Research Annual Report 2011

Transcription

1 Research Annual Report 2011 Netherlands Institute for Health Sciences (NIHES) Assessment, Treatment and Translational Research in Recontructive Surgery Epidemiology of diseases Basic epidemiologic research Clinical epidemiology Biostatistics Effects of screening and clinical interventions on population health Determinants of population health and primary prevention Clinical research in general practice. Implementation of diagnostic and interventional imaging technology Assessment of diagnostic and interventional imaging technology Development of acquisition and processing techniques for diagnostic imaging Structuring of medical knowledge Structuring of medical data Assessment, aetiology and course of child and adolescent psychiatry 13019, B&T Ontwerp en advies (

2 Research Annual Report 2011 Netherlands Institute for Health Sciences (NIHES) Adaptation of (future) patients to disease and treatment in order to improve counselling and guidance Health care management (theme 3) Quality and efficiency in health care (theme 2) Competition and regulation in health care (theme 1) 13019, B&T Ontwerp en advies (

3 EMC NIHES A - Assessment, Treatment and Translational Research in Recontructive Surgery Programme (brief description) The program `Assessment, Treatment and Translational Research in Reconstructive Surgery relates to research questions derived from three main patient groups: upper extremity disorders, craniofacial disorders and patients requiring reconstructions after oncological resection. Furthermore wound healing plays an important role in reconstructive surgery. Within these three patient groups, we share the same three research topics, which are often interrelated. 1) Development and evaluation of innovative clinical interventions, either in randomized or cohort studies. 2) Development and application of new assessment tools, such as new imaging techniques and measurement tools to be used for both diagnosis and outcome assessment. 3) Development and evaluation of innovative experimental interventions with a close relation to the clinic. Most clinical and translational research is multidisciplinary, resulting in collaboration with a large number of clinical and preclinical departments. Key Figures Department Sp1 Sp2 Sp3 Sp4 SpTot T1 T2 T3 Ttot IS FS OP Ptot oral and maxillofacial surgery 0,2 0,2 pediatric psychiatry 0,1 0,1 plastic and reconstructive surgery 3,65 4,4 8,05 rehabilitation 0,4 0,9 1,3 Total 4,35 5,3 9, Thesis Damen, T.H.C. (2011, november 04). Technical, psychological and economical aspects of DIEP flap breast reconstruction. EUR. Prom./coprom.: Prof. Dr. S.E.R. Hovius. Korstanje, J.W.H. (2011, november 16). Sound findings on hand dynamics. EUR. Prom./coprom.: Prof. Dr. S.E.R. Hovius & Prof. Dr. H.J. Stam. Nijhuis, T.H.J. (2011, december 16). Bridging the gap in relation to nerve injury. EUR. Prom./coprom.: Prof. Dr. S.E.R. Hovius. Verseijden, F. (2011, januari 07). Engineering vascularized adipose tissue. EUR (144 pag.). Prom./coprom.: Prof. Dr. S.E.R. Hovius, Prof. Dr. G.J.V.M. van Osch & Dr. S.O.P. Hofer. Article/Letter to the editor Bannink, N., Maliepaard, M., Raat, H., Joosten, K.F.M. & Mathijssen, I.M.J. (2011). Obstructive Sleep Apnea-Specific Quality of Life and Behavioral Problems in Children with Syndromic Craniosynostosis. Journal of Developmental and Behavioral Pediatrics, 32(3), Bannink, N., Maliepaard, M., Raat, H., Joosten, K.F.M. & Mathijssen, I.M.J. (2011). Reliability and Validity of the Obstructive Sleep Apnea-18 Survey in Healthy Children and Children With Syndromic Craniosynostosis. Journal of Developmental and Behavioral Pediatrics, 32(1), Becker, M.L., Paes, E.C., Sijs, I.H. van der & Nieuwenhoven, C.A. van (2011). The treatment of drug extravasation. Nederlands Tijdschrift voor Geneeskunde, 155. Bosch, D.G.M., Nieuwenhoven, C.A. van & Hoogeboom, A.J.M. (2011). Brachydactyly: a rare complication of sickle cell anaemia. Clinical Dysmorphology, 20(3),

4 Damen, T.H.C., Wei, W., Mureau, M.A.M., Tjong Joe Wai, R., Hofer, S.O.P., Essink-Bot, M.L., Hovius, S.E.R. & Polinder, S. (2011). Medium-term cost analysis of breast reconstructions in a single Dutch centre: A comparison of implants, implants preceded by tissue expansion, LD transpositions and DIEP flaps. Journal of Plastic, Reconstructive & Aesthetic Surgery, 64(8), Driessen, C., Bannink, N., Lequin, M.H., Veelen, M.L.C. van, Naus, N.C., Joosten, K.F.M. & Mathijssen, I.M.J. (2011). Are ultrasonography measurements of optic nerve sheath diameter an alternative to funduscopy in children with syndromic craniosynostosis? Clinical article. Journal of Neurosurgery- Pediatrics, 8(3), Elzen, M.E.P. van den, Versnel, S.L., Wolvius, E.B., Veelen, M.L.C. van, Vaandrager, J.M., Meulen, J.C. van der & Mathijssen, I.M.J. (2011). Long-term results after 40 years experience with treatment of rare facial clefts: Part 2-symmetrical median clefts. Journal of Plastic, Reconstructive & Aesthetic Surgery, 64(10), Eveleens, J.R.J., Mathijssen, I.M.J>, Lequin, M.H., Polling, J.R., Looman, C.W.N. & Simonsz, H.J. (2011). Vertical Position of the Orbits in Nonsyndromic Plagiocephaly in Childhood and Its Relation to Vertical Strabismus. Journal of Craniofacial Surgery, 22(1), Ferguson, N.M., Mathijssen, I.M.J., Hofer, S.O.P. & Mureau, M.A.M. (2011). Decision making in reconstruction of defects of the eyelid. Journal of Plastic Surgery and Hand Surgery, 45(1), Florisson, J.M.G., Dudink, J., Koning, I, Hop, W.C.J., Veelen, M.L.C. van, Mathijssen, I.M.J. & Lequin, M.H. (2011). Assessment of White Matter Microstructural Integrity in Children with Syndromic Craniosynostosis: A Diffusion-Tensor Imaging Study. Radiology, 261(2), Fuchs, S.P., Walbeehm, E.T. & Hovius, S.E.R. (2011). Biomechanical evaluation of the Pulvertaft versus the 'wrap around' tendon suture technique. Journal of Hand Surgery-European Volume, 36E(6), Gopie, JP, Timman, R., Hilhorst, M.T., Hofer, S.O.P., Mureau, M.A.M. & Tibben, A. (2011). Information-seeking behaviour and coping style of women opting for either implant or DIEP-flap breast reconstruction. Journal of Plastic, Reconstructive & Aesthetic Surgery, 64(9), Gopie, JP, Hilhorst, M.T., Kleijne, A, Timman, R., Menke-Pluymers, M.B.E., Hofer, S.O.P., Mureau, M.A.M. & Tibben, A. (2011). Women's motives to opt for either implant or DIEP-flap breast reconstruction. Journal of Plastic, Reconstructive & Aesthetic Surgery, 64(8), Hofer, S.O.P. & Mureau, M.A.M. (2011). Improving outcomes in aesthetic facial reconstruction. Perioperative Nursing Clinics, 6, Hovius, S.E.R., Kan, H.J., Smit, X., Selles, R.W., Cardoso, E & Khouri, R.K. (2011). Extensive Percutaneous Aponeurotomy and Lipografting: A New Treatment for Dupuytren Disease. Plastic and Reconstructive Surgery, 128(1), Huisstede, B.M.A., Hoogvliet, P., Paulis, W.D., Middelkoop, M. van, Hausman, M, Coert, J.H. & Koes, B.W. (2011). Effectiveness of Interventions for Secondary Raynaud's Phenomenon: A Systematic Review. Archives of Physical Medicine and Rehabilitation, 92(7), Jong, T. de, Mathijssen, I.M.J. & Hoogeboom, A.J.M. (2011). Additional Phenotypic Features of Muenke Syndrome in 2 Dutch Families. Journal of Craniofacial Surgery, 22(2), Jong, T. de, Toll, M.S., Gier, H.H.W. de & Mathijssen, I.M.J. (2011). Audiological Profile of Children and Young Adults With Syndromic and Complex Craniosynostosis. Archives of Otolaryngology-Head & Neck Surgery, 137(8),

5 Leen, M.W.F. van, Hovius, S.E.R., Neyens, J., Halfens, R. & Schols, J (2011). Pressure relief, cold foam or static air? a single center, prospecive, controlled randomized clinical trial in a Dutch nursing home. Journal of Tissue Viability, 20(1), Luijsterburg, A.J.M. & Vermeij-Keers, C. (2011). Ten Years Recording Common Oral Clefts With a New Descriptive System. Cleft Palate-Craniofacial Journal, 48(2), Michielsen, M.E., Selles, R.W., Geest, J.N. van der, Eckhardt, M., Yavuzer, M.G., Stam, H.J., Smits, M., Ribbers, G.M. & Bussmann, J.B.J. (2011). Motor Recovery and Cortical Reorganization After Mirror Therapy in Chronic Stroke Patients: A Phase II Randomized Controlled Trial. Neurorehabilitation and Neural Repair, 25(3), Michielsen, M.E., Smits, M., Ribbers, G.M., Stam, H.J., Geest, J.N. van der, Bussmann, J.B.J. & Selles, R.W. (2011). The neuronal correlates of mirror therapy: an fmri study on mirror induced visual illusions in patients with stroke. Journal of Neurology Neurosurgery and Psychiatry, 82(4), Molenaar, H.M., Selles, R.W., Willemsen, S.P., Hovius, S.E.R. & Stam, H.J. (2011). Growth Diagrams for Individual Finger Strength in Children Measured with the RIHM. Clinical Orthopaedics & Related Research, 469(3), Moolenburgh, S.E., Mac Lennan, L.M., Levendag, P.C., Munte, K., Scholtemeijer, M., Hofer, S.O.P. & Mureau, M.A.M. (2011). Reply: Nasal Reconstruction after Malignant Tumor Resection: An Algorithm for Treatment. Plastic and Reconstructive Surgery, 127(3), Moues, C.M., Heule, F. & Hovius, S.E.R. (2011). A review of topical negative pressure therapy in wound healing: sufficient evidence? American Journal of Surgery, 201(4), Mureau, M.A.M. (2011). Historical accounts of Netherlands Society for Plastic Surgery. IPRAS Journal, 6, Neck, J.W. van, Zuidema, Y.S., Smulders, M. & Balmus, KJ (2011). Unexpected healing of radiationinduced scalp lesions with OTR4120, a heparan sulfate mimetic. European Journal of Dermatology, 21(3), Nieminen, P, Morgan, NV, Fenwick, AL, Parmanen, S, Veistinen, L, Mikkola, ML, Spek, P.J. van der, Giraud, A, Judd, L, Arte, S, Brueton, LA, Wall, S.A., Mathijssen, I.M.J., Maher, ER, Wilkie, A.O.M., Kreiborg, S & Thesleff, I (2011). Inactivation of IL11 Signaling Causes Craniosynostosis, Delayed Tooth Eruption, and Supernumerary Teeth. American Journal of Human Genetics, 89(1), Nijhuis, T.H.J., Slatman, J., Ulrich, D.J.O. & Hovius, S.E.R. (2011). Gezichtstransplantatie: ` you need a face to face the world. Tijdschrift voor Gezondheidszorg en ethiek, 21(2), Nijhuis, T.H.J., Smits, E.S., Neck, J.W. van, Visser, G.H., Walbeehm, E.T., Blok, J.H. & Hovius, S.E.R. (2011). Ultrasound-guided needle positioning near the sciatic nerve to elicit compound muscle action potentials from the gastrocnemius muscle of the rat. Journal of Neuroscience Methods, 194(2), Overbeek, J.A., Penning- van Beest, F.J.A., Heintjes, E.M., Gerber, R.A., Cappelleri, J.C., Hovius, S.E.R. & Herings, R.M.C. (2011). Dupuytren's contracture: a retrospective database analysis to determine hospitalizations in the netherlands. BMC Research Notes, 4, 402. Perez-Amodio, S, Tra, W.M.W., Rakhorst, H.A., Hovius, S.E.R. & Neck, J.W. van (2011). Hypoxia Preconditioning of Tissue-Engineered Mucosa Enhances Its Angiogenic Capacity In Vitro. Tissue Engineering Part A, 17(11-12), Putter, C.E. de, Beeck, E.F. van, Looman, C.W.N., Toet, H., Hovius, S.E.R. & Selles, R.W. (2011). Trends in Wrist Fractures in Children and Adolescents, Journal of Hand Surgery-American Volume, 36A(11),

6 Rossen, M.E.E. van, Verduijn, PV & Mureau, M.A.M. (2011). Survival of pedicled pectoralis major flap after secondary myectomy of muscle pedicle including transection of thoracoacromial vessels: Does the flap remain dependent on its dominant pedicle? Journal of Plastic, Reconstructive & Aesthetic Surgery, 64(3), Rozendaal, A.M., Luijsterburg, A.J.M., Ongkosuwito, E.M., Vries, E. de & Vermeij-Keers, C. (2011). Decreasing prevalence of oral cleft live births in the Netherlands, Archives of Disease in Childhood. Fetal and Neonatal Edition, 96(3), F212-F216. Ruijs, A.C.J., Niehof, S.P., Hovius, S.E.R. & Selles, R.W. (2011). Cold-Induced Vasodilatation Following Traumatic Median or Ulnar Nerve Injury. Journal of Hand Surgery-American Volume, 36A(6), Smits, E.S., Nijhuis, T.H.J., Huygen, F.J.P.M., Selles, R.W., Hovius, S.E.R. & Niehof, S.P. (2011). Rewarming Patterns in Hand Fracture Patients With and Without Cold Intolerance. Journal of Hand Surgery-American Volume, 36A(4), Stokvis, A. & Coert, J.H. (2011). Operative treatment of painful neuromas. Nederlands Tijdschrift voor Geneeskunde, 155(18). Theeuwes, H.P., Gosselink, M.P., Bruynzeel, J.A., Kleinrensink, G.J. & Walbeehm, E.T. (2011). An Anatomical Study of the Length of the Neural Pedicle after the Bifurcation of the Thoracodorsal Nerve: Implications for Innervated Free Partial Latissimus Dorsi Flaps. Plastic and Reconstructive Surgery, 127(1), Tong, M., Tuk, B., Hekking-Weijma, J.M., Pleumeekers, M.M., Boldewijn, MB, Hovius, S.E.R. & Neck, J.W. van (2011). Heparan sulfate glycosaminoglycan mimetic improves pressure ulcer healing in a rat model of cutaneous ischemia-reperfusion injury. Wound Repair and Regeneration, 19(4), Ulrich, D.J.O., Piatkowski, A & Pallua, N (2011). Anterior interosseous nerve syndrome: retrospective analysis of 14 patients. Archives of Orthopaedic and Trauma Surgery, 131(11), Ulrich, D.J.O., Smeets, R., Unglaub, F, Woltje, M & Pallua, N (2011). Effect of Oxidized Regenerated Cellulose/Collagen Matrix on Proteases in Wound Exudate of Patients With Diabetic Foot Ulcers. Journal of Wound Ostomy and Continence Nursing, 38(5), Ulrich, D.J.O., Doorn, H.C. van & Hovius, S.E.R. (2011). Fat injection for treatment of painful neuroma after episiotomy. International Journal of Gynecology & Obstetrics, 115(3), Verbruggen, S.C.A.T., Betue, C.T.I. de, Schierbeek, H., Chacko, S., Adrichem, L.N.A. van, Verhoeven, J.J., Goudoever, J.B. van & Joosten, K.F.M. (2011). Reducing glucose infusion safely prevents hyperglycemia in post-surgical children. Clinical Nutrition, 30, Vermeulen, G.M., Slijper, H.P., Feitz, R., Hovius, S.E.R., Moojen, TM & Selles, R.W. (2011). Surgical Management of Primary Thumb Carpometacarpal Osteoarthritis: A Systematic Review. Journal of Hand Surgery-American Volume, 36A(1), Viddeleer, AR, Sijens, P.E., Ooijen, P.M.A. van, Kuypers, P.D.L., Hovius, S.E.R. & Oudkerk, M. (2011). MR intensity measurements of nondenervated muscle in patients following severe forearm trauma. Nmr in Biomedicine, 24(7),

7 EMC NIHES Epidemiology of diseases Programme (brief description) This program includes scientific research in cardiovascular epidemiology, neuroepidemiology and ophthalmologic epidemiology. Cardiovascular epidemiologic research focuses on the determinants of atherosclerosis and coronary heart disease in the elderly, and on cardiovascular diseases in women. The research is based on the Rotterdam Study and addresses inflammation markers and hemostasis as determinants of cardiovascular diseases in the elderly, and the effects of menopause, endogenous hormones and hormone replacement therapy in women. Neuroepidemiologic research focuses on the etiology of neurodegenerative and cerebrovascular diseases, including dementia and Alzheimer's disease, Parkinson's disease, stroke and cerebral white matter lesions. The research emphasizes the role of vascular factors in the etiology of these diseases, with use of state of the art neuroimaging techniques. Ophthalmological epidemiologic research focuses on determinants of macula degeneration and glaucoma. The emphasis is on the putative role of genetic factors and vascular factors in etiology of these diseases. Key Figures Department Sp1 Sp2 Sp3 Sp4 SpTot T1 T2 T3 Ttot IS FS OP Ptot epidemiology 6,14 7,84 3,27 17,25 neurology 0,08 0,08 pediatric psychiatry 0,05 0,35 0,4 Total 6,27 8,19 3,27 17, Article/Letter to the editor Arking, DE, Junttila, MJ, Goyette, P, Huertas-Vazquez, A, Eijgelsheim, M., Blom, MT, Newton-Cheh, C, Reinier, K, Teodorescu, C, Uy-Evanado, A, Carter-Monroe, N, Kaikkonen, KS, Kortelainen, ML, Boucher, G, Lagace, C, Moes, A, Zhao, XQ, Kolodgie, F, Rivadeneira, F., Hofman, A., Witteman, J.C.M., Uitterlinden, A.G., Marsman, RF, Pazoki, R, Bardai, A., Koster, RW, Dehghan, A., Hwang, SJ, Bhatnagar, P, Post, W., Hilton, G, Prineas, RJ, Li, M., Kottgen, A, Ehret, G, Boerwinkle, E., Coresh, J, Kao, WHL, Psaty, B.M., Tomaselli, G.F., Sotoodehnia, N, Siscovick, D.S., Burke, GL, Marban, E, Spooner, PM, Cupples, L.A., Jui, J, Gunson, K, Kesaniemi, YA, Wilde, A.A.M., Tardif, JC, O'Donnell, CJ, Bezzina, C.R., Virmani, R., Stricker, B.H.C., Tan, H.L., Albert, CM, Chakravarti, A, Rioux, JD, Huikuri, HV & Chugh, SS (2011). Identification of a Sudden Cardiac Death Susceptibility Locus at 2q24.2 through Genome-Wide Association in European Ancestry Individuals. PLoS Genetics, 7(6). Artigas, MS, Loth, D.W., Wain, LV, Gharib, SA, Obeidat, M, Tang, WB, Zhai, GJ, Zhao, JH, Smith, AV, Huffman, JE, Albrecht, E, Jackson, CM, Evans, DM, Cadby, G, Fornage, M, Manichaikul, A, Lopez, LM, Johnson, T, Aldrich, MC, Aspelund, T, Barroso, I, Campbell, H, Cassano, PA, Couper, DJ, Eiriksdottir, G, Franceschini, N, Garcia, M, Gieger, C, Gislason, GK, Grkovic, I, Hammond, CJ, Hancock, DB, Harris, T.B., Ramasamy, A, Heckbert, SR, Heliovaara, M, Homuth, G., Hysi, PG, Alan, L, Jankovic, S, Joubert, BR, Karrasch, S, Klopp, N, Koch, B, Kritchevsky, SB, Launer, L.J., Liu, YM, Loehr, LR, Lohman, K, Loos, RJF, Lumley, T, Balushi, KA Al, Ang, WQ, Barr, RG, Beilby, J, Blakey, JD, Boban, M, Boraska, V, Brisman, J, Britton, JR, Brusselle, GG, Cooper, C., Curjuric, I, Dahgam, S, Deary, IJ, Ebrahim, S, Eijgelsheim, M., Francks, C, Gaysina, D, Granell, R., Gu, XJ, Hankinson, J.L., Hardy, R, Harris, SE, Henderson, J., Henry, A, Hingorani, AD, Hofman, A., Holt, P.G., Hui, JN, Hunter, ML, Imboden, M, Jameson, KA, Kerr, SM, Kolcic, I, Kronenberg, F, Liu, JZ, Marchini, J, McKeever, T, Morris, A.D., Olin, AC, Porteous, D.J., Postma, D.S., Rich, SS, Ring, SM, Rivadeneira Ramirez, F., Rochat, T, Sayer, AA, Sayers, I, Sly, P.D., Smith, G.D., Sood, A, Starr, JM, Uitterlinden, A.G., Vonk, JM, Wannamethee, SG, Whincup, PH, Wijmenga, C., Williams, OD, Wong, A, Mangino, M, Marciante, KD, McArdle, WL, Meibohm, B, Morrison, AC, North, KE, Omenaas, E, Palmer, LJ, Pietilainen, KH, Pin, I, Polasek, O, Pouta, A, Psaty, B.M., Hartikainen, AL, Rantanen, T, Ripatti, S, Rotter, JI, Rudan, I, Rudnicka, AR, Schulz, H., Shin, SY, Spector, T.D., Surakka, I, Vitart, V, Volzke, H, Wareham, NJ, Warrington, NM, Wichmann, HE, Wild, SH, Wilk, JB, Wjst, M, Wright, AF, Zgaga, L, Zemunik, T, Pennell, CE, Nyberg, F, Kuh, D, Holloway, JW, Boezen, H.M., Lawlor, DA, Morris, RW, Probst-Hensch, N, Kaprio, J, Wilson, JF,

8 Hayward, C, Kahonen, M, Heinrich, J., Musk, AW, Jarvis, DL, Glaser, S, Jarvelin, MR, Stricker, B.H.C., Elliott, P., O'Connor, GT, Strachan, DP, London, SJ, Hall, IP, Gudnason, V & Tobin, MD (2011). Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nature Genetics, 43(11), 1082-U70. Axenovich, T, Zorkoltseva, I, Belonogova, N, Koolwijk, L van, Borodin, P, Kirichenko, A, Babenko, V, Ramdas, W.D., Amin, N., Despriet, D., Vingerling, J.R., Lemij, H, Oostra, B.A., Klaver, C.C.W., Aulchenko, Y. & Duijn, C.M. van (2011). Linkage and association analyses of glaucoma related traits in a large pedigree from a Dutch genetically isolated population. Journal of Medical Genetics, 48(12), Ay, L., Jaddoe, V.W.V.K., Hofman, A., Moll, H.A., Raat, H., Steegers, E.A.P. & Hokken-Koelega, A.C.S. (2011). Foetal and postnatal growth and bone mass at 6 months: the Generation R study. Clinical Endocrinology, 74, Bakker, R., Kruithof, C.J., Steegers, E.A.P., Tiemeier, H.W., Mackenbach, J.P., Hofman, A. & Jaddoe, V.W.V.K. (2011). Assessment of Maternal Smoking Status During Pregnancy and the Associations With Neonatal Outcomes. Nicotine & Tobacco Research, 13(12), Bakker, R., Steegers, E.A.P., Hofman, A. & Jaddoe, V.W.V.K. (2011). Blood Pressure in Different Gestational Trimesters, Fetal Growth, and the Risk of Adverse Birth Outcomes. American Journal of Epidemiology, 174(7), Bakker, R., Steegers, E.A.P., Biharie, A.A., Mackenbach, J.P., Hofman, A. & Jaddoe, V.W.V.K. (2011). Explaining differences in birth outcomes in relation to maternal age: the Generation R Study Reply. Bjog-An International Journal of Obstetrics and Gynaecology, 118(9), Bakker, R., Timmermans, S., Steegers, E.A.P., Hofman, A. & Jaddoe, V.W.V.K. (2011). Folic Acid Supplements Modify the Adverse Effects of Maternal Smoking on Fetal Growth and Neonatal Complications. Journal of Nutrition, 141(12), Bakker, R., Steegers, E.A.P., Raat, H., Hofman, A. & Jaddoe, V.W.V.K. (2011). Maternal Caffeine Intake, Blood Pressure, and the Risk of Hypertensive Complications During Pregnancy. The Generation R Study. American Journal of Hypertension, 24(4), Barzouhi, A el, Elias-Smale, S.E., Dehghan, A., Vliegenthart-Proenca, R, Oudkerk, M., Hofman, A. & Witteman, J.C.M. (2011). Renal Function Is Related to Severity of Coronary Artery Calcification in Elderly Persons: The Rotterdam Study. PLoS One, 6(2). Becker, M.L., Visser, L.E., Schaik, R.H.N. van, Hofman, A., Uitterlinden, A.G. & Stricker, B.H.C. (2011). OCT1 polymorphism is associated with response and survival time in anti-parkinsonian drug users. Neurogenetics, 12(1), Bis, JC, Kavousi, M., Franceschini, N, Isaacs, A, Abecasis, GR, Schminke, U, Post, WS, Smith, AV, Cupples, L.A., Markus, HS, Schmidt, R., Huffman, JE, Lehtimaki, T, Baumert, J., Munzel, T, Heckbert, SR, Dehghan, A., North, K, Oostra, B.A., Bevan, S, Stoegerer, EM, Hayward, C, Raitakari, O, Meisinger, C, Schillert, A, Sanna, S, Volzke, H, Cheng, YC, Thorsson, B, Fox, CS, Rice, K, Rivadeneira, F., Nambi, V, Halperin, E, Petrovic, KE, Peltonen, L., Wichmann, HE, Schnabel, RB, Dorr, M, Parsa, A, Aspelund, T, Demissie, S, Kathiresan, S, Reilly, MP, Taylor, K., Uitterlinden, A., Couper, DJ, Sitzer, M, Kahonen, M, Illig, T, Wild, PS, Orru, M, Ludemann, J, Shuldiner, AR, Eiriksdottir, G, White, CC, Rotter, JI, Hofman, A., Seissler, J, Zeller, T, Usala, G, Ernst, F, Launer, L.J., D'Agostino, RB, O'Leary, DH, Ballantyne, C., Thiery, J, Ziegler, A, Lakatta, EG, Chilukoti, RK, Harris, T.B., Wolf, PA, Psaty, B.M., Polak, JF, Li, X., Rathmann, W, Uda, M, Boerwinkle, E., Klopp, N, Schmidt, H., Wilson, JF, Viikari, J, Koenig, W., Blankenberg, S, Newman, AB, Witteman, J.C.M., Heiss, G, Duijn, C.M. van, Scuteri, A, Homuth, G., Mitchell, B.D., Gudnason, V & O'Donnell, CJ (2011). Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque. Nature Genetics, 43(10), 940-U40.

9 Boehringer, S, Lijn, F. van der, Liu, F., Gunther, M, Sinigerova, S, Nowak, S, Ludwig, KU, Herberz, R, Klein, S., Hofman, A., Uitterlinden, A.G., Niessen, W.J., Breteler, M.M.B., Lugt, A. van der, Wurtz, RP, Nothen, MM, Horsthemke, B., Wieczorek, D, Mangold, E & Kayser, M. (2011). Genetic determination of human facial morphology: links between cleft-lips and normal variation. European Journal of Human Genetics, 19(11), Boer, R. de, Schaap, M., Lijn, F. van der, Vrooman, H.A., Groot, M. de, Lugt, A. van der, Ikram, M.A., Vernooij, M.W., Breteler, M.M.B. & Niessen, W.J. (2011). Statistical analysis of minimum cost path based structural brain connectivity. Neuroimage, 55(2), Boger, CA, Gorski, M, Li, M., Hoffmann, MM, Huang, CM, Yang, Q, Teumer, A, Krane, V, O'Seaghdha, CM, Kutalik, Z, Wichmann, HE, Haak, T., Boes, E, Coassin, S, Coresh, J, Kollerits, B, Haun, M, Paulweber, B, Kottgen, A, Li, G., Shlipak, M.G., Powe, N, Hwang, SJ, Dehghan, A., Rivadeneira, F., Uitterlinden, A., Hofman, A., Beckmann, J.S., Kramer, BK, Witteman, J.C.M., Bochud, M, Siscovick, D, Rettig, R, Kronenberg, F, Wanner, C, Thadhani, RI, Heid, IM, Fox, CS & Kao, WH (2011). Association of egfr-related Loci Identified by GWAS with Incident CKD and ESRD. PLoS Genetics, 7(9). Booij, JC, Bakker, A., Kulumbetova, J, Moutaoukil, Y, Smeets, B., Verheij, J., Kroes, HY, Klaver, C.C.W., Schooneveld, M Van, Bergen, A.A.B. & Florijn, RJ (2011). Simultaneous Mutation Detection in 90 Retinal Disease Genes in Multiple Patients Using a Custom-designed 300-kb Retinal Resequencing Chip. Ophthalmology, 118(1), 160-U268. Bos, D., Ikram, M.A., Elias-Smale, S.E., Krestin, G.P., Hofman, A., Witteman, J.C.M., Lugt, A. van der & Vernooij, M.W. (2011). Calcification in Major Vessel Beds Relates to Vascular Brain Disease. Arteriosclerosis Thrombosis & Vascular Biology, 31(10), Breteler, M.M.B. (2011). Mapping Out Biomarkers for Alzheimer Disease. Jama - Journal of the American Medical Association, 305(3), Brion, MJ, Zeegers, M., Jaddoe, V.W.V.K., Verhulst, F.C., Tiemeier, H.W., Lawlor, DA & Smith, G.D. (2011). Intrauterine Effects of Maternal Prepregnancy Overweight on Child Cognition and Behavior in 2 Cohorts. Pediatrics, 127(1), E202-E211. Brodaty, H, Breteler, M.M.B., DeKosky, ST, Dorenlot, P, Fratiglioni, L., Hock, C, Kenigsberg, PA, Scheltens, P. & Strooper, B De (2011). The World of Dementia Beyond Journal of American Geriatrics Society, 59(5), Broer, L., Koudstaal, P.J., Amin, N., Rivadeneira Ramirez, F., Uitterlinden, A.G., Hofman, A., Oostra, B.A., Breteler, M.M.B., Ikram, M.A. & Duijn, C.M. van (2011). Association of heat shock proteins with Parkinson's disease. European Journal of Epidemiology, 26(12), Broer, L., Ikram, A., Schuur, M., DeStefano, AL, Bis, JC, Liu, F., Rivadeneira, F., Uitterlinden, A.G., Beiser, AS, Longstreth, W.T., Hofman, A., Aulchenko, Y., Seshadri, S, Fitzpatrick, AL, Oostra, B.A., Breteler, M.M.B. & Duijn, C.M. van (2011). Association of HSP70 and its Co-Chaperones with Alzheimer's Disease. Journal of Alzheimers Disease, 25(1), Brugts, J.J., Isaacs, A, Maat, M.P.M. de, Boersma, E., Duijn, C.M. van, Akkerhuis, K.M., Uitterlinden, A.G., Witteman, J.C.M., Cambien, F., Ceconi, C., Remme, W, Bertrand, M, Ninomiya, T, Harrap, S, Chalmers, J, MacMahon, S, Fox, K, Ferrari, R., Simoons, M.L. & Danser, A.H.J. (2011). A pharmacogenetic analysis of determinants of hypertension and blood pressure response to angiotensin-converting enzyme inhibitor therapy in patients with vascular disease and healthy individuals. Journal of Hypertension, 29(3), Burdorf, A., Brand, T., Jaddoe, V.W.V.K., Hofman, A., Mackenbach, J.P. & Steegers, E.A.P. (2011). The effects of work-related maternal risk factors on time to pregnancy, preterm birth and birth weight: the Generation R Study. Occupational and Environmental Medicine, 68(3),

10 Cents, R.A.M., Tiemeier, H.W., Luijk, P.C.M., Jaddoe, V.W.V.K., Hofman, A., Verhulst, F.C. & Berg, M.P. van den (2011). Grandparental anxiety and depression predict young children's internalizing and externalizing problems. The Generation R study. Journal of Affective Disorders, 128, Cents, R.A.M., Tiemeier, H.W., Luijk, MPCM, Jaddoe, V.W.V.K., Hofman, A., Verhulst, F.C. & Berg, M.P. van den (2011). Grandparental anxiety and depression predict young children's internalizing and externalizing problems The generation R study. Journal of Affective Disorders, 128(1-2), Chambers, JC, Zhang, WH, Sehmi, J, Li, XZ, Wass, MN, Harst, P. van der, Holm, H, Sanna, S, Kavousi, M., Baumeister, SE, Coin, LJ, Deng, GH, Gieger, C, Heard-Costa, NL, Hottenga, J.J., Kuhnel, B, Kumar, V., Lagou, V, Liang, LM, Luan, JA, Vidal, PM, Leach, IM, O'Reilly, PF, Peden, JF, Rahmioglu, N, Soininen, P, Speliotes, EK, Yuan, X, Thorleifsson, G, Alizadeh, B.Z., Atwood, LD, Borecki, IB, Brown, MJ, Charoen, P, Cucca, F, Das, D., Geus, E.J.C. de, Dixon, AL, Doering, A, Ehret, G, Eyjolfsson, GI, Farrall, M, Forouhi, NG, Friedrich, N, Goessling, W, Gudbjartsson, DF, Harris, T.B., Hartikainen, AL, Heath, S, Hirschfield, GM, Hofman, A., Homuth, G., Hypponen, E, Janssen, H.L.A., Johnson, T, Kangas, AJ, Kema, I.P., Kuhn, JP, Lai, S, Lathrop, M, Lerch, MM, Li, Y., Liang, TJ, Lin, JP, Loos, RJF, Martin, NG, Moffatt, MF, Montgomery, GW, Munroe, PB, Musunuru, K, Nakamura, Y, O'Donnell, CJ, Olafsson, I, Penninx, BW, Pouta, A, Prins, BP, Prokopenko, I, Puls, R, Ruokonen, A, Savolainen, MJ, Schlessinger, D, Schouten, J.N.L., Seedorf, U, Sen-Chowdhry, S, Siminovitch, KA, Smit, J.H., Spector, T.D., Tan, WT, Teslovich, TM, Tukiainen, T, Uitterlinden, A.G., Klauw, M.M. van der, Vasan, RS, Wallace, C, Wallaschofski, H., Wichmann, HE, Willemsen, G, Wurtz, P, Xu, C., Yerges-Armstrong, LM, Abecasis, GR, Ahmadi, KR, Boomsma, D.I., Caulfield, M., Cookson, WO, Duijn, C.M. van, Froguel, P, Matsuda, K, McCarthy, MI, Meisinger, C, Mooser, V, Pietilainen, KH, Schumann, G, Snieder, H, Sternberg, MJE, Stolk, R.P., Thomas, H.C., Thorsteinsdottir, U, Uda, M, Waeber, G, Wareham, NJ, Waterworth, D.M., Watkins, H, Whitfield, JB, Witteman, J.C.M., Wolffenbuttel, B.H.R., Fox, CS, Ala- Korpela, M, Stefansson, K, Vollenweider, P, Volzke, H, Schadt, EE, Scott, J, Jarvelin, MR, Elliott, P. & Kooner, JS (2011). Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nature Genetics, 43(11), 1131-U129. Chote, A.A., Groot, C.J.M. de, Bruijnzeels, M.A., Redekop, W.K., Jaddoe, V.W.V.K., Hofman, A., Steegers, E.A.P., Mackenbach, J.P. & Foets, M.M.E. (2011). Ethnic differences in antenatal care use in a large multi-ethnic urban population in the Netherlands. Midwifery, 27(1), Chote, A.A., Koopmans, G.T., Redekop, W.K., Groot, C.J.M. de, Hoefman, R.J., Jaddoe, V.W.V.K., Hofman, A., Steegers, E.A.P., Mackenbach, J.P., Trappenburg, M.J. & Foets, M.M.E. (2011). Explaining Ethnic Differences in Late Antenatal Care Entry by Predisposing, Enabling and Need Factors in the Netherlands. The Generation R Study. Maternal and Child Health Journal, 15(6), Danaei, G, Finucane, MM, Lin, JK, Singh, GM, Paciorek, CJ, Cowan, MJ, Farzadfar, F, Stevens, GA, Lim, S.S., Riley, LM & Ezzati, M (2011). National, regional, and global trends in systolic blood pressure since 1980: systematic analysis of health examination surveys and epidemiological studies with 786 country-years and 5.4 million participants. Lancet (UK), 377(9765), Day-Williams, AG, Southam, L, Panoutsopoulou, K, Rayner, NW, Esko, T, Estrada, K, Helgadottir, HT, Hofman, A., Ingvarsson, T, Jonsson, H, Keis, A, Kerkhof, HJM, Thorleifsson, G, Arden, NK, Carr, A, Chapman, K, Deloukas, P, Loughlin, J, McCaskie, A, Ollier, WER, Ralston, S.H., Spector, T.D., Wallis, GA, Wilkinson, JM, Aslam, N, Birell, F, Carluke, I, Joseph, J, Rai, A., Reed, M, Walker, K, Doherty, SA, Jonsdottir, I, Maciewicz, RA, Muir, KR, Metspalu, A, Rivadeneira, F., Stefansson, K, Styrkarsdottir, U, Uitterlinden, A.G., Meurs, J.B.J. van, Zhang, WY, Valdes, A.M., Doherty, M & Zeggini, E (2011). A Variant in MCF2L Is Associated with Osteoarthritis. American Journal of Human Genetics, 89(3), Deelen, J, Beekman, M, Uh, HW, Helmer, Q, Kuningas, M., Christiansen, L, Kremer, D., Breggen, R van der, Suchiman, HED, Lakenberg, N, Akker, EB van den, Passtoors, WM, Tiemeier, H.W., Heemst, D van, Craen, AJ de, Rivadeneira Ramirez, F., Geus, EJ de, Perola, M, Ouderaa, FJ van der, Gunn, DA, Boomsma, D.I., Uitterlinden, A.G., Christensen, K., Duijn, C.M. van, Heijmans, B.T., Houwing- Duistermaat, J.J., Westendorp, R.G.J. & Slagboom, P.E. (2011). Genome-wide association study

11 identifies a single major locus contributing to survival into old age; the APOE locus revisited. Aging Cell, 10(4), Dehghan, A., Dupuis, J, Barbalic, M, Bis, JC, Eiriksdottir, G, Lu, C, Pellikka, N, Wallaschofski, H., Kettunen, J, Henneman, P., Baumert, J., Strachan, DP, Fuchsberger, C, Vitart, V, Wilson, JF, Pare, G, Naitza, S, Rudock, ME, Surakka, I, Geus, E.J.C. de, Alizadeh, B.Z., Guralnik, J, Shuldiner, A, Tanaka, T, Zee, RYL, Schnabel, RB, Nambi, V, Kavousi, M., Ripatti, S, Nauck, M., Smith, NL, Smith, AV, Sundvall, J, Scheet, P, Liu, YM, Ruokonen, A, Rose, LM, Larson, MG, Hoogeveen, RC, Freimer, N.B., Teumer, A, Tracy, RP, Launer, L.J., Buring, JE, Yamamoto, JF, Folsom, A.R., Sijbrands, E.J.G., Pankow, J, Elliott, P., Keaney, JF, Sun, W, Sarin, AP, Fontes, JD, Badola, S, Astor, BC, Hofman, A., Pouta, A, Werdan, K., Greiser, K.H., Kuss, O., Schwabedissen, HEMZ, Thiery, J, Jamshidi, Y, Nolte, I.M., Soranzo, N, Spector, T.D., Volzke, H, Parker, AN, Aspelund, T, Bates, D, Young, L, Tsui, K, Siscovick, D.S., Guo, XQ, Rotter, JI, Uda, M, Schlessinger, D, Rudan, I, Hicks, AA, Penninx, BW, Thorand, B, Gieger, C, Coresh, J, Willemsen, G, Harris, T.B., Uitterlinden, A.G., Jarvelin, MR, Rice, K, Radke, D, Salomaa, V, Dijk, KW van, Boerwinkle, E., Vasan, RS, Ferrucci, L, Gibson, QD, Bandinelli, S, Snieder, H, Boomsma, D.I., Xiao, XJ, Campbell, H, Hayward, C, Pramstaller, P.P., Duijn, C.M. van, Peltonen, L., Psaty, B.M., Gudnason, V, Ridker, P.M., Homuth, G., Koenig, W., Ballantyne, C.M., Witteman, J.C.M., Benjamin, EJ, Perola, M & Chasman, DI (2011). Meta-Analysis of Genome-Wide Association Studies in > Subjects Identifies Multiple Loci for C-Reactive Protein Levels. Circulation, 123(7), 731-U151. Demirkan, A., Amin, N., Isaacs, A, Jarvelin, MR, Whitfield, JB, Wichmann, HE, Kyvik, KO, Rudan, I, Gieger, C, Hicks, AA, Johansson, A, Hottenga, J.J., Smith, JJ, Wild, SH, Pedersen, NL, Willemsen, G, Mangino, M, Hayward, C, Uitterlinden, A.G., Hofman, A., Witteman, J.C.M., Montgomery, GW, Pietilainen, KH, Rantanen, T, Kaprio, J, Doring, A, Pramstaller, P.P., Gyllensten, U, Geus, E.J.C. de, Penninx, BW, Wilson, JF, Rivadeneria, F, Magnusson, PKE, Boomsma, D.I., Spector, T., Campbell, H, Hoehne, B, Martin, NG, Oostra, B.A., McCarthy, M, Peltonen-Palotie, L, Aulchenko, Y., Visscher, P.M., Ripatti, S, Janssens, A.C.J.W. & Duijn, C.M. van (2011). Genetic architecture of circulating lipid levels. European Journal of Human Genetics, 19(7), Demirkan, A., Penninx, BWJH, Hek, K., Wray, NR, Amin, N., Aulchenko, Y.S., Dyck, R. van, Geus, E.J.C. de, Hofman, A., Uitterlinden, A.G., Hottenga, J.J., Nolen, W.A., Oostra, B.A., Sullivan, PF, Willemsen, G, Zitman, F.G., Tiemeier, H.W., Janssens, A.C.J.W., Boomsma, D.I., Duijn, C.M. van & Middeldorp, C.M. (2011). Genetic risk profiles for depression and anxiety in adult and elderly cohorts. Molecular Psychiatry, 16(7), Dierckx, B., Tulen, J.H.M., Tharner, A., Jaddoe, V.W.V.K., Hofman, A., Verhulst, F.C. & Tiemeier, H.W. (2011). Low autonomic arousal as vulnerability to externalising behaviour in infants with hostile mothers. Psychiatry Research, 185, Dierckx, B., Tharner, A., Tulen, J.H.M., Jaddoe, V.W.V.K., Hofman, A., Verhulst, F.C. & Tiemeier, H.W. (2011). Spot the Red Herring: Breastfeeding, Fruitpuree, and Infant Autonomic Functioning-The Generation R Study. Pediatric Research, 70(4), Direk, N., Newson, R.S., Hofman, A., Kirschbaum, C & Tiemeier, H.W. (2011). Short and long-term effects of smoking on cortisol in older adults. International Journal of Psychophysiology, 80(2), Duncan, E.L., Danoy, P, Kemp, JP, Leo, PJ, McCloskey, E, Nicholson, GC, Eastell, R., Prince, R.L., Eisman, JA, Jones, G., Sambrook, PN, Reid, IR, Dennison, EM, Wark, J, Richards, JB, Uitterlinden, A.G., Spector, T.D., Esapa, C, Cox, RD, Brown, SDM, Thakker, R.V., Addison, KA, Bradbury, LA, Center, JR, Cooper, C., Cremin, C, Estrada, K, Felsenberg, D., Gluer, CC, Hadler, J, Henry, MJ, Hofman, A., Kotowicz, MA, Makovey, J, Nguyen, SC, Nguyen, T.V., Pasco, JA, Pryce, K, Reid, D.M., Rivadeneira, F., Roux, C, Stefansson, K, Styrkarsdottir, U, Thorleifsson, G, Tichawangana, R, Evans, DM & Brown, M.A. (2011). Genome-Wide Association Study Using Extreme Truncate Selection Identifies Novel Genes Affecting Bone Mineral Density and Fracture Risk. PLoS Genetics, 7(4). Durme, Y.M.T.A. van, Lahousse, L, Verhamme, K.M.C., Stolk, L., Eijgelsheim, M., Loth, D.W., Uitterlinden, A.G., Breteler, M.M.B., Joos, G.F., Hofman, A., Stricker, B.H.C. & Brusselle, GG (2011).

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13 Psaty, B.M., Abecasis, GR, Chakravarti, A, Elliott, P., Duijn, C.M. van, Newton-Cheh, C, Levy, D., Caulfield, MJ & Johnson, T (2011). Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature, 478(7367), Elens, L, Becker, M.L., Haufroid, V, Hofman, A., Visser, L.E., Uitterlinden, A.G., Stricker, BC & Schaik, R.H.N. van (2011). Novel CYP3A4 intron 6 single nucleotide polymorphism is associated with simvastatin-mediated cholesterol reduction in The Rotterdam Study. Pharmacogenetics Genomics, 21(12), Elias-Smale, S.E., Wieberdink, R.G., Odink, A.E., Hofman, A., Hunink, M.G.M., Koudstaal, P.J., Krestin, G.P., Breteler, M.M.B., Lugt, A. van der & Witteman, J.C.M. (2011). Burden of atherosclerosis improves the prediction of coronary heart disease but not cerebrovascular events: The Rotterdam Study. European Heart Journal, 32(16), Ernst, G.D.S., Jonge, L.L. de, Hofman, A., Lindemans, J., Russcher, H., Steegers, E.A.P. & Jaddoe, V.W.V.K. (2011). C-reactive protein levels in early pregnancy, fetal growth patterns, and the risk for neonatal complications: the Generation R Study. American Journal of Obstetrics and Gynecology, 205(2). Fornage, M, Debette, S, Bis, JC, Schmidt, H., Ikram, M.A., Dufouil, C., Sigurdsson, S, Lumley, T, DeStefano, AL, Fazekas, F., Vrooman, H.A., Shibata, DK, Maillard, P, Zijdenbos, A., Smith, AV, Gudnason, H, Boer, R. de, Cushman, M., Mazoyer, B, Heiss, G, Vernooij, M.W., Enzinger, C, Glazer, NL, Beiser, A, Knopman, DS, Cavalieri, M, Niessen, W.J., Harris, T.B., Petrovic, K, Lopez, OL, Au, R., Lambert, JC, Hofman, A., Gottesman, RF, Garcia, M, Heckbert, SR, Atwood, LD, Catellier, DJ, Uitterlinden, A.G., Yang, Q, Smith, NL, Aspelund, T, Romero, JR, Rice, K, Taylor, KD, Nalls, MA, Rotter, JI, Sharrett, R, Duijn, C.M. van, Amouyel, P, Wolf, PA, Gudnason, V, Lugt, A. van der, Boerwinkle, E., Psaty, B.M., Seshadri, S, Tzourio, C., Breteler, M.M.B., Mosley, TH, Schmidt, R., Longstreth, W.T., DeCarli, C. & Launer, L.J. (2011). Genome-Wide Association Studies of Cerebral White Matter Lesion Burden: The CHARGE Consortium. Annals of Neurology, 69(6), Fox, ER, Young, JH, Li, YL, Dreisbach, AW, Keating, BJ, Musani, SK, Liu, K.Y., Morrison, AC, Ganesh, S, Kutlar, A, Ramachandran, VS, Polak, JF, Fabsitz, R.R., Dries, DL, Farlow, DN, Redline, S, Adeyemo, A, Hirschorn, JN, Sun, YV, Wyatt, SB, Penman, AD, Palmas, W, Rotter, JI, Townsend, RR, Doumatey, AP, Tayo, BO, Mosley, TH, Lyon, HN, Kang, SJ, Rotimi, CN, Cooper, RS, Franceschini, N, Curb, J.D., Martin, LW, Eaton, CB, Kardia, SLR, Taylor, HA, Caulfield, MJ, Ehret, GB, Johnson, T, Chakravarti, A, Zhu, XF & Levy, D. (2011). Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study. Human Molecular Genetics, 20(11), Gaillard, R., Steegers, E.A.P., Hofman, A. & Jaddoe, V.W.V.K. (2011). Associations of maternal obesity with blood pressure and the risks of gestational hypertensive disorders. The Generation R Study. Journal of Hypertension, 29(5), Gaillard, R., Bakker, R., Willemsen, S.P., Hofman, A., Steegers, E.A.P. & Jaddoe, V.W.V.K. (2011). Blood pressure tracking during pregnancy and the risk of gestational hypertensive disorders: The Generation R Study. European Heart Journal, 32(24), Gaillard, R., Bakker, R., Steegers, E.A.P., Hofman, A. & Jaddoe, V.W.V.K. (2011). Maternal age during pregnancy is associated with third trimester blood pressure level: the generation R study. American Journal of Hypertension. Geelhoed, J.J.M., Duijn, C.M. van, Osch-Gevers, M. van, Steegers, E.A.P., Hofman, A., Helbing, W.A. & Jaddoe, V.W.V.K. (2011). Glucocorticoid receptor-9beta polymorphism is associated with systolic blood pressure and heart growth during early childhood. The Generation R Study. Early Human Development, Geelhoed, J.J.M., Marroun El, H., Verburg, B.O., Osch-Gevers, M. van, Hofman, A., Huizink, A.C., Moll, H.A., Verhulst, F.C., Helbing, W.A., Steegers, E.A.P. & Jaddoe, V.W.V.K. (2011). Maternal smoking

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15 C, Campion, D, Epelbaum, J, Dartigues, J.F., Tzourio, C., Alperovitch, A., Lathrop, M, Feulner, TM, Friedrich, P, Riehle, C, Krawczak, M, Schreiber, S., Mayhaus, M, Nicolhaus, S, Wagenpfeil, S, Steinberg, S, Stefansson, H, Stefansson, K, Snaedal, J, Bjornsson, S, Jonsson, PV, Chouraki, V, Genier-Boley, B, Hiltunen, M, Soininen, H., Combarros, O, Zelenika, D, Delepine, M., Bullido, M.J., Pasquier, F, Mateo, I, Frank-Garcia, A, Porcellini, E, Hanon, O, Coto, E, Alvarez, V, Bosco, P., Siciliano, G, Mancuso, M, Panza, F, Solfrizzi, V, Nacmias, B, Sorbi, S, Bossu, P, Piccardi, P, Arosio, B, Annoni, G, Seripa, D, Pilotto, A, Scarpini, E, Galimberti, D, Brice, A., Hannequin, D, Licastro, F, Jones, L, Holmans, PA, Jonsson, T, Riemenschneider, M, Morgan, K., Younkin, SG, Owen, M.J., O'Donovan, M, Amouyel, P & Williams, J. (2011). Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nature Genetics, 43(5), Holmes, MV, Newcombe, P, Hubacek, JA, Sofat, R, Ricketts, SL, Cooper, J, Breteler, M.M.B., Bautista, LE, Sharma, P., Whittaker, JC, Smeeth, L, Fowkes, FGR, Algra, A., Shmeleva, V, Szolnoki, Z, Roest, M., Linnebank, M., Zacho, J, Nalls, MA, Singleton, AB, Ferrucci, L, Hardy, J., Worrall, BB, Rich, SS, Matarin, M, Norman, PE, Flicker, L, Almeida, OP, Bockxmeer, FM van, Shimokata, H, Khaw, KT, Wareham, NJ, Bobak, M, Sterne, JAC, Smith, G.D., Talmud, P.J., Duijn, C.M. van, Humphries, SE, Price, JF, Ebrahim, S, Lawlor, DA, Hankey, GJ, Meschia, JF, Sandhu, MS, Hingorani, AD & Casas, JP (2011). Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials. Lancet (UK), 378(9791), Hondel, K.E. van den, Eijgelsheim, M., Ruiter, R. de, Witteman, J.C.M., Hofman, A. & Stricker, B.H.C. (2011). Effect of short-term NSAID use on echocardiographic parameters in elderly people: a population-based cohort study. Heart, 97(7), Hoorn, E.J., Rivadeneira Ramirez, F., Meurs, J.B.J. van, Ziere, G., Stricker, B.H.C., Hofman, A., Pols, H.A.P., Zietse, R., Uitterlinden, A.G. & Zillikens, M.C. (2011). Mild Hyponatremia as a Risk Factor for Fractures: The Rotterdam Study. Journal of Bone and Mineral Research, 26(8), Hooven, E.H. van den, Kluizenaar, Y. de, Pierik, F.H., Hofman, A., Ratingen, SW van, Zandveld, PYJ, Mackenbach, J.P., Steegers, E.A.P., Miedema, HME & Jaddoe, V.W.V.K. (2011). Air Pollution, Blood Pressure, and the Risk of Hypertensive Complications During Pregnancy The Generation R Study. Hypertension, 57(3), 406-U138. Ijsselstijn, L., Dekker, L.J.M., Koudstaal, P.J., Hofman, A., Sillevis Smitt, P.A.E., Breteler, M.M.B. & Luider, T.M. (2011). Serum Clusterin Levels Are Not Increased in Presymptomatic Alzheimer's Disease. Journal of Proteome Research, 10(4), Ijsselstijn, L., Dekker, L.J.M., Stingl, C., Weiden, M.M. van der, Hofman, A., Kros, J.M., Koudstaal, P.J., Sillevis Smitt, P.A.E., Ikram, M.A., Breteler, M.M.B. & Luider, T.M. (2011). Serum Levels of Pregnancy Zone Protein are Elevated in Presymptomatic Alzheimer's Disease. Journal of Proteome Research, 10(11), Ikram, M.A., Lugt, A. van der, Niessen, W.J., Krestin, G.P., Koudstaal, P.J., Hofman, A., Breteler, M.M.B. & Vernooij, M.W. (2011). The Rotterdam Scan Study: design and update up to European Journal of Epidemiology, 26(10), Jansen, P.W., Saridjan, N.S., Hofman, A., Jaddoe, V.W.V.K., Verhulst, F.C. & Tiemeier, H.W. (2011). Does Disturbed Sleeping Precede Symptoms of Anxiety or Depression in Toddlers? The Generation R Study. Psychosomatic Medicine, 73(3), Jong, F.J. de, Schrijvers, E.M.C., Ikram, M.K., Koudstaal, P.J., Jong, P.T.V.M. de, Hofman, A., Vingerling, J.R. & Breteler, M.M.B. (2011). Retinal vascular caliber and risk of dementia The Rotterdam Study. Neurology, 76(9), Jonge, L.L. de, Steegers, E.A.P., Ernst, G.D.S., Lindemans, J., Russcher, H., Hofman, A. & Jaddoe, V.W.V.K. (2011). C-reactive protein levels, blood pressure and the risks of gestational hypertensive complications: The Generation R Study. Journal of Hypertension, 29(12),