XVII Paavo Nurmi symposium



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XVII Paavo Nurmi symposium Future directions of hypertension: Tailor-made diagnostics and treatment Scientific Programme Paavo Nurmi Symposium web pages: www.paavonurmensaatio.fi/symposium_xvii Chairman of the organizers: professor Contact information: ilkka.porsti@uta.fi, Tel. +358 40 5486507 Fax +358 3 3551 6164

,, Topics: Adaptive immune system in hypertension Adipocyte-derived factors Common genetic variants and hypertension Endothelium-derived substances Experimental models of cardiovascular diseases Impact of life style on blood pressure Large and small arteries in hypertension Monogenic forms of hypertension and the epithelial sodium channel Mineralocorticoids and mineralocorticoid receptors Novel aspects of sodium metabolism Pharmacogenetics of drug treatment Pharmacotherapy and novel treatment modalities of hypertension Prediction of future cardiovascular risk Renovascular hypertension Reactive oxygen species The renin-angiotensin-aldosterone system Vascular ageing Scientific Committee: Frej Fyhrquist Timo Hiltunen Eero Mervaala Kaj Metsärinne Heikki Ruskoaho Timo Strandberg Ilkka Tikkanen Jaakko Tuomilehto Seppo Ylä-Herttuala Organizing Committee: Timo Hiltunen Eero Mervaala Kaj Metsärinne Timo Strandberg Ilkka Tikkanen

:Future directions of hypertension - tailor-made diagnostics and treatment Wednesday 7 September 2011 Thursday 8 September 2011 Friday 9 September 2011 08:00-09:00 Secretariat open Secretariat open 08:00-09:00 09:00-09:30 Session 2a Dominik Müller Session 5a Laurent Schild 09:00-09:30 Renin/prorenin receptor in hypertension Sodium from The epithelial sodium channel in Pathomechanisms transport to hypertension of hypertension. 09:35-10:05 Friedrich Luft storage. Sergei N. Orlov 09:35-10:05 Chairpersons: Frej Role of the immune system in Chairpersons: The Na+, K+, 2Cl- cotransporter (NKCC1) Fyhrquist, hypertensive target organ damage Timo Hiltunen, and hypertension Stéphane Laurent Michael Bader 10:10-10:45 Secretariat open Coffee break Coffee break 10:10-10:45 10:45-11:15 Session 2b Mark Caulfield Session 5b Toshiro Fujita 10:45-11:15 Pathomechanisms Genetics of blood pressure - small steps and giant leaps Sodium from Aldosterone, salt-sensitive hypertension and metabolic syndrome 11:20-11:50 Registration at of hypertension. Christian Delles transport to Jens Titze 11:20-11:50 Chairpersons: Proteomics in hypertension and other storage. Non-osmotic sodium storage Seppo Ylä- cardiovascular diseases Chairpersons: 11:55-12:25 Herttuala, Peter A. Doris Heikki Ruskoaho, Graham A. MacGregor 11:55-12:25 Friedrich Luft Hypertension and renal injury: Laurent Schild Salt: Action and implementation a bidirectional relationship 12:30-13:00 12:30-13:00 Lunch Lunch 13:00-13:30 Opening 13:00-13:30 Opening of XVII Paavo Nurmi Symposium 13:35-14:05 Session 1a Michael Bader Session 3 Hans Oberleithner 13:35-14:05 Experimental models of cardiovascular Endothelial cells as vascular salt sensors From basics to diseases - relevance for the clinic Vascular tone and 14:10-14:40 novel aspects on Rhian M. Touyz Anthony Heagerty 14:10-14:40 structure. therapeutics. Oxidative stress, noxes and hypertension: Perivascular fat, obesity and Chairpersons: Ilkka Chairpersons: What is the clinical significance? hypertension Pörsti, Rhian M. 14:45-15:15 Kimmo Kontula, Julie A. Johnson Catherine M. Shanahan 14:45-15:15 Touyz Toshiro Fujita. Pharmacogenomics of antihypertensive The truly hard form of atherosclerosis: drugs vascular extracellular matrix calcification 15:20-15:50 Coffee break Coffee break 15:20-15:50 15:50-16:20 Session 1b Timo Hiltunen Session 4 Stéphane Laurent 15:50-16:20 Can we predict the response to an antihypertensive agent? Prediction of future cardiovascular risk in asymptomatic hypertensive subjects 16:25-16:55 Stefanie Dimmeler Clinical 16:25-16:55 MicroRNA-based therapeutics for hypertension. Cardiovascular phenotyping of From basics to cardiovascular diseases Chairpersons: Ilkka hypertensive and normotensive subjects novel aspects on 17:00-17:30 Malcolm R. Law Tikkanen, Anthony Philip A. Kalra 17:00-17:30 therapeutics. A change in paradigm - Time for lowering Heagerty Current views on the management of Chairpersons: Eero of blood pressure in everyone over a atherosclerotic renovascular Mervaala, Peter A. certain age? hypertension Doris 17:35-17:50 Jaakko Tuomilehto Commantary: Is a lower blood pressure target in diabetic patients justified by trial evidence?

Dear Colleagues, We have the great pleasure to invite you to participate in the XVII International Paavo Nurmi Symposium on Future directions of hypertension - Tailor-made diagnostics and treatment,, on the 7-9th of September, 2011. XVII Paavo Nurmi symposium Paavo Nurmi was a supreme Finnish runner, who during the course of three Olympic Games won nine gold medals and three silvers. Although he took great care of his physical health, he suffered from myocardial infarction at the age of 60 and later also from stroke, despite the absence of all the known risk factors. He died from multiple complications of atherosclerosis at the age of 76. As Nurmi realized that the causes of atherosclerosis were far from being understood, he created a foundation in his name in 1968 for the purpose of financing research on cardiovascular diseases. The present symposium focusing on hypertension will be the 17th one funded by the Paavo Nurmi Foundation. The picturesque city of Porvoo is located about 50 km to the East of Helsinki, Finland, and is easily accessible for international participants by a 30-min drive from the Helsinki-Vantaa airport. The symposium venue (http://www.haikko.fi), is conveniently located by the Baltic sea about 6 km outside Porvoo, the second oldest town in Finland. The programme will include state-of-the-art lectures given by invited speakers, with a special emphasis on future aspects of clinical hypertension. The presentations will cover several timely issues including adaptive immune system and hypertension, cardiovascular risk prediction, endothelium-derived substances, hypertension genetics, life style and blood pressure, mineralocorticoid receptors, novel treatment modalities, pharmacogenetics, renovascular hypertension, reactive oxygen species, the renin-angiotensin system, and water-free sodium storage. We look forward to seeing you in, Finland in September 2011. On behalf of the Scientific and Organizing Committees,

Symposium Venue The symposium will take place in, Finland (http://www.haikko.fi), located 6 km outside the city of Porvoo, and 30- min drive from Helsinki-Vantaa international airport. Accommodation Hotel rooms for symposium delegates have been reserved, located in the historic Manor House or in the nearby Spa & Conference Hotel. Official language The official language of the symposium is English. Social Programme Welcome Reception and Symposium Dinner are included in the programme. The Haikko Spa is located by the sea and in the middle of a beautiful park, which provides versatile possibilities for leisure-time activities. Haikko also offers fishing and boat cruises through the unique archipelago. Contact information Sirpa Walker,, MD Symposium secretary Chairman of the organizers Email sirpa.walker@uta.fi Email ilkka.porsti@uta.fi Medical School, Arvo-Building Internal Medicine FIN-33014 University of Tampere, Finland Web pages http://paavonurmensaatio.fi/symposium_xvii