Scientific Programme

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1 1 Monday, March 18, 2013 Scientific Programme From Registration Opening remarks: Symposium s Organisers and Prof. Kai-Olaf Hinrichsen, Dean of Department of Chemistry, Technische Universität München Short lecture Opening lecture Prof. Luis Moroder, Max Planck Institute for Biochemistry Peptide chemistry in Germany: from the past to the present L1 Prof. William DeGrado, University of California San Francisco Coffee break Plenary lecture Design of therapeutics that act on membranes and membrane proteins L2 Prof. Thomas Carell, Ludwig-Maximilians-Universität München DNA bases beyond Watson and Crick Short lectures (SL) on posters (16 posters / 3 min each) (SL1-SL16) Poster viewing session I and Get Together (all posters without individual presentations) Tuesday, March 19, 2013 Session 1a: Peptides and peptidomimetics in medicine (Chair: Prof. Luis Moroder, Max Planck Institute for Biochemistry) L3 Prof. Annette Beck-Sickinger, University of Leipzig Immobilisation and controlled release of peptide and protein therapeutics L4 Dr. Tamis Dabre, University of Bern Cell penetrating peptide dendrimers

2 L5 Sebastian Hörner, Technische Universität Darmstadt Cube-octameric silsesquioxanes: nanoscaffolds for tumor imaging and drug delivery L6 Prof. Roland Brock, Radboud University Nijmegen Medical Centre Coffee break Chiral peptide variants shed light on the role of heparan sulfates in cellpenetrating peptide uptake Session 1b: Peptides and peptidomimetics in medicine (Chair: Dr. Hubert Kalbacher, University of Tübingen) L7 Prof. John Robinson, University of Zurich Protein epitope mimetics in drug and vaccine research L8 Prof. Jörg Rademann, Universität Leipzig Reactive peptides as tools for the identification of protein-specific small molecule fragments L9 Dr. Maja Köhn, EMBL Heidelberg A chemical toolbox to study the phosphatase PTP1B L10 Prof. Ines Neundorf, Universität zu Köln Synthesis and biological application of organometal complex-peptide conjugates L11 Prof. Hans Brückner, University of Giessen Lunch Exploring a thousand sequences of bioactive fungal peptaibols/peptaibiotics Session 2a: Peptide/protein structure, folding, and interactions (Chair: Prof. Johannes Buchner, Technische Universität München) L12 Prof. Johannes Buchner, Technische Universität München The peptide binding properties of the molecular chaperone BiP regulate antibody assembly L13 Dr. Felix Hausch, Max Planck Institute of Psychiatry München Biomimetic screening of class B G-protein coupled receptors L14 Markus Ritzefeld, Bielefeld University Single molecule monitoring of peptide/protein-dna interaction dynamics by simultaneous atomic force spectroscopy and FRET analysis

3 L15 Prof. Iris Antes, Technische Universität München Coffee break Computational prediction of protein-peptide binding Session 2b: Peptide/protein structure, folding, and interactions (Chair: Dr. Norma J. Greenfield) L16 Prof. Thomas Kiefhaber, Technische Universität München Conformational fluctuations in peptides and proteins detected by triplet-triplet energy transfer L17 Andreas Deeg, Ludwig-Maximilians-Universität München β-hairpin formation on the ns to µs timescale with different techniques: towards an understanding of structural dynamics in a light-triggered peptide L18 Prof. Dieter Langosch, Technische Universität München The backbone dynamics of the amyloid precursor protein transmembrane helix provides a rationale for the sequential cleavage mechanism of γ- secretase L19 Dr. Erik Strandberg, Karlsruhe Institute of Technology (KIT) Dynamics of membrane-bound peptides studied with solid state NMR: implications on the evaluation of helix tilt angles under hydrophobic mismatch Poster viewing session II (with beer and pretzels): presentation of posters with odd numbers and posters to SL1-SL Invited speakers and chairs highlights München short city tour and dinner Wednesday, March 20, 2013 Session 2c: Peptide/protein structure, folding, and interactions (Chair: Prof. Ulf Diederichsen, Georg-August University Göttingen) L20 Prof. Herbert Waldmann, Max-Planck-Institut für molekulare Physiologie Dynamic regulation of Ras localization and signaling L21 Dr. Irene Coin, The Salk Institute for Biological Studies Map of the peptide binding pocket of a class B G-protein coupled receptor L22 Andrea Groß, Friedrich-Alexander-Universität Erlangen-Nürnberg Exploring binding specificities of HIV-1 gp120 and CXCR4 through peptidepeptide interactions

4 L23 Malte Gersch, Technische Universität München Coffee break Cleavage site preferences and ligand-induced oligomerization defects in the ClpP family of proteases Session 3: Peptide self-assembly in disease and material science (Chair: Prof. Dieter Langosch, Technische Universität München) L24 Prof. Ehud Gazit, Tel Aviv University Molecular self-assembly of short aromatic peptides: from biology to nanotechnology and material science L25 Prof. Bernd Reif, Technische Universität München Amyloid aggregates and interference with small molecules L26 Dr. Yifat Miller, Ben-Gurion University Self-assembly of peptides: insight into the mechanisms and the link between amyloids diseases L27 Dr. Franziska Thomas, University of Bristol Lunch CC-Hex: a powerful tool for protein engineering Short lectures (SL) on posters (16 posters / 3 min each) (SL17-SL32) Poster session III (with coffee and sweets): presentation of posters with even numbers and posters to SL17-SL32 Session 4a: Peptide and protein synthesis (Chair: Prof. Hans Brückner, University of Giessen) L28 Prof. Henning Mootz, University of Münster Split inteins: mechanism and applications in protein semisynthesis L29 Peter Fransen, IRB Barcelona Pentrimers as multifunctional and multimodal platforms for diverse biomedical applications L30 Angelina Gross, Universität Bayreuth Convergent solid phase synthesis of peptide hydrazides of glycosylated human erythropoietin L31 Dr. Srinivas Banala, Technische Universität Berlin Studies towards the total synthesis of plantazolicin

5 L32 Friederike Inga Nollmann, Goethe Universität Frankfurt Killing two birds with one stone: a new total synthesis of xenematide A through D Conference dinner (Königlicher Hirschgarten, München) Thursday, March 21, 2013 Session 4b: Peptide and protein synthesis (Chair: Prof. Norbert Seewald, Bielefeld University) L33 Florian Karch, Ludwig-Maximilians-Universität München Synthesis of tumor associated MUC1 carbohydrate antigen conjugates with fluorinated amino acids or amino acid mimics L34 Dr. Gerbrand J. Van der Heden van Noort, Leiden Institute of Chemistry Synthetic methodology towards natural occurring post-translational modified peptides L35 Prof. Christian Ducho, University of Paderborn Synthesis of muraymycin nucleoside-peptide antibiotics and their analogues L36 Dr. Wolfgang Rapp, Rapp Polymere GmbH Coffee break Preventing failure in difficult sequences: an improved resin matrix, it s properties and application Session 1c: Peptides and peptidomimetics in medicine (Chair: Prof. Jutta Eichler, University Erlangen-Nürnberg) L37 Prof. Norbert Seewald, Bielefeld University Cytotoxic peptide-drug conjugates based on cryptophycins L38 Dr. Stefanie Neubauer, Technische Universität München Functionalization of αvβ3- or α5β1-selective integrin ligands for medicinal and biophysical investigations L39 Dr. Norbert Schaschke, University of Bielefeld Upgrading a natural product: inhibition of human β-tryptase by cyclotheonamide analogues

6 L40 Prof. Dieter Willbold, Research Centre Jülich and Heinrich-Heine-Universität Düsseldorf The Aβ-oligomer targeting D-enantiomeric peptide D3 is efficiently improving pathology and cognition of orally treated transgenic AD mice L41 Prof. Florian Seebeck, Universität Basel Artificial lantipeptides L42 Dr. Daniel Knappe, University of Leipzig Oncocin derived proline-rich antimicrobial peptide derivatives show superior activities in mice infected with Escherichia coli or Klebsiella pneumoniae and high margins of safety Closing remarks

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