Functional properties of fructans and their potential role in management of intestinal inflammatory pathologies

Save this PDF as:
 WORD  PNG  TXT  JPG

Size: px
Start display at page:

Download "Functional properties of fructans and their potential role in management of intestinal inflammatory pathologies"

Transcription

1 Functional properties of fructans and their potential role in management of intestinal inflammatory pathologies Dr.ssa Valentina Pasqualetti Unità di Ricerca di Scienze degli Alimenti e della Nutrizione Facoltà Dipartimentale di Medicina e Chirurgia

2 PLoS ONE 9(5): e9803; doi: /journal.pone Research Unit of Food and Nutrition Sciences Laboratory of Plant Biochemistry and Food Sciences (Centro Integrato di Ricerca) Unit of Gastroenterology (Policlinico Universitario)

3 Inulin Poaceae Liliaceae Asteraceae or Compositae Fructose linear polymer, β(2-1) glycosidic bonds, DP of (variable according to plant source, time of plant life cycle, processing conditions ). Mainly present in dicotyledon plants, especially Asteraceae or Compositae. Food industry: natural emulsifier and stabilizer; sugar and fat replacement. Pharmacology: carrier in «drug delivery» (hydrogels); adjuvant agent in vaccine formulation; possible excipient in pharmaceutical formulations.

4 Fructans: «Pro-healthy» effects Soluble dietary fibers which stimulate GI functions. Modulation of growth, composition and functionality of the microbiota (prebiotic and bifidogenic effect). Increase of mineral absorption (Ca 2+ and Mg 2+ ). Improvement of lipid metabolism. Regulation of endocrine gastrointestinal activities (appetite) by modulating the hormone balance. Regulation of immunoregulatory activitiy contributing to the body's defense. Reduction of colon cancer risk.

5 Fructans: TEAC reactivity (scavenging vs ABTS + ) ASC = nmol TE/mg GSH = nmol TE/mg p < 0.05 (ANOVA test) (3 DP 30) (DP 125) Total antiox capability of FOS is an typical attribute of this class of molecules that is determined by the overall structural characteristics of the polymer and not by its constituent units. They have a lower antiox power than ASC and GSH, however, unlike them, they pass along the whole GI tract without being absorbed and, therefore, they have positive action in colon, that is not reached by other antioxidant molecules which are absorbed in the first part of human gut.

6 In vitro simulation of the human digestive process Total antiox capability of Inulin pre- and post-digestion INU p = ns (ANOVA test) Total antiox capability of Ascorbate pre- and post-digestion ASC p < (ANOVA test) This supports the use of fructans in human nutrition as antioxidant molecules being able to reach the intestine (colon), maintaining unchanged their antioxidant properties.

7 Ex vivo experiments on human colon mucosa Ex vivo experimental model AIM: to test the real protective effects of INU in vivo, directly on the intestinal tissue subjected to pro-oxidant and pro-inflammatory stimulus (exposure to LPS from pathogenic strain of E. coli serotype 0111:B4)

8 TEAC reactivity and fructose quantification of supernatant and undernatant liquids Total antiox capability of supernatant and undernatant liquids p < (ANOVA test) Confirmed stability of INU to intestinal environment. Inability of INU to cross the intestinal mucosa (absence of translocations). No damage to the tissue during the preparation of the model that remains intact. INU plays a protective (antiox) effect directly to the site of inflammatory pathology by counteracting ox stress (ROS) in situ associated with the inflammatory process.

9 Oxidative damage to mucosal proteins L esposizione a LPS induce un danno ox alle cellule. Il trattamento con b INU è in grado di proteggere la mucosa intestinale contrastando e prevenendo a l ox irreversibile delle proteine mucosali. a Exposure to LPS induces an ox damage to the mucosal cells. Treatment with INU is able to protect the intestinal mucosa by counteracting and preventing the irreversible ox of mucosal proteins. p < 0.01 (ANOVA test)

10 p < 0.05 (Student t s test) Analysis of the motility of the SMCs a a a No morphological damage and significant change in the length of colon SMCs (Smooth Muscle Cells) compared to the control cells. a Resting Cell Length = 141,7 µm b a Exposure (30') to LPS-undernatant causes a reduction in the Ach-induced maximal contraction compared to the contraction induced in cells incubated with N-undernatant (damage contrasted and prevented by treatment with LPS+INU-undernatant).

11 Conclusions INULIN proven prebiotic and bifidogenic effect; extensive industrial use, security and lack of noticeable side effects; anti-inflammatory and antioxidant action; protective effect against intestinal motility impairment. Possible use of INU as ingredient with ROS scavenger action in the formulation of functional foods naturally enriched or fortified with it. Possible use of INU for the realization of new therapeutic opportunities as a potential clinical approach and medical strategy supporting the conventional anti-inflammatory drug treatment for the prevention of human IBD (Inflammatory Bowel Diseases) and IBS (Irritable Bowel Syndrome).

12 Acknowledgments Research Unit of Food and Nutrition Sciences Laboratory of Plant Biochemistry and Food Sciences (Centro Integrato di Ricerca Università Campus Bio-medico di Roma) Prof.ssa Laura De Gara Dr.ssa Vittoria Locato Unit of Gastroenterology (Policlinico Universitario Campus Bio-medico di Roma) Prof. Michele Cicala Prof.ssa Rossana Alloni Dr.ssa Annamaria Altomare Dr. Michele Pier Luca Guarino

Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome

Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome Andrew T. Gewirtz et al N A T U R E VOL 519 5 M A R C H 2 0 1 5 Background Incidence of IBD Fact 1: increasing

More information

Introduction. Pathogenesis of type 2 diabetes

Introduction. Pathogenesis of type 2 diabetes Introduction Type 2 diabetes mellitus (t2dm) is the most prevalent form of diabetes worldwide. It is characterised by high fasting and high postprandial blood glucose concentrations (hyperglycemia). Chronic

More information

Feeds and Feeding of Commercial Poultry. AgScience Poultry Science Curriculum Section 5

Feeds and Feeding of Commercial Poultry. AgScience Poultry Science Curriculum Section 5 Feeds and Feeding of Commercial Poultry AgScience Poultry Science Curriculum Section 5 Introduction Nutrition is one of the most important aspects of poultry production Comprises 60-70% of production cost

More information

Symptomspesifikke probiotikum. Linda Mulder, MSc. Vårseminaret 2014

Symptomspesifikke probiotikum. Linda Mulder, MSc. Vårseminaret 2014 Linda Mulder, MSc. Vårseminaret 2014 Content Background on probiotics Intestinal microbiota & health on 3 levels Indication-specific probiotics Strain-specific characteristics Monostrain vs. multispecies

More information

Inflammatory Bowel Disease

Inflammatory Bowel Disease Inflammatory Bowel Disease Digestive problems are among the most common conditions affecting Americans today. There are many different types of digestive problems, from gastrointestinal infections that

More information

High Fructose Corn Syrup High Fructose Corn Syrup (HFCS) High Fructose Corn Syrup (HFCS) HFCS - History HFCS - History HFCS - History HFCS History

High Fructose Corn Syrup High Fructose Corn Syrup (HFCS) High Fructose Corn Syrup (HFCS) HFCS - History HFCS - History HFCS - History HFCS History 1 2 3 4 High Fructose Corn Syrup Dianne Koehler, MNT High Fructose Corn Syrup (HFCS) u What is HFCS u HFCS history u Carbohydrate biochemistry u HFCS biochemistry u Health implications High Fructose Corn

More information

Migrene og mikroflora. Linda Mulder, MSc. Vårseminaret 2014

Migrene og mikroflora. Linda Mulder, MSc. Vårseminaret 2014 Migrene og mikroflora Linda Mulder, MSc. Vårseminaret 2014 Contents Introduction to migraine Introduction to intestinal barrier The role of the intestine & microbiota in migraine Finding the best probiotic

More information

INFLAMMATORY BOWEL DISEASE (IBD) MAKING THE MOST OF THE RELATIONSHIP WITH YOUR GASTROENTEROLOGIST

INFLAMMATORY BOWEL DISEASE (IBD) MAKING THE MOST OF THE RELATIONSHIP WITH YOUR GASTROENTEROLOGIST INFLAMMATORY BOWEL DISEASE (IBD) MAKING THE MOST OF THE RELATIONSHIP WITH YOUR GASTROENTEROLOGIST Why Is Seeing a Gastroenterologist Important? A gastroenterologist: Is the most qualified doctor to diagnose

More information

PROBIOTICS HEALTHY GUT, HEALTHY SKIN

PROBIOTICS HEALTHY GUT, HEALTHY SKIN By: Paula Simpson Co-Founder ZSS Pre and Probiotics for Healthy Skin The human gastrointestinal tract (GIT) is home to an incredible population of beneficial bacteria responsible for the complex, related

More information

International Aloe Science Council Certified Facility and Products

International Aloe Science Council Certified Facility and Products Aloe vera L. Simply, the most extensively tested Aloe vera available Aloecorp, Inc International Aloe Science Council Certified Facility and Products Qmatrix The GRAS Ingredient A Highly Purified Fraction

More information

Definition: What is the Microbiome- A Big Picture

Definition: What is the Microbiome- A Big Picture The Microbiome What is the Microbiome- A Big Picture Definition: The collection of genomes of the microbes (bacteria, bacteriophages, fungi, protozoa, and viruses) that live inside a human body Are we

More information

Rheumatoid Arthritis. Treating Inflammation. Sequoia Education Systems, Inc http://www.functionalmedicineuniversity.com 1. How is RA Diagnosed?

Rheumatoid Arthritis. Treating Inflammation. Sequoia Education Systems, Inc http://www.functionalmedicineuniversity.com 1. How is RA Diagnosed? Rheumatoid Arthritis Causes, Assessment and Treatment How is RA Diagnosed? The following labs make up the basics of ruling in or out RA. Citrullinated Peptide (anti-ccp) Antibodies Rheumatoid factor Erythrocyte

More information

Chapter 25: Metabolism and Nutrition

Chapter 25: Metabolism and Nutrition Chapter 25: Metabolism and Nutrition Chapter Objectives INTRODUCTION 1. Generalize the way in which nutrients are processed through the three major metabolic fates in order to perform various energetic

More information

In vitro co-culture model of the inflamed intestinal mucosa

In vitro co-culture model of the inflamed intestinal mucosa In vitro co-culture model of the inflamed intestinal mucosa Berlin, December 13, 2011 Eva-Maria Collnot, e.collnot@mx.uni-saarland.de Helmholtz Institute for Pharmaceutical Research Saarland Departement

More information

FAST FACTS ABOUT FULL MOTION

FAST FACTS ABOUT FULL MOTION FAST FACTS ABOUT FULL MOTION Osteoarthritis is the most frequent cause of physical disability among adults, impacting both quality of life and finances. Osteoarthritis affects more than 40 million Americans

More information

The Polyphenol Study. Effect of Dietary Polyphenols on Intestinal Microbiota, Intestinal Inflammation and Metabolic Syndrome

The Polyphenol Study. Effect of Dietary Polyphenols on Intestinal Microbiota, Intestinal Inflammation and Metabolic Syndrome The Polyphenol Study Effect of Dietary Polyphenols on Intestinal Microbiota, Intestinal Inflammation and Metabolic Syndrome Principal Investigator: Michael Lefevre, PhD What are Polyphenols? * Polyphenols

More information

Dysmetabolism of Bile Acids in feces: implications in human colon pathologies

Dysmetabolism of Bile Acids in feces: implications in human colon pathologies Dysmetabolism of Bile Acids in feces: implications in human colon pathologies SCD, Friday 30 January 2015, Girona Henri Duboc, MD, Phd Dysmetabolism of Bile Acids in feces : implications in human colon

More information

1. Essay: The Digestive and Absorption Processes of Macronutrients

1. Essay: The Digestive and Absorption Processes of Macronutrients Jenny Kim Professor Rosario Nutrition: Macronutrients Project June 26, 2014 1. Essay: The Digestive and Absorption Processes of Macronutrients Whenever we eat, the foods we ingest in our bodies undergo

More information

Nursing 113. Pharmacology Principles

Nursing 113. Pharmacology Principles Nursing 113 Pharmacology Principles 1. The study of how drugs enter the body, reach the site of action, and are removed from the body is called a. pharmacotherapeutics b. pharmacology c. pharmacodynamics

More information

Greyhound Sports Nutrition

Greyhound Sports Nutrition Greyhound Sports Nutrition Introduction Nutrition has the potential to have a real impact on the performance of racing greyhounds. There is evidence in both dogs and human athletes of the importance of

More information

Probiotics for the Treatment of Adult Gastrointestinal Disorders

Probiotics for the Treatment of Adult Gastrointestinal Disorders Probiotics for the Treatment of Adult Gastrointestinal Disorders Darren M. Brenner, M.D. Division of Gastroenterology Northwestern University, Feinberg School of Medicine Chicago, Illinois What are Probiotics?

More information

CHAPTER 21. CONSTIPATION, DIARRHEA, & IRRITABLE BOWEL, SELF-ASSESSMENT. 1. Which one of the following conditions is associated with constipation?

CHAPTER 21. CONSTIPATION, DIARRHEA, & IRRITABLE BOWEL, SELF-ASSESSMENT. 1. Which one of the following conditions is associated with constipation? CHAPTER 21. CONSTIPATION, DIARRHEA, & IRRITABLE BOWEL, SELF-ASSESSMENT QUESTIONS AND ANSWERS 1. Which one of the following conditions is associated with constipation? A. Hypotension B. Diabetes mellitus

More information

Give a NOD to diabetes:

Give a NOD to diabetes: Give a NOD to diabetes: NOD proteins ti link immunity it and metabolism tbli Jonathan Schertzer McMaster University McMaster University Faculty of Health Sciences Department of Biochemistry and Biomedical

More information

The Aloe Vera leaf is just % solid, with an average ph value of 4.55!

The Aloe Vera leaf is just % solid, with an average ph value of 4.55! The Aloe Vera leaf is just 0.5 1.5% solid, with an average ph value of 4.55! This solid material contains over 75 different nutrients including vitamins, minerals, enzymes, sugars, anthraquinones or phenolic

More information

Digestion, Absorption. How & where?

Digestion, Absorption. How & where? Digestion, Absorption How & where? What happens to food? Three processes Digestion Absorption Elimination Where do they occur? GI tract Overview of Digestion GI tract Gastrointestinal (GI) tract: series

More information

John I Allen, MD, MBA

John I Allen, MD, MBA Specialty Clinical Service Lines John I Allen, MD, MBA Minnesota Gastroenterology American Gastroenterological Association ICSI Accountable Care Organization Primary Care Specialty Care Outpatient Care

More information

What is Geriatric? Geriatric Nutrition of Companion Animals. Age Chart. Diseases Associated with Older Pets

What is Geriatric? Geriatric Nutrition of Companion Animals. Age Chart. Diseases Associated with Older Pets Geriatric Nutrition of Companion Animals What is Geriatric? Aging is a biologic process that results in progressive reduction of one s ability to maintain oneself under stress, leading to increased vulnerability

More information

LESSON 2.3 WORKBOOK. Part one: Glucose homeostasis in the blood storing energy

LESSON 2.3 WORKBOOK. Part one: Glucose homeostasis in the blood storing energy LESSON 2.3 WORKBOOK Part one: Glucose homeostasis in the blood storing energy Glucose metabolism takes place in all cells to make ATP. The liver plays an important role in regulating the levels of glucose

More information

Pathophysiology of Diarrhea

Pathophysiology of Diarrhea 1. Pathophysiology of Diarrhea 2. Case Presentation Page - 1 3. Diarrhea is the too rapid evacuation of too fluid sto... 4. The Amazing Intestines helsenet.info Page - 2 5. : Slide 5 6. Diarrhea helsenet.info

More information

BIOAVAILABILITY AND BIOEQIVALENCE

BIOAVAILABILITY AND BIOEQIVALENCE UNIT 5 BIOAVAILABILITY AND BIOEQIVALENCE S. SANGEETHA., M.PHARM., (Ph.d) Department of Pharmaceutics SRM College of Pharmacy SRM University BIOAVAILABILITY INTRODUCTION The bioavailability or systemic

More information

A Scientific Look at Nutrition. Supplement for CEV DVD #80121

A Scientific Look at Nutrition. Supplement for CEV DVD #80121 A Scientific Look at Nutrition Supplement for CEV DVD #80121 A Scientific Look at Nutrition Supplement for CEV DVD #80121 Goal: To understand the purpose and function of the six essential nutrients Objectives:

More information

Inflammatory Bowel Disease

Inflammatory Bowel Disease Inflammatory Bowel Disease Prolonged Remission With Supplements and Diet by Kelly Brown, BSc, ND Clinic One 286 McDermot Avenue Winnipeg, Manitoba R3B 1H6 204 957 5300 www.clinic-1.com Inflammatory bowel

More information

Special organ structures and functions conduct these tasks through the successive parts of the overall system.

Special organ structures and functions conduct these tasks through the successive parts of the overall system. Chapter 5 Digestion, Absorption, and Metabolism Chapter 5 Lesson 5.1 Key Concepts Through a balanced system of mechanical and chemical digestion, food is broken down into smaller substances and the nutrients

More information

Jeffrey Gordon Center for Genome Sciences Washington University, St. Louis, MO

Jeffrey Gordon Center for Genome Sciences Washington University, St. Louis, MO Jeffrey Gordon Center for Genome Sciences Washington University, St. Louis, MO jgordon@molecool.wustl.edu A transcendent view of ourselves We are composite of species: eukaryotic, bacterial, archaeal Our

More information

EXIGENCIA DE ESTUDIOS DE BIOEQUIVALENCIA A TRAVÉS DE METODOS IN VITRO

EXIGENCIA DE ESTUDIOS DE BIOEQUIVALENCIA A TRAVÉS DE METODOS IN VITRO EXIGENCIA DE ESTUDIOS DE BIOEQUIVALENCIA A TRAVÉS DE METODOS IN VITRO Q.F. ALEXIS ACEITUNO, PhD Jefe Subdepto. Biofarmacia & Bioequivalencia Agencia Nacional de Medicamentos Instituto de Salud Pública

More information

Absorption of Drugs. Transport of a drug from the GI tract

Absorption of Drugs. Transport of a drug from the GI tract Absorption of Drugs Absorption is the transfer of a drug from its site of administration to the bloodstream. The rate and efficiency of absorption depend on the route of administration. For IV delivery,

More information

Guidance for Industry

Guidance for Industry Guidance for Industry Food-Effect Bioavailability and Fed Bioequivalence Studies U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER)

More information

Dietary fibre: What is it and how to measure it correctly

Dietary fibre: What is it and how to measure it correctly Dietary fibre: What is it and how to measure it correctly Introduction It is generally recognized that dietary fibre is an essential part of the human food. In our western world the daily intake of dietary

More information

Cell-U-Loss What Is It?

Cell-U-Loss What Is It? Cell-U-Loss What Is It? Supports the appearance of healthy skin.* Supports body s natural detoxification through the kidneys, and healthy activity of the urinary tract.* Supports healthy elimination of

More information

GET THE GUTSY TRUTH ABOUT INFLAMMATORY BOWEL DISEASE EXPECT MORE FROM YOUR TREATMENT

GET THE GUTSY TRUTH ABOUT INFLAMMATORY BOWEL DISEASE EXPECT MORE FROM YOUR TREATMENT GET THE GUTSY TRUTH ABOUT INFLAMMATORY BOWEL DISEASE EXPECT MORE FROM YOUR TREATMENT Patient Education Forums - KOL Presentation What We Will Discuss Today Understanding Inflammatory Bowel Disease (IBD)

More information

Vitamins. Definition. Classification and function

Vitamins. Definition. Classification and function Vitamins Definition Vitamins are essential organic nutrients which, in contrast to other nutrients (carbohydrates, fats and proteins) do not provide any energy or growth boosters, but are necessary for

More information

Methods to assess effects of prebiotics in humans

Methods to assess effects of prebiotics in humans Methods to assess effects of prebiotics in humans Lieselotte Cloetens 1,2, Willem F. Broekaert 3,4, Björn Åkesson 1, Gunilla Önning 1, Jan A. Delcour 3, Kristin Verbeke 2 1 Biomedical Nutrition, Pure and

More information

Digestion, Absorption. How & where?

Digestion, Absorption. How & where? Digestion, Absorption How & where? What happens to food? Three processes Digestion Absorption Elimination Where do they occur? GI tract Overview of Digestion GI tract Gastrointestinal (GI) tract: series

More information

Starch is made up of long chains of glucose molecules joined together. It is found in foods like bread, rice, potatoes and pasta.

Starch is made up of long chains of glucose molecules joined together. It is found in foods like bread, rice, potatoes and pasta. FACTSHEET No. 25 Bread Introduction What are carbohydrates? Carbohydrates can be divided into two main groups, sugars and starch: Sugars: These can be made from one single sugar molecule (monosaccharides),

More information

Sweet-taste receptors, glucose absorption and insulin release: Are LCS nutritionally active?

Sweet-taste receptors, glucose absorption and insulin release: Are LCS nutritionally active? Sweet-taste receptors, glucose absorption and insulin release: Are LCS nutritionally active? Samuel V. Molinary, Ph.D. Consultant, Scientific & Regulatory Affairs ILSI/NA April 6, 2011 Washington, DC Why

More information

RICEO TM. Water Soluble Concentrate Powder Providing Natural Vitamin B Group and Minerals

RICEO TM. Water Soluble Concentrate Powder Providing Natural Vitamin B Group and Minerals RICEO TM Water Soluble Concentrate Powder Providing Natural Vitamin B Group and Minerals RICEO TM is a water-soluble powder extracted from defatted rice bran. It is mainly composed of carbohydrate, dietary

More information

GLUCOHelp. A fast-acting, clinically proven way to control blood glucose levels. Banaba Leaf Extract, Standardized to 18% Corosolic Acid

GLUCOHelp. A fast-acting, clinically proven way to control blood glucose levels. Banaba Leaf Extract, Standardized to 18% Corosolic Acid A fast-acting, clinically proven way to control blood glucose levels GLUCOHelp Banaba Leaf Extract, Standardized to 18% Corosolic Acid www.optipure.com 9 GLUCOHelp A fast-acting, clinically proven way

More information

Triple Action System. Promotes HGH - NITRIC OXIDE - SOD

Triple Action System. Promotes HGH - NITRIC OXIDE - SOD Triple Action System Promotes HGH - NITRIC OXIDE - SOD CORSENTIALS makes vibrant health simple. The CORSENTIALS system is composed of LifeWave s exclusive, patent-pending technologies that transform health

More information

NO More Heart Disease

NO More Heart Disease NO More Heart Disease Nitric Oxide Information NO is one of the simplest molecules in biology, comprised of just two atoms one atom of nitrogen (N) and one of oxygen (O). Through NO s structure is simple,

More information

Emphasis on Live Cost. What s Next in Feed Innovations / Additives? Feed Ingredients. Feed - Amino Acids 2/20/2014. Don McIntyre.

Emphasis on Live Cost. What s Next in Feed Innovations / Additives? Feed Ingredients. Feed - Amino Acids 2/20/2014. Don McIntyre. VA State Feed Association Roanoke, VA February 20, 2014 What s Next in Feed Innovations / Additives? Don McIntyre Dir. Research & Technical Service Emphasis on Live Cost 1. Poultry (monogastric) versus

More information

Nutritional Challenges After Surgery

Nutritional Challenges After Surgery Nutritional Challenges After Surgery L I N D A P A T A K I M S R D C S O L D C N S C M D A N D E R S O N C A N C E R C E N T E R H O U S T O N, T E X A S Objectives Identify the reasons that GIST and its

More information

Course Curriculum for Master Degree in Food Science and Technology/ Department of Nutrition and Food Technology

Course Curriculum for Master Degree in Food Science and Technology/ Department of Nutrition and Food Technology Course Curriculum for Master Degree in Food Science and Technology/ Department of Nutrition and Food Technology The Master Degree in Food Science and Technology / Department of Nutrition and Food Technology,

More information

Oral Bioavailability of Creatine Supplements: Is There Room for Improvement?

Oral Bioavailability of Creatine Supplements: Is There Room for Improvement? Oral Bioavailability of Creatine Supplements: Is There Room for Improvement? Donald W. Miller Associate Professor Department of Pharmacology and Therapeutics University of Manitoba Acknowledgements ISSN

More information

CapixylTM. The synergistic anti-aging hair complex for stronger and thicker hair

CapixylTM. The synergistic anti-aging hair complex for stronger and thicker hair CapixylTM The synergistic anti-aging hair complex for stronger and thicker hair The importance of hair in our lives cannot be overstated. Whether men or women lose their hair, they lose much more than

More information

DIET IN DISORDERS OF LIVER

DIET IN DISORDERS OF LIVER DIET IN DISORDERS OF LIVER See inside.. Introduction Liver diseases Dietary care & management Conclusion Introduction Liver is the largest gland in the body, which plays a vital role, performing many complex

More information

What is nanotoxicology?

What is nanotoxicology? What is nanotoxicology? How to estimate the potential hazard related to nanoparticles? Dissemination report October 2008 DR-225 200810-5 Project ID NMP2-CT-2005-515843 An European Integrated Project Supported

More information

Glutathione and Oxidative Stress - Part I

Glutathione and Oxidative Stress - Part I Glutathione and Oxidative Stress - Part I By: James L. Holly, MD Oxidative Stress refers to effects from endogenous (produced in the body) toxins (free radicals) produced in the body by normal metabolism

More information

Your Digestive System and How It Works

Your Digestive System and How It Works Your Digestive System and How It Works National Digestive Diseases Information Clearinghouse U.S. Department of Health and Human Services NATIONAL INSTITUTES OF HEALTH The digestive system is made up of

More information

A little knowledge can make a big difference.

A little knowledge can make a big difference. Chronic Intestinal Pseudo-obstruction Pediatric and Adolescent Gastrointestinal Motility & Pain Program Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, Louisiana

More information

NUTRIENTS: THEIR INTERACTIONS

NUTRIENTS: THEIR INTERACTIONS NUTRIENTS: THEIR INTERACTIONS TEACHER S GUIDE INTRODUCTION This Teacher s Guide provides information to help you get the most out of Nutrients: Their Interactions. The contents in this guide will allow

More information

Summary and conclusion 2013

Summary and conclusion 2013 The work presented in the thesis is focused on the problems related to the prostate gland. Benign prostatic hyperplasia (BPH) and prostate cancer (PCa) are the two major problems associated with prostate.

More information

Institute of Biochemistry I - Pathobiochemistry

Institute of Biochemistry I - Pathobiochemistry Institute of Biochemistry I - Pathobiochemistry Johann Wolfgang Goethe-University Our mission It is the intention to elucidate biochemical signatures with relevance to inflammation and hypoxia, thus contributing

More information

Respect It. Protect It. Learn More About It.

Respect It. Protect It. Learn More About It. YOUR DIGESTIVE SYSTEM FUELS YOUR LIFE. Respect It. Protect It. Learn More About It. Digestive disorders can happen to anyone, at any age. The Canadian Digestive Health Foundation (CDHF) estimates 20 million

More information

ADD PROFI TO YOUR RECIPE ADD PROFIT TO YOUR BUSINESS ADD PROTEIN ADD FIBER ADD TRUST ADD VALUE ADD DEALERS INGREDIENTS

ADD PROFI TO YOUR RECIPE ADD PROFIT TO YOUR BUSINESS ADD PROTEIN ADD FIBER ADD TRUST ADD VALUE ADD DEALERS INGREDIENTS PROFI TO YOUR RECIPE ADD PROFIT TO YOUR BUSINESS ADD PROTEIN ADD FIBER ADD TRUST ADD VALUE ADD DEALERS INGREDIENTS PROFI CAN HELP CONSUMERS MEET DAILY PROTEIN GOALS A concentrated complete vegetable protein

More information

Call for Expressions of Interest

Call for Expressions of Interest Call for Expressions of Interest Arla Foods Dairy Health and Nutrition Excellence Center Arla Foods, Sønderhøj 10, 8260 Viby J - E-mail: hejan@arlafoods.com Phone: 2095 1241 September 2015 2016 Call Introduction

More information

ALI 334: STRESS THE FIRE WITHIN US

ALI 334: STRESS THE FIRE WITHIN US ALI 334: STRESS THE FIRE WITHIN US UNDERSTANDING CHRONIC STRESS By: Aziza Amarshi, BSc, RPh, RHN OBJECTIVE OF THIS COURSE 1. What is stress? Difference between acute and chronic stress 2. Identify Chronic

More information

Nutrition and Toxicants in Autoimmune Disease: Implications for Prevention and Treatment

Nutrition and Toxicants in Autoimmune Disease: Implications for Prevention and Treatment Nutrition and Toxicants in Autoimmune Disease: Implications for Prevention and Treatment Collaborative on Health and the Environment June 17, 2014 Ted Schettler MD, MPH 1 Autoimmune diseases Autoimmunity

More information

Introduction to Enteris BioPharma

Introduction to Enteris BioPharma Introduction to Enteris BioPharma Enteris BioPharma Intelligent Solutions for Oral Drug Delivery Privately held, New Jersey based biotech company Owned solely by Victory Park Capital, a large Chicago based

More information

Carbohydrates, Lipids, and Proteins 3.2

Carbohydrates, Lipids, and Proteins 3.2 Carbohydrates, Lipids, and Proteins 3.2 Organic vs. Inorganic compounds Organic compounds contain carbon and are found in living organisms Exceptions: hydrocarbonates, carbonates, oxides of carbon. Inorganic

More information

DO YOU HAVE AN IRRITABLE BOWEL?

DO YOU HAVE AN IRRITABLE BOWEL? DO YOU HAVE AN IRRITABLE BOWEL? The name says it all. The Term irritable bowel conjures up visions of burping, bloating, upper and lower bowel wind, maybe acid reflux from your stomach as well as constipation

More information

TOP 12 FOODS JESUS ATE

TOP 12 FOODS JESUS ATE TOP 12 FOODS JESUS ATE WHAT WOULD JESUS HAVE EATEN? Over the past several years, with the increasing interest in eating and living healthier, the question about what Jesus might have eaten has become a

More information

GI TRACT ORGANS ACCESSORY ORGANS

GI TRACT ORGANS ACCESSORY ORGANS Digestive System GI TRACT ORGANS Oral cavity Oropharynx Esophagus Stomach Small intestine Large Intestine Anus ACCESSORY ORGANS Salivary glands Pancreas Liver Gall bladder GI TRACT LAYERS Mucosa Submucosa

More information

Digestive System Why is digestion important? How is food digested? Physical Digestion and Movement

Digestive System Why is digestion important? How is food digested? Physical Digestion and Movement Digestive System The digestive system is made up of the digestive tract a series of hollow organs joined in a long, twisting tube from the mouth to the anus and other organs that help the body break down

More information

Problems of the Digestive System

Problems of the Digestive System The American College of Obstetricians and Gynecologists f AQ FREQUENTLY ASKED QUESTIONS FAQ120 WOMEN S HEALTH Problems of the Digestive System What are some common digestive problems? What is constipation?

More information

PRODUCT PROFILE. Soothing, hydrating and protective gel For external use only. Description. Regulatory status. Cosmetic. Dosage. 1 application per day

PRODUCT PROFILE. Soothing, hydrating and protective gel For external use only. Description. Regulatory status. Cosmetic. Dosage. 1 application per day PRODUCT PROFILE PRODUCT PROFILE Description Regulatory status Dosage Principle ingredients Soothing, hydrating and protective gel For external use only Cosmetic 1 application per day Zinc Gluconate and

More information

The Omega-3 Debate. Presented by Terry Lemerond. Telephone: Access Code:

The Omega-3 Debate. Presented by Terry Lemerond. Telephone: Access Code: The Omega-3 Debate Presented by Terry Lemerond Quick Review of Omega-3 Fatty Acids Essential Human body can t make them Must be acquired through food Benefits Reduce risk of many chronic diseases Cancer,

More information

THE DIGESTIVE SYSTEM

THE DIGESTIVE SYSTEM THE DIGESTIVE SYSTEM What is digestion? Digestion is the process of breaking down food so that it's small enough to be absorbed and used by the body for energy or in other bodily functions. Digestion involves

More information

Blood Testing Protocols. Disclaimer

Blood Testing Protocols. Disclaimer Blood Testing Protocols / Page 2 Blood Testing Protocols Here are the specific test protocols recommend by Dr. J.E. Williams. You may request these from your doctor or visit www.readyourbloodtest.com to

More information

The Pancreas. The Pancreas and Digestive Functions Pancreatic Secretions. Pancreatic enzymes basics. Development Pancreatic removal

The Pancreas. The Pancreas and Digestive Functions Pancreatic Secretions. Pancreatic enzymes basics. Development Pancreatic removal The Pancreas Why all the fuss? The Pancreas and Digestive Functions Pancreatic Secretions Pancreatic HCO3 - (bicarbonate) secretion Secretin is a hormone Secretin from S-cells in duodenum in response to

More information

IRRITABLE BOWEL SYNDROME. Kevin W. Olden, M.D., FACG Mayo Clinic

IRRITABLE BOWEL SYNDROME. Kevin W. Olden, M.D., FACG Mayo Clinic IRRITABLE BOWEL SYNDROME Kevin W. Olden, M.D., FACG Mayo Clinic What is the Irritable Bowel Syndrome? The irritable bowel syndrome (IBS) is a disorder of bowel function (as opposed to being due to an anatomic

More information

Call 2014: High throughput screening of therapeutic molecules and rare diseases

Call 2014: High throughput screening of therapeutic molecules and rare diseases Call 2014: High throughput screening of therapeutic molecules and rare diseases The second call High throughput screening of therapeutic molecules and rare diseases launched by the French Foundation for

More information

Why Chelated Minerals are Not Created Equal

Why Chelated Minerals are Not Created Equal Source: ALBION LABORATORIES INC. - A collation of the chapters on the Albion website: http://www.albionminerals.com/knowledge/chelates-not-created-equal Why Chelated Minerals are Not Created Equal Once

More information

Digestive System Notes

Digestive System Notes Digestive System Notes Structure Function Relation Mouth cavity Mechanical digestion by teeth; chemical digestion of starch by saliva. Salivary glands Three pairs of glands which secrete saliva containing

More information

DiAgRaMs- RAAK PRO. Shirley Kartaram

DiAgRaMs- RAAK PRO. Shirley Kartaram DiAgRaMs- RAAK PRO Standardization of the bicycle ergometer test as challenge model to assess nutritional effects on intestinal health and the immune system Shirley Kartaram Department Innovative Testing

More information

Chapter. Energy Balance and Weight Management: Finding Your Equilibrium

Chapter. Energy Balance and Weight Management: Finding Your Equilibrium Chapter 9 Energy Balance and Weight Management: Finding Your Equilibrium Regulation of intake Hunger Prompts eating; physiological desire Satiation Signals to stop eating Satiety Lack of hunger Appetite

More information

Anti-Inflammatory Drugs from Plant and Marine Sources

Anti-Inflammatory Drugs from Plant and Marine Sources D. A. Lewis Anti-Inflammatory Drugs from Plant and Marine Sources 1989 BirkhauserVerlag Basel Boston Berlin TABLE OF CONTENTS Page No. Preface. Acknowledgements..12 SECTION I : INFLAMMATION AND INFLAMMATORY

More information

A network to collect and store Italian food composition data

A network to collect and store Italian food composition data A network to collect and store Italian food composition data S Salvini 1, P Gnagnarella 2, F Concina 1, L Marletta 3, E Camilli 3, M Parpinel 1 simonetta.salvini58@gmail.com 1 Dipartimento di Scienze Mediche

More information

what is Fibersol-HS? Physical Characteristics Typical Essential Properties Fibersol-HS can be used to reduce calories and sugars.

what is Fibersol-HS? Physical Characteristics Typical Essential Properties Fibersol-HS can be used to reduce calories and sugars. fiber fit for all! F ibersol- HS has been specially designed for applications where replacing liquid honey and sugar to reduce calories and adding fiber are beneficial! what is Fibersol-HS? Fibersol -HS

More information

Dietary Management of Inflammatory Bowel Disease

Dietary Management of Inflammatory Bowel Disease Dietary Management of Inflammatory Bowel Disease Crohn s disease and chronic ulcerative colitis are two diseases that are together classified as inflammatory bowel disease (IBD) and result in an inflammation

More information

General characteristics

General characteristics Carbohydrates General characteristics The term carbohydrate is derived from the french: hydrate de carbone Compounds composed of C, H, and O Empirical formula: (CH 2 O) n Our body derives energy from the

More information

Inflammatory Bowel Disease (IBD) and Ulcerative Colitis

Inflammatory Bowel Disease (IBD) and Ulcerative Colitis Inflammatory Bowel Disease (IBD) and Ulcerative Colitis Here are some words to help you understand this disease. There are pictures on the next page so you can see these parts in a body. Bowels: The bowels

More information

The effects that are in play when the enzyme-substrate complex forms: The chains needed for catalysis are in the active site

The effects that are in play when the enzyme-substrate complex forms: The chains needed for catalysis are in the active site The effects that are in play when the enzyme-substrate complex forms: The proximity effect: The orientation effect: The catalytic effect: The energy effect: The enzyme has to join up with the substrate

More information

Frequently Asked Questions: Ai-Detox

Frequently Asked Questions: Ai-Detox What is Ai-Detox? Frequently Asked Questions: Ai-Detox Ai-Detox is a Chinese herbal medicinal formula, produced using state of the art biotechnology, which ensures the utmost standards in quality and safety.

More information

Nutrition of Hybrid Striped Bass

Nutrition of Hybrid Striped Bass Nutrition of Hybrid Striped Bass Importance of nutrition Maximize growth Maintain health & avoid deficiency diseases Minimize lipid deposition in product Minimize off-flavor Reduce cost of production General

More information

The Use of Anti-Inflammatory Nutrition To Slow The Aging Process. Dr. Barry Sears President Inflammation Research Foundation

The Use of Anti-Inflammatory Nutrition To Slow The Aging Process. Dr. Barry Sears President Inflammation Research Foundation The Use of Anti-Inflammatory Nutrition To Slow The Aging Process Dr. Barry Sears President Inflammation Research Foundation Anti-Aging Is Best Defined As Slowing The Development Of Chronic Disease Chronic

More information

Endocrine System: Practice Questions #1

Endocrine System: Practice Questions #1 Endocrine System: Practice Questions #1 1. Removing part of gland D would most likely result in A. a decrease in the secretions of other glands B. a decrease in the blood calcium level C. an increase in

More information

and Antigen Presentation

and Antigen Presentation 1 Innate Immunity and Antigen Presentation Andrew Lichtman, MD PhD Brigham and Women's Hospital Harvard Medical School 2 Lecture outline Innate immunity Receptors and mechanisms Roles in disease Antigen

More information

Balancing Hormones through Diet. THE GLYCEMIC INDEX (GI) is a physiologically based measure of carbohydrate quality a

Balancing Hormones through Diet. THE GLYCEMIC INDEX (GI) is a physiologically based measure of carbohydrate quality a Balancing Hormones through Diet THE GLYCEMIC INDEX (GI) is a physiologically based measure of carbohydrate quality a comparison of carbohydrates (gram for gram) based on their immediate effect on blood

More information

SMALL AND LARGE INTESTINE SECRETIONS

SMALL AND LARGE INTESTINE SECRETIONS SMALL AND LARGE INTESTINE SECRETIONS Objectives At the end of lecture student should be able to know, Digestive system Digestive system secretions Small intestine Component of small intestine Intestinal

More information

FDA s Generally Recognized As Safe (GRAS) Notification Program: Live Microbial Cultures Used in Food

FDA s Generally Recognized As Safe (GRAS) Notification Program: Live Microbial Cultures Used in Food FDA s Generally Recognized As Safe (GRAS) Notification Program: Live Microbial Cultures Used in Food Shayla West-Barnette, PhD Supervisory Consumer Safety Officer/Microbiology Reviewer Division of Biotechnology

More information