Angiogenesis, Exudation, and Degeneration February 7, 2015 Mandarin Oriental, Miami, Florida

Transcription

1 Angiogenesis, Exudation, and Degeneration 2015 February 7, 2015 Mandarin Oriental, Miami, Florida Program Directors: Philip J. Rosenfeld, MD, PhD and Harry W. Flynn, Jr., MD Course Associate Director: Carmen A. Puliafito, MD, MBA PROGRAM Subject to Change Saturday, February 7, :00 am Registration and Continental Breakfast 7:55 Welcome and Overview Philip J. Rosenfeld, MD, PhD; Harry W. Flynn, Jr., MD; and Carmen A. Puliafito, MD, MBA Session I: Dry Age-Related Macular Degeneration Moderator: Philip J. Rosenfeld, MD, PhD 8:00 AMD Genetics-Functional Impact of Common and Rare Variants Johanna M. Seddon, MD, SCM 8:10 Subcellular Basis of How RPE Autofluorescence Varies in AMD Christine A. Curcio, PhD, FARVO 8:20 Complement and the Extracellular Matrix in Early Macular Degeneration Eric Pierce, MD, PhD 8:30 Determination of Extracellular Matrix Changes in the Inner Choroid of Subjects with Age-Related Macular and Its Relationship with Rod Dysfunction Karl G. Csaky, MD, PhD 8:40 Update on Reticular Pseudodrusen (Subretinal Drusenoid Deposits) Richard Spaide MD 8:50 The Association Between Reticular Pseudodrusen and Delayed Dark Adaptation? Catherine Cukras, MD

2 9:00 Widefield OCT Imaging: AMD, Choroidal Thickness, and Reticular Pseudodrusen Karen Schaal, MD 9:10 GA Progression in the AREDS2 Emily Y. Chew, MD 9:20 Outcome Variables in AMD Clinical Trials Frederick Ferris, MD 9:30 OCT Angiography in AMD Nadia Waheed, MD Session II: Neovascular AMD I: Does Anti-VEGF Therapy Induce Macular Atrophy? Moderators: Philip J. Rosenfeld, MD, PhD and Carmen Puliafito MD, MBA Panelists: Daniel Martin, MD; Glenn J. Jaffe, MD; Usha Chakravarthy, MD; SriniVas R. Sadda, MD; K. Bailey Freund, MD; and Giovanni Staurenghi, MD 9:40 CATT: Beyond Choice of Drug Daniel Martin, MD 9:50 Retina Morphology/Visual Acuity Correlations in the Second Year of CATT and Beyond Glenn J. Jaffe, MD 10:00 Atrophy, Geographic Atrophy, and Lesion Involution in the IVAN Study Usha Chakravarthy, MD 10:10 Macular Atrophy in the HARBOR Study SriniVas R. Sadda, MD 10:20 Geographic Atrophy in Patients Receiving Anti-Vascular Endothelial Growth Factor for Neovascular Age-Related Macular Degeneration K. Bailey Freund, MD 10:30 Geographic Atrophy and Anti VEGF Treatment: Is There a Correlation? Giovanni Staurenghi, MD 10:40 Panel Discussion

3 Session III: Emerging Technologies and Therapies in AMD Moderator: Carmen A. Puliafito, MD, MBA 10:50 Top Innovations in Retina - A VC Perspective Emmett Cunningham 11:00 Using Mobile Technology for Global Photographic Screening and Treatment of Retinal Diseases Mark S. Blumenkranz, MD 11:10 Lampalizumab Clinical Trial Update Carl D. Regillo, MD 11:20 Role of Genetics in the Growth Rate of GA Kang Zhang, MD, PhD 11:30 C3 Inhibition in AMD Philip J. Rosenfeld, MD, PhD 11:40 Geographic Atrophy: Teaching An Old Drug New Tricks Jayakrishna Ambati, MD 11:50 Nanosecond Laser Therapy for Drusen in Intermediate AMD Robyn Guymer, MD 12:00 The Rationale for Mitochondrial Targeted Therapeutics in Dry AMD Scott Cousins, MD Session IV: Stem Cells for Retinal Diseases Moderator: Wen-Hsiang Lee, MD, PhD 12:10 Safety and Technical Aspects of Subretinal Injection for Delivery of Cell and Gene Therapy Steven Schwartz, MD 12:20 Retinal Transplantation of ips Cell-Derived RPE Sheet for Age-Related Macular Degeneration Masayo Takahashi, MD, PhD 12:30 h-esc Derived RPE Transplantation for Atrophic AMD and Stargardt Disease Ninel Z. Gregori, MD

4 12:40 Phase I/II Study of the Safety and Preliminary Efficacy of Human Neural Stem Cells (HuCNS-SC) in AMD with Geographic Atrophy: Interim Analysis Theodore Leng, MD, MS 12:50 Cell Therapy for Atrophic Age Related Macular Degeneration: CNTO Year Phase 1/2 Results Allen C. Ho, MD 1:00 Embryonic Stem Cell-Derived RPE: The California Project David R. Hinton, MD 1:10 Lunch Session V: Neovascular AMD II Moderator: Philip J. Rosenfeld, MD, PhD 2:00 Effect of Anti-VEGF Therapy on Choroidal Thickness Stephan Michels, MD, MBA 2:10 Why Night Vision Matters in AMD: Lessons from HARBOR Ronald Frenkel, MD 2:20 How Did PEDs Respond in the HARBOR Study? Elias Reichel, MD 2:30 Efficacy of Intravitreal Injection of Conbercept in Polypoidal Choroidal Vasculopathy Xiaoxin Li, MD 2:40 Conbercept in Neovascular AMD Patients with Very Poor Visual Acuity: The LAMP Trial Xiaoyan Ding, M.D. Ph.D 2:50 Intravitreal Ziv-Aflibercept for the Treatment of Neovascular AMD Michel E. Farah, MD 3:00 Anti-VEGF DARPin (abicipar pegol) in Neovascular AMD David M. Brown, MD, FACS

5 Session VI: Neovascular AMD III Moderator: Jaclyn L. Kovach, MD 3:10 Oral VEGF Inhibition for Neovascular AMD Jason S. Slakter, MD 3:20 VEGF Inhibition with Encapsulated Cell Technology Peter K. Kaiser, MD 3:30 Continuous VEGF Suppression and Anti-VEGF Gene Therapy Thomas W. Chalberg, PhD 3:40 Anti-PDGF Pretreatment in AMD - Results of a Pilot Study Evaluating VEGF/PDGF Crosstalk Pravin U. Dugel, MD 3:50 Combined Anti-PDGF/Anti-VEGF Therapy in Neovascular AMD Jeffrey S. Heier, MD 4:00 Update on Squalamine Eye Drops for Neovascualar AMD Lawrence J. Singerman, MD, FACS, FICS 4:10 Radiation for Wet AMD: The European Clinical Experience and STAR Trial Update Darius M. Moshfeghi, MD Session VI: Chorioretinal, Vitreomacular, and Venous Occlusive Diseases Moderator: Harry W. Flynn, Jr., MD 4:20 Chronic Central Serous Chorioretinopathy in Elderly Patients Lawrence A. Yannuzzi, MD 4:30 MacTel Project Update Martin Friedlander, MD, PhD 4:40 CNTF for Optic Nerve Disease Thomas Albini, MD 4:50 Current Clinical Trials for Hereditary Chorioretinal Degenerations Byron L. Lam, MD 5:00 Peripheral Retinal Vascular Findings in Adults and Children Michael T. Trese, MD

6 5:10 Update on Aflibercept for BRVO David S. Boyer, MD 5:20 OCT Angiography of Diabetes Jay S. Duker, MD 5:30 DRCR.net Update: Protocol T Harry W. Flynn, Jr., MD Session VII: Diabetes Moderator: Andrew A. Moshfeghi, MD, MBA 5:40 RIDE and RIDE: An Update on Ranibizumab for Diabetic Retinopathy Baruch D. Kuppermann, MD, PhD 5:50 Update on Aflibercept for DME Diana V. Do, MD 6:00 Ozurdex for Diabetic Macular Edema: The ORVO Study Peter A. Campochiaro, MD 6:10 Promising Therapies in Development for DME: TIE-2 Activator, Integrin Peptide, and Vascular Adhesion Protein-1 Quan Dong Nguyen, MD, MSc 6:20 Adjourn/Cocktail Reception