RITMIR024 - STEM CELL RESEARCH IN CARDIOLOGY

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1 1. SCOPE AND METHODOLOGY 2. REPORT SYNOPSIS 2.1 General Definitions Myoblasts Pluripotent Cells Multipotent Cells Progenitor Cells Role of Stem Cells in Repairing the Heart Stem Cell Therapy Stem Cells in Cardiology Cell Based Myocardial Repair Cord Blood Stem Cells in Regenerative Medicine Cardiocytes 2.2 Segmentation of Stem Cells in Cardiology Exhibit 1. Segmentation of Global Stem Cells Market in Cardiology by Source and by Type Source Allogenic Autogenic Type Bone Marrow Stem Cells Embryonic Stem Cells 2.3 Stem Cells in Cardiology - Global Market Analysis Exhibit 2. Stem Cells in Cardiology - Global Market Historic, Estimations and Predictions ( ) in US$ Million Exhibit 3. Stem Cells in Cardiology List of Major Global Companies 3. MARKET DYNAMICS 3.1 Market Overview 3.2 Global Stem Cells Market Exhibit 4. Stem Cells - Global Market Historic, Estimations and Predictions ( ) by Geographic Region for North America, Europe, Asia-Pacific and Rest of World in US$ Million Exhibit 5. Stem Cells - Global Market Shares (2010, 2015 & 2020) by Geographic Regions by North America, Europe, i

2 Asia-Pacific and Rest of World 3.3 Global Market for Stem Cells in Cardiology Exhibit 6. Stem Cells in Cardiology - Global Market Historic, Estimations and Predictions ( ) by Geographic Regions for North America, Europe, Asia-Pacifc and Rest of World in US$ Million Exhibit 7. Stem Cells in Cardiology - Global Market Shares (2010, 2015 & 2020) by Geographic Regions for North America, Europe, Asia-Pacifc and Rest of World 3.3 (I) North American Market for Stem Cells in Cardiology Exhibit 8. List of Major North American Stem Cells in Cardiology Companies Exhibit 9. Prevalence of Cardiovascular Diseases 2005 in the US Exhibit 10. US Death Rates for Cardiovascular and Non-Cardiovascular Disease 3.3 (II) European Market for Stem Cells in Cardiology Exhibit 11. List of Major European Stem Cells in Cardiology Companies Exhibit 12. Cardiovascular Disease: Death Statistics in Europe Exhibit 13. Death Statistics by Cause in Europe 3.3 (III) Asia-Pacific Market for Stem Cells in Cardiology Exhibit 14. List of Major Asia-Pacific Stem Cells in Cardiology Companies Exhibit 15. Death Statistics for Cardiovascular Disease in Asia-Pacific 3.3 (IV) Rest of World Market for Stem Cells in Cardiology Exhibit 16. List of Major Rest of World Stem Cells in Cardiology Companies Exhibit 17. Death Statistics for Cardiovascular Disease in Rest of World 3.4 Analysis by Source Exhibit 18. Stem Cells Market in Cardiology by Source - Global Market Historic, Estimations and Predictions ( ) for Allogenic and Autogenic Stem Cell Transplantation in US$ Million Exhibit 19. Stem Cells Market in Cardiology by Source - Global Market Shares (2010, 2015 & 2020) by Source for Allogenic and Autogenic Stem Cells 3.5 Analysis by Type Exhibit 20. Stem Cells in Cardiology by Type - Global Market Historic, Estimations and Predictions ( ) for Bone Marrow Stem Cells, Embryonic Stem Cells and Other in US$ Million Exhibit 21. Stem Cells in Cardiology by Type - Global Market Shares (2010, 2015 & 2020) for Bone Marrow Stem Cell, Embryonic Stem Cell and Other 3.6 Market Trends Israel Leads in Stem Cell Based Research Treating Heart Diseases with Stem Cells ii

3 Cord Blood Stem Cells Based Therapies for Diseases of the Heart and Blood Vessels Cord Blood Stem Cell Therapies for Enhancing the Performance of Heart s Ventricles, and Repairing Arteries and Veins Effectiveness of Cord Blood Stem Cells for Treating Congenital Heart Problems Effectiveness of Cord Blood Stem Cells Based Therapies for Treating Peripheral Vascular Disease Outlook for Cord Blood Stem Cells Based Medical Therapies Inactivation of P66sch Gene Provides a Solution to Rapid Aging of Stem Cells in the Heart, and Higher Risk of Heart Failure, Caused by Diabetes Mesenchymal Stem Cells from Bone Marrow Prompts Angiogenesis and Bring in Changes in Diabetic Cardiomyopathy Endothelial Progenitor Cells for Vascular Repairs Treating Cardiovascular Diseases with Endothelial Progenitor Cells Transplanted Fetal Cardiomyocytes Effective as Pacemaker in the Heart Adult Bone Marrow Stem Cells Used for Reproducing Myocardium in Case of Ischemic Heart Disease Multipotent Meso-Angioblast Collected from Dorsal Aorta is Capable of Self-Renewal, and Transformation into Majority of Cells Forming Mesodermal Tissues 3.7 Company Profiles - Major Players in Stem Cells in Cardiology Market Aastrom Biosciences, Inc. (USA) Advanced Cell Technology, Inc. (USA) Aldagen, Inc. (USA) Athersys, Inc. (USA) Axordia Ltd. (UK) Baxter International (USA) Bioheart, Inc. (USA) More. 3.8 Major Product Innovations/Launches in Stem Cell Research - Cardiology GSK and HSCI in Research Collaboration for Stem Cells Gamida Cell and Biologics Delivery Systems in Collaboration Agreement PerkinElmer Establishes Stem Cell Research Center Geron Reports Positive Results for Embryonic Stem Cell Therapy for Heart Failure New Type of Stem Cells Discovered on Epicardium by Scientists iii

4 Aastrom Starts Phase II Clinical Trials Using Cells from Patient s Own Bone Marrow to Treat Chronic Heart Failure Angioblast Systems Gets FDA Approval for Phase 2 Trial Pluristem Therapeutics Qualified as a Good Manufacturing Practices (GMP) Site for the More Stem Cells in Cardiology Market Outlook 4. PRODUCT/TECHNOLOGY RESEARCH 4.1 Introduction Coronary Angiography Cardiovascular Diseases Major Common Causes of CHD Myocardial Infarction Symptoms of MI Risk Factors Possible Therapies to Treat MI Adult Stem Cells in Myocardial Infarction Mobilized Stem Cells in Treating Myocardial Infarction Congestive Heart Failure Left-Sided Failure Right-Sided Failure Myocardial Rupture Risk Factors Classification of Myocardial Rupture Symptoms of Myocardial Rupture Treatment of Myocardial Rupture Cardiomyopathy Systemic Disease Causing Cardiomyopathy Extrinsic Cardiomyopathy Ischemic Cardiomyopathy Symptoms of Ischemic Cardiomyopathy Cord Blood Cells to Treat Ischemia iv

5 Intrinsic Cardiomyopathy Dilated Cardiomyopathy or DCM Hypertrophic Cardiomyopathy Arrhythmogenic Right Ventricular Cardiomyopathy Restrictive Cardiomyopathy Non Compaction Cardiomyopathy Malignant Cardiomyopathy/Accelerated Cardiomyopathy Signs and Symptoms Treatment Coronary Heart Disease Symptoms of Angina Pectoris Kinds of Angina Stable Angina Unstable Angina Hypertensive Heart Disease Symptoms Valvular Heart Disease Types of Valvular Diseases Inflammatory Heart Disease Stem Cells - Cardiology Bone Marrow Stem Cells Mononuclear Bone Marrow (MNBM) Stem Cells Heart Muscle Regeneration with Bone Marrow Stem Cells Introduction Adult Stem Cells Haematopoietic Stem Cells Mesenchymal Stem Cells Endothelial Progenitor Cells Myoblast Cells Fetal Cardiomyocytes Stem Cell Delivery Autologous Stem Cells v

6 Autologous Skeletal Myoblasts Delivery of Autologous Myoblasts by Catheter Functional Assessment of Stem Cell Therapy Cardiac Stem Cells Biology of Stem Cells Sources of Stem cells Allogenic Stem Cell Transplantation Autologous Stem Cell Transplantation Exhibit 22. Stem Cells Market in Cardiology by Source - Global Market Historic, Estimations and Predictions ( ) for Allogenic and Autogenic Stem Cell Transplantation in US$ Million Exhibit 23. Stem Cells Market in Cardiology by Source - Global Market Shares (2010, 2015 & 2020) by Source for Allogenic and Autogenic Stem Cells Autologous Products and their Allogenic Counterparts - Manufacturing Risks, Product Development and Business Models Stem Cells as Therapeutics The Ideal Cell Types for Cardiac Stem Cell Therapy Embryonic Stem Cells Embryonic Stem Cells for Treating Cardiovascular Diseases Lineage Specific Differentiation of Embryonic Stem Cells Induction of Cardiogenesis in Embryonic Stem Cells- Via Down regulation of Notch1 Gene Signaling Transformation of Embryonic Stem Cells into Cardiomyocytes Cardiomyocytes from Human Embryonic Stem Cells Stem Cells in Mitochondrial Faults and Toxicology Cord Blood Stem Cells in Treating Heart Diseases Exhibit 24. Stem Cells in Cardiology by Type - Global Market Historic, Estimations and Predictions ( ) for Bone Marrow Stem Cells, Embryonic Stem Cells and Other in US$ Million Exhibit 25. Stem Cells in Cardiology - Global Market Shares (2010, 2015 & 2020) by Type for Bone Marrow Stem Cell, Embryonic Stem Cell and Other Adult Stem Cells in Treating Heart Diseases Introduction Adult Stem Cell Therapy Improves Cardiac Function and Blood Flow Mesenchymal Stem Cells in Treating Heart Disease vi

7 Transformation of Mesenchymal Stem Cells into Cardiovascular Tissue Cells Human Cord Blood Mesenchymal Stem Cells Bone Marrow-Derived Stem Cells (BMSC) Administered through Intra-myocardial Injection Clinical Studies with Selected Bone Marrow Stem Cells Other Research Studies Gene Based Stem Cell Therapy Catheter - Device for Cardiac Stem Cell Delivery Uses Catheter Implantation Techniques of Stem Cell Delivery Transvascular Method Transendocardial Approach Transepicardial Approach Stem Cell Mobilization to the Injured Myocardium Stem Cell Imaging Cell Tracking by Use of Noninvasive Imaging Direct Labeling of Cells by Making Use of Magnetic Resonance Agents The Drawbacks of Magnetic Labeling Direct Labeling of Cells Using Radionuclides Nanoparticle Labeling Reporter Genes for Cardiovascular Cell Imaging The Future Prospects of Stem Cell Imaging Imaging to Assess the Functional Effects of Cell therapy Myocardial Perfusion Cell Therapy Issues Inconsistencies Cardiac Stem Cell Therapy with Emphasis on Certain Issues Yet to be Resolved Clinical Issues Involved in Cardiac Cell-Repair Therapy Disadvantages of Stem Cell Therapy in Cardiovascular Diseases Stem Cell Research and Regulatory Issues - A Summary Cardiac Muscle Regeneration Concerns Regarding Cell Therapy vii

8 The Principles of Stem Cell Research, Legal and Other Social Issues The Science of Stem Cells Embryonic Stem Cell Research in the UK Regulations Regarding Research on Embryo and Embryonic Stem Cells in the UK European Regulations International Regulation of Stem Cell Research Related Issues in Stem Cell Research Embryonic Stem Cell Research and Related Issues Regulation of Product Development The EU Tissue Directive Tissue Traceability and Donor Confidentiality Achieving Patient Trust in Stem Cell Therapy Intellectual Property Rights Intellectual Property Rights in the United Kingdom Intellectual Property Rights in Europe Opportunity Costs, Resource Allocation and Equity Longevity, Immortality and Individual Identity 4.2 Stem Cell Research in Cardiology Research Briefs 5. CORPORATE DIRECTORY 6. PATENTS INFORMATION viii

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