Finnish Society of Toxicology 34th Annual Symposium Orion Pharma, Espoo, Finland PREDICTIVE TOXICOLOGY AND DRUG SAFETY TESTING

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1 Finnish Society of Toxicology 34th Annual Symposium Orion Pharma, Espoo, Finland PREDICTIVE TOXICOLOGY AND DRUG SAFETY TESTING Sponsors collaborators:

2 Day 1, Monday 13 May :30-9:30 Registration & poster hanging 9:30-10:00 Opening: Reijo Salonen, Orion Pharma Kirsi Vähäkangas, UEF, President of FST 10:00-11:15 Predictive toxicology, Chair: Kirsi Vähäkangas Keynote lecture 45 min Olavi Pelkonen, University of Oulu Predictive toxicology - from simple to complex by integration Marja-Leena Toivonen, Orion Pharma Current challenges in drug safety testing 11:15-12:45 Cardiac safety in vivo and in vitro, Chair Kaisa Unkila Risto Kerkelä, University of Oulu Preclinical strategies for identifying mechanisms of cardiotoxicity Ari-Pekka Koivisto, Orion Pharma Emerging technologies: inducible pluripotent stem cells Tarja Lehtimäki, Orion Pharma In vivo cardiac safety 12:45-13:45 Lunch 13:45-14:45 Genotox and Reactive metabolites, Chair Markku Pasanen Risto Juvonen, University of Eastern Finland Steps to understand and predict bioactivation of drugs Teija Oinonen, Orion Pharma Testing for genotoxicity metabolic considerations 14:45-15:15 Coffee break 15:15-16:45 Product related issues - Case examples, Chair Kaisa Unkila Leena Sopanen, Orion Pharma Nonclinical safety of COMT inhibitors Pertti Pellinen, Santen Nonclinical safety testing of ocular drugs- case Tafluprost Risto Lammintausta, Hormos Medical Ospemifene case 17:00 - Wine & snacks + Annual meeting of FST 19:30 Symposium Dinner at Restaurant Sevilla, Tapiola Garden Hotel (at the participant s own expenses, ca. 30 for Tapas buffet, first drink courtesy of Covance Laboratories Ltd)

3 Day 2, Tuesday 14 May :00-9:45 Keynote lecture, Chair Kai Savolainen Bengt Fadeel, Karolinska Institutet Understanding the synthetic and biological identities of nanomaterials - implications for nanomedicine 9:45-10:45 Biomarkers for toxicity, Chair Risto Juvonen Markku Pasanen, University of Eastern Finland Biomarkers from regulatory point of view Kristiina Haasio, Orion Pharma Kidney and liver biomarkers in drug development 10:45-12:30 Poster viewing and Lunch 12:30-13:30 Toxicological modeling, Chair Markku Pasanen Hannu Raunio University of Eastern Finland Modeling as a tool in toxicology Julius Sipilä Orion Pharma Use of structural alerts in early drug discovery 13:30-14:00 Two 10 min oral presentations on posters (selected based on abstracts) Poster award 14:00-14:30 Coffee break 14:30-15:30 Preclinical safety evaluation for novel therapies, Chair Katri Talvioja Tiina Palomäki, FIMEA Preclinical safety testing of biologicals Sari Pesonen, Oncos Therapeutics Safety assessment of oncolytic viruses 15:30-15:45 Closing: Kirsi Vähäkangas (16:00 Annual meeting of Fincopa) (for members of the Finnish consensus platform for alternatives)

4 Practical issues o The official language of presentations and all written material is English o Congress venue: Head quarter of Orion Corporation, Orionintie 1, Espoo o Lunch and coffee/tea are provided by courtesy of Orion Pharma o If you have any questions, please contact Organizing committee: or o Abstracts and Posters: o Abstract (max. 300 words, names and organization information excluded) should be sent by an to: the deadline for abstract submission is EXTENDED TO ! o Poster size is preferably ca. 70 x 100 cm). If you wish to present a larger poster, this should be mentioned when submitting the abstract. Limited space is available. o Based on abstracts FST board will invite two presentations to be given orally. o Best poster will be awarded by the FST. Registration fees: o 50 for members of FST o 100 non-members o Doctoral students, please check sponsoring with your graduate school. o Master s-students are welcome to attend symposium free of charge. Also students need to register! o Registration payments: to the bank account of FST, IBAN FI Payment should be transferred before registration, by 12 April Please, indicate the name of the participant in the receipt. Registration: o All participants need to register by , by sending to the address: o Please, include the following information: confirmation of your payment (receipt) member/non-member/ student (and the name of the study program and university) speaker / poster-presenter / other need for special diets for the dinner table reservation, please indicate if you participate the social event (at your own expenses, ca. 30 for Tapas buffet) Sponsoring: 1) Booth at the symposium venue and advertisement in the program leaflet: 300 2) Advertisement in the program leaflet 100 Social event: o Symposium Dinner at restaurant Sevilla, Sokos Hotel Tapiola Garden in the evening of 13 May 2013 (at participant s expenses)

5 Accommodation: o Participants are kindly asked to make reservations by themselves. Organizers have made preliminary reservations for Hotel Tapiola Garden (booked till 15 April 2013). o Reservations: Sokos Hotels Myyntipalvelu Puhelin: / yksittäiset huonevaraukset Sähköposti: Reservation code: Toksikologi o Prices per night: 110 single-room. o Check availability of other hotels in Helsinki or Espoo via the internet (e.g. booking.com, hotels.com). Access to the symposium venue: Orion Corporation s Headquarter, Orionintie 1, Espoo o Check: o Public transportation from Helsinki or Tapiola: Orion can be reached e.g. by regional buses No. 107 and 109 departing from Helsinki Kamppi bus terminal. The journey takes around 25 minutes. Check your connections and timetable with using the street address (Orionintie 1) as the final destination. o Access from Espoo railway station or Helsinki-Vantaa airport: public transportation options are limited (check reittiopas.fi for details). o Private car: Parking is free of charge on Orion s parking areas o Registration desk is located at the main entrance

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