Research Annual Report 2010

Transcription

1 Research Annual Report 2010 Netherlands Institute for Health Sciences (NIHES) Assessment, Treatment and Translational Research in Recontructive Surgery Epidemiology of diseases Basic epidemiologic research Clinical epidemiology Biostatistics Effects of screening and clinical interventions on population health Determinants and primary prevention Clinical research in general practice. Implementation of diagnostic and interventional imaging technology Assessment of diagnostic and interventional imaging technology Development of acquisition and processing techniques for diagnostic imaging Structuring of medical knowledge Structuring of medical data 11771, B&T Ontwerp en advies (

2 Research Annual Report 2010 Netherlands Institute for Health Sciences (NIHES) Assessment, aetiology and course of child and adolescent psychiatry Adaptation of (future) patients to disease and treatment in order to improve counselling and guidance Health care management (theme 3) Quality and efficiency in health care (theme 2) Competition and regulation in health care (theme 1) 11771, B&T Ontwerp en advies (

3 EMC NIHES A - Assessment, Treatment and Translational Research in Recontructive Surgery Programme in brief design The program `Assessment, Treatment and Translational Research in Reconstructive Surgery relates to research questions derived from three main patient groups: upper extremity disorders, craniofacial disorders and patients requiring reconstructions after oncological resection. Furthermore wound healing plays an important role in reconstructive surgery. Within these three patient groups, we share the same three research topics, which are often interrelated. 1) Development and evaluation of innovative clinical interventions, either in randomized or cohort studies. 2) Development and application of new assessment tools, such as new imaging techniques and measurement tools to be used for both diagnosis and outcome assessment. 3) Development and evaluation of innovative experimental interventions with a close relation to the clinic. Most clinical and translational research is multidisciplinary, resulting in collaboration with a large number of clinical and preclinical departments. Key figures Department SP1 SP2 SP3 SP4 Sptot T1 T2 T3 Ttot IS FS OP Ptot oral and maxillofacial surgery 0, ,2 pediatric psychiatry 0, ,1 plastic and reconstructive surgery 3, ,65 8,55 rehabilitation ,5 0,5 Total 4, ,15 9, Thesis Bannink, N. (2010, september 01). Obstructive sleep apnea in children with syndromic craniosynostosis. EUR (185 pag.) (Rotterdam: Optima Grafische Communicatie). Prom./coprom.: Prof. Dr. S.E.R. Hovius, Dr. I.M.J. Mathijssen & Dr. K.F.M. Joosten. Bruggeman, J.P. (2010, oktober 22). Biodegradable polyol-based polymers. A polymer platform for biomedical applications. EUR. Prom./coprom.: Prof. Dr. S.E.R. Hovius. Molenaar, H.M. (2010, juni 10). Measuring hand strength in children. EUR. Prom./coprom.: Prof. Dr. S.E.R. Hovius & Prof. Dr. H.J. Stam. Rath, S. (2010, juni 04). Early active mobilization of tendon transfers. EUR. Prom./coprom.: Prof. Dr. S.E.R. Hovius & Prof. Dr. H.J. Stam. Stokvis, A. (2010, september 24). Surgical management of painful neuromas. EUR. Prom./coprom.: Prof. Dr. S.E.R. Hovius. Ultee, J. (2010, juni 15). Outcome following peripheral nerve injury of the forearm. EUR. Prom./coprom.: Prof. Dr. S.E.R. Hovius. Versnel, S.L.. Let s face it! Causes, treatment and consequences of rare facial clefts. EUR. Prom./coprom.: Prof. Dr. S.E.R. Hovius & Prof.Dr. J. Passchier. Artikel/Letter to the editor Ananta, M & Coert, J.H. (2010). Prevention of wound infection after release of Apert acrosyndactyly. Plastic and Reconstructive Surgery, 126(1), 42e-43e. Bannink, N., Mathijssen, I.M.J. & Joosten, K.F.M. (2010). Can parents predict obstructive sleep apnea in children with syndromic or complex craniosynostosis? International Journal of Oral and Maxillofacial Surgery, 39, Bannink, N., Maliepaard, M., Raat, H., Joosten, K.F.M. & Mathijssen, I.M.J. (2010). Health-related quality of life in children and adolescent with syndromic craniosynostosis. Journal of Plastic, Reconstructive & Aesthetic Surgery, 63, Bannink, N., Nout, E., Wolvius, E.B., Hoeve, L.J., Joosten, K.F.M. & Mathijssen, I.M.J. (2010). Obstructive sleep apnea in children with syndromic craniosynostosis: long-term respiratory outcome of midface advancement. International Journal of Oral and Maxillofacial Surgery, 39(2), Bannink, N., Mathijssen, I.M.J. & Joosten, K.F.M. (2010). Use of ambulatory polysomnography in children with syndromic craniosynostisis. Journal of Craniofacial Surgery, 21(5), Boender, Z.J., Ultee, J. & Hovius, S.E.R. (2010). Cognitive capacity: No association with recovery of sensibility by Semmes Weinstein test score after peripheral nerve injury of the forearm. Journal of Plastic, Reconstructive & Aesthetic Surgery, 63(2), Bruggeman, J.P., Bettinger, CJ & Langer, R (2010). Biodegradable xylitol-based elastomers: In vivo behavior and biocompatibility. Journal of Biomedical Materials Research Part A, 95A(1), Coert, J.H. (2010). Pathophysiology of nerve regeneration and nerve reconstruction in burned patients. Burns, 36(5),

4 Colaris, J.W., Linden, M.W. van der, Selles, R.W., Coene, N, Allema, J.H. & Verhaar, J.A.N. (2010). Pronation and supination after forearm fractures in children: Reliability of visual estimation and conventional goniometry measurement. Injury-International Journal of the Care of the Injured, 41(6), Damen, T.H.C., Timman, R., Kunst, EH, Gopie, JP, Bresser, P.J.C., Seynaeve, C., Menke - Pluijmers, M.B.E., Mureau, M.A.M., Hofer, S.O.P. & Tibben, A. (2010). High satisfaction rates in women after DIEP flap breast reconstruction. Journal of Plastic, Reconstructive & Aesthetic Surgery, 63(1), Driel, A.A. van, Mureau, M.A.M., Goldstein, DP, Gilbert, RW, Irish, J.C., Gullane, P.J., Neligan, P.C. & Hofer, S.O.P. (2010). Aesthetic and Oncologic Outcome after Microsurgical Reconstruction of Complex Scalp and Forehead Defects after Malignant Tumor Resection: An Algorithm for Treatment. Plastic and Reconstructive Surgery, 126(2), Florisson, J.M.G., Veelen, M.L.C. van, Bannink, N., Adrichem, L.N.A. van, Meulen, J.J.N.M. van der, Bartels, M.C. & Mathijssen, I.M.J. (2010). Papilledema in Isolated Single-Suture Craniosynostosis: Prevalence and Predictive Factors. Journal of Craniofacial Surgery, 21(1), Gooskens, S.L.M., Oranje, A.P., Adrichem, L.N.A. van, Waard- van der Spek, F.B. de, Hollander, J.C. den, Ven, C.P. van de & Heuvel-Eibrink, M.M. van den (2010). Imatinib mesylate for children with dermatofibrosarcoma protuberans (DFSP). Pediatric Blood & Cancer, 55, Haeseker, G.A., Mureau, M.A.M. & Faber, F.W.M. (2010). Lateral Column Lengthening for Acquired Adult Flatfoot Deformity Caused by Posterior Tibial Tendon Dysfunction Stage II: A Retrospective Comparison of Calcaneus Osteotomy with Calcaneocuboid Distraction Arthrodesis. Journal of Foot & Ankle Surgery, 49(4), Hofer, S.O.P. & Mureau, M.A.M. (2010). Pedicled Perforator Flaps in the Head and Neck. Clinics in Plastic Surgery, 37(4), Hossaini, S.M., Duraku, L., Sarac, C, Jongen, J.L.M. & Holstege, J.C. (2010). Differential distribution of activated spinal neurons containing glycine and/or GABA and expressing c-fos in acute and chronic pain models. Pain, 151(2), Huisstede, B.M., Randsdorp, M.S., Coert, J.H., Glerum, S., Middelkoop, M. van & Koes, B.W. (2010). Carpal Tunnel Syndrome. Part II: Effectiveness of Surgical Treatments-A Systematic Review. Archives of Physical Medicine and Rehabilitation, 91(7), Jong, T. de, Bannink, N., Bredero-Boelhouwer, H.H., Veelen, M.L.C. van, Bartels, M.C., Hoeve, L.J., Hoogeboom, A.J.M., Wolvius, E.B., Lequin, M.H., Meulen, J.J.N.M. van der, Adrichem, L.N.A. van, Vaandrager, J.M., Ongkosuwito, E.M., Joosten, K.F.M. & Mathijssen, I.M.J. (2010). Long-term functional outcome in 167 patients with syndromic craniosynostosis; defining a syndrome-specific risk profile. Journal of Plastic, Reconstructive & Aesthetic Surgery, 63(10), Korstanje, J.H., Selles, R.W., Stam, H.J., Hovius, S.E.R. & Bosch, J.G. (2010). Development and validation of ultrasound speckle tracking to quantify tendon displacement. Journal of Biomechanics, 43(7), Korstanje, J.H., Schreuders, A.R., Sijde, K. van der, Hovius, S.E.R., Bosch, J.G. & Selles, R.W. (2010). Ultrasonographic Assessment of Long Finger Tendon Excursion in Zone V During Passive and Active Tendon Gliding Exercises. Journal of Hand Surgery-American Volume, 35A(4), Kusters, F.J.G., Walbeehm, E.T. & Niehof, S.P. (2010). Neural influence on cold induced vasodilatation using a new set-up for bilateral measurement in the rat hind limb. Journal of Neuroscience Methods, 193(1), Mathijssen, I.M.J. & Meulen, J.C. van der (2010). Guidelines for reconstruction of the eyelids and canthal regions. Journal of Plastic, Reconstructive & Aesthetic Surgery, 63(9), Molenaar, H.M., Selles, R.W., Zuidam, J.M., Willemsen, S.P., Stam, H.J. & Hovius, S.E.R. (2010). Growth Diagrams for Grip Strength in Children. Clinical Orthopaedics & Related Research, 468(1), Molenaar, H.M., Kraker, M. de, Zuidam, J.M., Hovius, S.E.R., Stam, H.J. & Selles, R.W. (2010). Visual Feedback and Weight Reduction of a Grip Strength Dynamometer Do Not Increase Reliability in Healthy Children. Journal of Hand Therapy, 23(3), Moolenburgh, S.E., Mac Lennan, L.M., Levendag, P.C., Munte, K., Scholtemeijer, M., Hofer, S.O.P. & Mureau, M.A.M. (2010). Nasal Reconstruction after Malignant Tumor Resection: An Algorithm for Treatment. Plastic and Reconstructive Surgery, 126(1), Nijhuis, T.H.J., Brzezicki, G, Klimczak, A & Siemionow, M (2010). ISOGENIC VENOUS GRAFT SUPPORTED WITH BONE MARROW STROMAL CELLS AS A NATURAL CONDUIT FOR BRIDGING A 20 mm NERVE GAP. Microsurgery, 30(8), Nijhuis, T.H.J., Smits, E.S., Jaquet, J.B., Oosterom, F.J.T. van, Selles, R.W. & Hovius, S.E.R. (2010). PREVALENCE AND SEVERITY OF COLD INTOLERANCE IN PATIENTS AFTER HAND FRACTURE. Journal of Hand Surgery-European Volume, 35E(4), Nout, E., Mathijssen, I.M.J., Meulen, J.J.N.M. van der, Veelen, M.L.C. van, Koning, A.H.J., Lequin, M.H. & Wolvius, E.B. (2010). Internal carotid dissection after Le Fort III distraction in Apert syndrome: A case report. Journal of Cranio-Maxillofacial Surgery, 38(7), Nout, E., Bouw, F.P., Veenland, J.F., Hop, W.C.J., Wal, K.G.H. van der, Mathijssen, I.M.J. & Wolvius, E.B. (2010). Three- Dimensional Airway Changes after Le Fort III Advancement in Syndromic Craniosynostosis Patients. Plastic and Reconstructive Surgery, 126(2),

5 Ongkosuwito, E.M., Gijt, P de, Wattel, E, Carels, CEL & Kuijpers-Jagtman, A.M. (2010). Dental Development in Hemifacial Microsomia. Journal of Dental Research, 89(12), Pourrier, SD, Nieuwstraten, W., Cranenburgh, B Van, Schreuders, A.R., Stam, H.J. & Selles, R.W. (2010). Three cases of referred sensation in traumatic nerve injury of the hand: implication for understanding central nervous system reorganization. Journal of Rehabilitation Medicine, 42(4), Rath, S., Schreuders, A.R., Stam, H.J., Hovius, S.E.R. & Selles, R.W. (2010). Early Active Motion versus Immobilization after Tendon Transfer for Foot Drop Deformity: A Randomized Clinical Trial. Clinical Orthopaedics & Related Research, 468(9), Rath, S., Schreuders, A.R. & Selles, R.W. (2010). Early postoperative active mobilisation versus immobilisation following tibialis posterior tendon transfer for foot-drop correction in patients with Hansen's disease. Journal of Plastic, Reconstructive & Aesthetic Surgery, 63(3), Rozendaal, A.M., Luijsterburg, A.J.M., Mohangoo, A.D., Ongkosuwito, E.M., Anthony, S. & Vermeij-Keers, C. (2010). Validation of the NVSCA Registry for Common Oral Clefts: Study Design and First Results. Cleft Palate-Craniofacial Journal, 47(5), Schuitema, O.P., Mathijssen, I.M.J. & Mureau, M.A.M. (2010). Reconstruction of an extensive traumatic hemipelvectomy defect using a free lower leg fillet flap. Journal of Plastic, Reconstructive & Aesthetic Surgery, 63(1), E116-E117. Soeters, J.N.M., Selles, R.W. & Stam, H.J. (2010). Intrinsic plus positioning of fingers due to bowstringing at the metacarpophalangeal joint. Journal of Hand Surgery-European Volume, 35E(2), Spaans, AJ, Slijper, H.P., Moojen, TM & Feitz, R. (2010). Open wedge correctieosteotomie voor malunited extra-articulaire distale radiusfracturen. Nederlands Tijdschrift voor Plastische Chirurgie, 1, Spiegelberg, L., Djasim, U.M., Neck, J.W. van, Wolvius, E.B. & Wal, K.G.H. van der (2010). Hyperbaric Oxygen Therapy in the Management of Radiation-Induced Injury in the Head and Neck Region: A Review of the Literature. Journal of Oral and Maxillofacial Surgery, 68(8), Stenekes, MW, Coert, J.H., Nicolai, JPA, Mulder, T., Geertzen, JHB, Paans, AM & Jong, B.M. de (2010). Cerebral consequences of dynamic immobilisation after primary digital flexor tendon repair. Journal of Plastic, Reconstructive & Aesthetic Surgery, 63(12), Stokvis, A., Coert, J.H. & Neck, J.W. van (2010). Insufficient pain relief after surgical neuroma treatment: Prognostic factors and central sensitisation. Journal of Plastic, Reconstructive & Aesthetic Surgery, 63(9), Stokvis, A., Avoort, D.J.J.C. van der, Neck, J.W. van, Hovius, S.E.R. & Coert, J.H. (2010). Surgical management of neuroma pain: A prospective follow-up study. Pain, 151(3), Twigg, SRF, Wilkie, A.O.M., Versnel, S.L. & Mathijssen, I.M.J. (2010). Median facial cleft dysmorphism in three siblings: case report and review of the literature. Cleft Palate-Craniofacial Journal, 47(4), Verseijden, F., Sluijs, S.J. van, Farrell, E.J., Neck, J.W. van, Hovius, S.E.R., Hofer, S.O.P. & Osch, G.J.V.M. van (2010). Prevascular Structures Promote Vascularization in Engineered Human Adipose Tissue Constructs Upon Implantation. Cell Transplantation, 19(8), Versnel, S.L., Duivenvoorden, H.J., Passchier, J. & Mathijssen, I.M.J. (2010). Satisfaction with facial appearance and its determinants in adults with severe congenital facial disfigurement: A case-referent study. Journal of Plastic, Reconstructive & Aesthetic Surgery, 63(10), Visser, N.J., Damen, T.H.C., Timman, R., Hofer, S.O.P. & Mureau, M.A.M. (2010). Surgical Results, Aesthetic Outcome, and Patient Satisfaction after Microsurgical Autologous Breast Reconstruction following Failed Implant Reconstruction. Plastic and Reconstructive Surgery, 126(1), Walbeehm, E.T. (2010). European locums Reconsider the locum system. British Medical Journal, 340. Walbeehm, E.T. (2010). Locum issues Time to tackle the system. British Medical Journal, 341. Zuidam, J.M., Kraker, M. de, Selles, R.W. & Hovius, S.E.R. (2010). Evaluation of Function and Appearance of Adults With Untreated Triphalangeal Thumbs. Journal of Hand Surgery-American Volume, 35A(7), Zuidam, J.M., Dees, E.E.C., Selles, R.W. & Hovius, S.E.R. (2010). IMPLICATIONS FOR TREATMENT OF VARIATIONS IN LENGTH OF THE FIRST METACARPAL IN DIFFERENT TYPES OF TRIPHALANGEAL THUMBS. Journal of Hand Surgery- European Volume, 35E(1), Zuijdendorp, H.M., Tra, W.M.W., Neck, J.W. van, Mollis, L & Coert, J.H. (2010). Delay of denervation atrophy by sensory protection in an end-to-side neurorrhaphy model: A pilot study. Journal of Plastic, Reconstructive & Aesthetic Surgery, 63(12), Part of book - abstract Hovius, S.E.R. & Nieuwenhoven, C.A. van (2010). Clinical: Section VI Nerves: Nerve compression syndromes of the upper limb. In JR Urbaniak (Ed.), Hand Surgery Worldwide, International Reconstruction of a Beautiful and Ready Instrument of the Mind (pp ). 225

6 Hovius, S.E.R. (2010). Post traumatic Stress Disorder (PTSD). In FESSH 2010 Bucharest, Instructional Course (pp ). Meulen, J.C. van der, Groot Swanson, G de & Hovius, S.E.R. (2010). History: The Netherlands. In JR Urbaniak (Ed.), Hand Surgery Worldwide, International Reconstruction of a Beautiful and ready instrument of the mind (pp ). Nieuwenhoven, C.A. van & Hovius, S.E.R. (2010). Carpal Tunnel Syndrome in Children. In Moon Sang Chung (Ed.), Hand Surgery 2010 IFSSH (International Federation of Societies for Surgery of the Hand (pp ). 226

7 EMC NIHES Epidemiology of diseases Programme in brief design This program includes scientific research in cardiovascular epidemiology, neuroepidemiology and ophthalmologic epidemiology. Cardiovascular epidemiologic research focuses on the determinants of atherosclerosis and coronary heart disease in the elderly, and on cardiovascular diseases in women. The research is based on the Rotterdam Study and addresses inflammation markers and hemostasis as determinants of cardiovascular diseases in the elderly, and the effects of menopause, endogenous hormones and hormone replacement therapy in women. Neuroepidemiologic research focuses on the etiology of neurodegenerative and cerebrovascular diseases, including dementia and Alzheimer's disease, Parkinson's disease, stroke and cerebral white matter lesions. The research emphasizes the role of vascular factors in the etiology of these diseases, with use of state of the art neuroimaging techniques. Ophthalmological epidemiologic research focuses on determinants of macula degeneration and glaucoma. The emphasis is on the putative role of genetic factors and vascular factors in etiology of these diseases. Key figures Department SP1 SP2 SP3 SP4 Sptot T1 T2 T3 Ttot IS FS OP Ptot epidemiology 3,23 10,68 3,08 0,75 17,74 internal medicine 0 1, ,5 neurology 0, ,2 Total 3,43 12,18 3,08 0,75 19, Thesis Dehghan, A. (2010, maart 31). Novel risk factors for type II diabetes mellitus and coronary heart disease. EUR. Prom./coprom.: Prof. Dr. J.C.M. Witteman & Prof. Dr. E.J.G. Sijbrands. Mook-Kanamori, D.O. (2010, november 24). Genetic and environmental influences on early growth. The Generation R Study. EUR (241 pag.) (Rotterdam: Optima Grafische Communicatie). Prom./coprom.: Prof. Dr. A. Hofman, Prof. Dr. E.A.P. Steegers & Dr. V.W.V.K. Jaddoe. Artikel/Letter to the editor Alberts, VP, Bos, M.J., Koudstaal, P.J., Hofman, A., Witteman, J.C.M., Stricker, B.H.C. & Breteler, M.M.B. (2010). Heart failure and the risk of stroke: the Rotterdam Study. European Journal of Epidemiology, 25(11), Anttila, V, Stefansson, H, Kallela, M, Todt, U, Terwindt, G.M., Calafato, MS, Nyholt, DR, Dimas, AS, Freilinger, T, Muller- Myhsok, B, Artto, V, Inouye, M, Alakurtti, K, Kaunisto, MA, Hamalainen, E, Vries, B de, Stam, AH, Weller, CM, Heinze, A, Heinze-Kuhn, K, Goebel, I, Borck, G, Gobel, H, Steinberg, S, Wolf, C, Bjornsson, A, Gudmundsson, G, Kirchmann, M, Hauge, A, Werge, T, Schoenen, J., Eriksson, JG, Hagen, K, Stovner, L, Wichmann, E, Meitinger, T, Alexander, M, Moebus, S, Schreiber, S., Aulchenko, Y.S., Breteler, M.M.B., Uitterlinden, A.G., Hofman, A., Duijn, C.M. van, Tikka-Kleemola, P, Vepsalainen,., Lucae, S, Tozzi, F, Muglia, P, Barrett, J, Kaprio, J, Farkkila, M, Peltonen, L., Stefansson, K, Zwart, JA, Ferrari, M.D., Olesen, J, Daly, M., Wessman, M, Maagdenberg, A.M.J.M., Dichgans, M, Kubisch, C, Dermitzakis, ET, Frants, R.R. & Palotie, A (2010). Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1. Nature Genetics, 42(10), Baas, DC, Ho, L., Ennis, S, Merriam, JE, Tanck, M.W.T., Uitterlinden, A.G., Jong, P.T.V.M. de, Cree, AJ, Griffiths, HL, Rivadeneira, F., Hofman, A., Duijn, C.M. van, Smith, R.T., Barile, GR, Gorgels, TGMF, Vingerling, J.R., Klaver, C.C.W., Lotery, AJ, Allikmets, R. & Bergen, A.A.B. (2010). The Complement Component 5 Gene and Age-Related Macular Degeneration. Ophthalmology, 117(3), Baas, DC, Despriet, D.D., Gorgels, T.G.M.F., Bergeron-Sawitzke, J, Uitterlinden, A.G., Hofman, A., Duijn, C.M. van, Merriam, JE, Smith, R.T., Barile, GR, Brink, J.B., Vingerling, J.R., Klaver, C.C.W., Allikmets, R., Dean, M & Bergen, A.A.B. (2010). The ERCC6 Gene and Age-Related Macular Degeneration. PLoS One, 5(11). Bakker, R., Pluimgraaff, L.E., Steegers, E.A.P., Raat, H., Tiemeier, H.W., Hofman, A. & Jaddoe, V.W.V.K. (2010). Associations of light and moderate maternal alcohol consumption with fetal growth characteristics in different periods of pregnancy: The Generation R Study. International Journal of Epidemiology, 39(3), Bakker, R., Steegers, E.A.P., Obradov, A, Raat, H., Hofman, A. & Jaddoe, V.W.V.K. (2010). Maternal caffeine intake from coffee and tea, fetal growth, and the risks of adverse birth outcomes: the Generation R Study. American Journal of Clinical Nutrition, 91(6), Bakker, R., Steegers, E.A.P., Mackenbach, J.P., Hofman, A. & Jaddoe, V.W.V.K. (2010). Maternal smoking and blood pressure in different trimesters of pregnancy: The Generation R Study. Journal of Hypertension, 28(11), Barbalic, M, Dupuis, J, Dehghan, A., Bis, JC, Hoogeveen, RC, Schnabel, RB, Nambi, V, Bretler, M, Smith, NL, Peters, A., Lu, C, Tracy, RP, Aleksic, N, Heeriga, J, Keaney, JF, Rice, K, Lip, G.Y.H., Vasan, RS, Glazer, NL, Larson, MG, Uitterlinden, A.G., Yamamoto, J, Durda, P, Haritunians, T, Psaty, B.M., Boerwinkle, E., Hofman, A., Koenig, W., Jenny, NS, Witteman, J.C.M., Ballantyne, C. & Benjamin, EJ (2010). Large-scale genomic studies reveal central role of ABO in sp-selectin and sicam-1 levels. Human Molecular Genetics, 19(9),

8 Batenburg-Eddes, T. van, Groot, L. de, Steegers, E.A.P., Hofman, A., Jaddoe, V.W.V.K., Verhulst, F.C. & Tiemeier, H.W. (2010). Fetal Programming of Infant Neuromotor Development: The Generation R Study. Pediatric Research, 67(2), Becker, M.L., Visser, L.E., Schaik, R.H.N. van, Hofman, A., Uitterlinden, A.G. & Stricker, B.H.C. (2010). Influence of genetic variation in CYP3A4 and ABCB1 on dose decrease or switching during simvastatin and atorvastatin therapy. Pharmacoepidemiology and Drug Safety, 19(1), Becker, M.L., Visser, L.E., Schaik, R.H.N. van, Hofman, A., Uitterlinden, A.G. & Stricker, B.H.C. (2010). Interaction between polymorphisms in the OCT1 and MATE1 transporter and metformin response. Pharmacogenetics Genomics, 20(1), Beurskens, L.W.J.E., Tibboel, D., Lindemans, J., Duvekot, J.J., Overbeek, T.E., Veenma, D.C.M., Klein, A. de, Greer, JJ & Steegers-Theunissen, R.P.M. (2010). Retinol Status of Newborn Infants Is Associated With Congenital Diaphragmatic Hernia. Pediatrics, 126(4), Blauw, HM, Al-Chalabi, A, Andersen, PM, Vught, PWJ Van, Diekstra, FP, Es, MA van, Saris, CGJ, Groen, EJN, Rheenen, W van, Koppers, M, Slot, R van 't, Strengman, E., Estrada, K, Rivadeneira, F., Hofman, A., Uitterlinden, A.G., Kiemeney, LA, Vermeulen, SHM, Birve, A, Waibel, S, Meyer, T, Cronin, S, McLaughlin, RL, Hardiman, O, Sapp, PC, Tobin, MD, Wain, LV, Tomik, B, Slowik, A, Lemmens, R, Rujescu, D, Schulte, C, Gasser, T., Brown, RH, Landers, JE, Robberecht, W, Ludolph, A.C., Ophoff, R.A., Veldink, J.H. & Berg, L.H. van den (2010). A large genome scan for rare CNVs in amyotrophic lateral sclerosis. Human Molecular Genetics, 19(20), Blom, E.A., Jansen, P.W., Verhulst, F.C., Hofman, A., Raat, H., Jaddoe, V.W.V.K., Coolman, M., Steegers, E.A.P. & Tiemeier, H.W. (2010). Perinatal complications increase the risk of postpartum depression. The Generation R Study. Bjog-An International Journal of Obstetrics and Gynaecology, 117(11), Boer, R. de, Vrooman, H.A., Ikram, M.A., Vernooij, M.W., Breteler, M.M.B., Lugt, A. van der & Niessen, W.J. (2010). Accuracy and reproducibility study of automatic MRI brain tissue segmentation methods. Neuroimage, 51(3), Brugts, J.J., Isaacs, A.J., Boersma, E., Duijn, C.M. van, Uitterlinden, A.G., Remme, W, Bertrand, M, Ninomiya, T, Ceconi, C., Chalmers, J, MacMahon, S, Fox, K, Ferrari, R., Witteman, J.C.M., Danser, A.H.J., Simoons, M.L. & Maat, M.P.M. de (2010). Genetic determinants of treatment benefit of the angiotensin-converting enzyme-inhibitor perindopril in patients with stable coronary artery disease. European Heart Journal, 31(15), Brugts, M.P., Duijn, C.M. van, Hofland, L.J., Witteman, J.C.M., Lamberts, S.W.J & Janssen, J.A.M.J.L. (2010). IGF-I Bioactivity in an Elderly Population Relation to Insulin Sensitivity, Insulin Levels, and the Metabolic Syndrome. Diabetes, 59(2), Combarros, O, Warden, DR, Hammond, N, Cortina-Borja, M, Belbin, O, Lehmann, MG, Wilcock, GK, Brown, K., Kehoe, PG, Barber, R, Coto, E, Alvarez, V, Deloukas, P, Gwilliam, R, Heun, R, Kolsch, H, Mateo, I, Oulhaj, A, Arias-Vasquez, A, Schuur, M., Aulchenko, Y.S., Ikram, M.A., Breteler, M.M.B., Duijn, C.M. van, Morgan, K., Smith, AD & Lehmann, DJ (2010). The dopamine beta-hydroxylase-1021c/t polymorphism is associated with the risk of Alzheimer's disease in the Epistasis Project. BMC Medical Genetics, 11. Coolman, M., Groot, C.J.M. de, Jaddoe, V.W.V.K., Hofman, A., Raat, H. & Steegers, E.A.P. (2010). Medical record validation of maternally reported history of preeclampsia. Journal of Clinical Epidemiology, 63(8), Czudowska, M.A., Ramdas, W.D., Wolfs, R.C.W., Hofman, A., Jong, P.T.V.M. de, Vingerling, J.R. & Jansonius, N.M. (2010). Incidence of Glaucomatous Visual Field Loss: A Ten-Year Follow-up from the Rotterdam Study. Ophthalmology, 117(9), Debette, S, Bis, JC, Fornage, M, Schmidt, H., Ikram, M.A., Sigurdsson, S, Heiss, G, Struchalin, M, Smith, AV, Lugt, A. van der, DeCarli, C., Lumley, T, Knopman, DS, Enzinger, C, Eiriksdottir, G, Koudstaal, P.J., DeStefano, AL, Psaty, B.M., Dufouil, C., Catellier, DJ, Fazekas, F., Aspelund, T, Aulchenko, Y.S., Beiser, A, Rotter, JI, Tzourio, C., Shibata, DK, Tscherner, M, Harris, T.B., Rivadeneira, F., Atwood, LD, Rice, K, Gottesman, RF, Buchem, M.A. van, Uitterlinden, A.G., Kelly-Hayes, M, Cushman, M., Zhu, YC, Boerwinkle, E., Gudnason, V, Hofman, A., Romero, JR, Lopez, O, Duijn, C.M. van, Au, R., Heckbert, SR, Wolf, PA, Mosley, TH, Seshadri, S, Breteler, M.M.B., Schmidt, R., Launer, L.J. & Longstreth, W.T. (2010). Genome-Wide Association Studies of MRI-Defined Brain Infarcts Meta-Analysis From the CHARGE Consortium. Stroke, 41(2), Devore, E.E., Grodstein, F., Rooij, F.J.A. van, Hofman, A., Stampfer, M.J., Witteman, J.C.M. & Breteler, M.M.B. (2010). Dietary Antioxidants and Long-term Risk of Dementia. Archives of Neurology, 67(7), Duijts, L., Jaddoe, V.W.V.K., Hofman, A. & Moll, H.A. (2010). Prolonged and Exclusive Breastfeeding Reduces the Risk of Infectious Diseases in Infancy. Pediatrics, 126(1), E18-E25. Durme, Y.M.T.A. van, Eijgelsheim, M., Joos, G.F., Hofman, A., Uitterlinden, A.G., Brusselle, GG & Stricker, B.H.C. (2010). Hedgehog-interacting protein is a COPD susceptibility gene: the Rotterdam Study. European Respiratory Journal, 36(1), Durmus, B., Mook-Kanamori, D.O., Holzhauer, S., Hofman, A., Beek, E.M. van der, Boehm, G., Steegers, E.A.P. & Jaddoe, V.W.V.K. (2010). Growth in foetal life and infancy is associated with abdominal adiposity at the age of 2 years: The Generation R Study. Clinical Endocrinology, 72(5), Eijgelsheim, M., Newton-Cheh, C, Sotoodehnia, N, Bakker, PIW de, Muller, M., Morrison, AC, Smith, AV, Isaacs, A.J., Sanna, S, Dorr, M, Navarro, P, Fuchsberger, C, Nolte, I.M., Geus, E.J.C. de, Estrada, K, Hwang, SJ, Bis, JC, Ruckert, IM, Alonso, A., Launer, L.J., Hottenga, J.J., Rivadeneira Ramirez, F., Noseworthy, PA, Rice, KM, Perz, S, Arking, DE, Spector, T.D., Kors, J.A., Aulchenko, Y.S., Tarasov, KV, Homuth, G., Wild, SH, Marroni, F, Gieger, C, Licht, CM, Prineas, RJ, Hofman, A., Rotter, JI, Hicks, AA, Ernst, F, Najjar, SS, Wright, AF, Peters, A., Fox, ER, Oostra, B.A., Kroemer, HK, Couper, D, Volzke, H, Campbell, H, Meitinger, T, Uda, M, Witteman, J.C.M., Psaty, B.M., Wichmann, HE, Harris, T.B., Kaab, S, Siscovick, D.S., Jamshidi, Y, 228

9 Uitterlinden, A.G., Folsom, A.R., Larson, MG, Wilson, JF, Penninx, BW, Snieder, H, Pramstaller, P.P., Duijn, C.M. van, Lakatta, EG, Felix, SB, Gudnason, V, Pfeufer, A, Heckbert, SR, Stricker, B.H.C., Boerwinkle, E. & O'Donnell, CJ (2010). Genome-wide association analysis identifies multiple loci related to resting heart rate. Human Molecular Genetics, 19(19), Elias-Smale, S.E., Odink, A.E., Wieberdink, R.G., Hofman, A., Hunink, M.G.M., Krestin, G.P., Koudstaal, P.J., Breteler, M.M.B., Lugt, A. van der & Witteman, J.C.M. (2010). Carotid, aortic arch and coronary calcification are related to history of stroke: The Rotterdam Study. Atherosclerosis, 212(2), Elias-Smale, S.E., Proenca, RV, Koller, M.T., Kavousi, M., Rooij, F.J.A. van, Hunink, M.G.M., Steyerberg, E.W., Hofman, A., Oudkerk, M.. & Witteman, J.C.M. (2010). Coronary Calcium Score Improves Classification of Coronary Heart Disease Risk in the Elderly The Rotterdam Study. Journal of the American College of Cardiology, 56(17), Ellinor, PT, Lunetta, KL, Glazer, NL, Pfeufer, A, Alonso, A., Chung, MK, Sinner, MF, Bakker, PIW de, Mueller, M, Lubitz, SA, Fox, E, Darbar, D, Smith, NL, Smith, JD, Schnabel, RB, Soliman, EZ, Rice, KM, Wagoner, DR Van, Beckmann, BM, Noord, C. van, Wang, K, Ehret, GB, Rotter, JI, Hazen, SL, Steinbeck, G, Smith, AV, Launer, L.J., Harris, T.B., Makino, S, Nelis, M, Milan, DJ, Perz, S, Esko, T, Kottgen, A, Moebus, S, Newton-Cheh, C, Li, M., Moehlenkamp, S, Wang, T.J., Kao, WHL, Vasan, RS, Nothen, MM, MacRae, CA, Stricker, B.H.C., Hofman, A., Uitterlinden, A.G., Levy, D., Boerwinkle, E., Metspalu, A, Topol, E.J., Chakravarti, A, Gudnason, V, Psaty, B.M., Roden, DM, Meitinger, T, Wichmann, HE, Witteman, J.C.M., Barnard, J, Arking, DE, Benjamin, EJ, Heckbert, SR & Kaab, S (2010). Common variants in KCNN3 are associated with lone atrial fibrillation. Nature Genetics, 42(3), 240-U36. Euser, S.M., Sattar, N, Witteman, J.C.M., Bollen, ELEM, Sijbrands, E.J.G., Hofman, A., Perry, IJ, Breteler, M.M.B. & Westendorp, R.G.J. (2010). A Prospective Analysis of Elevated Fasting Glucose Levels and Cognitive Function in Older People Results From PROSPER and the Rotterdam Study. Diabetes, 59(7), Flohil, S.C., Vries, E. de, Meurs, J.B.J. van, Fang, Y., Stricker, B.H.C., Uitterlinden, A.G. & Nijsten, T.E.C. (2010). Vitamin D- binding protein polymorphisms are not associated with development of (multiple) basal cell carcinomas. Experimental Dermatology, 19(12), Freathy, RM, Mook-Kanamori, D.O., Sovio, U, Prokopenko, I, Timpson, NJ, Berry, DJ, Warrington, NM, Widen, E, Hottenga, J.J., Kaakinen, M, Lange, LA, Bradfield, JP, Kerkhof, M., Marsh, JA, Magi, R, Chen, C.M., Lyon, HN, Kirin, M, Adair, LS, Aulchenko, Y.S., Bennett, AJ, Borja, JB, Bouatia-Naji, N, Charoen, P, Coin, LJM, Cousminer, DL, Geus, E.J.C. de, Deloukas, P, Elliott, P, Evans, DM, Froguel, P, Glaser, B., Groves, CJ, Hartikainen, AL, Hassanali, N, Hirschhorn, JN, Hofman, A., Holly, J.M.P., Hypponen, E, Kanoni, S, Knight, BA, Laitinen, J, Lindgren, CM, McArdle, WL, O'Reilly, PF, Pennell, CE, Postma, D.S., Pouta, A, Ramasamy, A, Rayner, NW, Ring, SM, Rivadeneira, F., Shields, BM, Strachan, DP, Surakka, I, Taanila, A, Tiesler, C, Uitterlinden, A.G., Duijn, C.M. van, Wijga, A.H., Willemsen, G, Zhang, HT, Zhao, JH, Wilson, JF, Steegers, E.A.P., Hattersley, A.T., Eriksson, JG, Peltonen, L., Mohlke, KL, Grant, S.F.A., Hakonarson, H, Koppelman, G.H., Dedoussis, GV, Heinrich, J., Gillman, MW, Palmer, LJ, Frayling, T.M., Boomsma, D.I., Smith, G.D., Power, C, Jaddoe, V.W.V.K., Jarvelin, MR & McCarthy, MI (2010). Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nature Genetics, 42(5), 430- U73. Geelhoed, J.J.M., Taal, H.R., Steegers, E.A., Arends, L.R., Lequin, M., Moll, H.A., Hofman, A., Heijden, A.J. van der & Jaddoe, V.W.V.K. (2010). Kidney growth curves in healthy children from the third trimester of pregnancy until the age of two years. The Generation R Study. Pediatric Nephrology, 25(2), Geelhoed, M.J.J., Steegers, E.A.P., Koper, J.W., Rossum, E.F.C. van, Moll, H.A., Raat, H., Tiemeier, H.W., Hofman, A. & Jaddoe, V.W.V.K. (2010). Glucocoricoid receptor gene polymorphisms do not affect growth in fetal and early postnatal life. The Generation R Study. BMC Medical Genetics, 11(39). Gelok, S., Janssens, A.C.J.W., Tiemeier, H.W., Liu, F., Lopez-Leon, S, Zorkoltseva, IV, Axenovich, T.I., Swieten, J.C. van, Uitterlinden, A.G., Hofman, A., Aulchenko, Y.S., Oostra, B.A. & Duijn, C.M. van (2010). A Genome-Wide Screen for Depression in Two Independent Dutch Populations. Biological Psychiatry, 68(2), Groen, E. de, Mohangoo, A.D., Jongste, J.C. de, Wouden, J.C. van der, Moll, H.A., Jaddoe, V.W.V.K., Hofman, A., Koning, H.J. de & Raat, H. (2010). Early detection and counselling intervention of asthma symptoms in preschool children: study design of a cluster randomised controlled trial. Bmc Public Health, 10, 555. Groen, H.C., Simons, L., Bouwhuijsen, Q.J.A. van den, Bosboom, EMH, Gijsen, F.J.H., Giessen, A.G. van der, Vosse, F.N. van de, Hofman, A., Steen, A.F.W. van der, Witteman, J.C.M., Lugt, A. van der & Wentzel, J.J. (2010). MRI-based quantification of outflow boundary conditions for computational fluid dynamics of stenosed human carotid arteries. Journal of Biomechanics, 43(12), Hancock, DB, Eijgelsheim, M., Wilk, JB, Gharib, SA, Loehr, LR, Marciante, KD, Franceschini, N, Durme, Y.M.T.A. van, Chen, TH, Barr, RG, Schabath, MB, Couper, DJ, Brusselle, GG, Psaty, B.M., Duijn, C.M. van, Rotter, JI, Uitterlinden, A.G., Hofman, A., Punjabi, NM, Rivadeneira Ramirez, F., Morrison, AC, Enright, P.L., North, KE, Heckbert, SR, Lumley, T, Stricker, B.H.C., O'Connor, GT & London, SJ (2010). Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. Nature Genetics, 42(1), 45-U61. Heijer, T. den, Lijn, F. van der, Koudstaal, P.J., Hofman, A., Lugt, A. van der, Krestin, G.P., Niessen, W.J. & Breteler, M.M.B. (2010). A 10-year follow-up of hippocampal volume on magnetic resonance imaging in early dementia and cognitive decline. Brain, 133, Heine-Broring, RC, Brouwer, I.A., Proenca, RV, Rooij, F.J.A. van, Hofman, A., Oudkerk, M., Witteman, J.C.M. & Geleijnse, J.M. (2010). Intake of fish and marine n-3 fatty acids in relation to coronary calcification: the Rotterdam Study. American Journal of Clinical Nutrition, 91(5),