JUNE 2-3, 2014 CONNECT.

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1 JUNE 2-3, 2014 CONNECT. GROW. SUCCEED.

2 THIRD INDUSTRIAL CELL CULTURE TECHNOLOGY CONFERENCE JUNE 2-3, 2014 Laupheim s historical castle, Schloss Großlaupheim, Germany Rentschler Biotechnologie GmbH is delighted to announce the third Laupheimer Zelltage industrial cell culture conference, which will focus on Processes for Virus-based Biologics. Novel virus-based carrier technologies, such as virus-like particles (Cervarix and Gardasil ), are breaking into new vaccine sectors and helping to provide the overall vaccine market with double-digit compound annual growth rates. The first approval of gene therapeutics (Glybera ) in Europe at the end of 2012, as well as various other reports of success from further gene therapy trials, are bolstering confidence in the potential of gene therapy. This will significantly boost capital flow and hopefully lead to the long-awaited break in gene therapy, especially as oncolytic viruses or magic bullets are attracting more and more attention in cancer therapy. Common to all of these virus-based biologics is their high degree of complexity, creating the necessity for high levels of understanding of virus and cell biology as well as a multiplicity of innovative technologies. The manufacturing of virus-based biologics is setting new standards for process development and analytical and regulatory requirements. EVENT HIGHLIGHT Processes for Virus-based Biologics encompass all aspects related to platform technologies for the manufacturing and control of viral biopharmaceuticals, including viral vectors, oncolytic viruses and virus-based vaccines. The third industrial cell culture conference will bring together international academic and industrial experts in cell culture and process technology for the production of virus-based biologics. It is the first conference of its type, and is eagerly awaited by the scientific and industrial community. Rentschler s Facilities can be visited before the Monday afternoon meeting. Capacity is limited, so make sure you register early!

3 AGENDA 1. DAY JUNE 2, INTRODUCTORY PROGRAM 14:00 Tour of Rentschler s Facility Rentschler Biotechnologie GmbH 17:00 Reception Kulturhaus Schloss Großlaupheim 18:00 Rentschler Welcome Rentschler Biotechnologie GmbH Keynote Lecture CHO Genome and CHO Quasi-Species - Impacts on Manufacturing and Future 19:30 Dinner & Exhibition at the Historical Castle Florian M. Wurm Swiss Federal Institute of Technology Lausanne, Switzerland Kulturhaus Schloss Großlaupheim 2. DAY JUNE 3, SCIENTIFIC PROGRAM 09:00 Morning Welcome Chair Oncolytic Virotherapy: A Promising Weapon to Defeat Cancer? 09:10 Re-Engineering Vesicular Stomatitis Virus to Enhance Efficacy and Abrogate Toxicity 09:40 YB-1 Based Virotherapy: Basics and Achievements 10:10 The Production and Purification of Two Oncolytic Viruses for Human Clinical Trials Treating Cancer Dorothee von Laer, ViraTherapeutics Innsbruck, Austria Per Sonne Holm, XVir München, Germany Marc Federspiel, Mayo Clinic Rochester/Minnesota, USA 10:40 Coffee Break Foyer Schloss Großlaupheim

4 Recent Achievements in Gene Therapeutics Development and Application 11:00 Helper-dependent Adenoviral Vectors for the Treatment of Osteoarthritis 11:30 The Use of Insect Cells to Produce a Complex Gene Therapy Product 12:00 In Vivo Barriers for Gene Therapy and Virotherapy Kilian Guse, GeneQuine Biotherapeutics Hamburg, Germany Harald Petry, UniQure B.V. Amsterdam, Netherlands Stefan Kochanek University Hospital Ulm, Germany 12:30 Lunch Break and Exhibition Foyer Schloss Großlaupheim Trends in Manufacturing and Control of Virus-based Biologics 14:30 Novel Molecular Tools and Process Technologies Towards Commercial Manufacturing of Recombinant Viral Vectors Rentschler Biotechnologie GmbH 15:00 Efficient Production of Viral Vectors and Viral Vaccines Amine Kamen, Human Health Therapeutics, Ottawa/Ontario, Canada 15:30 Coffee Break Foyer Schloss Großlaupheim 15:50 Approach of PAT in Development: New Tools for Oncolytic Virus Production 16:20 Development and Control of a Production Process of Virus Particles for the Use in Cancer Therapy Marianne Gras, Transgene Illkirch-Graffenstaden, France Peter Czermak, Institute of Bioprocess Engineering and Pharmaceutical Technology Giessen, Germany 16:50-18:00 Final Remarks and Farewell Get-together

5 REGISTRATION Register online at The conference fee is 150 and includes transportation and meals. Students attend at no charge. Registration deadline: April 2, 2014 VENUE Schloss Großlaupheim, Claus-Graf-Stauffenberg-Straße 15, Please make your room reservations when you register. ACCOMMODATION Rooms have been set aside for participants at the Maritim Hotel Ulm and must be booked by April 4, Reference Laupheimer Zelltage when booking: Maritim Hotel Ulm, Basteistraße 40, Ulm, Germany Phone: +49(0) , Fax: +49(0) , A shuttle bus will run between the hotel and the conference venue. CONTACT If you have any questions about the conference, accommodations, venue or travel, please contact: Corina Glöggler Rentschler Biotechnologie GmbH, Erwin-Rentschler-Straße 21, Tel.: +49(0) , Fax: +49(0)

6 Rentschler Biotechnologie GmbH Erwin-Rentschler-Straße Laupheim Germany phone: fax: June 2, 2014 Facility-Tour at B30 Ulm Biberach P June 2-3, 2014 mann at Schloss Großlaupheim P HOW TO GET TO LAUPHEIM BY CAR Take the A8 Stuttgart Munich Enter the B10 at Ulm West and follow the signs to Friedrichshafen. Continue on the B10 Exit the B10 at the junction B10/B30 and follow the signs to Friedrichshafen for approx. 20 km. Take the Laupheim Mitte exit and follow the signs.

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