NUVISAN Pharma Services

Size: px
Start display at page:

Download "NUVISAN Pharma Services"

Transcription

1 NUVISAN Pharma Services CESI MS Now available! 1st CRO in Europe! At the highest levels of quality. LABORATORY SERVICES Equipment update

2 STATE OF THE ART AT NUVISAN CESI MS Now available! 1st CRO in Europe! In order to keep up with the latest developments in the field of cgmp regulated biopharmaceutical analytics, NUVISAN has added several Mass Spectrometry (MS) techniques to its repertoire. We will be the first CRO in Europe to provide the coupled method of CESI-MS (Capillary Electrophoresis + Electrospray Ionization + Mass Spectrometry) which will enable us to identify and analyze proteines in a way that all existing approaches could not provide for State-of-the-art and complementary platforms for GMP-testing of Chemical Entities and Biopharmaceuticals A team of experts dedicated to your projects High flexibility High throughput capabilities Staff turn over less than 2% Center of excellence for GMP testing of Biopharmaceuticals Biopharmaceuticals. Director Pharmaceutical Analytics Phone: Fax: Senior Manager Business Development Mobile: Fax:

3 GMP C T O M P L I A N Capillary Electrophoresis (CE) is an ideal separation technique for highly charged and polar molecules, which can be challenging for liquid (LC) or gas chromatography (GC). In addition, CE offers advantages of minimal sample volumes (nl pl), high separation efficiency, and fast injection-to-injection times. As an automated system it provides reproducible and quantitative results, time after time. Quality control of therapeutical proteins Molecular weight estimation pi determination and charge heterogeneity Carbohydrate analysis of glycoproteins Formula weight and counter ion replacement analysis Single enantiomer drug purity assays Advanced capillary isoelectric focusing (cief) PA 800 plus Pharmaceutical Analysis System Ultra performance liquid chromatography (UPLC) in combination with high resolution mass spectrometry is a traditionally founded and well established analysis methodology for the qualification, quantification and identification of diverse compounds. Quantitative peptide mapping Analysis of intact and reduced therapeutic monoclonal antibodies (mab) Simultaneous quantitative and qualitative analysis of proteolytic digests of therapeutic monoclonal antibodies Quaternary UPLCs in combination with the AB SCIEX Q-TOF 5600 mass spectrometer allows high speed, maximum sensitivity and high resolution power to deliver comprehensive qualitative exploration, rapid profiling and quantitation in a single run. SWATH Acquisition provides comprehensive quantitative MS/MS data on every component in one sample. 5

4 CESI MASS SPECTROMETRY CESI MS Now available! 1st CRO in Europe! 3 6 Capillary electrophoresis with an integrated electrospray ionization source (CESI) combines high efficiency and ultra-low flow (5 30 nl/min) with reduced ion suppression. Coupled with high resolution mass spectrometery (HRMS) results in greatly improved sensitivity. Intact antibody characterization Peptide mapping CESI 8000 High performance separation-esi module in combination with the AB SCIEX Q-TOF 5600 Systems

5 56 Enzyme immunoassay (EIA)/enzyme-linked immunosorbent assay (ELISA) is a fully automated antibody based detection assay with an enzyme as the reporter label for routine validation of multitudes of compounds. Quantitation of residual protein A Quantitation of residual CHO host cell proteins Tecan Freedom EVO 200 and Infinite 200 PRO NanoQuant

6 Our resources become yours. Fully integrated Contract Research Organisation with over 30 years of serving the pharmaceutical industry. ADDRESS Im Wirrigen Waltrop, Germany Phone: Fax: CONTACT Director Pharmaceutical Analytics Phone: Fax:

Agilent 6000 Series LC/MS Solutions CONFIDENCE IN QUANTITATIVE AND QUALITATIVE ANALYSIS

Agilent 6000 Series LC/MS Solutions CONFIDENCE IN QUANTITATIVE AND QUALITATIVE ANALYSIS Agilent 6000 Series LC/MS Solutions CONFIDENCE IN QUANTITATIVE AND QUALITATIVE ANALYSIS AGILENT 6000 SERIES LC/MS SOLUTIONS UNRIVALED ACHIEVEMENT AT EVERY LEVEL The Agilent 6000 Series of LC/MS instruments

More information

Overview. Introduction. AB SCIEX MPX -2 High Throughput TripleTOF 4600 LC/MS/MS System

Overview. Introduction. AB SCIEX MPX -2 High Throughput TripleTOF 4600 LC/MS/MS System Investigating the use of the AB SCIEX TripleTOF 4600 LC/MS/MS System for High Throughput Screening of Synthetic Cannabinoids/Metabolites in Human Urine AB SCIEX MPX -2 High Throughput TripleTOF 4600 LC/MS/MS

More information

A Generic Kit-Based Approach for Quantifying Monoclonal Antibody Drugs Through Direct Digestion of Discovery Study Samples

A Generic Kit-Based Approach for Quantifying Monoclonal Antibody Drugs Through Direct Digestion of Discovery Study Samples A Generic Kit-Based Approach for Quantifying Monoclonal Antibody Drugs Through Direct Digestion of Discovery Study Samples Mary Lame, Hua Yang, Sherri Naughton, and Erin Chambers Waters Corporation, Milford,

More information

Biotechpharma company profile

Biotechpharma company profile Biotechpharma company profile October 2013 1 History 2004 Biotechpharma UAB established as a proteomic research company in Vilnius, Lithuania 2005 Company became a member of UK s Northway group, investing

More information

Analysis of the Vitamin B Complex in Infant Formula Samples by LC-MS/MS

Analysis of the Vitamin B Complex in Infant Formula Samples by LC-MS/MS Analysis of the Vitamin B Complex in Infant Formula Samples by LC-MS/MS Stephen Lock 1 and Matthew Noestheden 2 1 AB SCIEX Warrington, Cheshire (UK), 2 AB SCIEX Concord, Ontario (Canada) Overview A rapid,

More information

API 3200 LC/MS/MS SYSTEM. Performance, productivity and value combined

API 3200 LC/MS/MS SYSTEM. Performance, productivity and value combined API 3200 LC/MS/MS SYSTEM Performance, productivity and value combined API 3200 LC/MS/MS SYSTEM Reliability, reproducibility, and confidence in your data. With an unmatched heritage of technological innovation

More information

The Scheduled MRM Algorithm Enables Intelligent Use of Retention Time During Multiple Reaction Monitoring

The Scheduled MRM Algorithm Enables Intelligent Use of Retention Time During Multiple Reaction Monitoring The Scheduled MRM Algorithm Enables Intelligent Use of Retention Time During Multiple Reaction Monitoring Delivering up to 2500 MRM Transitions per LC Run Christie Hunter 1, Brigitte Simons 2 1 AB SCIEX,

More information

LC-MS/MS for Chromatographers

LC-MS/MS for Chromatographers LC-MS/MS for Chromatographers An introduction to the use of LC-MS/MS, with an emphasis on the analysis of drugs in biological matrices LC-MS/MS for Chromatographers An introduction to the use of LC-MS/MS,

More information

MultiQuant Software Version 3.0 for Accurate Quantification of Clinical Research and Forensic Samples

MultiQuant Software Version 3.0 for Accurate Quantification of Clinical Research and Forensic Samples MultiQuant Software Version 3.0 for Accurate Quantification of Clinical Research and Forensic Samples Fast and Efficient Data Review, with Automatic Flagging of Outlier Results Adrian M. Taylor and Michael

More information

Retrospective Analysis of a Host Cell Protein Perfect Storm: Identifying Immunogenic Proteins and Fixing the Problem

Retrospective Analysis of a Host Cell Protein Perfect Storm: Identifying Immunogenic Proteins and Fixing the Problem Retrospective Analysis of a Host Cell Protein Perfect Storm: Identifying Immunogenic Proteins and Fixing the Problem Kevin Van Cott, Associate Professor Dept. of Chemical and Biomolecular Engineering Nebraska

More information

Biopharmaceutical Glycosylation Analysis

Biopharmaceutical Glycosylation Analysis Biopharmaceutical Glycosylation Analysis Glycosylation Analysis: Product Offering Molecular model of erythropoietin with complex N-linked glycans. Courtesy of M.R Wormald and R.A Dwek, Oxford Glycobioloy

More information

Introduction to Proteomics 1.0

Introduction to Proteomics 1.0 Introduction to Proteomics 1.0 CMSP Workshop Tim Griffin Associate Professor, BMBB Faculty Director, CMSP Objectives Why are we here? For participants: Learn basics of MS-based proteomics Learn what s

More information

WATERS QUANTITATIVE ANALYSIS solutions

WATERS QUANTITATIVE ANALYSIS solutions More sensitivity. More speed. What more can you ask for in a complete quantitative analysis solution? WATERS QUANTITATIVE ANALYSIS solutions THE CHALLENGE OF QUANTITATIVE ANALYSIS Tandem mass spectrometry,

More information

ASMS Regulated Bioanalysis Interest Group (RBIG) Workshop. Antibody-Drug Conjugates (ADC) A Complex Problem in Regulated Bioanalysis.

ASMS Regulated Bioanalysis Interest Group (RBIG) Workshop. Antibody-Drug Conjugates (ADC) A Complex Problem in Regulated Bioanalysis. ASMS Regulated Bioanalysis Interest Group (RBIG) Workshop Antibody-Drug Conjugates (ADC) A Complex Problem in Regulated Bioanalysis June 17, 2014 Presiding: Dr. Keyang Xu (Genentech) and Dr. Fabio Garofolo

More information

MRMPilot Software: Accelerating MRM Assay Development for Targeted Quantitative Proteomics

MRMPilot Software: Accelerating MRM Assay Development for Targeted Quantitative Proteomics MRMPilot Software: Accelerating MRM Assay Development for Targeted Quantitative Proteomics With Unique QTRAP and TripleTOF 5600 System Technology Targeted peptide quantification is a rapidly growing application

More information

Increasing the Multiplexing of High Resolution Targeted Peptide Quantification Assays

Increasing the Multiplexing of High Resolution Targeted Peptide Quantification Assays Increasing the Multiplexing of High Resolution Targeted Peptide Quantification Assays Scheduled MRM HR Workflow on the TripleTOF Systems Jenny Albanese, Christie Hunter AB SCIEX, USA Targeted quantitative

More information

AB SCIEX TOF/TOF 4800 PLUS SYSTEM. Cost effective flexibility for your core needs

AB SCIEX TOF/TOF 4800 PLUS SYSTEM. Cost effective flexibility for your core needs AB SCIEX TOF/TOF 4800 PLUS SYSTEM Cost effective flexibility for your core needs AB SCIEX TOF/TOF 4800 PLUS SYSTEM It s just what you expect from the industry leader. The AB SCIEX 4800 Plus MALDI TOF/TOF

More information

Thermo Scientific PepFinder Software A New Paradigm for Peptide Mapping

Thermo Scientific PepFinder Software A New Paradigm for Peptide Mapping Thermo Scientific PepFinder Software A New Paradigm for Peptide Mapping For Conclusive Characterization of Biologics Deep Protein Characterization Is Crucial Pharmaceuticals have historically been small

More information

Bioservices. Your lab just got bigger

Bioservices. Your lab just got bigger Bioservices Your lab just got bigger Bioservices Expansive bioservices with a global advantage Lonza Bioservices emphasizes accuracy, precision and specificity to provide shortened delivery times and increased

More information

Technology Transfer of CMC Activities for MAb Manufacturing. 2010 ge healthcare (www.gelifesciences.com)

Technology Transfer of CMC Activities for MAb Manufacturing. 2010 ge healthcare (www.gelifesciences.com) M a n u f a c t u r i n g OPERATIONS Technology Transfer of CMC Activities for MAb Manufacturing by Patricia Seymour, Susan Dana Jones, Howard L. Levine With combined 2009 revenues estimated to be over

More information

MultiQuant Software 2.0 for Targeted Protein / Peptide Quantification

MultiQuant Software 2.0 for Targeted Protein / Peptide Quantification MultiQuant Software 2.0 for Targeted Protein / Peptide Quantification Gold Standard for Quantitative Data Processing Because of the sensitivity, selectivity, speed and throughput at which MRM assays can

More information

Cell Discovery 360: Explore more possibilities.

Cell Discovery 360: Explore more possibilities. Cell Discovery 360: Explore more possibilities. Flexible solutions for the BioPharma laboratory Blood Banking Capillary Electrophoresis Centrifugation Flow Cytometry Genomics Lab Automation Lab Tools Particle

More information

Factors Influencing LC/MS/MS Moving into Clinical and Research Laboratories

Factors Influencing LC/MS/MS Moving into Clinical and Research Laboratories Factors Influencing LC/MS/MS Moving into Clinical and Research Laboratories Matthew Clabaugh, Market Development AACC Workshop St. Louis, MO September 17,18 2013 Factors Influencing LCMSMS Moving into

More information

Using Natural Products Application Solution with UNIFI for the Identification of Chemical Ingredients of Green Tea Extract

Using Natural Products Application Solution with UNIFI for the Identification of Chemical Ingredients of Green Tea Extract Using Natural Products Application Solution with UNIFI for the Identification of Chemical Ingredients of Green Tea Extract Lirui Qiao, 1 Rob Lewis, 2 Alex Hooper, 2 James Morphet, 2 Xiaojie Tan, 1 Kate

More information

LC-MS/MS, the new reference method for mycotoxin analysis

LC-MS/MS, the new reference method for mycotoxin analysis LC-MS/MS, the new reference method for mycotoxin analysis What is necessary for the implementation of the multi-residue mycotoxin method in an analytical laboratory? Azel Swemmer azel@fdalab.co.za AFMA

More information

The Facts on Equine Drug Testing

The Facts on Equine Drug Testing The Facts on Equine Drug Testing CONTACT Travis Mays, MS Interim Section Head Analytical Chemistry, Drug Testing Laboratory Toxicology Laboratory 979.845.3414 tmays@ LIMITATIONS IN DRUG TESTING While advancements

More information

Thermo Scientific Prelude SPLC System FPO. Making LC/MS accessible. to clinical research and toxicology labs

Thermo Scientific Prelude SPLC System FPO. Making LC/MS accessible. to clinical research and toxicology labs Thermo Scientific Prelude SPLC System FPO Making LC/MS accessible to clinical research and toxicology labs Specifically designed to make the power of LC/MS accessible Analysis of target compounds in complex

More information

Analysis of Polyphenols in Fruit Juices Using ACQUITY UPLC H-Class with UV and MS Detection

Analysis of Polyphenols in Fruit Juices Using ACQUITY UPLC H-Class with UV and MS Detection Analysis of Polyphenols in Fruit Juices Using ACQUITY UPLC H-Class with UV and MS Detection Evelyn Goh, Antonietta Gledhill Waters Pacific, Singapore, Waters Corporation, Manchester, UK A P P L I C AT

More information

Cliquid ChemoView 3.0 Software Simple automated analysis, from sample to report

Cliquid ChemoView 3.0 Software Simple automated analysis, from sample to report PRODUCT BULLETIN Cliquid ChemoView 3.0 Software for Routine Screening and Quantitation Cliquid ChemoView 3.0 Software Simple automated analysis, from sample to report KEY FEATURES Secure user login that

More information

Unique Software Tools to Enable Quick Screening and Identification of Residues and Contaminants in Food Samples using Accurate Mass LC-MS/MS

Unique Software Tools to Enable Quick Screening and Identification of Residues and Contaminants in Food Samples using Accurate Mass LC-MS/MS Unique Software Tools to Enable Quick Screening and Identification of Residues and Contaminants in Food Samples using Accurate Mass LC-MS/MS Using PeakView Software with the XIC Manager to Get the Answers

More information

Drive Process Productivity

Drive Process Productivity Solutions for the Biopharmaceutical Industry Drive Process Productivity Innovative solutions from a proven technology leader Your partner in productivity Whether you are developing a process for a novel

More information

In-Depth Qualitative Analysis of Complex Proteomic Samples Using High Quality MS/MS at Fast Acquisition Rates

In-Depth Qualitative Analysis of Complex Proteomic Samples Using High Quality MS/MS at Fast Acquisition Rates In-Depth Qualitative Analysis of Complex Proteomic Samples Using High Quality MS/MS at Fast Acquisition Rates Using the Explore Workflow on the AB SCIEX TripleTOF 5600 System A major challenge in proteomics

More information

Waters Core Chromatography Training (2 Days)

Waters Core Chromatography Training (2 Days) 2015 Page 2 Waters Core Chromatography Training (2 Days) The learning objective of this two day course is to teach the user core chromatography, system and software fundamentals in an outcomes based approach.

More information

泛 用 蛋 白 質 體 學 之 質 譜 儀 資 料 分 析 平 台 的 建 立 與 應 用 Universal Mass Spectrometry Data Analysis Platform for Quantitative and Qualitative Proteomics

泛 用 蛋 白 質 體 學 之 質 譜 儀 資 料 分 析 平 台 的 建 立 與 應 用 Universal Mass Spectrometry Data Analysis Platform for Quantitative and Qualitative Proteomics 泛 用 蛋 白 質 體 學 之 質 譜 儀 資 料 分 析 平 台 的 建 立 與 應 用 Universal Mass Spectrometry Data Analysis Platform for Quantitative and Qualitative Proteomics 2014 Training Course Wei-Hung Chang ( 張 瑋 宏 ) ABRC, Academia

More information

DRUG METABOLISM. Drug discovery & development solutions FOR DRUG METABOLISM

DRUG METABOLISM. Drug discovery & development solutions FOR DRUG METABOLISM DRUG METABLISM Drug discovery & development solutions FR DRUG METABLISM Fast and efficient metabolite identification is critical in today s drug discovery pipeline. The goal is to achieve rapid structural

More information

EKSIGENT EKSPERT NANOLC 400. Unmatched flexibility for low flow LC/MS

EKSIGENT EKSPERT NANOLC 400. Unmatched flexibility for low flow LC/MS EKSIGENT EKSPERT NANOLC 4 Unmatched flexibility for low flow LC/MS EKSIGENT EKSPERT NANOLC 4 Focused ekspertise In 23, Eksigent changed the way scientists looked at nanoscale chromatography with the introduction

More information

Overview. Triple quadrupole (MS/MS) systems provide in comparison to single quadrupole (MS) systems: Introduction

Overview. Triple quadrupole (MS/MS) systems provide in comparison to single quadrupole (MS) systems: Introduction Advantages of Using Triple Quadrupole over Single Quadrupole Mass Spectrometry to Quantify and Identify the Presence of Pesticides in Water and Soil Samples André Schreiber AB SCIEX Concord, Ontario (Canada)

More information

Metabolomic Profiling of Accurate Mass LC-MS/MS Data to Identify Unexpected Environmental Pollutants

Metabolomic Profiling of Accurate Mass LC-MS/MS Data to Identify Unexpected Environmental Pollutants Metabolomic Profiling of Accurate Mass LC- Data to Identify Unexpected Environmental Pollutants André Schreiber 1, David Cox 1, Nadia Pace 1, Christopher Borton 2 1 AB SCIEX, Concord, ntario, Canada; 2

More information

Application Note # LCMS-62 Walk-Up Ion Trap Mass Spectrometer System in a Multi-User Environment Using Compass OpenAccess Software

Application Note # LCMS-62 Walk-Up Ion Trap Mass Spectrometer System in a Multi-User Environment Using Compass OpenAccess Software Application Note # LCMS-62 Walk-Up Ion Trap Mass Spectrometer System in a Multi-User Environment Using Compass OpenAccess Software Abstract Presented here is a case study of a walk-up liquid chromatography

More information

Quantification of Multiple Therapeutic mabs in Serum Using microlc-esi-q-tof Mass Spectrometry

Quantification of Multiple Therapeutic mabs in Serum Using microlc-esi-q-tof Mass Spectrometry Quantification of Multiple Therapeutic mabs in Serum Using microlc-esi-q-tof Mass Spectrometry Paula Ladwig, David Barnidge, Mindy Kohlhagen, John Mills, Maria Willrich, Melissa R. Snyder and David Murray

More information

A High Throughput Automated Sample Preparation and Analysis Workflow for Comprehensive Forensic Toxicology Screening using LC/MS/MS

A High Throughput Automated Sample Preparation and Analysis Workflow for Comprehensive Forensic Toxicology Screening using LC/MS/MS A High Throughput Automated Sample Preparation and Analysis Workflow for Comprehensive Forensic Toxicology Screening using LC/MS/MS AB SCIEX QTRAP 4500 LC/MS/MS System and Gerstel, Inc. MultiPurpose Sampler

More information

Session 1. Course Presentation: Mass spectrometry-based proteomics for molecular and cellular biologists

Session 1. Course Presentation: Mass spectrometry-based proteomics for molecular and cellular biologists Program Overview Session 1. Course Presentation: Mass spectrometry-based proteomics for molecular and cellular biologists Session 2. Principles of Mass Spectrometry Session 3. Mass spectrometry based proteomics

More information

PRODUCTION AND QUALITY CONTROL OF MEDICINAL PRODUCTS DERIVED BY RECOMBINANT DNA TECHNOLOGY

PRODUCTION AND QUALITY CONTROL OF MEDICINAL PRODUCTS DERIVED BY RECOMBINANT DNA TECHNOLOGY PRODUCTION AND QUALITY CONTROL OF MEDICINAL PRODUCTS DERIVED BY RECOMBINANT DNA TECHNOLOGY Guideline Title Production and Quality Control of Medicinal Products derived by recombinant DNA Technology Legislative

More information

Effects of Intelligent Data Acquisition and Fast Laser Speed on Analysis of Complex Protein Digests

Effects of Intelligent Data Acquisition and Fast Laser Speed on Analysis of Complex Protein Digests Effects of Intelligent Data Acquisition and Fast Laser Speed on Analysis of Complex Protein Digests AB SCIEX TOF/TOF 5800 System with DynamicExit Algorithm and ProteinPilot Software for Robust Protein

More information

Building innovative drug discovery alliances. Evotec Munich. Quantitative Proteomics to Support the Discovery & Development of Targeted Drugs

Building innovative drug discovery alliances. Evotec Munich. Quantitative Proteomics to Support the Discovery & Development of Targeted Drugs Building innovative drug discovery alliances Evotec Munich Quantitative Proteomics to Support the Discovery & Development of Targeted Drugs Evotec AG, Evotec Munich, June 2013 About Evotec Munich A leader

More information

Proteomics in Practice

Proteomics in Practice Reiner Westermeier, Torn Naven Hans-Rudolf Höpker Proteomics in Practice A Guide to Successful Experimental Design 2008 Wiley-VCH Verlag- Weinheim 978-3-527-31941-1 Preface Foreword XI XIII Abbreviations,

More information

A Hybrid Microchip/Capillary Electrophoresis Mass Spectrometry Platform for Rapid and Ultrasensitive Bioanalysis

A Hybrid Microchip/Capillary Electrophoresis Mass Spectrometry Platform for Rapid and Ultrasensitive Bioanalysis A Hybrid Microchip/Capillary Electrophoresis Mass Spectrometry Platform for Rapid and Ultrasensitive Bioanalysis Ryan Kelly 1, Chenchen Wang, Cheng S. Lee, Richard D. Smith, Keqi Tang 1 Environmental Molecular

More information

Aiping Lu. Key Laboratory of System Biology Chinese Academic Society APLV@sibs.ac.cn

Aiping Lu. Key Laboratory of System Biology Chinese Academic Society APLV@sibs.ac.cn Aiping Lu Key Laboratory of System Biology Chinese Academic Society APLV@sibs.ac.cn Proteome and Proteomics PROTEin complement expressed by genome Marc Wilkins Electrophoresis. 1995. 16(7):1090-4. proteomics

More information

Brochure More information from http://www.researchandmarkets.com/reports/2172993/

Brochure More information from http://www.researchandmarkets.com/reports/2172993/ Brochure More information from http://www.researchandmarkets.com/reports/2172993/ Proteomics Today. Protein Assessment and Biomarkers Using Mass Spectrometry, 2D Electrophoresis,and Microarray Technology.

More information

Analytical Testing Methods

Analytical Testing Methods Analytical Testing Methods Updated: February 2005 Background The Mandatory Guidelines for Federal Workplace Drug Testing Programs require a laboratory to conduct two analytical tests before a urine specimen

More information

aurora ICP-MS Innovation with Integrity The Science of Sensitivity ICP-MS

aurora ICP-MS Innovation with Integrity The Science of Sensitivity ICP-MS aurora ICP-MS The Science of Sensitivity Innovation with Integrity ICP-MS Powers the Business of Quantification aurora ICP-MS enhanced value package Bruker s ICP-MS is famous for its innovative and unique

More information

Accurate Mass Screening Workflows for the Analysis of Novel Psychoactive Substances

Accurate Mass Screening Workflows for the Analysis of Novel Psychoactive Substances Accurate Mass Screening Workflows for the Analysis of Novel Psychoactive Substances TripleTOF 5600 + LC/MS/MS System with MasterView Software Adrian M. Taylor AB Sciex Concord, Ontario (Canada) Overview

More information

Definition of the Measurand: CRP

Definition of the Measurand: CRP A Reference Measurement System for C-reactive Protein David M. Bunk, Ph.D. Chemical Science and Technology Laboratory National Institute of Standards and Technology Definition of the Measurand: Human C-reactive

More information

Contents. Contributors. 1 Quality control and regulation 1 C.J. MOORES

Contents. Contributors. 1 Quality control and regulation 1 C.J. MOORES Contents Contributors Preface xiii xiv 1 Quality control and regulation 1 C.J. MOORES 1.1 Introduction 1 1.2 The quality of medicines 2 1.2.1 The meaning of quality 2 1.2.2 Medicines are special 3 1.2.3

More information

Advances in LC-MS bioanalysis for drug research and development 液 相 质 谱 生 物 样 品 分 析 技 术 在 新 药 研 发 中 的 新 进 展

Advances in LC-MS bioanalysis for drug research and development 液 相 质 谱 生 物 样 品 分 析 技 术 在 新 药 研 发 中 的 新 进 展 Advances in LC-MS bioanalysis for drug research and development 液 相 质 谱 生 物 样 品 分 析 技 术 在 新 药 研 发 中 的 新 进 展 张 杰 DMPK, Novartis Institutes for BioMedical Research ( 诺 华 ), New Jersey 2014 南 京 国 际 药 代 会

More information

amazon SL Innovation with Integrity Setting New Standards in Performance, Simplicity and Value Ion Trap MS

amazon SL Innovation with Integrity Setting New Standards in Performance, Simplicity and Value Ion Trap MS amazon SL Setting New Standards in Performance, Simplicity and Value Innovation with Integrity Ion Trap Best-In-Class Ion Trap Mass Spectrometer for Routine Analysis The amazon SL entry-level system is

More information

ProteinScape. Innovation with Integrity. Proteomics Data Analysis & Management. Mass Spectrometry

ProteinScape. Innovation with Integrity. Proteomics Data Analysis & Management. Mass Spectrometry ProteinScape Proteomics Data Analysis & Management Innovation with Integrity Mass Spectrometry ProteinScape a Virtual Environment for Successful Proteomics To overcome the growing complexity of proteomics

More information

Lipid analysis by multiple "omic" mass spectrometry platforms Where we ve been, where we are, and where we re going

Lipid analysis by multiple omic mass spectrometry platforms Where we ve been, where we are, and where we re going Lipid analysis by multiple "omic" mass spectrometry platforms Where we ve been, where we are, and where we re going Jeff McDonald Department of Molecular Genetics UT Southwestern Medical Center Dallas,

More information

Mass Spectrometry Signal Calibration for Protein Quantitation

Mass Spectrometry Signal Calibration for Protein Quantitation Cambridge Isotope Laboratories, Inc. www.isotope.com Proteomics Mass Spectrometry Signal Calibration for Protein Quantitation Michael J. MacCoss, PhD Associate Professor of Genome Sciences University of

More information

MAB Solut. MABSolys Génopole Campus 1 5 rue Henri Desbruères 91030 Evry Cedex. www.mabsolut.com. is involved at each stage of your project

MAB Solut. MABSolys Génopole Campus 1 5 rue Henri Desbruères 91030 Evry Cedex. www.mabsolut.com. is involved at each stage of your project Mabsolus-2015-UK:Mise en page 1 03/07/15 14:13 Page1 Services provider Department of MABSolys from conception to validation MAB Solut is involved at each stage of your project Creation of antibodies Production

More information

B i o s o l u t i o n s

B i o s o l u t i o n s B i o s o l u t i o n s Implementation of pharmatracker TM : A case study Prepared by Ocimum Biosolutions Ocimumbio Solutions August 2006 All rights reserved. 2 B i o s o l u t i o n s an ISO 9001:2000

More information

Chapter 14. Modeling Experimental Design for Proteomics. Jan Eriksson and David Fenyö. Abstract. 1. Introduction

Chapter 14. Modeling Experimental Design for Proteomics. Jan Eriksson and David Fenyö. Abstract. 1. Introduction Chapter Modeling Experimental Design for Proteomics Jan Eriksson and David Fenyö Abstract The complexity of proteomes makes good experimental design essential for their successful investigation. Here,

More information

Simultaneous qualitative and quantitative analysis using the Agilent 6540 Accurate-Mass Q-TOF

Simultaneous qualitative and quantitative analysis using the Agilent 6540 Accurate-Mass Q-TOF Simultaneous qualitative and quantitative analysis using the Agilent 654 Accurate-Mass Q-TOF Technical Overview Authors Pat Perkins Anabel Fandino Lester Taylor Agilent Technologies, Inc. Santa Clara,

More information

M.Sc. in Nano Technology with specialisation in Nano Biotechnology

M.Sc. in Nano Technology with specialisation in Nano Biotechnology M.Sc. in Nano Technology with specialisation in Nano Biotechnology Nanotechnology is all about designing, fabricating and controlling materials, components and machinery with dimensions on the nanoscale,

More information

DrugDiscovery Technologies

DrugDiscovery Technologies I I Industry xperts I RedefinesBusinessAcumen Biotechnology DrugDiscovery Technologies AGlobalMarketOverview Thereportreviews,analyzesandprojects theglobalmarketfordrugdiscoverytechnologies fortheperiod2010-2020

More information

Toxicology/DAU Testing by Mass Spectrometry

Toxicology/DAU Testing by Mass Spectrometry Toxicology/DAU Testing by Mass Spectrometry AACC Conference: Mass Spectrometry in the Clinical Lab September 17, 2013 Kara Lynch, PhD, DABCC University of California San Francisco Disclosures Research

More information

Urine Drug Testing. Why drug test? Set the Standard!

Urine Drug Testing. Why drug test? Set the Standard! Urine Drug Testing Urine drug testing is a valuable tool for the physician when making treatment decisions. Patients and physicians benefit from safe and effective treatment of pain but there are always

More information

La Protéomique : Etat de l art et perspectives

La Protéomique : Etat de l art et perspectives La Protéomique : Etat de l art et perspectives Odile Schiltz Institut de Pharmacologie et de Biologie Structurale CNRS, Université de Toulouse, Odile.Schiltz@ipbs.fr Protéomique et Spectrométrie de Masse

More information

Simultaneous Qualitative and Quantitative Data Acquisition for Research of Diabetes Drugs

Simultaneous Qualitative and Quantitative Data Acquisition for Research of Diabetes Drugs Liquid Chromatography Mass Spectrometry SSI-LCMS-068 Simultaneous Qualitative and Quantitative Data Acquisition for Research of Diabetes Drugs LCMS-8050 Summary By utilizing the LCMS-8050 s ultrafast scan

More information

AxION edoor. Web-Based, Open-Access Mass Spectrometry Software

AxION edoor. Web-Based, Open-Access Mass Spectrometry Software AxION edoor Web-Based, Open-Access Mass Spectrometry Software 2 AxION edoor is the open-access software solution for today s fast-paced laboratory. It is designed to operate and optimize the management

More information

Catalent Biologics & Clinical Supplies The SMART Solution

Catalent Biologics & Clinical Supplies The SMART Solution Catalent Biologics & Clinical Supplies The SMART Solution Advanced Technology and Integrated Solutions From DNA to Clinical Supply & Cold Chain Distribution Dr. Florian Schwaak Account Manager Germany

More information

Application Note # LCMS-81 Introducing New Proteomics Acquisiton Strategies with the compact Towards the Universal Proteomics Acquisition Method

Application Note # LCMS-81 Introducing New Proteomics Acquisiton Strategies with the compact Towards the Universal Proteomics Acquisition Method Application Note # LCMS-81 Introducing New Proteomics Acquisiton Strategies with the compact Towards the Universal Proteomics Acquisition Method Introduction During the last decade, the complexity of samples

More information

Guidance for Industry. Monoclonal Antibodies Used as Reagents in Drug Manufacturing

Guidance for Industry. Monoclonal Antibodies Used as Reagents in Drug Manufacturing Guidance for Industry Monoclonal Antibodies Used as Reagents in Drug Manufacturing U.S. Department of Health and Human Services Food and Drug Administration enter for Drug Evaluation and Research (DER)

More information

XEVO TQ MS PHARMACEUTICAL APPLICATION NOTEBOOK

XEVO TQ MS PHARMACEUTICAL APPLICATION NOTEBOOK XEV TQ MS PHARMACEUTICAL APPLICATIN NTEBK Xevo TQ MS: Pharmaceutical Applications The Changing Face of LC/MS: From Experts to Users...3 Improving MS/MS Sensitivity using Xevo TQ MS with ScanWave...11 Simultaneous

More information

H y B rid i Z ation- elis a. elis a. Bioanalytical o verview. ecl

H y B rid i Z ation- elis a. elis a. Bioanalytical o verview. ecl lc- icp-ms lc-ms/ms G yros H y B rid i Z ation- elis a elis a Bioanalytical o verview ecl icp-ms Bioanalytical Overview One of the world s largest offerings for bioanalysis of small molecules and biologics,

More information

EMABling Antibody Production Platform

EMABling Antibody Production Platform EMABling Antibody Production Platform An industrial solution for the production of therapeutic antibodies with high cytotoxic activity B IOMANUFACTURING EMABling : A fully integrated development platform

More information

ProteinPilot Report for ProteinPilot Software

ProteinPilot Report for ProteinPilot Software ProteinPilot Report for ProteinPilot Software Detailed Analysis of Protein Identification / Quantitation Results Automatically Sean L Seymour, Christie Hunter SCIEX, USA Pow erful mass spectrometers like

More information

Per Andrén Dept. of Pharmaceutical Biosciences Medical Mass Spectrometry, Uppsala University, Uppsala, Sweden

Per Andrén Dept. of Pharmaceutical Biosciences Medical Mass Spectrometry, Uppsala University, Uppsala, Sweden Lung Imaging in Inhaled Product Development Novartis, Horsham, UK, 2011-11-09 Mapping Drug Deposition using Imaging Mass Spectrometry Per Andrén Dept. of Pharmaceutical Biosciences Medical Mass Spectrometry,

More information

Increasing Quality While Maintaining Efficiency in Drug Chemistry with DART-TOF MS Screening

Increasing Quality While Maintaining Efficiency in Drug Chemistry with DART-TOF MS Screening Increasing Quality While Maintaining Efficiency in Drug Chemistry with DART-TOF MS Screening Application Note Forensics Author Erin Shonsey Director of Research Alabama Department of Forensic Science Abstract

More information

Analysis of Intact Antibodies using HPLC-Chip technology combined with True High Definition QTOF Mass Spectrometry

Analysis of Intact Antibodies using HPLC-Chip technology combined with True High Definition QTOF Mass Spectrometry Analysis of Intact Antibodies using HPLC-Chip technology combined with True High Definition QTOF Mass Spectrometry Ravindra Gudihal Application Scientist Agilent Technologies, India Structure and modifications

More information

Guide to Reverse Phase SpinColumns Chromatography for Sample Prep

Guide to Reverse Phase SpinColumns Chromatography for Sample Prep Guide to Reverse Phase SpinColumns Chromatography for Sample Prep www.harvardapparatus.com Contents Introduction...2-3 Modes of Separation...4-6 Spin Column Efficiency...7-8 Fast Protein Analysis...9 Specifications...10

More information

Selvita Integrated drug discovery collaborations

Selvita Integrated drug discovery collaborations Selvita Integrated drug discovery collaborations Magdalena Żabka Selvita overview Origins Polish biotechnology research company headquartered in Krakow Mission Resources We deliver comprehensive solutions

More information

FREQUENTLY ASKED QUESTIONS Hair Testing

FREQUENTLY ASKED QUESTIONS Hair Testing MRCH 2011 FREUENTLY SKED UESTIONS Hair Testing DRUGS & CUTOFFS TECHNICL EXPLNTIONS What testing methodology is used for hair tests? two-tiered testing process is used: 1) portion of the hair sample is

More information

GenScript USA Inc. Open Position List

GenScript USA Inc. Open Position List GenScript USA Inc. is a world leader in developing and marketing innovative biotechnology products. Our dedication to innovation has led GenScript to generate a continuous flow of services and products

More information

Analyzing Small Molecules by EI and GC-MS. July 2014

Analyzing Small Molecules by EI and GC-MS. July 2014 Analyzing Small Molecules by EI and GC-MS July 2014 Samples Appropriate for GC-MS Volatile and semi-volatile organic compounds Rule of thumb,

More information

KMS-Specialist & Customized Biosimilar Service

KMS-Specialist & Customized Biosimilar Service KMS-Specialist & Customized Biosimilar Service 1. Polyclonal Antibody Development Service KMS offering a variety of Polyclonal Antibody Services to fit your research and production needs. we develop polyclonal

More information

Industry Perspective: Advantages of Open Access and Walkup LC/ MS Supporting Protein Drug Discovery and Development

Industry Perspective: Advantages of Open Access and Walkup LC/ MS Supporting Protein Drug Discovery and Development Industry Perspective: Advantages of Open Access and Walkup LC/ MS Supporting Protein Drug Discovery and Development Dawn Stickle, Agilent Technologies Originally presented by Eric Fang, Novartis Overview

More information

Introduction to Proteomics

Introduction to Proteomics Introduction to Proteomics Why Proteomics? Same Genome Different Proteome Black Swallowtail - larvae and butterfly Biological Complexity Yeast - a simple proteome 6,113 proteins = 344,855 tryptic peptides

More information

Henry Shion, Robert Birdsall, Steve Cubbedge, and Weibin Chen Waters Corporation, Milford, MA, USA APPLICATION BENEFITS INTRODUCTION WATERS SOLUTIONS

Henry Shion, Robert Birdsall, Steve Cubbedge, and Weibin Chen Waters Corporation, Milford, MA, USA APPLICATION BENEFITS INTRODUCTION WATERS SOLUTIONS Development of Integrated Informatics Workflows for the Automated Assessment of Comparability for Antibody Drug Conjugates (ADCs) Using LC-UV and LC-UV/MS Henry Shion, Robert Birdsall, Steve Cubbedge,

More information

Advanced BioDesign Outlines Solutions. Antibody Overview. by Advanced BioDesign. Project Start. Immunogenicity. Selecting Your Antigen

Advanced BioDesign Outlines Solutions. Antibody Overview. by Advanced BioDesign. Project Start. Immunogenicity. Selecting Your Antigen Advanced BioDesign Outlines Solutions by Advanced BioDesign Antibody Overview Launching an immunisation programme is an important experimental step that needs care. With Advanced BioDesign, you may develop

More information

Your partner in immunology

Your partner in immunology Your partner in immunology Expertise Expertise Reactivity Reactivity Quality Quality Advice Advice Who are we? Specialist of antibody engineering Covalab is a French biotechnology company, specialised

More information

8. SUMMARY AND CONCLUSION

8. SUMMARY AND CONCLUSION 238 8. SUMMARY AND CONCLUSION The present work aimed to assess the applicability of High Performance Liquid Chromatography with Mass Spectrometry (HPLC-MS) for analysis of different class of drugs in rat,

More information

Monoclonal Antibody Fragment Separation and Characterization Using Size Exclusion Chromatography Coupled with Mass Spectrometry

Monoclonal Antibody Fragment Separation and Characterization Using Size Exclusion Chromatography Coupled with Mass Spectrometry Monoclonal ntibody Fragment Separation and haracterization Using Size Exclusion hromatography oupled with Mass Spectrometry uthors Haiying hen Katherine McLaughlin Sepax Technologies, Inc. 5 Innovation

More information

Automated Solid Phase Extraction (SPE) of EPA Method 1694 for Pharmaceuticals and Personal Care Products in Large Volume Water Samples

Automated Solid Phase Extraction (SPE) of EPA Method 1694 for Pharmaceuticals and Personal Care Products in Large Volume Water Samples Automated Solid Phase Extraction (SPE) of EPA Method 1694 for Pharmaceuticals and Personal Care Products in Large Volume Water Samples Keywords Application Note ENV0212 This collaboration study was performed

More information

Ionization efficiency, ion suppression and detection sensitivity of CESI-MS

Ionization efficiency, ion suppression and detection sensitivity of CESI-MS Ionization efficiency, ion suppression and detection sensitivity of CESI-MS Gabor Jarvas 1,2, Bryan Fonslow 1,3, and Andras Guttman 2,3 1 The Scripps Research Institute, La Jolla, CA 92037; 2 Horvath Csaba

More information

6. ANALYTICAL METHODS

6. ANALYTICAL METHODS 45 6.1 BIOLOGICAL MATERIALS No methods were located that are routinely used for the detection of BCEE in biological materials. Norpoth et al. (1986) reported a method for measuring thiodiglycolic acid

More information

Chemistry 321, Experiment 8: Quantitation of caffeine from a beverage using gas chromatography

Chemistry 321, Experiment 8: Quantitation of caffeine from a beverage using gas chromatography Chemistry 321, Experiment 8: Quantitation of caffeine from a beverage using gas chromatography INTRODUCTION The analysis of soft drinks for caffeine was able to be performed using UV-Vis. The complex sample

More information

Eden Biodesign ebook Monoclonal Antibody Production: Building the Platform

Eden Biodesign ebook Monoclonal Antibody Production: Building the Platform Eden Biodesign ebook Monoclonal Antibody Production: Building the Platform CHAPTER 1: Overview CHAPTER 2: Challenges CHAPTER 3: Purification Methodology CHAPTER 4: Results CHAPTER 5: About Eden Biodesign

More information

Mass Spectrometry Based Proteomics

Mass Spectrometry Based Proteomics Mass Spectrometry Based Proteomics Proteomics Shared Research Oregon Health & Science University Portland, Oregon This document is designed to give a brief overview of Mass Spectrometry Based Proteomics

More information

Analysis of proteins

Analysis of proteins Analysis of proteins Western blot Protein seperation (liqiuid chromatography) Mass spectrometry Assaying of protein in... Blood (e.g. viral infections, pregnancy test) Cells Tissue Urin (bladder infection)

More information