AGENDA! ! Wednesday!May!28th:!! 16h00!'!19h30!!! Registration!! 18h00!'!19h30!!!! BBQ!!!! 20h00!!!! Meeting!Opening!!
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1 WednesdayMay28th: 16h00'19h30 Registration 18h00'19h30 BBQ 20h00 MeetingOpening 20h00'20h05 20h05 20h15 20h15 21h15 AGENDA WelcomeNotes:Jean'YvesMasson IntroductionofKeynoteSpeaker:DanDurocher KeynoteAddress:RogerAGreenberg(UniversityofPennsylvania) InterchromosomalHomologySearchesDriveDirectionalALTTelomereMovement andsynapsis 21h15' Social ThursdayMay29th: 07h00 Breakfast(until10am) 8h00'8h55 Registration Gettothebreak(1) 08h55'09h00 09h00 09h25 IntroductionbytheChair:GrantBrown JacquesCôté(UniversitéLaval) RegulationofgenomestabilitybytheNuA4acetyltransferasecomplex: chromatinandbeyond VictoriaFell(Schild'PoulterLab;UniversityofWesternOntario) 09h25 09h50 Ku70S155regulatescellcyclecheckpointsandDNAdamagesignaling 09h50 10h15 NicoleL.Batenburg(Zhulab;McMasterUniversity) RoleofCockayneSyndromeGroupB(CSB)ProteininRegulatingATMActivationand DNADoubleStrandBreakRepair 10h15 10h40 AaronA.Goodarzi(UniversityofCalgary) OpposingISWI'andCHD'classchromatinremodelingactivitiesorchestrateArtemis' dependentheterochromaticdnadoublestrandbreakrepair 10h40 11h05 CoffeeBreak Newwaystolookatcancercells 2
2 11h05'11h10 IntroductionbytheChair:YannickDoyon 11h10 11h35 EsterFalconer(Lansdorplab;BCCancerAgency) High'resolution,high'throughputprofilingofgenomicstructuralheterogeneityof singlecancercellsusingstrand'seq. 11h35 12h00 SabineMai(UniversityofManitoba) Telomeredysfunctionandgenomicinstability 12h00 12h25 StephenMeyn(UniversityofToronto) Quantitativeanalysisofextrachromosomaltelomere'repeatDNAinindividual humancellsbyhalo'fish 12h25 13h45 Lunch 13h50 15h00 PosterSessionA(EVENnumbersarepresented) 15h00 16h10 PosterSessionB(ODDnumbersarepresented) 16h10 16h25 CoffeeBreak Talesofchromosomesandtelomeres 16h25 16h30 IntroductionbytheChair:MomchilVodenicharov 16h30 16h55 DamienD Amours(UniversitédeMontréal) Thepolo'boxdomainofCdc5promotesadaptationtoDNAdamagebytargetingpolo kinaseactivitytocentrosomes 16h55 17h20 TinaL.Sing(Brownlab;UniversityofToronto) TheRSCcomplexfunctionstomaintainploidyinSaccharomycescerevisiae 17h20 17h45 EmilioCusanelli(Chartrandlab;UniversitédeMontréal) Lossofsister'chromatidcohesionatshorttelomeres. 17h45 18h00 EmmanuelBajon(Wellingerlab;UniversitédeSherbrooke) Yeasttelomerasefinallyendsupasingle 18h00 18h15 PierreBillon(Côtélab;UniversitéLaval) PCNAacetylationregulateserror'proneTLSactivities 18h15 19h55 Supper ConsequencesofimpairingDNArepair 19h55 20h00 IntroductionbytheChair:KirkMcManus 20h00 20h25 NirajJoshi(Massonlab;UniversitéLaval) TheidentificationofFancd2DNAbindingdomainsrevealshiddennuclearlocalization sequences 20h25 20h40 FrédérickBouffard(F.Durocherlab;UniversitéLaval) 3
3 20h40 21h05 21h05 21h30 21h30 21h45 AnalysisofasplicingisoformoftheFancEgeneanditsimpactonDNArepair efficiency. NicolasMalaquin(Rodierlab;UniversitédeMontréal) Chromatinstresstriggercellularsenescenceandrapidinflammatorysecretion withoutdnadamage. DindialRamotar(UniversitédeMontréal) ThehistoneH2BR95AmutantisdefectiveinrecruitingtheFACTcomplexprotein Spt16andcausingtelomericdysfunctionthataltersdrugresponses HaoDing(UniversityofManitoba) MousemodelingofRTEL1function 21h45' Social FridayMay30th: 07h00 Breakfast(until10am) Gettothebreak(2) 08h55 09h00 IntroductionbytheChair:RaymundJ.Wellinger 09h00 09h25 GuyPoirier(UniversitéLaval) TowardssystematicidentificationofADP'ribosylatedresiduesinmammalianPARPs 09h25 09h50 GirishM.Shah(UniversitéLaval) Poly(ADP'ribose)polymerase'1andPARylation:Newplayersinmammalian nucleotideexcisionrepair 09h50 10h15 ZubaidahRamdzan(Nepveulab;McGillUniversity) RAS'TransformationinCancerCellsRequiresCUX1'DependentRepairof OxidativeDNADamage 10h15 10h40 JavierM.DiNoia(IRCMMontréal) AIDcoordinatesDNAbreakingandrepairduringantibodyclassswitchrecombination. 10h40 11h05 CoffeeBreak Telomerasefunctioninhealthanddisease 11h05 11h10 11h10 11h25 11h25 11h40 11h40 11h55 IntroductionbytheChair:FrancisRodier THORmethylationprovidesinsightintothetelomeremaintenancelandscapeof malignantgliomas. JohannaMancini(Autexierlab;McGillUniversity) Selectivetelomereshorteningincancercellsbya Pt(II)PhenanthroimidazoleG'quadruplexligand. TaraBeattie(UniversityofCalgary) Influenceoftelomeredynamicsondiseaseprogressionandresponseto therapeuticsinbonemarrowfailuresyndromes. 4
4 11h55 12h10 Judy%M.%Wong(UniversityofBritishColumbia) Non=canonicaltelomerasefunctions,toprotectagainstgenotoxicevents. 12h10 12h25 Nezaha%Ozlem%Arat(Harringtonlab;UniversitédeMontréal) Theimportanceoftelomereintegrityinthestabilityofstemcelldifferentiation 12h25 13h55 Lunch% What%happens%at%the%break%.. 13h55 14h00 IntroductionbytheChair:Louis%Flamand 14h00 14h25 RNF168andRNF169directlyinteractwithhistoneH2A ubiquitylatedonlysine13and15 14h25 14h40 Razq%Hakem(UniversityofToronto) RNF168SubstratesandItsInVivoFunctions 14h40 15h05 Michael%J.%Hendzel(UniversityofAlberta) Ubiquitin=dependentregulationofATMretentionindouble=strand break=associatedfoci. 15h05 15h30 El%Bachir%Affar(UniversitédeMontréal) RoleofTheTumorSuppressorandDeubiquitinaseBAP1inDNADouble=Strand BreakRepair. 15h30 15h45 Hemanta%Adhikary(Massonlab;UniversitéLaval) FormationofDNAdouble=strandbreaksbythemeioticrecombinationproteinSpo11. 15h45 16h10 CoffeeBreak 16h10 16h15 IntroductionofKeynoteSpeaker:RaymundJ.Wellinger 16h15 17h15 Keynote%Presentation:%Peter%Baumann%(Stowers%Institute%for%Medical%Research)% % % % TelomeraseBiogenesisandTelomereArchitecture 18h30 Banquet Social=Prizes Saturday%May%31st:%% 07h00 Breakfast(until10am)andlunchboxpickup 10h30 Coachtotheairport% % % 5
5 Canadian&Symposium&on&Telomeres&and&Genome&Integrity& Official'documents:VisitorstoCanadamustholdavalidpassportand,insomecases,avisa. Formoreinformation,pleasevisittheCitizenshipandImmigrationCanadawebsite: ' Getting'to'Québec'City':' By' air:' Visitors can fly to Québec City, located in the northeastern region of North America.QuébecCity,infact,isamere90minutesflightfromToronto.Efficientrailandroad networks link Québec City to bordering provinces and states. For international travelers, Québec CityJJean Lesage Airport is the most convenient way to reach the city. In order to findataxi,alimousineorothermeansoftransportation,pleasegototheinformationdesk insidetheterminalbeforethesecuritycheckpoint.travellingintaxitomanoirdulacdelage isabout60$. Freeshuttle from the airport to Manoir du Lac Delage: A shuttle bus will leave from the airport on May 28th at 13h15 and 16h15 to Manoir du Lac Delage. Please follow the indications for Canadian& Symposium& on& Telomeres& and& Genome& Integrity& just outside the arrivals.theairportisfairlysmall,itwillbeeasytofind. & By' train:' VIA Rail Canada trains run daily from Toronto, Ottawa and Montréal to QuébecCity.TherearetwotrainstationsinQuébecCity:GareduPalais(CentralStation)and GaredeSainteJFoy.Fromthere,youwillneedtotakeaTaxitoManoirduLacDelage.' Meeting' location: Manoir du Lac Delage. ( Please seedirectionsfromtheairporttomanoirdulacdelageinthefollowingpages.
6 De $ a'r)p)rt,ea-./esage (YQB) 7 fr)9,ea-./esage airp)rt Tourner à droite sur Route de l Aéroport. Tur$ right *$t* R*ute de. A1r*p*rt3 Tourner à gauche sur boul. Wilfrid-Hamel. Tur$.eft *$t* B*u.3 Wi.frid7Ha:e.3 À gauche, rejoindre Autoroute 40 E/Autoroute 73 N en direction de Saguenay/Sainte- Anne-de-Beaupré. Tur$.eft t* :erge *$t* Aut*r*ute 40 E>Aut*r*ute 73 A t*wardsague$ay>sai$te7a$$e7de7beaupr13 Suivre Autoroute 40 E/Autoroute 73 N. Eerge *$t* Aut*r*ute 40 E>Aut*r*ute 73 A3 40, avenue du Lac, Lac-Delage, G3C 5C4 Tél. : / Sans frais
7 Prendre la sortie 142E pour Autoroute 40E/Autoroute 73N en direction de Saguenay/Sainte-Anne-de-Beaupré. Ta#e exit 142E t- stay -0 Aut-r-ute 40 E5Aut-r-ute 73 8 t-wardsague0ay5sai0te A00e de Beaupre? Prendre la sortie 167, direction Stoneham/Tewkesbury/Lac-Delage. Ta#e exit 167 f-r QuCbec 371 t-ward St-0ehaG5Tew#esbury5HacIDeKage? Tournez à gauche sur 1 re Avenue (panneaux pour Québec 371 S). Tur0 Keft -0t- 1e Ave0ue (sig0s f-r QuCbec 371 S)? Continuez sur Avenue Tewkesbury/QC-371 S (panneaux pour Lac-Delage /Stoneham /Tewkesbury). C-0ti0ue -0t- Av Tew#esbury5QCI371 S (sig0s f-r Hac DeKage5St-0ehaG)? Tournez à gauche sur Chemin de la Grande Ligne. Tur0 Keft -0t- CheGi0 de Ka Gra0de Hig0e? Tournez à droite sur Avenue du Lac? Tur0 right -0t- Av du Hac? Tournez à gauche sur Rue du Pied des Pentes. Tur0 Keft -0t- Rue du Pied des Pe0tes? Le stationnement se trouve à votre gauche. The par#i0g is -0 y-ur Keft? 40, avenue du Lac, Lac-Delage, G3C 5C4 Tél. : / Sans frais
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