Angiogenesis, Exudation, and Degeneration 2016. February 6, 2016. Bascom Palmer Eye Institute

Angiogenesis, Exudation, and Degeneration 2016 February 6, 2016 Bascom Palmer Eye Institute Miami,florida Sponsored by the University of Miami Miller School of Medicine

BASCOM PALMER EYE INSTITUTE Angiogenesis, Exudation, and Degeneration 2016 invites you to join us in February 2016 for our thirteenth annual angiogenesis meeting. This unique and exciting symposium entitled Angiogenesis, Exudation, and Degeneration 2016 will be held February 6, 2016 at the Mandarin Oriental Hotel in Miami, Florida. The meeting will feature an exceptional gathering of basic scientists, clinicians, and healthcare experts, all focused on understanding and treating neovascular and exudative diseases of the eye. The meeting will highlight the revolutionary pharmacotherapies now in development and clinical practice for the management of neovascular AMD, macular edema, diabetic retinopathy, and retinopathy of prematurity with a special emphasis on the present and future financial impact of these drugs on clinical practices and Medicare. Mandarin Oriental Hotel, Miami

COURSE CO-DIRECTORS Philip J. Rosenfeld, MD, PhD University of Miami Miller School of Medicine Course Co-Director Harry W. Flynn, Jr., MD The J. Donald M. Gass Distinguished Chair in Ophthalmology University of Miami Miller School of Medicine Course Co-Director Carmen A. Puliafito, MD, MBA Dean, Keck School of Medicine May S. and John Hooval Dean s Chair in Medicine and Health Management University of Southern California Course Associate Director COURSE DESCRIPTION Angiogenesis 2016 follows the tradition of excellence established by the widely acclaimed Angiogenesis programs between 2004 and 2015. Designed for retinal specialists, general ophthalmologists and researchers, the current program will review the latest therapies for exudative eye diseases and the use of these new treatments in clinical practice. We will emphasize current and future treatments for a broad spectrum of retinal diseases with special emphasis on age-related macular degeneration and diabetic retinopathy. COURSE OBJECTIVES Upon completion of this program, participants should be able to: Enhance patient care by evaluating the current global use of anti-vegf drugs for exudative ocular diseases Manage patients with anti-vegf therapy through the preferred dosing practices Improve management skills by evaluating all the risks associated with injections of an anti-vegf drugs Analyze the rationale for emerging treatments for different macular and retinal degenerative conditions Analyze results of clinical trials in exudative and non-exudative macular diseases and apply to clinical practice Evaluate the benefits and limitations of combination therapies for exudative macular diseases Evaluate the benefits and limitations of different imaging strategies for macular diseases Understand the emerging imaging technology known as OCT angiography Enhance patient care by analyzing the genetic basis for different macular and retinal degenerative conditions

PROGRAM Subject to change Saturday, February 6, 2016 7:00 am Registration and Continental Breakfast 7:55 Welcome and Overview Philip J. Rosenfeld, MD, PhD; Harry W. Flynn, Jr., MD and Carmen A. Puliafito, MD, MBA Session I: Top Innovations in Retina Moderator: Carmen A. Puliafito, MD, MBA 8:00 Top Innovations in Retina A VC s Perspective? Emmett T. Cunningham, Jr., MD. PhD, MPH 8:10 OCT Angiography Where We Stand in 2016 Jay S. Duker, MD Session II: Imaging of Retinovascular Diseases Moderator: Carmen A. Puliafito, MD, MBA 8:20 Diabetic Maculopathy Grading Using OCT Angiographic Capillary Perfusion Mapping Andre Romano, MD 8:30 Volume Rendered Angiographic and Structural Optical Coherence Tomography of Diabetic Retinopathy Richard F. Spaide, MD 8:40 Automated Segmentation and Quantification of Angiographic Features on Ultra-Widefield Fluorescein Angiography Justis P. Ehlers, MD 8:50 Does Wide-field Guided Pan-Retinal Ablation Decrease the Treatment Burden of Anti-VEGF Management of DME? David M. Brown, MD, FACS Session III: Retinovascular Diseases Moderator: Harry W. Flynn, Jr., MD 9:00 DRCR.net Update Harry W. Flynn, Jr., MD 9:10 Update on Ranibizumab for Diabetic Retinopathy from the Ride and Rise Studies David S. Boyer, MD 9:20 Update on Aflibercept for DME Diana V. Do, MD 9:30 Aflibercept for Recalcitrant DME Elias Reichel, MD 9:40 Pharmacotherapy in Development for Diabetic Macular Edema Quan Dong Nguyen, MD, MSc 9:50 Update on the MacTel Project Martin Friedlander, MD, PhD 10:00 Update on AZOOR Lawrence A. Yannuzzi, MD

Session IV: Age-Related Macular Degeneration I Moderator: Philip J. Rosenfeld, MD, PhD 10:10 Evidence for Mitochondrial Dysfunction in AMD Pathology Deborah Ferrington, PhD 10:20 Photoreceptor Energy Needs and Angiogenesis in AMD Lois Smith, MD, PhD 10:30 Reticular Macular Disease, the Choroid, and Cardiovascular Disease Theodore Smith, MD 10:40 OCT Angiography in Dry Age Related Macular Degeneration Nadia Waheed, MD 10:50 Neovascular Intermediate AMD: A New Stage of Non-Exudative AMD Luiz Roisman, MD 11:00 Differential Diagnosis of Macular Atrophy: An Angio OCT Study Giovanni Staurenghi, MD Session V: Age-Related Macular Degeneration II Moderator: Carmen A. Puliafito, MD, MBA 11:10 Update from the Classification of Atrophy Meeting I SriniVas R. Sadda, MD 11:20 Update from the Classification of Atrophy Meeting II Frank Holz, MD 11:30 Nascent GA Detected with En Face OCT Imaging Karen B. Schaal, MD 11:40 Automated Choroidal Thickness Measurements from Widefield OCT Fang Zheng, MD 11:50 Peripheral Retinal Changes Associated with AMD on Widefield Fundus Photography Emily Y. Chew, MD Session VI: AMD: Emerging Therapies and Ongoing Clinical Trials Moderator: Philip J. Rosenfeld, MD, PhD 12:00 pm Preclinical Efficacy of MTP-131, a Mitochondrial Targeting Drug, in Mouse Models for Dry AMD Scott W. Cousins, MD 12:10 Modified Nucleoside Reverse Transcriptase Inhibitor for Atrophic and Neovascular AMD Jayakrishna Ambati, MD 12:20 Emixustat Update Lukas Scheibler, PhD 12:30 Lampalizumab Update Brandon Busbee, MD

12:40 Complement C5 Inhibition for AMD Parisa Zamiri, MD, PhD 12:50 Complement C5 Inhibition in AMD Cedric G. Francois, MD, PhD 1:00 Non-Damaging Laser Therapy of the Macula: Mechanisms and Applications Daniel Palanker, PhD 1:10 Lunch Session VII: Macular Neovascularization and Imaging Moderator: Carmen A. Puliafito, MD, MBA 2:00 Efficacy and Safety of Conbercept Ophthalmic Injection in Treatment of Choroidal Neovascularization Secondary to Pathological Myopia (Shiny Trial) Youxin Chen, MD 2:10 Imaging-histology Correlations in Pigment Epithelium Detachment Christine A. Curcio, PhD, FARVO 2:20 Widefield En Face Swept Source OCT Imaging of Retinal Pigment Epithelial Detachment Brian Goldhagen, MD 2:30 Quantitative OCT Angiography of Type 1, 2 and 3 Neovascularization After Anti-VEGF Therapy David Sarraf, MD Session VIII: Macular Neovascularization: Clinical Management Moderator: Jaclyn L. Kovach, MD 2:40 Reasons for Retreatment in CATT and IVAN: Contributions from OCT, Visual Acuity, Angiography, and Dilated Fundus Exam Maureen Maguire, PhD 2:50 Changes in Neovascular Activity Following Continuous Anti-VEGF Administration: 52 Week Results in the VIEW Studies Darius M. Moshfeghi, MD 3:00 The Effect of Switching Drugs in AMD Daniel F. Martin, MD 3:10 The Effect of Switching Anti-VEGF Drugs in DME Frederick L. Ferris, III, MD 3:20 Automation of OCT Report Interpretation- the Future of Monitoring Patients for Disease Activity Anat Loewenstein, MD 3:30 Automated, Remote, Intravitreal Injection: A New Perspective Stephan Michels, MD, MBA

Session IX: Macular Neovascularization and Emerging Therapies I Moderator: Zohar Yehoshua, MD, PhD 3:40 Genetic Analysis of VIEW 1 Neovascular AMD Patients Philip J. Rosenfeld, MD, PhD 3:50 A Genetic Analysis of CNV Occurring in CSC and the Pachychoroid Spectrum K. Bailey Freund, MD 4:00 Intravitreal Ziv-Aflibercept for Exudative Macular Diseases Michel E. Farah, MD 4:10 Optimizing Regimen of Neovascular AMD Therapy Via Combined PDGF/VEGF Antagonism Pravin U. Dugel, MD 4:20 Aflibercept Combination Therapies: Aflibercept/Anti- ANG 2 and Aflibercept/Anti-PDGF Jeffrey S. Heier, MD 4:30 CrossMab Antibody with Dual Inhibition of VEGF-A and Angiopoietin-2 for Exudative AMD and DME Karl G. Csaky, MD, PhD 4:40 Update on Anti-VEGF RTH258 and DARPin for CNV in AMD Lawrence J. Singerman, MD, FACS, FICS Session X: Macular Neovascularization and Emerging Therapies II Moderator: Philip J. Rosenfeld, MD, PhD 4:50 Delivery of the Future: An Update on the Encapsulated Cell Therapy Program Allen C. Ho, MD 5:00 Long-Acting Delivery of Ranibizumab Daniel M. Miller, MD, PhD 5:10 Orally Available Tyrosine Kinase Inhibitor X-82 in Neovascular AMD Philip J. Rosenfeld, MD, PhD 5:20 Topical Squalamine Lactate Ophthalmic Solution for the Treatment of Retinal Disease Jason S. Slakter, MD 5:30 Icon-1 in the Treatment of Neovascular AMD Carl D. Regillo, MD, FACS 5:40 Advances in Gene Therapy for Exudative ARMD Mark S. Blumenkranz, MD 5:50 Gene Transfer of Retinostat, a Lentiviral Vector Expressing Endostatin and Angiostatin, for Neovascular AMD Peter A. Campochiaro, MD 6:00 Adjourn/Cocktail Reception

SPEAKERS Jayakrishna Ambati, MD Professor and Vice Chair of Ophthalmology & Visual Sciences Professor of Physiology Dr. E Vernon Smith & Eloise C. Smith Endowed Chair Department of Ophthalmology & Visual Sciences University of Kentucky Lexington, KY Mark S. Blumenkranz, MD H.J. Smead Professor and Chair Director, Byers Eye Institute at Stanford Stanford University School of Medicine Palo Alto, CA David S. Boyer, MD Clinical Keck School of Medicine University of Southern California Senior Partner, Retina-Vitreous Associates Medical Group Los Angeles, CA David M. Brown, MD, FACS Clinical Baylor College of Medicine Director of Clinical Research Retina Consultants of Houston Houston, TX Brandon G. Busbee, MD Partner, Tennessee Retina Nashville, TN Peter A. Campochiaro, MD George S. and Dolores Dore Eccles and Neuroscience Wilmer Eye Institute The Johns Hopkins University School of Medicine Baltimore, MD Youxin Chen, MD Professor and Deputy Director of Ophthalmology Peking Union Medical College Hospital Beijing City, China Emily Y. Chew, MD Deputy Director, Division of Epidemiology and Clinical Applications National Eye Institute/NIH Bethesda, MD Scott W. Cousins, MD Robert Machemer, MD, Professor of Ophthalmology and Immunology Vice Chair for Research Director, Duke Center for Macular Diseases Duke Eye Center Duke University Durham, NC Karl G. Csaky, MD, PhD Senior Scientist, Chief Medical Officer Retina Foundation of the Southwest Dallas, TX Emmett T. Cunningham, Jr., MD, PhD, MPH Adjunct California Pacific Medical Center Stanford University School of Medicine The Francis I. Proctor Foundation, UCSF Hillsborough, CA Christine A. Curcio, PhD, FARVO Director, Age-related Maculopathy Histopathology Laboratory University of Alabama School of Medicine EyeSight Foundation Vision Research Labs Birmingham, AL Diana V. Do, MD Vice Chair for Education Director of the Carl Camras Center for Innovative Clinical Trials in Ophthalmology Stanley M. Truhlsen Eye Institute University of Nebraska Medical Center Omaha, NE Pravin U. Dugel, MD Clinical Keck School of Medicine University of Southern California Los Angeles, CA Managing Partner, Retina Consultants of Arizona Jay S. Duker, MD Professor and Chairman of Ophthalmology Director, New England Eye Center Tufts Medical Center Tufts University School of Medicine New England Eye Center Boston, MA Justis P. Ehlers, MD Assistant Cleveland Clinic Cleveland, OH Michel E. Farah, MD President, Vision Institute Paulista School of Medicine Paulo Federal University Sao Paulo, Brazil Frederick L. Ferris, III, MD Director, Division of Epidemiology and Clinical Applications Clinical Director, National Eye Institute/NIH Bethesda, MD Deborah Ferrington, PhD Professor Elaine and Robert Larson Endowed Vision Research Chair Department of Ophthalmology and Visual Neurosciences University of Minnesota Minneapolis, MN Cedric G. Francois, MD, PhD Apellis Pharmaceuticals Crestwood, KY K. Bailey Freund, MD Clinical Associate Professor of Ophthalmology New York University School of Medicine Vitreous Retina Macula Consultants of New York New York, NY Martin Friedlander, MD, PhD Professor, Department of Cell and Molecular Biology Chief, Retina Services, Division of Ophthalmology The Scripps Research Institute Scripps Clinic La Jolla, CA Brian Goldhagen, MD Assistant Professor of Clinical Ophthalmology University of Miami Miller School of Medicine Miami, FL Jeffrey S. Heier, MD Director, Vitreo-Retina Service Ophthalmic Consultants of Boston Boston, MA Allen C. Ho, MD Director, Retina Research Wills Eye Hospital Thomas Jefferson University Philadelphia, PA Professor Frank G. Holz Director and Chairman, Department of Ophthalmology University of Bonn Bonn, Germany

Jaclyn L. Kovach, MD Associate Professor of Clinical Ophthalmology at Naples University of Miami Miller School of Medicine Naples, FL Anat Loewenstein, MD Chairman, Department of Ophthalmology Tel Aviv Medical Center Tel Aviv, Israel Maureen Maguire, PhD Carolyn F. Jones University of Pennsylvania Philadelphia, PA Daniel F. Martin, MD Barbara and A.Malachi Mixon III Institute Chair in Ophthalmology Chairman, Cole Eye Institute Cleveland Clinic Cole Eye Institute Cleveland, OH Stephan Michels, MD, MBA Professor and Vice Chair Department of Ophthalmology City Hospital Triemli Zurich, Switzerland Daniel M. Miller, MD, PhD Voluntary Associate Professor Department of Ophthalmology University of Cincinnati Cincinnati Eye Institute Cincinnati, OH Darius M. Moshfeghi, MD Associate Byers Eye Institute at Stanford/Horngren Family Vitreoretinal Center Stanford University School of Medicine Palo Alto, CA Quan Dong Nguyen, MD, MSc Professor and Chairman Director of the Stanley M. Truhlsen Eye Institute McGaw Memorial Endowed Chair in Ophthalmology University of Nebraska Medical Center Omaha, NE Daniel Palanker, PhD Professor Department of Ophthalmology and Hansen Experimental Physics Laboratory Stanford University Palo Alto, CA Carl D. Regillo, MD, FACS Director, Retina Service Wills Eye Institute Thomas Jefferson University Bryn Mawr, PA Elias Reichel, MD Professor and Vice Chair of Ophthalmology Director, Vitreoretinal Service New England Eye Center Tufts Medical Center Tufts University School of Medicine Boston, MA Luiz Roisman, MD Post-Doctoral Associate University of Miami Miller School of Medicine Miami, FL Andre Romano, MD Instituto da Visao Sao Paulo, Brazil SriniVas R. Sadda, MD Director, Retina Service, Doheny Eye Institute David Geffen School of Medicine University of California Los Angeles Los Angeles, CA David Sarraf, MD Clinical Retinal Disorders and Ophthalmic Genetics Division Stein Eye Institute, UCLA Los Angeles, CA Karen B. Schaal, MD Post-Doctoral Associate University of Miami Miller School of Medicine Miami, FL Lukas Scheibler, PhD Executive Vice President Acucela Seattle, WA Lawrence J. Singerman, MD, FACS, FICS Voluntary University of Miami Miller School of Medicine Clinical Case Western Reserve University Retina Associates of Cleveland, Inc. Beachwood, OH Jason S. Slakter, MD Clinical New York University School of Medicine Partner, Vitreous-Retina Macula Consultants of New York New York, NY Lois Smith, MD, PhD Harvard Medical School Boston Children s Hospital Boston, MA Theodore Smith, MD NYU Langone Medical Center New York, NY Richard F. Spaide, MD Vitreous Retina Macula Consultants of New York New York, NY Giovanni Staurenghi, MD Department of Biomedical and Clinical Sciences University of Milan Milan, Italy Nadia Waheed, MD Assistant Tufts Medical School Tufts New England Eye Center Boston, MA Lawrence A. Yannuzzi, MD Professor of Clinical Ophthalmology College of Physicians and Surgeons Columbia University School of Medicine Manhattan Eye and Ear Hospital New York, NY Zohar Yeshoshua, MD, PhD Assistant Professor of Clinical Ophthalmology University of Miami Miller School of Medicine Miami, FL Parisa Zamiri, MD, PhD Director, Translational Medicine Novartis Institute for Biomedical Research Cambridge, MA Fang Zheng, MD Post-Doctoral Associate University of Miami Miller School of Medicine Miami, FL

INFORMATION Angiogenesis, Exudation, and Degeneration 2016 Date Saturday, February 6, 2016: 7:55 am to 6:00 pm LOCATION Mandarin Oriental Miami, Miami, Florida 500 Brickell Key Drive, Miami, FL 33131 Reservations: (800) 526-6566, Direct: (305) 913-8288 Mandarin Oriental Miami is one of America s finest hotels and recently voted Best Urban Hotel by Miami Herald s Readers Choice South Florida s Finest survey-best of South Florida. Ideally located on prestigious Brickell Key, its deluxe, waterfront location perfectly befits the opulence you ll find within. The rooms are luxurious, the awardwinning restaurants are some of the finest in Miami and the spa is one of the most beautiful in the world. The hotel s extensive leisure facilities make it the perfect choice for a conference or a holiday in Miami. HOTEL RESERVATIONS For hotel information and reservations, please call 305-913-8288 or 800-526-6566. The special hotel rate for conference attendees is $399 per night for single or double plus tax. The Mandarin Oriental will extend the special group rate for three days prior and three days after the main program dates, subject to availability. Check-in time is 3:00 pm; Check-out time is 12:00 noon. We suggest you make your hotel reservations as soon as possible as the winter months are the height of South Florida s tourist season. Bascom Palmer s preferred room rate will be released after January 13, 2016. Reservations and deposits received after that time are subject to current rates and availability. Please contact the Mandarin Oriental Miami for hotel cancellation policies. For additional information visit: www.mandarinoriental.com/miami CONFERENCE FEES Registration rate is $475. Conference fees include course materials, opening reception, continental breakfast, lunch and refreshment breaks. CANCELLATION POLICY Conference tuition, less a $50 cancellation fee, is refundable if notice is received by January 23, 2016. No refunds shall be considered after January 23, 2016 or after sixty (60) days following payment.

ACCREDITATION: The University of Miami Leonard M. Miller School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. CREDIT DESIGNATION: The University of Miami Leonard M. Miller School of Medicine designates this live activity for a maximum of 9.25 AMA PRA Category 1 Credits. Physicians should claim only the credit commensurate with the extent of their participation in the activity. DISCLOSURE AND CONFLICT OF INTEREST RESOLUTION: All conflicts of interest of any individual(s) in a position to control the content of this CME activity will be identified and resolved prior to this educational activity being provided. Disclosure about provider and faculty relationships, or the lack thereof, will be provided to learners. SERVICES FOR THE DISABLED If special arrangements are required for an individual with a disability to attend this conference, please contact Karen Davila at (305) 326-6110 on or before January 14, 2016. REGISTRATION Space is limited. Please register early. To register by internet: Please visit: http://bascompalmer.org/cme/angiogenesis/registration To register by mail: Please complete the registration form and return with your check or credit card payment to: Department of Continuing Medical Education 1400 NW 10th Ave., Suite 508 Miami, FL 33136 (Att: Karen Davila) To register by fax: Please complete the registration form and return with your credit card payment to (305) 326-6518. For more information contact: Department of Continuing Medical Education at (305) 326-6110 / Email: bascompalmercme@miami.edu www.bascompalmer.org

REGISTRATION FORM Angiogenesis, Exudation, and Degeneration 2016 Saturday, February 6, 2016 Registration is limited, so please register early. Last Name / First Name (as you want it to appear on name badge) / Degree Last Four Digits of Social Security Number (for record keeping purposes only) Specialty / Sub-specialty Affiliated Institution Address (Check box if new address) o City/State Country / Zip or Postal Code Office phone Office fax Email REGISTRATION: $475 o Enclosed is my check made payable to Angiogenesis 2016 o Please bill my credit card: o Mastercard o Visa o American Express Card number Security code Expiration date Billing zip code Name on card Signature Online: http://bascompalmer.org/cme/angiogenesis/registration By fax: Please complete this registration form with your credit card payment and fax to (305) 326-6518. By mail: Please complete this registration form and return with your check or credit card payment to: Continuing Medical Education Department 1400 NW 10th Ave., Suite 508 Miami, FL 33136 (Attn: Karen Davila)