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1 Why choose the IVF Centers Prof. Zech for your fertility treatment?

2

3 The IVF Centers Prof. Zech are a leading group of private clinics in Europe that have committed themselves to excellence and aim at helping couples to realize their desire to have children. In order to assist you in conceiving a healthy child as early as the first treatment-cycle if possible, we perform at the highest level and use all reasonable means available while always giving priority to the safety and health of all persons involved in the process.

4 you should ask your fertility center ?Questions 1. Does the team of the center actually work 7 days a week? It is only if the entire team works at weekends, too, that you can actually provide a basis for an intended blastocyst culture and can therefore say Yes to this specific procedure. - Egg retrieval on Monday Transfer on Saturday - Egg retrieval on Tuesday Transfer on Sunday - Follicular punctures should also be possible at weekends and on public holidays 2. How many people are on the team? How many medical doctors and biologists are currently working at the center? Larger teams ensure a continuous high quality level and are able to provide optimum patient care during weekends and public holidays, too.

5 3. How experienced are the doctors and staff members at your chosen center? The long-term experience of the entire team is decisive for successfully performing blastocyst selection. 4. How many Elective Single Embryo Transfers have been performed so far? Does the team aim at avoiding the occurrence of multiple pregnancies by providing counseling with respect to Elective Single Embryo Transfer (safety for mother and child)? 5. Has the clinic implemented a certified quality management? In house quality manager Certifications Documentation software 6. Does the clinic perform the IMSI procedure correctly? Technically not a minimal version of it Do they use the best technical devices in accordance with the latest scientific findings? Did they establish a system to clearly classify the IMSI results? 7. Does the clinic apply a safe freezing technique Efficiency and safety, e.g. vitrification using VitriSafe Is the clinic in a position to perform cryopreservation at all stages of embryonic development incl. unfertilized ova? 5

6 8. Is the presence of a fetal heartbeat primarily decisive in order to classify a treatment as successful or is it sufficient to have a positive pregnancy test? Does the clinic keep track of the progress of each couple s pregnancy? Does the clinic collect data on birth and state of health of the children? 9. Does the clinic offer their staff members training programs? Do they continually and critically analyze new scientific evidence and consider and adopt such findings as treatment standards? Do they make it compulsory for their employees to take part in international conferences? Do their employees give lectures at international congresses? Do the employees regularly present their scientific papers to an expert audience? 10. Do they offer proper training for new staff members? Clearly structured training programs Personnel development as a living process Promoting cooperation, extending individual horizons and increasing flexibility Developing creative powers 6

7

8 Locations The IVF Centers Prof. Zech are a family-run group of fertility clinics headquartered in Bregenz (A). Austria Bregenz Salzburg Italy Merano Czech Republic Pilsen Switzerland Niederuzwil Liechtenstein Vaduz Partner institutes Nigeria Belgium 8

9 pilsen Germany Czech Republic bregenz niederuzwil Salzburg vaduz Switzerland merano Austria Italy 9

10 Services You are in good hands IVF Oocyte Activation ICSI Ultrasonic Folliculometry IMSI via 3D-imaging for PICSI exact volume count Blastocyst Selection Assisted Hatching (also by means of Spindle View time lapse analysis) In Vitro Maturation ISME-T Contract for IVF-Fund (A) Sperm Donation Egg Donation Cryopreservation (ova, pronuclei, embryos, blastocysts, semen) Pre-Implantation Diagnostics: PKD (PBD), PGD, PGS using FISH, PCR and CGH (e.g. 24Sure) for the diagnosis of aneuploidies, translocations, monogenetic diseases, HLA typing 10

11 Quality through size and experience > 120 Employees Experience > 25 medical doctors in the fields of reproductive medicine and genetics > 50 biologists and technical/scientific staff members 11

12 Experience = 10 Babies 12

13 To date, the IVF Centers Prof. Zech have assisted couples in realizing their dream by enabling the birth of more than babies. 13

14 The IVF Centers Prof. Zech aim to be the most renowned treatment provider with regard to fertility issues, an unfulfilled desire for a child and fertility preservation with the highest possible chance of an intact pregnancy and the birth of a healthy child. 14

15 15

16 Principles What matters most to us Well-being of patients The compassionate, individual care for patients makes a considerable contribution to our above average therapeutic success State-of-the-art medicine at the cutting edge of science The IVF Centers Prof. Zech have significantly contributed to the advancement of IVF techniques 16

17 Patient safety Patient safety is paramount Ethical principles are our first priority We strictly adhere to the respective national and international ethical and legal framework conditions Excellent team of employees Continuous medical, technical and scientific training are the best guarantee for satisfied patients 17

18 Differentiating features Always one step ahead Experience gained in many countries with different legal provisions Well above-average baby-take-home rate is documented Application of the most advanced IVF techniques Consistent standards Scientific work evidenced by the ongoing publication of papers in renowned journals International scientific networking and business partners Patents and technologies/technology platforms 18

19 Application of the most advanced IVF techniques Foundation of the IVF Centers as private clinics First systematically performed blastocyst culture and first vitrification using VitriSafe in Austria. First IVF unit world-wide to be awarded the ISO certification First Sono-AVC in Zech Center First successful ICSI in Austria 2007 The first to establish a standardized IMSI procedure To date... more than babies were born after fertility treatment at the IVF Centers Prof. Zech 6 clinics in 5 European countries thousands of ICSIs have already been successfully performed and more ICSI procedures are being added every day thousands of successfully realized IMSI procedures blastocyst culture including the selection of the best embryos for transfer and the vitrification technique are permanent features of our daily work the Sono AVC is currently used as routine procedure at all IVF Centers Prof. Zech 19

20 Differentiating features Documented well above-average baby-take-home rate Institutionalized national IVF register with mandatory reporting requirement ( Central evaluation of 3-D Sono AVC results for the optimal selection of follicles Optimum realization of blastocyst cultures since 1997 Consistent standards 1997: The worldwide first DIN ISO 9001 certified IVF center Successful implementation of all the requirements in accordance with the EU Directive 2004/23 at all IVF Centers Prof. Zech Intracytoplasmic morphologically selected sperm injection (IMSI) Pre-implantation diagnostics: PKD (PBD)/PGD/PGS (co-development of new technologies through co-operations and partnering) using FISH, PCR and CGH (e.g. 24Sure) for the diagnosis of aneuploidies, translocations, monogenetic diseases and HLA typing In house development and application of the Dynamed software ( Job-rotation and continuous further training within the IVF Centers Prof. Zech In house and external ring trials Regular training and lectures via video conferences All centers are subject to a central quality management Individual care for our patients plays a key role at all our centers Mandatory participation of employees in congresses and conferences (incl. subsequent reporting) 20

21 Networking International scientific networking and business partners Research Scientific work evidenced by the ongoing publication of papers in renowned journals 21

22 22 Left picture: City of Salzburg [photo Tourismus Salzburg] Upper picture: IVF Centers Prof. Zech Bregenz (A) Bottom picture: IVF Centers Prof. Zech Pilsen (CZ)

23 We are at your disposal throughout Europe IVF Centers Prof. Zech Bregenz Römerstrasse 2 A-6900 Bregenz Tel Fax Web: IVF Centers Prof. Zech Merano Mühlgraben 9 Fossato Mollini I Merano Tel Fax Web: IVF Centers Prof. Zech Niederuzwil Bahnhofstrasse 123a CH-9244 Niederuzwil Tel Fax Web: Addresses IVF Centers Prof. Zech Salzburg Innsbrucker Bundesstr. 35 A-5020 Salzburg Tel Fax Web: IVF Centers Prof. Zech Pilsen B. Smetany 2 CZ Pilsen Tel Fax Web: IVF Centers Prof. Zech Vaduz Zollstrasse 34 LI-9490 Vaduz Tel Web: 23

24 It is not just a feeling it is the facts that speak in favor of our centers!

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