UC CAI University of California Center for Accelerated Innovation
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1 UC CAI University f Califrnia Center fr Accelerated Innvatin Technlgy Cmmercializatin - First Steps September 11, 2014 Stephen F. Flaim, Ph.D., FACC, FAHA Senir Special Advisr, NHLBI Office f Translatinal Alliances & Crdinatin flaimsf@nhlbi.nih.gv
2 Speaker Backgrund Cardivascular physilgist UC Davis Academia Medicine & Physilgy, PSU Sch f Med Industry J&J, Squibb, Alliance, Trega, Galile Advisr vn Liebig Center, UCSD Investr Tech Cast Angels Entrepreneur - CardiCreate, OncFlur NHLBI Advisr t the Office f Translatinal Alliances & Crdinatin (OTAC) & the NCAI OTAC Cntact Pint: nhlbi_sbir@mail.gv
3 Agenda 1. Assessing Technlgy Readiness 2. Picking Technlgies at the Crrect Level f Readiness 3. Imprtant Interactins a. Campus Technlgy Transfer Offices and Others 4. License the Technlgy r Frm a Start-up
4 Assessing Technlgy Readiness General Criteria Nvel technlgy Prtectable (IP) Gd team Attractive market t partner/investr Maximum $200,000 (Fed $) + additinal $ (Center) Maximum 2 years in Center Exit Center after 2 years
5 Technlgy Exit Definitin f Exit at 2 years License t existing cmmercial entity License t start-up frmed t cmmercialize technlgy Attracts supprt fr additinal wrk (e.g. clinical trial) Returned t the institutin
6 Assessing Technlgy Readiness Technlgy Status Degree f Maturity LOW HIGH Hypthesis testing Basic research n the effect Basic effect bserved/cnfirmed (in vitr r in viv) Pre-clinical POC in prcess/cmplete General safety assessment cmpleted IND/IDE enabling studies underway/cmpleted Clinical testing initiated Clinical benefit/safety established
7 Assessing Technlgy Readiness Intellectual Prperty Status Degree f Maturity LOW HIGH Technlgy presented r published IP plan established (n prir public disclsure) Disclsure filed with Tech Transfer Office (TTO) Prvisinal patent(s) filed (US) Infrmal freedm-t-perate (FTO) cmplete Full patent(s) filed (US) Internatinal patent(s) filings initiated Frmal FTO cmplete US patent(s) issued/published Internatinal patent(s) issued/published
8 Assessing Technlgy Readiness Cmmercial Status Degree f Maturity LOW HIGH Slutin lking fr a prblem Multiple ptential applicatins defined Platfrm technlgy with multiple applicatins Target applicatins being discussed First cmmercial applicatin defined Custmer tractin btained Cmpetitive landscape defined G-t-market plan in develpment Business plan in develpment Investr/licensr term-sheet in play Frming a start-up t acquire technlgy
9 Picking Technlgies Technlgy Status Degree f Maturity LOW HIGH Hypthesis testing Basic research n the effect Basic effect bserved/cnfirmed (in vitr r in viv) Pre-clinical POC in prcess/cmplete General safety assessment cmpleted IND/IDE enabling studies underway/cmpleted Clinical testing initiated Clinical benefit/safety established
10 Picking Technlgies Intellectual Prperty Status Degree f Maturity LOW HIGH Technlgy presented r published IP plan established (n prir public disclsure) Disclsure filed with Tech Transfer Office (TTO) Prvisinal patent(s) filed (US) Infrmal freedm-t-perate (FTO) cmplete Full patent(s) filed (US) Internatinal patent(s) filings initiated Frmal FTO cmplete US patent(s) issued/published Internatinal patent(s) issued/published
11 Picking Technlgies Cmmercial Status Degree f Maturity LOW HIGH Slutin lking fr a prblem Multiple ptential applicatins defined Platfrm technlgy with multiple applicatins Target applicatins being discussed First cmmercial applicatin defined Custmer tractin btained Cmpetitive landscape defined G-t-market plan in develpment Business plan in develpment Investr/licensr term-sheet in play Frming a start-up t acquire technlgy
12 Eligible Prjects Ideal Team Technlgy lead Prfessr/Faculty/Pstdctral fellw Graduate/Undergraduate student Cmmercial/business lead Experienced entrepreneur B Schl ex-mba student Mentr/Advisr/Ptential Investr Tech Transfer Officer
13 Imprtant Interactins Campus Tech Transfer Office (TTO) Meet yur Tech Transfer Officer establish rapprt Yur TT Officer is yur partner Learn hw t create/file a disclsure File disclsure with TTO befre presenting r publishing Wrk with yur TT Officer t set patent claims and scpe Technlgy valuatin discussin Highest valuatin sught by wner f the technlgy Lwest valuatin sught by licensee f the technlgy
14 Pints f Discussin Understand Wh wns the technlgy? Institutin - Faculty, staff, pstdc, graduate student Undergraduate student Technlgy valuatin Highest valuatin sught by wner f the technlgy Lwest valuatin sught by licensee f the technlgy Ding a start-up? Yu are the licensee
15 Imprtant Interactins Cmmercial/Business Lead Defining the technlgy is nly half the battle Mst innvatr/technlgists lack business skills Cmpetitive landscape Target market Custmer base G-t-market strategy Overall business plan preparatin Investrs avid technlgist-led prjects Engage early with a cmmercial/business lead
16 Imprtant Interactins Mentr/Advisr/Ptential Investr Experienced (retired?) executive Been there dne that Seeking t pay back Lking fr a way t engage/stay active Angel investr interested in University technlgies Help with team frmatin Team mentr/advisr Extensive supprt/investr netwrk in the cmmunity Engage a mentr early in the prject
17 License the Technlgy vs. Frming a Start-Up Pints t Cnsider Institutin wns the IP Institutin wants t license Yu are part f the Institutin Institutin will ask fr yur help Set value f IP Determine fields f applicatin Define the patent claims
18 License the Technlgy vs. Frming a Start-Up Rle f Scientist/Innvatr in a Start-up Maintaining yur academic status? Cannt be cmpany emplyee r fficer Cnsulting time usually allwed Best rle Funder & Chair f Science Advisry Bard Ding a start-up but n real business experience? Dn t try t learn n the jb Bring in an experienced CEO Becme Chief Technlgy Officer
19 License the Technlgy vs. Frming a Start-Up Key Questins fr the Scientist/Innvatr Are yu ready t leave academia? Pstdc ready t g full-time int a start-up? D yu have passin fr the technlgy? Is there an experienced business lead/ceo? Mst investrs avid start-ups led by scientist/innvatr D yu have legal cunsel? Crprate law - cmpany frmatin Transactin law license negtiatins with the institutin IP law - maintenance/develpment f IP D yu have investr interest/tractin?
20 License the Technlgy vs. Frming a Start-Up Missing key cmpnents fr a start-up? License may be the crrect path frward Seek t d what s best fr the prduct!
21 UC CAI University f Califrnia Center fr Accelerated Innvatin Questins? Stephen F. Flaim, Ph.D., FACC, FAHA Senir Special Advisr, NHLBI Office f Translatinal Alliances & Crdinatin flaimsf@nhlbi.nih.gv
22 Finding/Engaging a Business Lead Business Schl - Executive MBA prgram Experienced scientists with full-time jbs Seeking t gain business skills/becme entrepreneurs Night and weekend classes Lab-t-Market Class Need t develp cmmercial aspects f a technlgy prject Respect fr their business expertise These are nt students They add significant value t the prject May be yur first CEO Prepare t prvide sme incentive beynd the class wrk
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