas of the organism s cells. As a basis for understanding this concept: 1.
The Autonomic Nervous System Physiology Study Guide, Chapter 9
Name: The Autonomic Nervous System Physiology Study Guide, Chapter 9 Lab Time: 1 Part I. Clinical Applications and Short Essay 1. After surgery, patients are often temporarily unable to urinate, and bowel
ADRENERGIC RECEPTOR AGONIST,CLASSIFICATION AND MECHANISM OF ACTION.
ADRENERGIC RECEPTOR AGONIST,CLASSIFICATION AND MECHANISM OF ACTION. LEARNING OBJECTIVES At the end of lecture students should be able to know, Adrenergic receptor agonist, Classification and mechanism
Brain & Mind. Bicester Community College Science Department
B6 Brain & Mind B6 Key Questions How do animals respond to changes in their environment? How is information passed through the nervous system? What can we learn through conditioning? How do humans develop
Nursing 113. Pharmacology Principles
Nursing 113 Pharmacology Principles 1. The study of how drugs enter the body, reach the site of action, and are removed from the body is called a. pharmacotherapeutics b. pharmacology c. pharmacodynamics
RNA & Protein Synthesis
RNA & Protein Synthesis Genes send messages to cellular machinery RNA Plays a major role in process Process has three phases (Genetic) Transcription (Genetic) Translation Protein Synthesis RNA Synthesis
Cells & Cell Organelles
Cells & Cell Organelles The Building Blocks of Life H Biology Types of cells bacteria cells Prokaryote - no organelles Eukaryotes - organelles animal cells plant cells Cell size comparison Animal cell
The Background for the Diabetes Detection Model
The Background for the Diabetes Detection Model James K. Peterson Department of Biological Sciences and Department of Mathematical Sciences Clemson University November 23, 2014 Outline The Background for
Energy Production In A Cell (Chapter 25 Metabolism)
Energy Production In A Cell (Chapter 25 Metabolism) Large food molecules contain a lot of potential energy in the form of chemical bonds but it requires a lot of work to liberate the energy. Cells need
Reproductive System & Development: Practice Questions #1
Reproductive System & Development: Practice Questions #1 1. Which two glands in the diagram produce gametes? A. glands A and B B. glands B and E C. glands C and F D. glands E and F 2. Base your answer
6023-1 - Page 1. Name: 4) The diagram below represents a beaker containing a solution of various molecules involved in digestion.
Name: 6023-1 - Page 1 1) Which one of the following situations indicates a serious organ system malfunction? A) Mitochondria stop functioning in a unicellular organism exposed to pollutants. B) White blood
Regulation of Metabolism. By Dr. Carmen Rexach Physiology Mt San Antonio College
Regulation of Metabolism By Dr. Carmen Rexach Physiology Mt San Antonio College Energy Constant need in living cells Measured in kcal carbohydrates and proteins = 4kcal/g Fats = 9kcal/g Most diets are
Issues Relevant to Endocrine Disruptor Screening
Concepts of Endocrinology: Issues Relevant to Endocrine Disruptor Screening Raphael J. Witorsch, Ph.D. Professor Emeritus Physiology and Biophysics School of Medicine Virginia i i Commonwealth University
Proteins and Nucleic Acids
Proteins and Nucleic Acids Chapter 5 Macromolecules: Proteins Proteins Most structurally & functionally diverse group of biomolecules. : o Involved in almost everything o Enzymes o Structure (keratin,
Integration of Metabolism
I. Central Themes of Metabolism 1. ATP is the universal energy carrier. Integration of Metabolism Bryant Miles 2. ATP is generated by the oxidation of metabolic fuels Glucose Fatty Acids Amino Acids 3.
The Molecules of Cells
The Molecules of Cells I. Introduction A. Most of the world s population cannot digest milk-based foods. 1. These people are lactose intolerant because they lack the enzyme lactase. 2. This illustrates
Chapter 5. Endocrine Regulation of Glucose Metabolism
Chapter 5 Endocrine Regulation of Glucose Metabolism Overview of Glucose Homeostasis Glucose metabolism is critical to normal physiological functioning. Glucose acts both as a source of energy and as a
Control of Gene Expression
Control of Gene Expression What is Gene Expression? Gene expression is the process by which informa9on from a gene is used in the synthesis of a func9onal gene product. What is Gene Expression? Figure
Fight or Flight Response: Play-by-Play
One of the most remarkable examples of cell communication is the fight or flight response. When a threat occurs, cells communicate rapidly to elicit physiological responses that help the body handle extraordinary
Chapter 3 Molecules of Cells
Bio 100 Molecules of cells 1 Chapter 3 Molecules of Cells Compounds containing carbon are called organic compounds Molecules such as methane that are only composed of carbon and hydrogen are called hydrocarbons
Name Date Period. 2. When a molecule of double-stranded DNA undergoes replication, it results in
DNA, RNA, Protein Synthesis Keystone 1. During the process shown above, the two strands of one DNA molecule are unwound. Then, DNA polymerases add complementary nucleotides to each strand which results
1. The diagram below represents a biological process
1. The diagram below represents a biological process 5. The chart below indicates the elements contained in four different molecules and the number of atoms of each element in those molecules. Which set
BIOLOGICAL MEMBRANES: FUNCTIONS, STRUCTURES & TRANSPORT
BIOLOGICAL MEMBRANES: FUNCTIONS, STRUCTURES & TRANSPORT UNIVERSITY OF PNG SCHOOL OF MEDICINE AND HEALTH SCIENCES DISCIPLINE OF BIOCHEMISTRY AND MOLECULAR BIOLOGY BMLS II / B Pharm II / BDS II VJ Temple
PRESTWICK ACADEMY NATIONAL 5 BIOLOGY CELL BIOLOGY SUMMARY
Name PRESTWICK ACADEMY NATIONAL 5 BIOLOGY CELL BIOLOGY SUMMARY Cell Structure Identify animal, plant, fungal and bacterial cell ultrastructure and know the structures functions. Plant cell Animal cell
Regulation of enzyme activity
1 Regulation of enzyme activity Regulation of enzyme activity is important to coordinate the different metabolic processes. It is also important for homeostasis i.e. to maintain the internal environment
The Endocrine System. You don t have to watch CSI to experience action-packed drama.
The Endocrine System: An Overview (pp. 595 596) Hormones (pp. 596 601) The Chemistry of Hormones (p. 596) Mechanisms of Hormone Action (pp. 596 598) Target Cell Specificity (p. 598) Half-Life, Onset, and
PHYSIOLOGICAL PSYCHOLOGY
UNIVERSITY OF CALICUT SCHOOL OF DISTANCE EDUCATION B Sc COUNSELLING PSYCHOLOGY (2011 Admission Onwards) I Semester Complementary Course PHYSIOLOGICAL PSYCHOLOGY QUESTION BANK 1. are the basic units of
H H N - C - C 2 R. Three possible forms (not counting R group) depending on ph
Amino acids - 0 common amino acids there are others found naturally but much less frequently - Common structure for amino acid - C, -N, and functional groups all attached to the alpha carbon N - C - C
The Lipid Bilayer Is a Two-Dimensional Fluid
The Lipid Bilayer Is a Two-Dimensional Fluid The aqueous environment inside and outside a cell prevents membrane lipids from escaping from bilayer, but nothing stops these molecules from moving about and
Cellular Energy: ATP & Enzymes. What is it? Where do organism s get it? How do they use it?
Cellular Energy: ATP & Enzymes What is it? Where do organism s get it? How do they use it? Where does Energy come from? Ultimately, from the sun. It is transferred between organisms in the earth s lithosphere,
BIOLOGICAL MOLECULES OF LIFE
BIOLOGICAL MOLECULES OF LIFE C A R B O H Y D R A T E S, L I P I D S, P R O T E I N S, A N D N U C L E I C A C I D S The Academic Support Center @ Daytona State College (Science 115, Page 1 of 29) Carbon
Mammalian Physiology. Cellular Membranes Membrane Transport UNLV. PHYSIOLOGY, Chapter 1 Berne, Levy, Koeppen, Stanton UNIVERSITY OF NEVADA LAS VEGAS
Mammalian Physiology Cellular Membranes Membrane Transport UNLV 1 UNIVERSITY OF NEVADA LAS VEGAS PHYSIOLOGY, Chapter 1 Berne, Levy, Koeppen, Stanton Objectives Describe the structure of the cell membrane
T Cell Maturation,Activation and Differentiation
T Cell Maturation,Activation and Differentiation Positive Selection- In thymus, permits survival of only those T cells whose TCRs recognize self- MHC molecules (self-mhc restriction) Negative Selection-
1. What has a higher stored energy potential per gram, glycogen or triglycerides? Explain.
Lipid Metabolism 1. What has a higher stored energy potential per gram, glycogen or triglycerides? Explain. 2. How can excess acetyl CoA trapped in the mitochondria, be utilized as a substrate for fatty
Lecture 1 MODULE 3 GENE EXPRESSION AND REGULATION OF GENE EXPRESSION. Professor Bharat Patel Office: Science 2, 2.36 Email: b.patel@griffith.edu.
Lecture 1 MODULE 3 GENE EXPRESSION AND REGULATION OF GENE EXPRESSION Professor Bharat Patel Office: Science 2, 2.36 Email: b.patel@griffith.edu.au What is Gene Expression & Gene Regulation? 1. Gene Expression
Introduction to Animal Systems
Human Body Systems Introduction to Animal Systems Recurring Themes in Biology 1. Correlation between structure and function( seen at many levels) 2. Life is organized at many levels from Smallest ----
CENTRAL TEXAS COLLEGE SYLLABUS FOR BIOL 2402 ANATOMY & PHYSIOLOGY II (BIOL 2402) Semester Hours Credit: 4 INSTRUCTOR:
I. INTRODUCTION CENTRAL TEXAS COLLEGE SYLLABUS FOR BIOL 2402 ANATOMY & PHYSIOLOGY II (BIOL 2402) Semester Hours Credit: 4 INSTRUCTOR: A. Human Anatomy and Physiology II is designed for students entering
Copyright 2000-2003 Mark Brandt, Ph.D. 54
Pyruvate Oxidation Overview of pyruvate metabolism Pyruvate can be produced in a variety of ways. It is an end product of glycolysis, and can be derived from lactate taken up from the environment (or,
Course Curriculum for Master Degree in Medical Laboratory Sciences/Clinical Microbiology, Immunology and Serology
Course Curriculum for Master Degree in Medical Laboratory Sciences/Clinical Microbiology, Immunology and Serology The Master Degree in Medical Laboratory Sciences / Clinical Microbiology, Immunology or
73 Cell Communication
73 Cell Communication and Multicellularity CHATEROUTLIE 7. What Are Signals, and How Do Cells Respond to Them? 7.2 How Do Signal Receptors Initiate a Cellular Response? 7.3 How Is the Response to a Signal
Biological Membranes. Impermeable lipid bilayer membrane. Protein Channels and Pores
Biological Membranes Impermeable lipid bilayer membrane Protein Channels and Pores 1 Biological Membranes Are Barriers for Ions and Large Polar Molecules The Cell. A Molecular Approach. G.M. Cooper, R.E.
Digestion, Absorption. How & where?
Digestion, Absorption How & where? What happens to food? Three processes Digestion Absorption Elimination Where do they occur? GI tract Overview of Digestion GI tract Gastrointestinal (GI) tract: series
Carbohydrates, proteins and lipids
Carbohydrates, proteins and lipids Chapter 3 MACROMOLECULES Macromolecules: polymers with molecular weights >1,000 Functional groups THE FOUR MACROMOLECULES IN LIFE Molecules in living organisms: proteins,