New Horizons in IVF Genetic Diagnosis

Transcription

1 Final program New Horizons in IVF Genetic Diagnosis 4th 7th October 2012 in IVF Spain, Alicante

2 We would like to introduce our new revolutionary genetic test kit to open new horizons in genetic diagnosis applied to IVF. This workshop intends to be interdisciplinary and interactive, allowing not only deep inside into the newest results, but also demo shows and hands-on training regarding the most advanced biopsy techniques around PGD and PGS on Polar Body and trophoectoderm. Personal letter & Description It will be a pleasure to meet you in Alicante. We will be organizing this workshop with small selected groups of professionals. Yours, Santiago Munné Course description including main topics The course will focus on the state of the art of molecular screening of embryos in the context of IVF, on realistic scenarios regarding the further development of this field, and on the ethical and social implications. Background: reproductive scientists and clinicians aim at the (further) development of preimplantation genetic screening (PGS), i.e. a systematic offer embryo testing to (all) IVF patients and/or the offer of wider embryo testing to (all) applicants of PGD. At present, the use of microarrays is being explored as a promising technology in this context as it allows for a more comprehensive screening of embryos than is possible with non-molecular techniques. At the same time, microarray screening leads to a host of difficult ethical questions. These regard the definition of the precise aims of embryo screening, the handling of unsought information, the possibility of informed consent, the prospect of additional selection for non-medical traits, etc. Should it become possible in the (near) future to screen IVFembryos on the basis of whole genome sequencing (regarded by some experts as a realistic scenario), these questions will only become more difficult, presenting the field with some real challenges and dilemmas. Course objectives 1. To present an overview of current and realistically expected developments in preimplantation genetic screening (PGS) and preconceptional screening (PCS), including the use of microarrays and the possible introduction of WGS-based screening 2. To raise awareness of the complex ethical issues involved and to systematically identify the main dilemmas and challenges arising in this context 3. To promote discussions, evaluations and participation in clinical trials. Target audience The target audience consists of clinicians and scientific working in IVF, PGD, PGS (gynaecologists, embryologists, clinical geneticists, molecular geneticists, etc.) interested in the development of this field.

3 Dr. med. Jon Aizpurua, Spain IVF Spain, Alicante Prof. Juan Àlvarez, Spain Director of the Institute of Male Infertility, Unidad de La Mujer, La Coruna Invited Speakers Dr. med. Mathias Bloechle, Germany Director Kinderwunschzentrum an der Gedächtniskirche Berlin Priv.-Doz. Dr. med. Tina Buchholz, Germany Praxis für Gynäkologie und Genetik, Labor für Reproduktionsgenetik, München Prof. Maria Jesús Buxó, Spain Bioetics Committee to the Spanish Government and Chair of Anthropology Univ. Barcelona Dr. Buenaventura Coroleu, Spain Head of Fertility Service Instituto Universitario Dexeus R. Daser, Germany???? Prof. Dr. Alan Handyside, UK Genetic Laboratory The Bridge Centre London Prof. Dr. med. Karsten Held, Germany Head of Reprogenetics Germany Prof. Dr. José Antonio Horcajadas, Spain University P. Olavide, Sevilla and Scientific advisor of IVF Spain Peter Humaidan, Denmark The Fertility Clinic, Skive Regional Hospital Prof. Dr. med. Jan-Steffen Krüssel, Germany Universitätsfrauenklinik Düsseldorf, Koordinator UniKiD Nikola Kuhrt, Germany Journalist Der Spiegel Dr. SG Lin Tan, Canada Mc Gill University, Montreal Fernando Lozano, Spain Head of Loeber & Lozano Spanish-German Law Firm Dr. Julio Martin, Spain Head of Monogenetic Disease Laboratory at IVI, Valencia Prof. Santiago Munné, USA Director at IRMS, Saint Barnabas Medical Center, President of Reprogenetics and Recombine Dr. med. Andreas Schmutzler, Germany Kinderwunschzentrum im UK Schleswig Holstein, Campus Kiel Prof. Dr. med. Michael von Wolff, Switzerland Abteilung für Gynäkologische Endokrinologie und Reproduktionsmedizin Universitäts-Frauenklinik Inselspital Bern Prof. Dagan Wells, UK University of Oxford, Head of Reprogenetics UK

4 October 4, Thursday Benefits and problems of genetic diagnosis due to applied techniques and legal framework Program 9:30 Reception and inscription >> Spit sample collection to match your genome with that of gamete donors of IVF-Spain for optimal (and fun) results 10:00 Welcome and Opening Overview of legal differences in genetic diagnosis inside Europe. Fernando Lozano 10:30 Legal status of PGD in Germany/Swisse/Austria/Italy Mathias Bloechle 11:00 Recruitment for PGD patients in Germany Karsten Held 11:30 Preconceptional screening as a source of new PGD cases José Antonio Horcajadas 12:00 Coffee break 12:30 Ethical and social aspects of preimplantational and preconceptional diagnosis in Europe. Nicola Kuhrt (tbc) >> Lectures in german/english Invited mainly german / swiss / austrian / italian doctors 13:30 Lunch break 16:00 PGD and PGS practice in Europe: possible paths from the legal and ethical point of view. María Jesús Buxó 17:00 Discussion panel: Genetic diagnosis. Future and society Peter Humaidan / Fernando Lozano / María Jesús Buxó / Alan Handyside / Mathias Bloechle / Dagan Wells 18:00 Biopsing and Genetic Diagnosis demonstration at IVF Spain 20:00 Welcome Dinner at Husa Hotel 13:00 Use of new genetic tools as mainstream future direction of reproductive medicine Alan Handyside (tbc)

5 October 5, Friday PGS for suitable embryo selection Program 9:00 Overview of genetic developments, available tools and reliability to increase success in IVF Dagan Wells 9:30 Trophoectoderm biopsy with and without freezing: US research results José Antonio Horcajadas (tbc) 10:00 Techniques and Feasibility of Polar Body Biopsy (PBB) R. Daser (tbc) / Tina Buchholz (tbc) 10:30 Freezing and sampling of Polar Body Biopsies, making PGS affordable to all. Jon Aizpurua Coffee break Aneuploidy in differently stimulated and non stimulated cycles 11:30 IVM development, results and aneuploidy SG Lin Tan 12:00 Natural Cycle and mild stimulation as aneuploidy protection Michael von Wolff 12:30 Is there a relationship between gonadotrophine dosis and induced aneuploidy depending on age? Jan-Steffen Kruessel (tbc) / Peter Humaidan (tbc) 13:00 hgh and new stimulation approaches in older patients, an overview Buenaventura Coroleu 13:30 Lunch break 16:30 Biopsing and Genetic Diagnosis demonstration at IVF Spain 17:30 Presentation of studies PBB Eshre Study, Andreas Schmutzler PBB vs. PGS Study, Jan Kruessel Currrent studies to improve PGS in USA, Dagan Wells Recombine ethnic groups study, Santi Munné 20:00 Jamon and Flamenco Dinner at Saleri Restaurant

6 October 6, Saturday Genetic diagnosis and embryo feasibility Program 9:00 Combined PGD and PGS with CGH and array technologies. Santiago Munné 9:30 DGP and monogenic diseases: historical overview and new tendencies Julio Martín 10:00 Impact of male genetics on embryonic feasibility, new approaches Juan Álvarez 10:30 Morphokynetics as a marker of embryo feasibility and euploidy? Alan Handyside Coffee break 11:30 Breakthrough to a new era: preconceptional screening as a new paragigm and prerequisite for preimplantational and prenatal screening José Antonio Horcajadas 12:00 Benefits of preconceptional screening in donor matching and IVF praxis Dagan Wells, Jon Aizpurua 16:00 Description of ongoing studies to start kick off meetings Recombine in different ethnic groups PBB in aged women vs. PGS and CGH Natural cycle vs. classical stimulation under the scope of oocyte euploidy Morphogenetics vs. PGS on PB; a correlation study 17:00 Hands on training >> Reporting of results of the Recombine test of participants and best matches. 20:00 Closing Dinner at Volvo Oceans Race Club 12:30 Discussion Lunch break

7 October 7, Sunday Program Sailing to the future 10:00 Kick off meetings on Blue Lagoon Catamaran (capacity 100 people) 14:00 Working lunch at Tabarca Island

8 Jon Aizpurua Santiago Munné IVF Spain Avda. de Ansaldo, Alicante Phone and Fax: Hosts & Organizers

9 We express our gratidude to: Sponsors

10 WICARA Congress Organization GbR Managing Directors: Gabriele Wickert and José Aranzabal Amsterdamer Weg Dortmund Phone Fax Mobile Information & Registration Meeting Venue HUSA ALICANTE Golf & Spa Hotel **** Av. de las Naciones, s/n Alicante España Tel.: (+034) Fax: (+034)

11 Please fax or Registration & Accommodation Form 1 Participant Please type in block letters First Name Family Name Title Mailing Address O Office O Residence Institute Street No Zip Code Registration Fees including accomodation and social program Until September 1st, ,00 EUR After September 1st, ,00 EUR All cancellations must be faxed or ed Refund of registration fees will be as follows: Until September 15th, 2012: 100% refund (minus 50,00 EUR handling fee) After September 15th, 2012: no refund on cancellations Registration confirmation will be send by after full payment is recieved Accompanying person Fee for complete social program 150,00 EUR City Name State Fon Attendance Please indicate your attendance Fax Participant Accompanying Person address O Scientific Program October 4th 6th O O Welcome Dinner October 4th O O Jamon and Flamenco Dinner October 5th O O Closing Dinner October 6th O O Sailing to the future October 7th

12 Please fax or Registration & Accommodation Form 2 Methods of Payment Binding registration 1. Payment by debit advice procedure (Lastschrifteinzugsermächtigung) Participants from Germany or Participants with a bank account in Germany Total in Euro Date and signature Bank institution KTO BLZ 2. Payment by Bank Transfer Please make drafts payable to: WICARA Deutsche Apotheker- und Ärztebank KTO BLZ IBAN DE BIC DAAEDEDD Note to payee : IVF Spain October 2012 Please send fully completed registration form together with a copy of the bank transfer Bank charges are the responsibility of the payee Accomodation HUSA ALICANTE Golf & Spa Hotel **** Av. de las Naciones, s/n Alicante España Tel.: (+034) Fax: (+034) hotelhusaalicante@husa.es Registration includes 3 overnights at the HUSA Hotel Reservation will be made for: one double room / single occupancy base including breakfast Please indicate if you require any additional overnight before or after the meeting Date of arrival Date of departure