Research Annual Report 2011

Transcription

1 Research Annual Report 2011 Molecular Medicine (MM) Pharmacogenetics Clinical and experimental neuroendocrinology Regulation of calcium and bone metabolism Regulation of the bioactivity of thyroid hormone Signalling in reproduction and ageing Population genomics of complex disease Localisation, detection and radionuclide therapy of various diseases The musculoskeletal system and tissue-engineering in orthopaedics and otorhinolaryngology Regulation of follicle development, oocyte and endometrial embryo quality Pathophysiology of pediatric endocrine, metabolic and renal diseases Malignant transformation of hematopoietic stem cells: pathophysiology and development of therapy Hematopoiesis: regulation of the proliferation and differentiation of hematopoietic progenitor cells Molecular determinants of therapy response and outcome in childhood cancer Lymphoid differentiation and immunodeficiencies 13019, B&T Ontwerp en advies (

2 Research Annual Report 2011 Molecular Medicine (MM) Immune regulation and autoimmunity Diagnosis, classification and treatment evaluation of leukemias and malignant lymphomas Solid tumors between bench and bed Improving accuracy and therapeutic ratio in radiation oncology Hyperthermia: a treatment for cancer Photodynamic therapy Neuro-oncology and pain Pathophysiological aspects and treatment of gastro-intestinal diseases Innovative tumor model development/tumor vasculature/tumor targeting/locoregional control Clinical and experimental aspects of urological tumors Gynaecological oncology; basics, epidemiology and clinical aspects Developmental biology; pathophysiology of the newborn Experimental therapeutical approaches in inflammatory dermatoses and cutaneous oncology Translational genomics and proteomics of cancer 13019, B&T Ontwerp en advies (

3 Research Annual Report 2011 Molecular Medicine (MM) Translational pharmacology Neoplastic lesions and chronic inflammatation of the gastrointestinal tract Liverspecific immunopathology; mechanism and therapeutic modulation Human virus infections: immunity, therapy and epidemiology Infections due to bacteria, fungi and parasites: diagnosis, molecular mechanisms, epidemiology, therapy and prevention Clinical research in infectious diseases in adults Renal insufficiency and organ transplantation Cell biological and pathophysiological investigations on pulmonary diseases Neuromuscular and Neuroinflammatory Disorders Organ transplantation Genitourinary tract disorders in children Disorders of the gastrointestinal tract in childhood Clinical, epidemiological and basic research of infectious diseases and immunological diseases in children 13019, B&T Ontwerp en advies (

4 EMC MM Pharmacogenetics Programme (brief description) The focus of this program is on molecular markers that can predict the effectiveness or the risk of adverse reactions of therapeutic interventions. In particular, the contribution of genetic factors in the drug metabolism is investigated. Translational research is performed to define and evaluate the clinical significance of genetic polymorphisms in drug metabolizing enzymes (o.a. CYP450s, UGTs, TPMT and NAT genes), drug transporters (OATPS, OATS, ABC-Transporters) and drug targets (a.o. Folate-Dependant Emzymes). Drug classes include immuno-suppressives, anti-depressants, anti-cancer drugs, anaesthetics, antiarrhytmics, anti-viral drugs, anti-coagulation drugs, proton pump inhibitors, opioids and antirheumatoïd drugs. In addition, genetic and metabolic factors are investigated that determine the level of plasma homocysteine and its deleterious effect on methylation reactions. Key Figures Department Sp1 Sp2 Sp3 Sp4 SpTot T1 T2 T3 Ttot IS FS OP Ptot clinical chemistry 3,63 3,63 internal medicine 0,3 0,3 Total 3,93 3, Article/Letter to the editor Adams, D., Jonge, R. de, Cammen, T.J.M. van der, Zietse, R. & Hoorn, E.J. (2011). Acute kidney injury in patients presenting with hyponatremia. Journal of Nephrology, 24(6), Arking, DE, Junttila, MJ, Goyette, P, Huertas-Vazquez, A, Eijgelsheim, M., Blom, MT, Newton-Cheh, C, Reinier, K, Teodorescu, C, Uy-Evanado, A, Carter-Monroe, N, Kaikkonen, KS, Kortelainen, ML, Boucher, G, Lagace, C, Moes, A, Zhao, XQ, Kolodgie, F, Rivadeneira, F., Hofman, A., Witteman, J.C.M., Uitterlinden, A.G., Marsman, RF, Pazoki, R, Bardai, A., Koster, RW, Dehghan, A., Hwang, SJ, Bhatnagar, P, Post, W., Hilton, G, Prineas, RJ, Li, M., Kottgen, A, Ehret, G, Boerwinkle, E., Coresh, J, Kao, WHL, Psaty, B.M., Tomaselli, G.F., Sotoodehnia, N, Siscovick, D.S., Burke, GL, Marban, E, Spooner, PM, Cupples, L.A., Jui, J, Gunson, K, Kesaniemi, YA, Wilde, A.A.M., Tardif, JC, O'Donnell, CJ, Bezzina, C.R., Virmani, R., Stricker, B.H.C., Tan, H.L., Albert, CM, Chakravarti, A, Rioux, JD, Huikuri, HV & Chugh, SS (2011). Identification of a Sudden Cardiac Death Susceptibility Locus at 2q24.2 through Genome-Wide Association in European Ancestry Individuals. PLoS Genetics, 7(6). Becker, M.L., Visser, L.E., Schaik, R.H.N. van, Hofman, A., Uitterlinden, A.G. & Stricker, B.H.C. (2011). OCT1 polymorphism is associated with response and survival time in anti-parkinsonian drug users. Neurogenetics, 12(1), Bis, JC, Kavousi, M., Franceschini, N, Isaacs, A, Abecasis, GR, Schminke, U, Post, WS, Smith, AV, Cupples, L.A., Markus, HS, Schmidt, R., Huffman, JE, Lehtimaki, T, Baumert, J., Munzel, T, Heckbert, SR, Dehghan, A., North, K, Oostra, B.A., Bevan, S, Stoegerer, EM, Hayward, C, Raitakari, O, Meisinger, C, Schillert, A, Sanna, S, Volzke, H, Cheng, YC, Thorsson, B, Fox, CS, Rice, K, Rivadeneira, F., Nambi, V, Halperin, E, Petrovic, KE, Peltonen, L., Wichmann, HE, Schnabel, RB, Dorr, M, Parsa, A, Aspelund, T, Demissie, S, Kathiresan, S, Reilly, MP, Taylor, K., Uitterlinden, A., Couper, DJ, Sitzer, M, Kahonen, M, Illig, T, Wild, PS, Orru, M, Ludemann, J, Shuldiner, AR, Eiriksdottir, G, White, CC, Rotter, JI, Hofman, A., Seissler, J, Zeller, T, Usala, G, Ernst, F, Launer, L.J., D'Agostino, RB, O'Leary, DH, Ballantyne, C., Thiery, J, Ziegler, A, Lakatta, EG, Chilukoti, RK, Harris, T.B., Wolf, PA, Psaty, B.M., Polak, JF, Li, X., Rathmann, W, Uda, M, Boerwinkle, E., Klopp, N, Schmidt, H., Wilson, JF, Viikari, J, Koenig, W., Blankenberg, S, Newman, AB, Witteman, J.C.M., Heiss, G, Duijn, C.M. van, Scuteri, A, Homuth, G., Mitchell, B.D., Gudnason, V & O'Donnell, CJ (2011). Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque. Nature Genetics, 43(10), 940-U40.

5 Boehringer, S, Lijn, F. van der, Liu, F., Gunther, M, Sinigerova, S, Nowak, S, Ludwig, KU, Herberz, R, Klein, S., Hofman, A., Uitterlinden, A.G., Niessen, W.J., Breteler, M.M.B., Lugt, A. van der, Wurtz, RP, Nothen, MM, Horsthemke, B., Wieczorek, D, Mangold, E & Kayser, M. (2011). Genetic determination of human facial morphology: links between cleft-lips and normal variation. European Journal of Human Genetics, 19(11), Boer, MGJ de, Gelinck, L.B.S., Zelst, B.D. van, Sande, W.W.J. van de, Willems, L.N.A., Dissel, J.T. van, Jonge, R. de & Kroon, F.P. (2011). beta-d-glucan and S-adenosylmethionine serum levels for the diagnosis of Pneumocystis pneumonia in HIV-negative Patients: A prospective study. Journal of Infection, 62(1), Boger, CA, Gorski, M, Li, M., Hoffmann, MM, Huang, CM, Yang, Q, Teumer, A, Krane, V, O'Seaghdha, CM, Kutalik, Z, Wichmann, HE, Haak, T., Boes, E, Coassin, S, Coresh, J, Kollerits, B, Haun, M, Paulweber, B, Kottgen, A, Li, G., Shlipak, M.G., Powe, N, Hwang, SJ, Dehghan, A., Rivadeneira, F., Uitterlinden, A., Hofman, A., Beckmann, J.S., Kramer, BK, Witteman, J.C.M., Bochud, M, Siscovick, D, Rettig, R, Kronenberg, F, Wanner, C, Thadhani, RI, Heid, IM, Fox, CS & Kao, WH (2011). Association of egfr-related Loci Identified by GWAS with Incident CKD and ESRD. PLoS Genetics, 7(9). Boger, CA, Chen, MH, Tin, A, Olden, M, Koettgen, A, Boer, I.H., Fuchsberger, C, O'Seaghdha, CM, Pattaro, C, Teumer, A, Liu, CT, Glazer, NL, Li, M., O'Conne, JR, Tanaka, T, Peralta, CA, Kutalik, Z, Luan, J, Zhao, JH, Hwang, SJ, Akylbekova, E, Kramer, H., Harst, P. van der, Smith, AV, Lohman, K, Andrade, M de, Hayward, C, Kollerits, B, Tonjes, A, Aspelund, T, Ingelsson, E, Eiriksdottir, G, Launer, L.J., Harris, T.B., Shuldiner, AR, Mitchell, B.D., Arking, DE, Franceschini, N, Boerwinkle, E., Egan, J, Hernandez, D., Reilly, M. O, Townsend, RR, Lumley, T, Siscovick, D.S., Psaty, B.M., Kestenbaum, B, Haritunians, T, Bergmann, S, Vollenweider, P, Waeber, G, Mooser, V, Waterworth, D, Johnson, AD, Florez, JC, Meigs, JB, Lu, XN, Turner, ST, Atkinson, EJ, Leak, TS, Aasarod, K, Skorpen, F, Syvanen, AC, Illig, T, Baumert, J., Koenig, W., Kramer, BK, Devuyst, O., Mychaleckyj, JC, Minelli, C, Bakker, SJL, Kedenko, L, Paulweber, B, Coassin, S, Endlich, K, Kroemer, HK, Biffar, R, Stracke, S, Volzke, H, Stumvol, M, Magi, R, Campbell, H, Vitart, V, Hastie, ND, Gudnason, V, Kardia, SLR, Liu, YM, Polasek, O, Curhan, G, Kronenberg, F, Prokopenko, I, Rudan, I, Arnlov, J, Hallan, S, Navis, G, Parsa, A, Ferrucci, L, Coresh, J, Shlipak, M.G., Bul, SB, Paterson, AD, Wichmann, HE, Wareham, NJ, Loos, RJF, Rotter, JI, Pramstaller, P.P., Cupples, L.A., Beckmann, J.S., Yang, QO, Heid, IM, Rettig, R, Dreisbach, AW, Bochud, M, Fox, CS & Kao, WHL (2011). CUBN Is a Gene Locus for Albuminuria. Journal of the American Society of Nephrology, 22(3), Bouamar, R., Hesselink, D.A., Schaik, R.H.N. van, Weimar, W., Macphee, I, Fijter, J de & Gelder, T. van (2011). Polymorphisms in CYP3A & ABCB1 are not associated with cyclosporine pharmacokinetics nor with clinical endpoints after renaltransplantation. Therapeutic Drug Monitoring, 33(4), Broer, L., Ikram, A., Schuur, M., DeStefano, AL, Bis, JC, Liu, F., Rivadeneira, F., Uitterlinden, A.G., Beiser, AS, Longstreth, W.T., Hofman, A., Aulchenko, Y., Seshadri, S, Fitzpatrick, AL, Oostra, B.A., Breteler, M.M.B. & Duijn, C.M. van (2011). Association of HSP70 and its Co-Chaperones with Alzheimer's Disease. Journal of Alzheimers Disease, 25(1), Brugts, J.J., Isaacs, A, Maat, M.P.M. de, Boersma, E., Duijn, C.M. van, Akkerhuis, K.M., Uitterlinden, A.G., Witteman, J.C.M., Cambien, F., Ceconi, C., Remme, W, Bertrand, M, Ninomiya, T, Harrap, S, Chalmers, J, MacMahon, S, Fox, K, Ferrari, R., Simoons, M.L. & Danser, A.H.J. (2011). A pharmacogenetic analysis of determinants of hypertension and blood pressure response to angiotensin-converting enzyme inhibitor therapy in patients with vascular disease and healthy individuals. Journal of Hypertension, 29(3), Catalona, WJ, Partin, AW, Sanda, MG, Wei, JT, Klee, GG, Bangma, C.H., Slawin, KM, Marks, LS, Loeb, S, Broyles, DL, Shin, SS, Cruz, AB, Chan, DW, Sokoll, LJ, Roberts, WL, Schaik, R.H.N. van & Mizrahi, IA (2011). A Multicenter Study of [-2]Pro-Prostate Specific Antigen Combined With Prostate Specific Antigen and Free Prostate Specific Antigen for Prostate Cancer Detection in the 2.0 to 10.0 ng/ml Prostate Specific Antigen Range. Journal of Urology, 185(5),

6 Chambers, JC, Zhang, WH, Sehmi, J, Li, XZ, Wass, MN, Harst, P. van der, Holm, H, Sanna, S, Kavousi, M., Baumeister, SE, Coin, LJ, Deng, GH, Gieger, C, Heard-Costa, NL, Hottenga, J.J., Kuhnel, B, Kumar, V., Lagou, V, Liang, LM, Luan, JA, Vidal, PM, Leach, IM, O'Reilly, PF, Peden, JF, Rahmioglu, N, Soininen, P, Speliotes, EK, Yuan, X, Thorleifsson, G, Alizadeh, B.Z., Atwood, LD, Borecki, IB, Brown, MJ, Charoen, P, Cucca, F, Das, D., Geus, E.J.C. de, Dixon, AL, Doering, A, Ehret, G, Eyjolfsson, GI, Farrall, M, Forouhi, NG, Friedrich, N, Goessling, W, Gudbjartsson, DF, Harris, T.B., Hartikainen, AL, Heath, S, Hirschfield, GM, Hofman, A., Homuth, G., Hypponen, E, Janssen, H.L.A., Johnson, T, Kangas, AJ, Kema, I.P., Kuhn, JP, Lai, S, Lathrop, M, Lerch, MM, Li, Y., Liang, TJ, Lin, JP, Loos, RJF, Martin, NG, Moffatt, MF, Montgomery, GW, Munroe, PB, Musunuru, K, Nakamura, Y, O'Donnell, CJ, Olafsson, I, Penninx, BW, Pouta, A, Prins, BP, Prokopenko, I, Puls, R, Ruokonen, A, Savolainen, MJ, Schlessinger, D, Schouten, J.N.L., Seedorf, U, Sen-Chowdhry, S, Siminovitch, KA, Smit, J.H., Spector, T.D., Tan, WT, Teslovich, TM, Tukiainen, T, Uitterlinden, A.G., Klauw, M.M. van der, Vasan, RS, Wallace, C, Wallaschofski, H., Wichmann, HE, Willemsen, G, Wurtz, P, Xu, C., Yerges-Armstrong, LM, Abecasis, GR, Ahmadi, KR, Boomsma, D.I., Caulfield, M., Cookson, WO, Duijn, C.M. van, Froguel, P, Matsuda, K, McCarthy, MI, Meisinger, C, Mooser, V, Pietilainen, KH, Schumann, G, Snieder, H, Sternberg, MJE, Stolk, R.P., Thomas, H.C., Thorsteinsdottir, U, Uda, M, Waeber, G, Wareham, NJ, Waterworth, D.M., Watkins, H, Whitfield, JB, Witteman, J.C.M., Wolffenbuttel, B.H.R., Fox, CS, Ala- Korpela, M, Stefansson, K, Vollenweider, P, Volzke, H, Schadt, EE, Scott, J, Jarvelin, MR, Elliott, P. & Kooner, JS (2011). Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nature Genetics, 43(11), 1131-U129. Day-Williams, AG, Southam, L, Panoutsopoulou, K, Rayner, NW, Esko, T, Estrada, K, Helgadottir, HT, Hofman, A., Ingvarsson, T, Jonsson, H, Keis, A, Kerkhof, HJM, Thorleifsson, G, Arden, NK, Carr, A, Chapman, K, Deloukas, P, Loughlin, J, McCaskie, A, Ollier, WER, Ralston, S.H., Spector, T.D., Wallis, GA, Wilkinson, JM, Aslam, N, Birell, F, Carluke, I, Joseph, J, Rai, A., Reed, M, Walker, K, Doherty, SA, Jonsdottir, I, Maciewicz, RA, Muir, KR, Metspalu, A, Rivadeneira, F., Stefansson, K, Styrkarsdottir, U, Uitterlinden, A.G., Meurs, J.B.J. van, Zhang, WY, Valdes, A.M., Doherty, M & Zeggini, E (2011). A Variant in MCF2L Is Associated with Osteoarthritis. American Journal of Human Genetics, 89(3), Deelen, J, Beekman, M, Uh, HW, Helmer, Q, Kuningas, M., Christiansen, L, Kremer, D., Breggen, R van der, Suchiman, HED, Lakenberg, N, Akker, EB van den, Passtoors, WM, Tiemeier, H.W., Heemst, D van, Craen, AJ de, Rivadeneira Ramirez, F., Geus, EJ de, Perola, M, Ouderaa, FJ van der, Gunn, DA, Boomsma, D.I., Uitterlinden, A.G., Christensen, K., Duijn, C.M. van, Heijmans, B.T., Houwing- Duistermaat, J.J., Westendorp, R.G.J. & Slagboom, P.E. (2011). Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited. Aging Cell, 10(4), Dehghan, A., Dupuis, J, Barbalic, M, Bis, JC, Eiriksdottir, G, Lu, C, Pellikka, N, Wallaschofski, H., Kettunen, J, Henneman, P., Baumert, J., Strachan, DP, Fuchsberger, C, Vitart, V, Wilson, JF, Pare, G, Naitza, S, Rudock, ME, Surakka, I, Geus, E.J.C. de, Alizadeh, B.Z., Guralnik, J, Shuldiner, A, Tanaka, T, Zee, RYL, Schnabel, RB, Nambi, V, Kavousi, M., Ripatti, S, Nauck, M., Smith, NL, Smith, AV, Sundvall, J, Scheet, P, Liu, YM, Ruokonen, A, Rose, LM, Larson, MG, Hoogeveen, RC, Freimer, N.B., Teumer, A, Tracy, RP, Launer, L.J., Buring, JE, Yamamoto, JF, Folsom, A.R., Sijbrands, E.J.G., Pankow, J, Elliott, P., Keaney, JF, Sun, W, Sarin, AP, Fontes, JD, Badola, S, Astor, BC, Hofman, A., Pouta, A, Werdan, K., Greiser, K.H., Kuss, O., Schwabedissen, HEMZ, Thiery, J, Jamshidi, Y, Nolte, I.M., Soranzo, N, Spector, T.D., Volzke, H, Parker, AN, Aspelund, T, Bates, D, Young, L, Tsui, K, Siscovick, D.S., Guo, XQ, Rotter, JI, Uda, M, Schlessinger, D, Rudan, I, Hicks, AA, Penninx, BW, Thorand, B, Gieger, C, Coresh, J, Willemsen, G, Harris, T.B., Uitterlinden, A.G., Jarvelin, MR, Rice, K, Radke, D, Salomaa, V, Dijk, KW van, Boerwinkle, E., Vasan, RS, Ferrucci, L, Gibson, QD, Bandinelli, S, Snieder, H, Boomsma, D.I., Xiao, XJ, Campbell, H, Hayward, C, Pramstaller, P.P., Duijn, C.M. van, Peltonen, L., Psaty, B.M., Gudnason, V, Ridker, P.M., Homuth, G., Koenig, W., Ballantyne, C.M., Witteman, J.C.M., Benjamin, EJ, Perola, M & Chasman, DI (2011). Meta-Analysis of Genome-Wide Association Studies in > Subjects Identifies Multiple Loci for C-Reactive Protein Levels. Circulation, 123(7), 731-U151. Demirkan, A., Amin, N., Isaacs, A, Jarvelin, MR, Whitfield, JB, Wichmann, HE, Kyvik, KO, Rudan, I, Gieger, C, Hicks, AA, Johansson, A, Hottenga, J.J., Smith, JJ, Wild, SH, Pedersen, NL, Willemsen, G, Mangino, M, Hayward, C, Uitterlinden, A.G., Hofman, A., Witteman, J.C.M., Montgomery, GW,

7 Pietilainen, KH, Rantanen, T, Kaprio, J, Doring, A, Pramstaller, P.P., Gyllensten, U, Geus, E.J.C. de, Penninx, BW, Wilson, JF, Rivadeneria, F, Magnusson, PKE, Boomsma, D.I., Spector, T., Campbell, H, Hoehne, B, Martin, NG, Oostra, B.A., McCarthy, M, Peltonen-Palotie, L, Aulchenko, Y., Visscher, P.M., Ripatti, S, Janssens, A.C.J.W. & Duijn, C.M. van (2011). Genetic architecture of circulating lipid levels. European Journal of Human Genetics, 19(7), Demirkan, A., Penninx, BWJH, Hek, K., Wray, NR, Amin, N., Aulchenko, Y.S., Dyck, R. van, Geus, E.J.C. de, Hofman, A., Uitterlinden, A.G., Hottenga, J.J., Nolen, W.A., Oostra, B.A., Sullivan, PF, Willemsen, G, Zitman, F.G., Tiemeier, H.W., Janssens, A.C.J.W., Boomsma, D.I., Duijn, C.M. van & Middeldorp, C.M. (2011). Genetic risk profiles for depression and anxiety in adult and elderly cohorts. Molecular Psychiatry, 16(7), Duncan, E.L., Danoy, P, Kemp, JP, Leo, PJ, McCloskey, E, Nicholson, GC, Eastell, R., Prince, R.L., Eisman, JA, Jones, G., Sambrook, PN, Reid, IR, Dennison, EM, Wark, J, Richards, JB, Uitterlinden, A.G., Spector, T.D., Esapa, C, Cox, RD, Brown, SDM, Thakker, R.V., Addison, KA, Bradbury, LA, Center, JR, Cooper, C., Cremin, C, Estrada, K, Felsenberg, D., Gluer, CC, Hadler, J, Henry, MJ, Hofman, A., Kotowicz, MA, Makovey, J, Nguyen, SC, Nguyen, T.V., Pasco, JA, Pryce, K, Reid, D.M., Rivadeneira, F., Roux, C, Stefansson, K, Styrkarsdottir, U, Thorleifsson, G, Tichawangana, R, Evans, DM & Brown, M.A. (2011). Genome-Wide Association Study Using Extreme Truncate Selection Identifies Novel Genes Affecting Bone Mineral Density and Fracture Risk. PLoS Genetics, 7(4). 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11 Maagdenberg, A.M.J.M. & Boomsma, D.I. (2011). Meta-analysis of genome-wide association for migraine in six population-based European cohorts. European Journal of Human Genetics, 19(8), Linde, D. van der, Yap, S.C., Dijk, APJ van, Budts, W, Pieper, P.G., Burgh, PH van der, Mulder, B.J.M., Witsenburg, M., Cuypers, J.A.A.E., Lindemans, J., Takkenberg, J.J.M. & Roos-Hesselink, J.W. (2011). Effects of Rosuvastatin on Progression of Stenosis in Adult Patients With Congenital Aortic Stenosis (PROCAS Trial). American Journal of Cardiology, 108(2), Liu, F., Struchalin, M.V., Duijn, J.K. van, Hofman, A., Uitterlinden, A.G., Duijn, C.M. van, Aulchenko, Y.S. & Kayser, M. (2011). Detecting Low Frequent Loss-of-Function Alleles in Genome Wide Association Studies with Red Hair Color as Example. PLoS One, 6(11). Loos, W.J., Graan, A.M. de, Bruijn, P. de, Schaik, R.H.N. van, Fessem, M.A.C. van, Lam, M.H., Mathijssen, R.H.J. & Wiemer, E.A.C. (2011). Simultaneous quantification of dextromethorphan and its metabolites dextrorphan, 3-methoxymorphinan and 3-hydroxymorphinan in human plasma by ultra performance liquid chromatography/tandem triple-quadrupole mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 54(2), Luijk, MPCM, Roisman, GI, Haltigan, JD, Tiemeier, H.W., Booth-LaForce, C, IJzendoorn, M.H. van, Belsky, J., Uitterlinden, A.G., Jaddoe, V.W.V.K., Hofman, A., Verhulst, F.C., Tharner, A. & Bakermans- Kranenburg, MJ (2011). Dopaminergic, serotonergic, and oxytonergic candidate genes associated with infant attachment security and disorganization? In search of main and interaction effects. Journal of Child Psychology and Psychiatry, 52(12), Manolopoulos, V.G., Dechairo, B, Huriez, A, Kuhn, A., LLerena, A, Schaik, R.H.N. van, Yeo, KTJ, Ragia, G & Siest, G (2011). Pharmacogenomics and personalized medicine in clinical practice. Pharmacogenomics, 12(5), Medici, M., Deure, W.M. van der, Verbiest, M., Vermeulen, SH, Hansen, PS, Kiemeney, LA, Hermus, ARMM, Breteler, M.M.B., Hofman, A., Hegedus, L, Kyvik, KO, Heijer, M. den, Uitterlinden, A.G., Visser, T.J. & Peeters, R.P. (2011). A large-scale association analysis of 68 thyroid hormone pathway genes with serum TSH and FT(4) levels. European Journal of Endocrinology, 164(5), Meestersy, RJW, Boer, E. den, Mathot, R.A.A., Jonge, R. de, Klaveren, R.J. van, Lindemans, J. & Luider, T.M. (2011). Ultrafast selective quantification of methotrexate in human plasma by highthroughput MALDI-isotope dilution mass spectrometry. Bioanalysis, 3(12), Nooijer, R.A. de, Nobel, J.M., Arets, H.G.M., Bot, A.G.M., Berkhout, FT van, Rijke, Y.B. de, Jonge, H.R. de & Bronsveld, I. (2011). Assessment of CFTR function in homozygous R117H-7T subjects. Journal of Cystic Fibrosis, 10(5), Obermann-Borst, S.A., Vujkovic, M., Vries, J.H. de, Wildhagen, M.F., Looman, C.W.N., Jonge, R. de, Steegers, E.A.P. & Steegers-Theunissen, R.P.M. (2011). A maternal dietary pattern characterised by fish and seafood in association with the risk of congenital heart defects in the offspring. Bjog-An International Journal of Obstetrics and Gynaecology, 118(10), Obermann-Borst, S.A., Driel, L.M.J.W. van, Helbing, W.A., Jonge, R. de, Wildhagen, M.F., Steegers, E.A.P. & Steegers-Theunissen, R.P.M. (2011). Congenital heart defects and biomarkers of methylation in children: a case-control study. European Journal of Clinical Investigation, 41(2), Ohlsson, C, Wallaschofski, H., Lunetta, KL, Stolk, L., Perry, JRB, Koster, A., Petersen, AK, Eriksson, J, Lehtimaki, T, Huhtaniemi, I.T., Hammond, GL, Maggio, M, Coviello, AD, Ferrucci, L, Heier, M, Hofman, A., Holliday, KL, Jansson, JO, Kahonen, M, karasik, D., Karlsson, MK, Kiel, DP, Liu, YM, Ljunggren, O, Lorentzon, M, Lyytikainen, LP, Meitinger, T, Mellstrom, D., Melzer, D, Miljkovic, I, Nauck, M., Nilsson, M, Penninx, B, Pye, S.R., Vasan, RS, Reincke, M, Rivadeneira, F., Tajar, A, Teumer, A, Uitterlinden, A.G., Ulloor, J, Viikari, J, Volker, U, Volzke, H, Wichmann, HE, Wu, TS, Zhuang, WV, Ziv, E, Wu, FCW, Raitakari, O, Eriksson, A, Bidlingmaier, M., Harris, T.B., Murray, A, Jong, F.H. de, Murabito, JM,

12 Bhasin, S, Vandenput, L & Haring, R (2011). Genetic Determinants of Serum Testosterone Concentrations in Men. PLoS Genetics, 7(10). Panoutsopoulou, K, Southam, L, Elliott, KS, Wrayner, N, Zhai, G., Beazley, C, Thorleifsson, G, Arden, NK, Carr, A, Chapman, K, Deloukas, P, Doherty, M, McCaskie, A, Ollier, WER, Ralston, S.H., Spector, T.D., Valdes, A.M., Wallis, GA, Wilkinson, JM, Arden, E, Battley, K, Blackburn, H, Blanco, FJ, Bumpstead, S, Cupples, L.A., Day-Williams, AG, Dixon, K, Doherty, SA, Esko, T, Evangelou, E, Felson, D, Gomez-Reino, JJ, Gonzalez, A., Gordon, A, Gwilliam, R, Halldorsson, BV, Hauksson, VB, Hofman, A., Hunt, SE, Ioannidis, JPA, Ingvarsson, T, Jonsdottir, I, Jonsson, H, Keen, R., Kerkhof, HJM, Kloppenburg, MG, Koller, N, Lakenberg, N, Lane, NE, Lee, AT, Metspalu, A, Meulenbelt, I., Nevitt, MC, O'Neill, F, Parimi, N, Potter, SC, Rego-Perez, I, Riancho, JA, Sherburn, K, Slagboom, P.E., Stefansson, K, Styrkarsdottir, U, Sumillera, M, Swift, D, Thorsteinsdottir, U, Tsezou, A, Uitterlinden, A.G., Meurs, J.B.J. van, Watkins, B, Wheeler, M, Mitchell, S, Zhu, Y., Zmuda, JM, Zeggini, E & Loughlin, J (2011). Insights into the genetic architecture of osteoarthritis from stage 1 of the arcogen study. Annals of the Rheumatic Diseases, 70(5), Pashaee, N, Bouamar, R., Hesselink, D.A., Roodnat, J.I., Schaik, R.H.N. van, Weimar, W. & Gelder, T. van (2011). CYP3A5 Genotype Is Not Related to the Intrapatient Variability of Tacrolimus Clearance. Therapeutic Drug Monitoring, 33(3), Rakhmanina, N.Y., Neely, MN, Schaik, R.H.N. van, Gordish-Dressman, HA, Williams, KD, Soldin, SJ & Anker, J.N. van den (2011). CYP3A5, ABCB1, and SLCO1B1 Polymorphisms and Pharmacokinetics and Virologic Outcome of Lopinavir/Ritonavir in HIV-Infected Children. Therapeutic Drug Monitoring, 33(4), Ramdas, W.D., Koolwijk, L.M.E. van, Cree, AJ, Janssens, A.C.J.W., Amin, N., Jong, P.T.V.M. de, Wolfs, R.C.W., Gibson, J, Kirwan, JF, Hofman, A., Rivadeneira, F., Oostra, B.A., Uitterlinden, A.G., Ennis, S, Lotery, AJ, Lemij, H.G., Klaver, C.C.W., Vingerling, J.R., Jansonius, N.M. & Duijn, C.M. van (2011). Clinical Implications of Old and New Genes for Open-Angle Glaucoma. Ophthalmology, 118(12), Ramdas, W.D., Koolwijk, L.M.E. van, Lemij, H.G., Pasutto, F, Cree, AJ, Thorleifsson, G, Janssen, SF, Jacoline, T, Amin, N., Rivadeneira Ramirez, F., Wolfs, R.C.W., Walters, GB, Jonasson, F, Weisschuh, N, Mardin, CY, Gibson, J, Zegers, RHC, Hofman, A., Jong, P.T.V.M. de, Uitterlinden, A.G., Oostra, B.A., Thorsteinsdottir, U, Gramer, E, Welgen-Lussen, UC, Kirwan, JF, Bergen, A.A.B., Reis, A., Stefansson, K, Lotery, AJ, Vingerling, J.R., Jansonius, N.M., Klaver, C.C.W. & Duijn, C.M. van (2011). Common genetic variants associated with open-angle glaucoma. Human Molecular Genetics, 20(12), Schaik, R.H.N. van, Kok, M. de, Sweep, F.C.G.J., Vliet, M. van, Fessem, M. van, Gelder, M.E. van, Seynaeve, C., Lindemans, J., Wesseling, J., Veer, L.J. van 't, Span, P.N., Laarhoven, H van, Sleijfer, S., Foekens, J.A., Linn, SC & Berns, P.M.J.J. (2011). The CYP2C19*2 genotype predicts tamoxifen treatment outcome in advanced breast cancer patients. Pharmacogenomics, 12(8), Schumann, G, Coin, LJ, Lourdusamy, A, Charoen, P, Berger, KH, Stacey, D, Desrivieres, S, Aliev, FA, Khan, AA, Amin, N., Aulchenko, Y.S., Bakalkin, G, Bakker, SJ, Balkau, B, Beulens, JW, Bilbao, A, Boer, R.A. de, Beury, D, Bots, M.L., Breetvelt, EJ, Cauchi, S, Cavalcanti-Proenca, C, Chambers, JC, Clarke, TK, Dahmen, N, Geus, EJ de, Dick, D, Ducci, F, Easton, A, Edenberg, HJ, Esk, T, Fernandez-Medarde, A, Foroud, T., Freimer, N.B., Girault, JA, Grobbee, D.E., Guarrera, S, Gudbjartsson, DF, Hartikainen, AL, Heath, AC, Hesselbrock, V, Hofman, A., Hottenga, J.J., Isohanni, MK, Kaprio, J, Khaw, KT, Kuehnel, B, Laitinen, J, Lobbens, S, Luan, JA, Mangino, M, Maroteaux, M, Matullo, G, McCarthy, MI, Mueller, C., Navis, G, Numans, M.E., Nunez, A, Nyholt, DR, Onland-Moret, CN, Oostra, B.A., O'Reilly, PF, Palkovits, M, Penninx, BW, Polidoro, S, Pouta, A, Prokopenko, I, Ricceri, F, Santos, E, Smit, J.H., Soranzo, N, Song, K, Sovio, U, Stumvoll, M., Surakk, I, Thorgeirsson, TE, Thorsteinsdottir, U, Troakes, C, Tyrfingsson, T, Tonjes, A, Uiterwaal, CS, Uitterlinden, A.G., Harst, P. van der, Schouw, Y.T. van der, Staehlin, O, Vogelzangs, N, Vollenweider, P, Waeber, G, Wareham, NJ, Waterworth, D.M., Whitfield, JB, Wichmann, EH, Willemsen, G, Witteman, J.C.M., Yuan, X, Zhai, GJ, Zhao, JH, Zhang, WH, Martin, NG, Metspalu, A, Doering, A, Scott, J, Spector, T.D., Loos, RJ, Boomsma, D.I., Mooser, V,

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