5 Th. 5 th Lugano Stem Cell Meeting. 20 th 21 st June Università della Svizzera Italiana Lugano Switzerland PRELIMINARY PROGRAM

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1 5 th Lugano Stem Cell Meeting Poster submission is now open for registration Deadline June 10 th, Th Università della Svizzera Italiana Lugano Switzerland 20 th 21 st June 2016 PRELIMINARY PROGRAM

2 PRELIMINARY PROGRAM Introduction Basic and translational research on stem cells for regenerating injured organs, including the heart and the brain, has experienced tremendous progress over the past decade. Besides cell types traditionally used in regenerative protocols, such as bone marrow-derived cells and mesenchymal stem cells, new candidate cell types for cardiac repair have emerged, most notably cardiacresident stem and progenitor cells. Meanwhile, induced pluripotent stem (ips) cells provide a unique opportunity of disease modelling and personalized medicine. The roles of molecular mediators of stem cell effects, such as paracrine factors including exosomes and noncoding RNA, are increasingly well understood and exploited in therapeutic strategies. The fifth edition of the Lugano Stem Cell Meeting provides a unique opportunity to discuss the above scientific issues with worldwide leaders in the field within a particularly comfortable context. As for the previous editions of the Meeting, the first day will be focused on basic research while the second day will be more specifically devoted to clinical applications and cell therapy trials. Spotlight sessions of this edition will highlight exosomes as paracrine mediators of functional effects of stem cells, noncoding RNA as critical regulators of cell function, and stem cell-based approaches for the treatment of neurological diseases. We look forward to welcoming you in Lugano, Prof. Tiziano Moccetti, Prof. Giuseppe Vassalli, Dr. Lucio Barile, Dr. Daniel Sürder

3 PRELIMINARY PROGRAM MONDAY 20 TH JUNE :30 09:00 Registration MORNING MONDAY 20 TH JUNE :00 09:10 Welcome Address - T. Moccetti 09:10 09:20 Introduction - G. Vassalli SESSION 1 Cellular and non cellular approaches for heart disfunction Chairman: G. Pompilio Panel: O. Binah, P. Ferdinandy, C. Gaetano 09:20 09:35 Autophagy-lysosomal pathway alterations in heart failure - A. Beltrami 09:35 09:50 Fate of cardiac stem cells in the adult heart - A. Leri 09:50 10:05 Long non-coding RNAs in post-ischemic heart failure - F. Martelli 10:05 10:35 Lecture Molecular approaches for cardiac regeneration - M. Giacca 10:35 11:00 Coffee break - POSTER SESSION SESSION 2 Extracellular vesicles: Emerging biomarkers and therapeutics Chairman: A. Leri Panel: G. Camussi, T. Tallone, G.Vassalli 11:00 11:15 Heterogeneous populations of extracellular vesicle subtypes - J.P. Sluijter 11:15 11:30 Cardiac exosomes for cardiac repair - L. Barile 11:30 11:45 Functional genomics of cardioprotection: role micrornas and exosomes P. Ferdinandy Lecture 11:45 12:15 Exosomes as therapeutic agents - E. Marbán 12:15 13:10 Lunch - POSTER SESSION

4 PRELIMINARY PROGRAM MONDAY 20 th JUNE 2016 SESSION 3 AFTERNOON MONDAY 20 th JUNE 2016 Cardiomyocytes specification from ESC or ips Chairman: J.P. Sluijter Panel: C. Altomare, L. Barile, A.Beltrami 13:10 13:25 ips cell-derived cardiomyocytes - P. Dell Era 13:25 13:40 Mathematical modelling of the action potential of human embryonic stem cell derived cardiomyocytes.- M. Jaconi 13:40 13:55 Electrophysiology of ips cell-derived cardiomyocytes - O. Binah 13:55 14:25 Lecture: Calcium handling in human induced pluripotent stem cell derived cardiomyocytes L. Gepstein SESSION 4 Neuroregeneration Chairman: P. Paganetti Panel: A. Faedo 14:25 14:45 Molecular and cellular control of neural stem cell activity - S. Jessberger 14:45 15:05 Attempts to characterize the limited capacity of the mammalian retina to regenerate photoreceptors - Y. Arsenijevik 15:05 15:35 Lecture A differentiation toolkit for the derivation of neurons from pluripotent stem cells, the example of Huntington s Disease A. Faedo 15:35 16:15 Coffee break - POSTER SESSION 16:15 16:45 Lecture Identification and characterization of hypoxia-regulated endothelial circular RNA. S. Dimmeler SESSION 5 Vascular aging, regeneration and diabetes Chairman: S. Dimmeler Panel: V. Lionetti, A. Beltrami 16:45 17:00 Epigenetics of diabetes - C. Gaetano 17:00 17:15 Molecular mechanisms of age-related endothelial dysfunction and CVD - G. Camici 17:15 17:30 Endothelial progenitor cell-derived exosomes - G. Camussi 17:30 17:40 POSTER AWARD - T. MOCCETTI

5 PRELIMINARY PROGRAM TUESDAY 21 S T JUNE :00 08:20 Registration MORNING TUESDAY 21 st JUNE :20 08:30 Welcome address - D. Sürder SESSION 6 How to design animal models in regeneration cardiovascular research translation of the unmet need Chairman: P. Anversa Panel: S. Bardelli, J. Kastrup, W. Wojakowski 08:30 08:42 Small animal models - V. Lionetti 08:42 08:54 Big animal models - M. Emmert 08:54 09:05 Discussion SESSION 7 Now it counts! Update on planned, resumed and ongoing trials Chairman: F. Ruschitzka Panel: R. Corti, G. Pompilio, A. Zeiher 09:05 09:17 The CHART program preliminary results and future objectives - TBE 09:17 09:29 DREAM-HF- Will the dream become true? - E. Perin 09:29 09:41 i.c. CD133+ cells in patients with No-option resistant angina results from the REGENT-VSEL trial - W. Wojakowski 09:41 09:53 Update on the ALLSTAR program - L. Marbán 09:53 10:05 Long term results of the MSC-HF trial - J. Kastrup 10:05 10:17 Update on the STEM-AMI OUTCOME trial - F. Achilli 10:17 10:29 Study design, rationale and status of the ESCORT trial - P. Menasché 10:29 10:45 Discussion 10:45 11:15 Coffee break SESSION 8 The big debate on meta analysis in cardiac regeneration Chairman: A. Mathur Panel: D. Locca, G. Pedrazzini 11:15 11:27 Why I prefer IPD based meta-analyses - M. Gyöngyosi 11:27 11:39 Why I prefer publication based meta-analyses - B. Dawn 11:39 11:51 How can they come together - A. Zeiher 11:51 12:05 Discussion 12:05 12:15 Closing Remarks - T. Moccetti 12:15 13:30 Lunch 13:30 14:15 Special Joint Lecture TBE - O. Atkof End of the 5 th Lugano Stem Cell Meeting

6 COURSE DIRECTORS - FACULTY SPONSORS COURSE DIRECTORS FACULTY SPONSORS

7 FINAL PROGRAMME GENERAL INFORMATION LOCATION The 5 th Lugano Stem Cell Meeting (LSCM) 2016 will take place in Lugano, the most important city in the Italian speaking part of Switzerland. This region is considered one of the most beautiful spots in Europe. VENUE The Symposium will take place at the Università della Svizzera Italiana, which is located 10 minutes walking distance of many hotels, shops and attractions. The venue is centrally located, and 30 minutes by taxi from the local airport (Lugano-Agno). The Milan Malpensa Airport is 1 hour by shuttle-bus from Lugano. By car: motorway exit Lugano Nord. CLIMATE June often presents a warm temperature (23-27 C), with possible rain-showers. CERTIFICATE OF ATTENDANCE A Certificate of Attendance will be given to the participants attending all sessions of the Symposium. ACCREDITATION FAMH: 10,5 credits. CONFERENCE LANGUAGE The conference language is English for all sessions. No translation is provided. POSTER SESSION Call for abstracts on the website The best poster will be awarded and will be presented as an oral presentation on June 20 th. Deadline poster submission: June 10 th, 2016 HOTEL ACCOMMODATION Participants are responsible for their own hotel booking. For assistance please contact: Amiconi Consulting Via Al Forte Lugano, Switzerland Phone: Fax: info@amiconiconsulting.ch WEB SITE On the web site of the Cardiocentro Ticino information is available about: Cardiocentro Ticino Venue Scientific program Conference secretariat contact details Call for Abstract For registration: CONFERENCE SECRETARIAT Please contact the secretariat in case of any query at the following address: Events and Communication Department Cardiocentro Ticino Via Tesserete Lugano Phone: / Fax: congressi@cardiocentro.org

8 5 th Lugano Stem Cell Meeting 20 th -21 st June 2016 Università della Svizzera Italiana Lugano - Switzerland Family name First name Institute Department Institute Address Institute Postal code (int. Code: ++) City Tel. Country Fax Registration fees Free registration for academy participants Euro 250 for industry participants Free registration for congress sponsors I would like to receive the brochure of the 9 th Interventional Symposium on High Risk and Innovative Cardiac Interventions Meet the Experts 2016 REGISTRATION FORM DEADLINE FOR REGISTRATION 1 S T JUNE 2016 TO BE RETURNED WITH ENCLOSURES TO Fondazione Cardiocentro Ticino Events and Communication Department Via Tesserete 48 CH-6900 Lugano Phone / Fax congressi@cardiocentro.org Associated Institute of the University of Zurich