12 th GERMAN PEPTIDE SYMPOSIUM. Darmstadt March 2015 PROGRAM

Transcription

1 12 th GERMAN PEPTIDE SYMPOSIUM Darmstadt March 2015 PROGRAM

2 WELCOME to the 12th German Peptide Symposium that will take place at the Technische Universität Darmstadt. The meeting covers all fields of peptide science ranging from peptide and protein synthesis, peptide structure to the application of peptides and peptidomimetics in medicine and material sciences. We would like to invite you to interact with colleagues and world-leading researches on our campus at Technische Universität Darmstadt Lichtwiese for fruitful discussions and exchange. At our symposium, both prominent and young researchers will have a chance to get together, to facilitate networking, discussions, and friendship. We are greatfull to our sponsors and exhibitors for their support which made this event possible. Thank you for joining us in Darmstadt. Organising Committee 2

3 Wednesday, March 18, 2015 PROGRAM From Registration Opening remarks (Symposium s Organisers) Session 1a: From Peptide Synthesis to Biomedical Applications (Chair: K. Schmitz, Darmstadt) Opening Lecture F. Albericio, Barcelona L1 Cyclic Peptides from the Nature to the Laboratory 15:50-16:10 S. Dobitz, Zürich L2 Oligoprolines as Scaffolds for Tumor Targeting with Hybrid Bombesin Analogues 16:10-16:30 O. Seitz, Berlin L3 Total Chemical Synthesis and Functional Characterization of Phosphorylated SH3 Protein Domains Coffee break 17: R. Araghi, Cambridge, USA L4 Rapid Library Screen for Extensive Optimization of Stapled Peptides R. Brock, Nijmegen L5 A Lactoferrin-derived Cell-penetrating Peptide for Kidney-specific Drug Targeting :00 Short lectures (SL) on posters SL1-SL18 (3 min each) 19: Poster viewing session I and Get Together with Lite Bites Presentation of posters with even numbers and posters to SL1-SL18 3

4 PROGRAM Thursday, March 19, 2015 Session 2a: Peptide Tools for Cell Biology (Chair: C. Cardoso, Darmstadt) R. Tampé, Frankfurt L6 Optochemical Biology In-situ Assembly of Macromolecular Complexes by Light B. Koksch, Berlin L7 Self-assembling Peptides for the Multivalent Presentation of Carbohydrates R. Wombacher, Heidelberg L8 Enzyme Mediated Peptide Labeling using Lipoic Acid Ligase (LplA) and Bioorthogonal Chemistry D. Imhof, Bonn L9 Heme-regulatory Motifs in Proteins Display Characteristic Binding Modes upon Heme Association Coffee break Session 2b: Peptides in Biomaterial Sciences (Chair: H. Kolmar, Darmstadt) D. Leigh, Manchester L10 Making the Tiniest Machines D. Löwik, Nijmegen L11 Peptide Based Materials for Cell Growth and Sensing M. Biesalski, Darmstadt L12 Functional, Microfluidic Papers for Bioanalytical Applications F. Hanßke, Berlin L13 Stabilization of Nanoparticles and Interfaces in Composite Materials via Peptide-polymer Conjugates K. Landfester, Mainz L14 Incorporation of Enzyme-specific Peptide Building Blocks in Nanocapsules for Biomedical Applications Lunch 4

5 PROGRAM Session 3a: Biosurfaces and Bioconjugation (Chair: J. Rademann, Berlin) MJ Vicent, Valencia L15 Polyglutamates as Versatile Drug Delivery Carriers :10 C. Barner-Kowollik, Karlsruhe L16 A Light Driven Toolbox for Encoding Biosurfaces and Polymers with Peptides and Synthetic Macromolecules B. Albada, Jerusalem L17 The SAM-Linker: Silyl-Acetylene Immobilization as a Strategy for the Synthesis of C-terminal Conjugated Peptides :50 C. Hackenberger, Berlin L18 Functional Peptide-Conjugates by Chemoselective Staudinger Reactions Coffee break Session 3b: Bioconjugation (Chair: C. Hackenberger, Berlin) :50 J. Bode, Zurich L19 Chemical Protein Synthesis with the KAHA Ligation 16:50-17:10 J. Rademann, Berlin L20 Protein-templated Formation of Peptide Bonds Employed for the Discovery of Enzyme Inhibitors: Bio-orthogonal Acylation Reactions A. Beck-Sickinger, Leipzig L21 Selective Labeling of Peptides and Proteins to Modulate Function B. Zakeri, Cambridge, USA L22 An Iron Grip: Molecular Superglues for Protein Nanotechnology S. Palei, Münster L23 Preparation of Semisynthetic Macrocycles Using Split Inteins :00 Poster viewing session II with Lite Bites and Beer Tasting Presentation of posters without short talk 5 presentation

6 PROGRAM Friday March 20, 2015 Session 4a: Peptides in Medicine (Chair: A. Tietze, Darmstadt) U. Sahin, Mainz L24 Targeting the Tumor Microenvironment with an Engineered Knottin Peptide C. Gruber, Wien L25 Circular Peptides as Immunosuppressive Therapeutics I. Neundorf, Cologne L26 Directing Cell Type Specificity to Cell-penetrating Peptides C. Birr, Heidelberg (Orpegen) L27 Peptides, the Natural Drugs: BEPECIN, a Fully Synthetic Peptide Drug Product from Gastric Juice Coffee break Session 4b: Peptides in Medicine (Chair: U. Diederichsen, Göttingen) P.E. Nielsen, Kopenhagen L28 Peptides for Cellular and in vivo Delivery of PNA Antisense Agents J. Eichler, Erlangen L29 HIV-1 Infection Enhancement by gp120-derived Peptides U. Haberkorn, Heidelberg L30 Display Methods for the Identification of Tumor Affine Peptides T. Weil, Ulm L31 Defined Polypeptide Hybrid Architectures for Biomedical Applications M. Dathe, Berlin L32 Membrane-recognizing and -translocating Arginine-rich Lipopeptides: Tools for the Development of Efficient Target Specific Carrier Systems Lunch

7 PROGRAM Short lectures on posters SL19-SL33 (3 min each) Poster session III (with coffee and sweets) Presentation of posters with odd numbers and posters to SL19-SL33 Session 5: Peptide Synthesis and Analysis (Chair: L. Moroder, Martinsried) :50 J. Collins, Matthews, NC (CEM) L33 An Improved Coupling Method for Peptide Synthesis at Elevated Temperatures 16:50-17:10 S. Knauer, Darmstadt L34 Merrifield Reloaded: Peptide Chemistry Goes Green S. Eissler, Bubendorf (BACHEM) L35 Substitution Determination of Fmoc-protected Resins G. Buntkowsky, Darmstadt L36 Para-Hydrogen Enhanced Polarization boosts the NMR-Intensities of Biomarkers E. Strandberg, Karlsruhe L37 Peptide Orientation in Membranes is Governed by Hydrophobic Matching and Lipid Spontaneous Curvature M. Przybylski, Konstanz L38 Fragmentation and Aggregation of Physiological and Parkinson-Synnucleins Revealed by Ion Mobility and Affinity Mass Spectrometry Conference dinner (Otto-Berndt-Halle, Darmstadt) 7

8 PROGRAM Saturday March 21, 2015 Session 6a: Peptides for Biomedical Research (Chair: O. Avrutina, Darmstadt) J. Cochran, Stanford L39 Engineered Cystine Knot Peptides: A New Class of Tumor Targeting Agents P. Timmerman, Lelystad L41 2-CLIPS Peptides: Discovery and Optimization of a Novel Class of Biopharmaceuticals C. Heinis, Lausanne L40 Phage Selection of Bicyclic Peptides for Application as Therapeutics C. Unverzagt, Bayreuth L 42 Convergent Approaches to Bioactive N-Glycoproteins Coffee break Session 6a: Peptides for Biomedical Research (Chair: C. Unverzagt, Bayreuth) H.-J. Fritz, Göttingen L43 Chip-Serology: Peptide Microarrays in Discovery and Mapping of Antibody Target Regions on Viral Antigens F. Breitling, Karlsruhe L44 Combinatorial Synthesis of High Density Peptide Arrays by Laser Induced forward Transfer of Solid Materials U. Diederichsen, Göttingen L45 Peptides Mediating Membrane Fusion H. Herce, Darmstadt L46 Drug Design and Transport Using Cell-Penetrating Peptides M. Manea, Konstanz L47 Tumor Targeting with Gonadotropin-releasing Hormone-III Peptide :10 T. Darbre, Bern L48 Combining Topology and Sequence Design for the Discovery of Potent Antimicrobial Peptide Dendrimers against Multidrug-Resistant Pseudomonas aeruginosa 13:10-13:15 Concluding Remarks/ End of meeting 8

9 INFORMATION POSTER AWARD Prizes will be awarded to the three best posters. LUNCH/ COFFEE BREAKS During the symposium coffee, snacks, and soft drinks will be provided. CONFERENCE DINNER Will take place at Otto-Berndt-Halle (TU Stadtmitte, S1/11), Alexanderstr. 4, Darmstadt 9

10 ORGANIZING COMMITTEE Prof. Dr. Harald Kolmar Department of Organic Chemistry and Biochemistry Prof. Dr. Katja Schmitz Department of Organic Chemistry and Biochemistry Dr. Olga Avrutina Department of Organic Chemistry and Biochemistry Dr. Alesia Tietze Department of Organic Chemistry and Biochemistry SPONSORS AND EXHIBITORS 10

11 CAMPUS MAP Technische Universität Darmstadt Hörsaal- und Medienzentrum Lichtwiese Building L4/02 Franziska-Braun-Strasse Darmstadt 11

12 CONTACT Barbara Diestelmann Technische Universität Darmstadt Clemens-Schöpf-Institut für Organische Chemie und Biochemie Alarich-Weiss-Str. 4 GERMANY [email protected] Phone: Fax: