Hanover Center for Optical Technologies - HOT

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1 Hanover Center for Optical Technologies - HOT apl. Prof. Dr. Bernhard Roth Bernhard.Roth@hot.uni-hannover.de Hannover, November 18 th, 2014 Hannoversches Zentrum für Optische Technologien

2 Hannoversches Zentrum für Optische Technologien 2 The HOT since 2007 fusion of activities in the field of optical technologies in own research center exploit existing knowledge in optical technologies explore new routes of research transfer knowledge into research, teaching and development

3 Hannoversches Zentrum für Optische Technologien 3 The Team Scientific and managing director 16 Scientists (physics, engineering, mathematics, informatics, biology, chemistry) Technician Team assistant Several students (M.Sc., B.Sc., assistants) Bernhard Roth Scientific / managing director

4 Hannoversches Zentrum für Optische Technologien 4 the research portfolio HOT - performs own and collaborative research

5 Hannoversches Zentrum für Optische Technologien 5 HOT research fields Active Microoptics Optical Coherence Tomography Confocal Microscopy Optical Sensing and Analytics Polymer Optics Holography Simulation and Optics Design Optofluidics Illumination Technology Optical Information

6 Hannoversches Zentrum für Optische Technologien 6 Multimodal imaging of melanoma Excision of suspicious skin lesions requires safety in situ: 0.5 cm safety margin < 2 mm: 1 cm safety margin > 2 mm: 2 cm safety margin To date there is no reliable method to determine the penetration depth of skin tumors If a high probability of cancer is suspected, resection margins of 1-2 cm are recommended at first excision. Dermatoscopy of a superficial melanoma with a tumor thickness of 0.56 mm according to Breslow Project goals: in-vivo measurement of melanoma thickness utilizing optical coherence tomography and optoacoustics additional diagnostics with Raman spectroscopy

7 OCT based medical navigation system Hannoversches Zentrum für Optische Technologien 7 Objective: Improvement of robot aided surgery for the implantation of artificial cochlea Methodology: Utilisation of an optical coherence tomograph (OCT) as an operative navigation aid Correlation with preoperative computer tomographic images (CT images) Cochlea implant source: Hanover Medical School HOT Activities: Optical simulation of the OCT set-up Development of calibration standards and strategies Correction of image distortion due to optical setup and refractive index of specimen Optical set-up of an OCT Project partners:

8 OCT in a Medical Navigation System Hannoversches Zentrum für Optische Technologien 8 Simulation of Photon Trajectory

9 Raman Spectroscopy and Optoacoustics in the Life Sciences Confocal Raman microscopy Resonant Raman spectroscopy Optoacoustics topics: biomolecules in situ foci: antioxidants (e.g. carotenoids), proteins (e.g. hemes) non-invasive analysis of tissue/cell culture/biofilms UV-induced photobiological and photochemical effects focus: Vitamin D 3 synthesis inverse simulations: optical properties, image reconstruction, photochemical kinetics Hannoversches Zentrum für Optische Technologien 9

10 Improved Inner Ear Diagnostics (LUH+MHH) Cluster of Excellence: Hearing4all (Fiber based) Raman spectroscopy of inner ear fluids, tissue and their constituents: main goals: analysis of protein composition of human perilymph correlation of perilymph Raman spectra with pathophysiological data from MS analysis development of non-invasive diagnostics using a fiber optic probe for Raman spectroscopy of the inner ear (from: Boenninghaus Lenarz, HNO) extras: Functional mechanisms of relevant target molecules (e.g. Connexin26) can be Regions of hcx26 protomer involved in temperature depending gating as suggested by Raman spectroscopy investigated in vitro. Kniggendorf et al., Biomed. Opt. Express 5, (2014) Hannoversches Zentrum für Optische Technologien 10

11 Hannoversches Zentrum für Optische Technologien 11 Embossing Hologramms Objective: Embossing of Computer Generated Holograms (CGH) into curved metal sheets Methodology: Calculation of die geometry using optical simulations (CGH) Fabrication of die by exposing the CGH into photoresist and galvanic molding of developed resist Lithographic set-up Embossing die into plane metal sheets and subsequent metal forming to obtain a curved metal sheet HOT Activities: Hologram exposed into resist Calculation of CGH Development of lithographic set-up Project partners: Embossed hologram

12 Hannoversches Zentrum für Optische Technologien 12 SFB/Transregio Planar Optronic Systems PlanOS Goal: realisation of novel sensor arrays in polymer foils

13 Hannoversches Zentrum für Optische Technologien 13 Adaptive Microoptics Aim: Development of an adaptive membrane lens for application in a confocal microscope Details: Polyimide as membrane material Electromagnetic actuation Closed-loop-control of membrane motion HOT Activities: Development of solid optical components Development of control soft- and hardware Implementation in confocal microscope Project partner:

14 InTex Intelligent textiles for the SHM of sewage pipes Hannoversches Zentrum für Optische Technologien 14 Objective: Development of a textile sensor system for the Structural Health Monitoring (SHM) of sewage pipes Methodology: Textile sensor system based on humidity and strain sensitive Fiber Bragg Gratings (FBGs) and Optical Time Domain Reflectometry (OTDR) Integrating the textile sensor system in concrete HOT Activities: Project coordination Development of fiber optic humidity and strain sensors Project partners: Quelle OSA Optical SHM of sewage pipes Koppler Fiber optic humidity sensor based on FBGs λ T λ RH

15 Thank you Hannoversches Zentrum für Optische Technologien 15

16 Teaching Coordination of Masters Course Optical Technologies Open for students with B.Sc. in Physics, Mechanical Engineering or related Courses at HOT Lectures: Laser Measurement Laser Spectroscopy in Life Sciences Optical Measurement Technology Laboratory courses (holography, microscopy, ) Student research projects, M.Sc., B.Sc. Hannoversches Zentrum für Optische Technologien 16