Scientific Committee. Andrés Cervantes (ESMO, GEICO) Antonio González (ESMO, GEICO) Andrés Poveda (ESMO, GEICO) Jan B. Vermorken (ESMO, GEICO)

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1 Under the Auspices of Organized by 10th International Symposium Advanced Ovarian Cancer: Optimal Therapy. Update Valencia, Spain, 6th March 2015 Directors Andrés Poveda Fundación Instituto Valenciano de Oncología, Valencia, Spain Jan B. Vermorken Antwerp University Hospital, Edegem, Belgium

2 Scientific Committee Andrés Cervantes (ESMO, GEICO) Antonio González (ESMO, GEICO) Andrés Poveda (ESMO, GEICO) Jan B. Vermorken (ESMO, GEICO)

3 10th International Symposium Advanced Ovarian Cancer: Optimal Therapy. Update Valencia, Spain, 6th March :30-08:45 Welcome 08:45-09:25 Keynote Lecture: Progress in the treatment of ovarian cancer. Lessons from Homologous Recombination Deficiency Stanley B. Kaye, The Royal Marsden Hospital, Sutton, Surrey, United Kingdom SESSION - 1 CRITICAL ISSUES FOR FURTHER DEVELOPMENT IN OVARIAN CANCER Chairs: Douglas A. Levine, Memorial Sloan Kettering Cancer Center, New York (NY), USA Ignacio Romero, Fundación Instituto Valenciano de Oncología, Valencia, Spain 09:25-09:45 The molecular genetics of epithelial ovarian cancer Michael J. Birrer, Massachusetts General Hospital, Boston (MA), USA 09:45-10:05 Immunology Lana Kandalaft, Ludwig Institute for Cancer Research, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland 10:05-10:15 Discussion

4 SESSION - 2 INNOVATIONS IN THE APPROACH TO BORDERLINE TUMORS AND EPITHELIAL OVARIAN CANCER Chairs: Jonathan S. Berek, Sergi Martínez, Hospital Clínic Universitari, Barcelona, Spain 10:15-10:35 Molecular pathology of borderline tumors Anais Malpica, The University of Texas MD Anderson Cancer Center, Houston (TX), USA 10:35-10:55 Optimal approach to borderline tumors Andreas Du Bois, Kliniken Essen-Mitte, Essen, Germany 10:55-11:15 Molecular imaging in invasive ovarian carcinoma An Reyners, University Medical Center Groningen, Groningen, The Netherlands 11:15-11:35 Neoadjuvant chemotherapy in ovarian cancer revisited? Sven Mahner, University Medical Center Hamburg-Eppendorf, Hamburg, Germany 11:35-11:45 Discussion 11:45-12:15 Coffee break SESSION - 3 CLINICAL IMPACT OF TARGETED THERAPIES Chairs: Sandro Pignata, National Cancer Institute, Naples, Italy Andrés Poveda, Fundación Instituto Valenciano de Oncología, Valencia, Spain 12:15-12:35 Antiangiogenic agents Bradley J. Monk, St. Joseph s Hospital and Medical Center, Phoenix (AZ), USA 12:35-12:55 PARP inhibitors Jonathan A. Ledermann, University College London Cancer Institute, London, United Kingdom 12:55-13:15 Other targeted agents David R. Spriggs, Memorial Sloan Kettering Cancer Center, New York (NY), USA 13:15-13:30 Discussion 13:30-15:00 Lunch

5 SESSION - 4 DIFFERENTIATED APPROACH TO EPITHELIAL OVARIAN CANCER Chairs: Antonio González, MD Anderson Cancer Center, Madrid, Spain Isabelle Ray-Coquard, Centre Léon Berard, Lyon, France 15:00-15:20 Maintenance therapy in non-selected histotypes Jacobus Pfisterer, Gynecologic Oncology Center, Kiel, Germany 15:20-15:40 Low grade serous David M. Gershenson, The University of Texas MD Anderson Cancer Center, Houston (TX), USA 15:40-16:00 Clear cell tumors Keiichi Fujiwara, Saitama Medical University International Medical Center, Saitama, Japan 16:00-16:20 Mucinous tumors Timothy Perren, Leeds Institute of Cancer Medicine and Pathology, St James's University Hospital, Leeds, United Kingdom 16:20-16:30 Discussion 16:30-17:00 Coffee break SESSION - 5 STANDARD OF CARE OF OVARIAN CANCER IN 2015 Chairs: Andrés Cervantes, Hospital General Universitario, Va lencia, Spain Jan B. Vermorken, Antwerp University Hospital, Edeg em, Belgium 17:00-17:30 Primary disease Michael A. Bookman, University of Arizona Cancer Center, Tucson (AZ), USA 17:30-18:00 Recurrent disease Eric Pujade-Lauraine, Hôpital Hotel-Dieu, Paris, France 18:00-18:30 Patient reported outcomes in ovarian cancer clinical trials. Missed opportunities Michael Friedlander, The Prince of Wales Hospital, Randwick, Australia 18:30-18:45 Discussion 18:45-19:00 Remarks and conclusions Andrés Poveda, Fundación Instituto Valenciano de Oncología, Valencia, Spain

6 Venue Palau de la Música Iturbi Meeting Room Paseo de la Alameda, Valencia, Spain Language The official language of the symposium is English. Simultaneous translation into Spanish will be provided. Symposium secretariat

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